2Q2ZA

Crystal structure of ksp in complex with inhibitor 22
Total Genus 93
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
93
sequence length
345
structure length
330
Chain Sequence
NIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Kinesin spindle protein (KSP) inhibitors. Part 8: Design and synthesis of 1,4-diaryl-4,5-dihydropyrazoles as potent inhibitors of the mitotic kinesin KSP.
pubmed doi rcsb
molecule tags Cell cycle
source organism Homo sapiens
molecule keywords Kinesin-like protein KIF11
total genus 93
structure length 330
sequence length 345
chains with identical sequence B
ec nomenclature
pdb deposition date 2007-05-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 2q2zA00
1F9WA 3KARA 4ZHIA 4GKRA 3ZCWA 2VB6A 2X7DA 2Y5WA 1VFVA 2ZFLA 4E7SA 1LKXA 5LT2A 4PJMA 1MNEA 1MMGA 4PK4A 4PFPA 2FMEA 4DBRA 2ZFKA 1VOMA 2OWMA 1I6IA 1MMNA 2XT3A 1D0XA 3K3BA 4E7ZA 1FMVA 3LREA 1VFZA 1BG2A 2X2RA 1X88A 1CZ7A 2X7CA 1FMWA 1YRSA 2FL2A 4A5YA 4ANJA 3CJOA 1KK7A 4ETPA 3DC4A 1MMDA 4PJJA 2FKYA 3T0QA 4BBGA 5LT4A 1II6A 1SDMA 4HNAK 1GOJA 1LVKA 1F9UA 2Q2ZA 1D1AA 2UYIA 4Y05A 1MMAA 2Q2YA 1D0YA 2ZFJA 3K5EA 3HQDA 4A28A 2PG2A 3CNZA 3X2TA 1Q0BA 3B6UA 4A14A 4A51A 1T5CA 4DBQA 5LT1A 3DCBA 4AS7A 3KENA 1BR2A 2GRYA 4BXNA 3ZFCA 4B7BA 4AP0A 2UYMA 1D1BA 4PFOA 2MYSA 2Y65A 4A1ZA 1V8JA 4LNUK 2GM1A 1BR1A 3NWNA 5LT0A 1VFWA 4PJLA 5LT3A 1V8KA 3ZFDA 4FRZA 1D1CA 1G8XA 1D0ZA 2VASA 3B6VA 1MKJA 2IEHA 3H4SA 1F9TA 4A50A 3L1CA 1I5SA 3COBA 4UBFA 3BFNA 3WPNA 2VVGA 2ZFIA 3L9HA 2XAEA 1F9VA 2V26A 3PXNA 4PJNA 1VFXA 1N6MA 2X7EA 4H1GA 3WRDA 3KINA 2ZFMA 2G1QA 2HEHA 2WOGA 4BN2A 5GSZA 4ZCAA 2FL6A 1BR4A 5HLEA 2X51A 1RY6A 3U06A 2NCDA 3GBJA 2KINA
chains in the Genus database with same CATH superfamily
1F9WA 2O0AA 3KARA 4GKRA 4ZHIA 3ZCWA 2VB6A 2X7DA 2Y5WA 1VFVA 2ZFLA 4E7SA 1LKXA 5LT2A 4PJMA 1MNEA 1MMGA 4PK4A 4PFPA 4GKPA 2FMEA 4DBRA 2ZFKA 1VOMA 2OWMA 1I6IA 1MMNA 2XT3A 1D0XA 3K3BA 4E7ZA 1FMVA 3LREA 1VFZA 1BG2A 2X2RA 1X88A 1CZ7A 2X7CA 1FMWA 1YRSA 2FL2A 4A5YA 4ANJA 3CJOA 1KK7A 4ETPA 3DC4A 1MMDA 4PJJA 2FKYA 3T0QA 4BBGA 5LT4A 1II6A 1SDMA 4HNAK 1GOJA 1LVKA 1F9UA 2Q2ZA 1D1AA 4ETPB 2UYIA 4Y05A 1MMAA 2Q2YA 1D0YA 2ZFJA 3K5EA 3HQDA 4A28A 2PG2A 3CNZA 3X2TA 1Q0BA 3B6UA 4A14A 4A51A 1T5CA 4DBQA 5LT1A 3DCBA 4AS7A 3KENA 1BR2A 2GRYA 4BXNA 3ZFCA 4B7BA 4AP0A 2UYMA 1D1BA 4PFOA 2MYSA 2Y65A 4A1ZA 1V8JA 4LNUK 2GM1A 1BR1A 3NWNA 5LT0A 1VFWA 4PJLA 5LT3A 1V8KA 3ZFDA 4FRZA 1D1CA 1G8XA 1D0ZA 2VASA 3B6VA 1MKJA 2IEHA 3H4SA 4GKQA 1F9TA 4A50A 3L1CA 1I5SA 3COBA 4UBFA 3BFNA 3WPNA 2VVGA 2ZFIA 3L9HA 2XAEA 1F9VA 2V26A 3PXNA 4PJNA 1VFXA 1N6MA 2X7EA 4H1GA 3WRDA 3KINA 2ZFMA 2G1QA 2HEHA 2WOGA 4BN2A 5GSZA 4ZCAA 2FL6A 1BR4A 5HLEA 2X51A 1RY6A 3U06A 2NCDA 3GBJA 2KINA
chains in the Genus database with same CATH topology
1F9WA 3KARA 4ZHIA 4GKRA 3ZCWA 2VB6A 2X7DA 2Y5WA 1VFVA 2ZFLA 4E7SA 1LKXA 5LT2A 4PJMA 1MNEA 1MMGA 4PK4A 4PFPA 2FMEA 4DBRA 2ZFKA 1VOMA 2OWMA 1I6IA 1MMNA 2XT3A 1D0XA 3K3BA 4E7ZA 1FMVA 3LREA 1VFZA 1BG2A 2X2RA 1X88A 1CZ7A 2X7CA 1FMWA 1YRSA 2FL2A 4A5YA 4ANJA 3CJOA 1KK7A 4ETPA 3DC4A 1MMDA 4PJJA 2FKYA 3T0QA 4BBGA 5LT4A 1II6A 1SDMA 4HNAK 1GOJA 1LVKA 1F9UA 2Q2ZA 1D1AA 2UYIA 4Y05A 1MMAA 2Q2YA 1D0YA 2ZFJA 3K5EA 3HQDA 4A28A 2PG2A 3CNZA 3X2TA 1Q0BA 3B6UA 4A14A 4A51A 1T5CA 4DBQA 5LT1A 3DCBA 4AS7A 3KENA 1BR2A 2GRYA 4BXNA 3ZFCA 4B7BA 4AP0A 2UYMA 1D1BA 4PFOA 2MYSA 2Y65A 4A1ZA 1V8JA 4LNUK 2GM1A 1BR1A 3NWNA 5LT0A 1VFWA 4PJLA 5LT3A 1V8KA 3ZFDA 4FRZA 1D1CA 1G8XA 1D0ZA 2VASA 3B6VA 1MKJA 2IEHA 3H4SA 1F9TA 4A50A 3L1CA 1I5SA 3COBA 4UBFA 3BFNA 3WPNA 2VVGA 2ZFIA 3L9HA 2XAEA 1F9VA 2V26A 3PXNA 4PJNA 1VFXA 1N6MA 2X7EA 4H1GA 3WRDA 3KINA 2ZFMA 2G1QA 2HEHA 2WOGA 4BN2A 5GSZA 4ZCAA 2FL6A 1BR4A 5HLEA 2X51A 1RY6A 3U06A 2NCDA 3GBJA 2KINA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1F9W A;  3KAR A;  4ZHI A;  4GKR A;  3ZCW A;  2VB6 A;  2X7D A;  2Y5W A;  1VFV A;  2ZFL A;  4E7S A;  1LKX A;  5LT2 A;  4PJM A;  1MNE A;  1MMG A;  4PK4 A;  4PFP A;  2FME A;  4DBR A;  2ZFK A;  1VOM A;  2OWM A;  1I6I A;  1MMN A;  2XT3 A;  1D0X A;  3K3B A;  4E7Z A;  1FMV A;  3LRE A;  1VFZ A;  1BG2 A;  2X2R A;  1X88 A;  1CZ7 A;  2X7C A;  1FMW A;  1YRS A;  2FL2 A;  4A5Y A;  4ANJ A;  3CJO A;  1KK7 A;  4ETP A;  3DC4 A;  1MMD A;  4PJJ A;  2FKY A;  3T0Q A;  4BBG A;  5LT4 A;  1II6 A;  1SDM A;  4HNA K;  1GOJ A;  1LVK A;  1F9U A;  2Q2Z A;  1D1A A;  2UYI A;  4Y05 A;  1MMA A;  2Q2Y A;  1D0Y A;  2ZFJ A;  3K5E A;  3HQD A;  4A28 A;  2PG2 A;  3CNZ A;  3X2T A;  1Q0B A;  3B6U A;  4A14 A;  4A51 A;  1T5C A;  4DBQ A;  5LT1 A;  3DCB A;  4AS7 A;  3KEN A;  1BR2 A;  2GRY A;  4BXN A;  3ZFC A;  4B7B A;  4AP0 A;  2UYM A;  1D1B A;  4PFO A;  2MYS A;  2Y65 A;  4A1Z A;  1V8J A;  4LNU K;  2GM1 A;  1BR1 A;  3NWN A;  5LT0 A;  1VFW A;  4PJL A;  5LT3 A;  1V8K A;  3ZFD A;  4FRZ A;  1D1C A;  1G8X A;  1D0Z A;  2VAS A;  3B6V A;  1MKJ A;  2IEH A;  3H4S A;  1F9T A;  4A50 A;  3L1C A;  1I5S A;  3COB A;  4UBF A;  3BFN A;  3WPN A;  2VVG A;  2ZFI A;  3L9H A;  2XAE A;  1F9V A;  2V26 A;  3PXN A;  4PJN A;  1VFX A;  1N6M A;  2X7E A;  4H1G A;  3WRD A;  3KIN A;  2ZFM A;  2G1Q A;  2HEH A;  2WOG A;  4BN2 A;  5GSZ A;  4ZCA A;  2FL6 A;  1BR4 A;  5HLE A;  2X51 A;  1RY6 A;  3U06 A;  2NCD A;  3GBJ A;  2KIN A; 
#chains in the Genus database with same CATH topology
 1F9W A;  2O0A A;  3KAR A;  4GKR A;  4ZHI A;  3ZCW A;  2VB6 A;  2X7D A;  2Y5W A;  1VFV A;  2ZFL A;  4E7S A;  1LKX A;  5LT2 A;  4PJM A;  1MNE A;  1MMG A;  4PK4 A;  4PFP A;  4GKP A;  2FME A;  4DBR A;  2ZFK A;  1VOM A;  2OWM A;  1I6I A;  1MMN A;  2XT3 A;  1D0X A;  3K3B A;  4E7Z A;  1FMV A;  3LRE A;  1VFZ A;  1BG2 A;  2X2R A;  1X88 A;  1CZ7 A;  2X7C A;  1FMW A;  1YRS A;  2FL2 A;  4A5Y A;  4ANJ A;  3CJO A;  1KK7 A;  4ETP A;  3DC4 A;  1MMD A;  4PJJ A;  2FKY A;  3T0Q A;  4BBG A;  5LT4 A;  1II6 A;  1SDM A;  4HNA K;  1GOJ A;  1LVK A;  1F9U A;  2Q2Z A;  1D1A A;  4ETP B;  2UYI A;  4Y05 A;  1MMA A;  2Q2Y A;  1D0Y A;  2ZFJ A;  3K5E A;  3HQD A;  4A28 A;  2PG2 A;  3CNZ A;  3X2T A;  1Q0B A;  3B6U A;  4A14 A;  4A51 A;  1T5C A;  4DBQ A;  5LT1 A;  3DCB A;  4AS7 A;  3KEN A;  1BR2 A;  2GRY A;  4BXN A;  3ZFC A;  4B7B A;  4AP0 A;  2UYM A;  1D1B A;  4PFO A;  2MYS A;  2Y65 A;  4A1Z A;  1V8J A;  4LNU K;  2GM1 A;  1BR1 A;  3NWN A;  5LT0 A;  1VFW A;  4PJL A;  5LT3 A;  1V8K A;  3ZFD A;  4FRZ A;  1D1C A;  1G8X A;  1D0Z A;  2VAS A;  3B6V A;  1MKJ A;  2IEH A;  3H4S A;  4GKQ A;  1F9T A;  4A50 A;  3L1C A;  1I5S A;  3COB A;  4UBF A;  3BFN A;  3WPN A;  2VVG A;  2ZFI A;  3L9H A;  2XAE A;  1F9V A;  2V26 A;  3PXN A;  4PJN A;  1VFX A;  1N6M A;  2X7E A;  4H1G A;  3WRD A;  3KIN A;  2ZFM A;  2G1Q A;  2HEH A;  2WOG A;  4BN2 A;  5GSZ A;  4ZCA A;  2FL6 A;  1BR4 A;  5HLE A;  2X51 A;  1RY6 A;  3U06 A;  2NCD A;  3GBJ A;  2KIN A; 
#chains in the Genus database with same CATH homology
 1F9W A;  3KAR A;  4ZHI A;  4GKR A;  3ZCW A;  2VB6 A;  2X7D A;  2Y5W A;  1VFV A;  2ZFL A;  4E7S A;  1LKX A;  5LT2 A;  4PJM A;  1MNE A;  1MMG A;  4PK4 A;  4PFP A;  2FME A;  4DBR A;  2ZFK A;  1VOM A;  2OWM A;  1I6I A;  1MMN A;  2XT3 A;  1D0X A;  3K3B A;  4E7Z A;  1FMV A;  3LRE A;  1VFZ A;  1BG2 A;  2X2R A;  1X88 A;  1CZ7 A;  2X7C A;  1FMW A;  1YRS A;  2FL2 A;  4A5Y A;  4ANJ A;  3CJO A;  1KK7 A;  4ETP A;  3DC4 A;  1MMD A;  4PJJ A;  2FKY A;  3T0Q A;  4BBG A;  5LT4 A;  1II6 A;  1SDM A;  4HNA K;  1GOJ A;  1LVK A;  1F9U A;  2Q2Z A;  1D1A A;  2UYI A;  4Y05 A;  1MMA A;  2Q2Y A;  1D0Y A;  2ZFJ A;  3K5E A;  3HQD A;  4A28 A;  2PG2 A;  3CNZ A;  3X2T A;  1Q0B A;  3B6U A;  4A14 A;  4A51 A;  1T5C A;  4DBQ A;  5LT1 A;  3DCB A;  4AS7 A;  3KEN A;  1BR2 A;  2GRY A;  4BXN A;  3ZFC A;  4B7B A;  4AP0 A;  2UYM A;  1D1B A;  4PFO A;  2MYS A;  2Y65 A;  4A1Z A;  1V8J A;  4LNU K;  2GM1 A;  1BR1 A;  3NWN A;  5LT0 A;  1VFW A;  4PJL A;  5LT3 A;  1V8K A;  3ZFD A;  4FRZ A;  1D1C A;  1G8X A;  1D0Z A;  2VAS A;  3B6V A;  1MKJ A;  2IEH A;  3H4S A;  1F9T A;  4A50 A;  3L1C A;  1I5S A;  3COB A;  4UBF A;  3BFN A;  3WPN A;  2VVG A;  2ZFI A;  3L9H A;  2XAE A;  1F9V A;  2V26 A;  3PXN A;  4PJN A;  1VFX A;  1N6M A;  2X7E A;  4H1G A;  3WRD A;  3KIN A;  2ZFM A;  2G1Q A;  2HEH A;  2WOG A;  4BN2 A;  5GSZ A;  4ZCA A;  2FL6 A;  1BR4 A;  5HLE A;  2X51 A;  1RY6 A;  3U06 A;  2NCD A;  3GBJ A;  2KIN A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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