2Q2ZA

Crystal structure of ksp in complex with inhibitor 22
Total Genus 93
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
93
sequence length
345
structure length
330
Chain Sequence
b'NIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNK'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Kinesin-like protein KIF11
publication title Kinesin spindle protein (KSP) inhibitors. Part 8: Design and synthesis of 1,4-diaryl-4,5-dihydropyrazoles as potent inhibitors of the mitotic kinesin KSP.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Cell cycle
total genus 93
structure length 330
sequence length 345
chains with identical sequence B
ec nomenclature
pdb deposition date 2007-05-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 2q2zA00
1MMAA 3ZFCA 3U06A 3ZFDA 2OWMA 1V8KA 4ZHIA 3LREA 1KK7A 2X7EA 3PXNA 1F9WA 2PG2A 1D1AA 4A50A 1LVKA 4PJMA 4FRZA 2VB6A 1VFVA 5LT0A 2X7DA 2Q2ZA 4H1GA 4A5YA 4PJNA 4GKRA 3B6UA 2HEHA 1YRSA 3K5EA 1VFZA 4A28A 4DBQA 5GSZA 3WPNA 2ZFIA 4LNUK 1FMVA 2Q2YA 2FL2A 1SDMA 2ZFMA 1F9TA 1D1CA 1II6A 3KINA 5LT2A 2FKYA 1Q0BA 1N6MA 3DC4A 3L1CA 4A51A 2NCDA 2KINA 3X2TA 3WRDA 2V26A 2ZFLA 3T0QA 1D0YA 3DCBA 1GOJA 4E7ZA 2XAEA 3ZCWA 5LT1A 4A1ZA 2GRYA 4PK4A 2FMEA 2MYSA 2ZFKA 4A14A 4BN2A 3KENA 3CJOA 1BR1A 1X88A 1FMWA 4BBGA 3KARA 1BR2A 3BFNA 4PFPA 2X7CA 4ANJA 1MMDA 4HNAK 2X51A 1F9VA 2FL6A 2VVGA 1I5SA 3H4SA 2Y65A 4ZCAA 1VFWA 1D0ZA 4BXNA 1CZ7A 2Y5WA 5LT3A 4PJJA 1G8XA 1I6IA 4PFOA 1F9UA 1MKJA 2UYIA 2XT3A 1MMGA 3HQDA 4AS7A 1T5CA 5HLEA 5LT4A 4DBRA 1D0XA 1RY6A 4UBFA 3GBJA 4E7SA 4PJLA 2G1QA 2WOGA 4Y05A 2IEHA 1D1BA 1VOMA 4AP0A 1MMNA 3K3BA 3CNZA 4ETPA 2UYMA 3L9HA 1MNEA 1VFXA 2ZFJA 1BG2A 2X2RA 1BR4A 4B7BA 2VASA 3NWNA 3COBA 1LKXA 2GM1A 3B6VA 1V8JA
chains in the Genus database with same CATH superfamily
1MMAA 3ZFCA 3U06A 3ZFDA 2OWMA 1V8KA 4ZHIA 3LREA 1KK7A 2X7EA 3PXNA 1F9WA 2PG2A 1D1AA 4A50A 1LVKA 4PJMA 4FRZA 2VB6A 1VFVA 5LT0A 2X7DA 2Q2ZA 4H1GA 4A5YA 4PJNA 4GKRA 3B6UA 2HEHA 1YRSA 3K5EA 1VFZA 4GKQA 4A28A 4DBQA 3WPNA 5GSZA 2ZFIA 4LNUK 1FMVA 2Q2YA 2FL2A 1SDMA 2O0AA 2ZFMA 1F9TA 1D1CA 1II6A 3KINA 5LT2A 2FKYA 1Q0BA 1N6MA 3DC4A 3L1CA 4A51A 2NCDA 2KINA 3X2TA 3WRDA 2V26A 2ZFLA 3T0QA 1D0YA 4ETPB 3DCBA 1GOJA 4E7ZA 2XAEA 3ZCWA 5LT1A 4A1ZA 4GKPA 2GRYA 4PK4A 2FMEA 2MYSA 2ZFKA 4A14A 4BN2A 3KENA 3CJOA 1BR1A 1X88A 1FMWA 4BBGA 3KARA 1BR2A 3BFNA 4PFPA 2X7CA 4ANJA 1MMDA 4HNAK 2X51A 1F9VA 2FL6A 2VVGA 1I5SA 3H4SA 2Y65A 4ZCAA 1VFWA 1D0ZA 4BXNA 1CZ7A 2Y5WA 5LT3A 4PJJA 1G8XA 1I6IA 4PFOA 1F9UA 1MKJA 2UYIA 2XT3A 1MMGA 3HQDA 4AS7A 1T5CA 5HLEA 5LT4A 4DBRA 1D0XA 1RY6A 4UBFA 3GBJA 4E7SA 4PJLA 2G1QA 2WOGA 4Y05A 2IEHA 1D1BA 1VOMA 4AP0A 1MMNA 3K3BA 3CNZA 4ETPA 2UYMA 3L9HA 1MNEA 1VFXA 2ZFJA 1BG2A 2X2RA 1BR4A 4B7BA 2VASA 3NWNA 3COBA 1LKXA 2GM1A 3B6VA 1V8JA
chains in the Genus database with same CATH topology
1MMAA 3ZFCA 3U06A 3ZFDA 2OWMA 1V8KA 4ZHIA 3LREA 1KK7A 2X7EA 3PXNA 1F9WA 2PG2A 1D1AA 4A50A 1LVKA 4PJMA 4FRZA 2VB6A 1VFVA 5LT0A 2X7DA 2Q2ZA 4H1GA 4A5YA 4PJNA 4GKRA 3B6UA 2HEHA 1YRSA 3K5EA 1VFZA 4A28A 4DBQA 5GSZA 3WPNA 2ZFIA 4LNUK 1FMVA 2Q2YA 2FL2A 1SDMA 2ZFMA 1F9TA 1D1CA 1II6A 3KINA 5LT2A 2FKYA 1Q0BA 1N6MA 3DC4A 3L1CA 4A51A 2NCDA 2KINA 3X2TA 3WRDA 2V26A 2ZFLA 3T0QA 1D0YA 3DCBA 1GOJA 4E7ZA 2XAEA 3ZCWA 5LT1A 4A1ZA 2GRYA 4PK4A 2FMEA 2MYSA 2ZFKA 4A14A 4BN2A 3KENA 3CJOA 1BR1A 1X88A 1FMWA 4BBGA 3KARA 1BR2A 3BFNA 4PFPA 2X7CA 4ANJA 1MMDA 4HNAK 2X51A 1F9VA 2FL6A 2VVGA 1I5SA 3H4SA 2Y65A 4ZCAA 1VFWA 1D0ZA 4BXNA 1CZ7A 2Y5WA 5LT3A 4PJJA 1G8XA 1I6IA 4PFOA 1F9UA 1MKJA 2UYIA 2XT3A 1MMGA 3HQDA 4AS7A 1T5CA 5HLEA 5LT4A 4DBRA 1D0XA 1RY6A 4UBFA 3GBJA 4E7SA 4PJLA 2G1QA 2WOGA 4Y05A 2IEHA 1D1BA 1VOMA 4AP0A 1MMNA 3K3BA 3CNZA 4ETPA 2UYMA 3L9HA 1MNEA 1VFXA 2ZFJA 1BG2A 2X2RA 1BR4A 4B7BA 2VASA 3NWNA 3COBA 1LKXA 2GM1A 3B6VA 1V8JA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1MMA A;  3ZFC A;  3U06 A;  3ZFD A;  2OWM A;  1V8K A;  4ZHI A;  3LRE A;  1KK7 A;  2X7E A;  3PXN A;  1F9W A;  2PG2 A;  1D1A A;  4A50 A;  1LVK A;  4PJM A;  4FRZ A;  2VB6 A;  1VFV A;  5LT0 A;  2X7D A;  2Q2Z A;  4H1G A;  4A5Y A;  4PJN A;  4GKR A;  3B6U A;  2HEH A;  1YRS A;  3K5E A;  1VFZ A;  4A28 A;  4DBQ A;  5GSZ A;  3WPN A;  2ZFI A;  4LNU K;  1FMV A;  2Q2Y A;  2FL2 A;  1SDM A;  2ZFM A;  1F9T A;  1D1C A;  1II6 A;  3KIN A;  5LT2 A;  2FKY A;  1Q0B A;  1N6M A;  3DC4 A;  3L1C A;  4A51 A;  2NCD A;  2KIN A;  3X2T A;  3WRD A;  2V26 A;  2ZFL A;  3T0Q A;  1D0Y A;  3DCB A;  1GOJ A;  4E7Z A;  2XAE A;  3ZCW A;  5LT1 A;  4A1Z A;  2GRY A;  4PK4 A;  2FME A;  2MYS A;  2ZFK A;  4A14 A;  4BN2 A;  3KEN A;  3CJO A;  1BR1 A;  1X88 A;  1FMW A;  4BBG A;  3KAR A;  1BR2 A;  3BFN A;  4PFP A;  2X7C A;  4ANJ A;  1MMD A;  4HNA K;  2X51 A;  1F9V A;  2FL6 A;  2VVG A;  1I5S A;  3H4S A;  2Y65 A;  4ZCA A;  1VFW A;  1D0Z A;  4BXN A;  1CZ7 A;  2Y5W A;  5LT3 A;  4PJJ A;  1G8X A;  1I6I A;  4PFO A;  1F9U A;  1MKJ A;  2UYI A;  2XT3 A;  1MMG A;  3HQD A;  4AS7 A;  1T5C A;  5HLE A;  5LT4 A;  4DBR A;  1D0X A;  1RY6 A;  4UBF A;  3GBJ A;  4E7S A;  4PJL A;  2G1Q A;  2WOG A;  4Y05 A;  2IEH A;  1D1B A;  1VOM A;  4AP0 A;  1MMN A;  3K3B A;  3CNZ A;  4ETP A;  2UYM A;  3L9H A;  1MNE A;  1VFX A;  2ZFJ A;  1BG2 A;  2X2R A;  1BR4 A;  4B7B A;  2VAS A;  3NWN A;  3COB A;  1LKX A;  2GM1 A;  3B6V A;  1V8J A; 
#chains in the Genus database with same CATH topology
 1MMA A;  3ZFC A;  3U06 A;  3ZFD A;  2OWM A;  1V8K A;  4ZHI A;  3LRE A;  1KK7 A;  2X7E A;  3PXN A;  1F9W A;  2PG2 A;  1D1A A;  4A50 A;  1LVK A;  4PJM A;  4FRZ A;  2VB6 A;  1VFV A;  5LT0 A;  2X7D A;  2Q2Z A;  4H1G A;  4A5Y A;  4PJN A;  4GKR A;  3B6U A;  2HEH A;  1YRS A;  3K5E A;  1VFZ A;  4GKQ A;  4A28 A;  4DBQ A;  3WPN A;  5GSZ A;  2ZFI A;  4LNU K;  1FMV A;  2Q2Y A;  2FL2 A;  1SDM A;  2O0A A;  2ZFM A;  1F9T A;  1D1C A;  1II6 A;  3KIN A;  5LT2 A;  2FKY A;  1Q0B A;  1N6M A;  3DC4 A;  3L1C A;  4A51 A;  2NCD A;  2KIN A;  3X2T A;  3WRD A;  2V26 A;  2ZFL A;  3T0Q A;  1D0Y A;  4ETP B;  3DCB A;  1GOJ A;  4E7Z A;  2XAE A;  3ZCW A;  5LT1 A;  4A1Z A;  4GKP A;  2GRY A;  4PK4 A;  2FME A;  2MYS A;  2ZFK A;  4A14 A;  4BN2 A;  3KEN A;  3CJO A;  1BR1 A;  1X88 A;  1FMW A;  4BBG A;  3KAR A;  1BR2 A;  3BFN A;  4PFP A;  2X7C A;  4ANJ A;  1MMD A;  4HNA K;  2X51 A;  1F9V A;  2FL6 A;  2VVG A;  1I5S A;  3H4S A;  2Y65 A;  4ZCA A;  1VFW A;  1D0Z A;  4BXN A;  1CZ7 A;  2Y5W A;  5LT3 A;  4PJJ A;  1G8X A;  1I6I A;  4PFO A;  1F9U A;  1MKJ A;  2UYI A;  2XT3 A;  1MMG A;  3HQD A;  4AS7 A;  1T5C A;  5HLE A;  5LT4 A;  4DBR A;  1D0X A;  1RY6 A;  4UBF A;  3GBJ A;  4E7S A;  4PJL A;  2G1Q A;  2WOG A;  4Y05 A;  2IEH A;  1D1B A;  1VOM A;  4AP0 A;  1MMN A;  3K3B A;  3CNZ A;  4ETP A;  2UYM A;  3L9H A;  1MNE A;  1VFX A;  2ZFJ A;  1BG2 A;  2X2R A;  1BR4 A;  4B7B A;  2VAS A;  3NWN A;  3COB A;  1LKX A;  2GM1 A;  3B6V A;  1V8J A; 
#chains in the Genus database with same CATH homology
 1MMA A;  3ZFC A;  3U06 A;  3ZFD A;  2OWM A;  1V8K A;  4ZHI A;  3LRE A;  1KK7 A;  2X7E A;  3PXN A;  1F9W A;  2PG2 A;  1D1A A;  4A50 A;  1LVK A;  4PJM A;  4FRZ A;  2VB6 A;  1VFV A;  5LT0 A;  2X7D A;  2Q2Z A;  4H1G A;  4A5Y A;  4PJN A;  4GKR A;  3B6U A;  2HEH A;  1YRS A;  3K5E A;  1VFZ A;  4A28 A;  4DBQ A;  5GSZ A;  3WPN A;  2ZFI A;  4LNU K;  1FMV A;  2Q2Y A;  2FL2 A;  1SDM A;  2ZFM A;  1F9T A;  1D1C A;  1II6 A;  3KIN A;  5LT2 A;  2FKY A;  1Q0B A;  1N6M A;  3DC4 A;  3L1C A;  4A51 A;  2NCD A;  2KIN A;  3X2T A;  3WRD A;  2V26 A;  2ZFL A;  3T0Q A;  1D0Y A;  3DCB A;  1GOJ A;  4E7Z A;  2XAE A;  3ZCW A;  5LT1 A;  4A1Z A;  2GRY A;  4PK4 A;  2FME A;  2MYS A;  2ZFK A;  4A14 A;  4BN2 A;  3KEN A;  3CJO A;  1BR1 A;  1X88 A;  1FMW A;  4BBG A;  3KAR A;  1BR2 A;  3BFN A;  4PFP A;  2X7C A;  4ANJ A;  1MMD A;  4HNA K;  2X51 A;  1F9V A;  2FL6 A;  2VVG A;  1I5S A;  3H4S A;  2Y65 A;  4ZCA A;  1VFW A;  1D0Z A;  4BXN A;  1CZ7 A;  2Y5W A;  5LT3 A;  4PJJ A;  1G8X A;  1I6I A;  4PFO A;  1F9U A;  1MKJ A;  2UYI A;  2XT3 A;  1MMG A;  3HQD A;  4AS7 A;  1T5C A;  5HLE A;  5LT4 A;  4DBR A;  1D0X A;  1RY6 A;  4UBF A;  3GBJ A;  4E7S A;  4PJL A;  2G1Q A;  2WOG A;  4Y05 A;  2IEH A;  1D1B A;  1VOM A;  4AP0 A;  1MMN A;  3K3B A;  3CNZ A;  4ETP A;  2UYM A;  3L9H A;  1MNE A;  1VFX A;  2ZFJ A;  1BG2 A;  2X2R A;  1BR4 A;  4B7B A;  2VAS A;  3NWN A;  3COB A;  1LKX A;  2GM1 A;  3B6V A;  1V8J A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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