1YRSA

Crystal structure of ksp in complex with inhibitor 1
Total Genus 104
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
104
sequence length
345
structure length
330
Chain Sequence
NIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Kinesin-like protein KIF11
publication title Kinesin spindle protein (KSP) inhibitors. Part 1: The discovery of 3,5-diaryl-4,5-dihydropyrazoles as potent and selective inhibitors of the mitotic kinesin KSP
pubmed doi rcsb
source organism Homo sapiens
molecule tags Cell cycle
total genus 104
structure length 330
sequence length 345
chains with identical sequence B
ec nomenclature
pdb deposition date 2005-02-04

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 1yrsA00
1YRSA 3BFNA 2X7EA 3B6VA 1VFXA 1LVKA 1KK7A 2FMEA 2GM1A 1FMWA 4H1GA 1VOMA 3WRDA 3PXNA 2ZFLA 1D1CA 3ZCWA 4PJMA 3K5EA 1F9TA 3COBA 1VFVA 4ZCAA 2IEHA 3ZFCA 1D0XA 5LT4A 4A51A 2V26A 2Q2ZA 4A1ZA 4E7ZA 1D0ZA 4BN2A 4DBRA 2ZFIA 3B6UA 4AS7A 2KINA 4GKRA 1MMAA 2X51A 3X2TA 1BR1A 3LREA 4AP0A 3K3BA 2WOGA 1BR4A 5LT0A 1D1AA 1FMVA 1VFWA 4FRZA 1N6MA 3CNZA 5LT1A 3DCBA 3NWNA 2UYIA 4ZHIA 3L1CA 4A5YA 2X7CA 1F9WA 4HNAK 5LT3A 2Q2YA 4E7SA 1F9VA 2VASA 4A28A 4A14A 3KARA 2FKYA 5GSZA 2MYSA 1V8JA 4PJNA 3L9HA 5HLEA 1MNEA 1D1BA 1I5SA 3T0QA 3CJOA 2Y65A 1T5CA 4BXNA 2FL6A 1F9UA 2XT3A 1VFZA 2HEHA 5LT2A 1MMDA 2UYMA 1D0YA 3WPNA 4A50A 2XAEA 2NCDA 3GBJA 2G1QA 4DBQA 4Y05A 3H4SA 2ZFJA 1LKXA 4PFPA 4UBFA 4LNUK 1X88A 4ETPA 2VB6A 1V8KA 2X2RA 2VVGA 2Y5WA 4PFOA 4BBGA 3HQDA 4B7BA 1I6IA 1RY6A 2FL2A 1BG2A 1CZ7A 3DC4A 3KINA 3KENA 3U06A 4PJJA 1MMGA 1GOJA 1G8XA 1II6A 1MKJA 2GRYA 2PG2A 2OWMA 4PJLA 2ZFMA 2X7DA 3ZFDA 4PK4A 1BR2A 1SDMA 2ZFKA 1Q0BA 1MMNA 4ANJA
chains in the Genus database with same CATH superfamily
1YRSA 3BFNA 2X7EA 3B6VA 1VFXA 1LVKA 1KK7A 2FMEA 2GM1A 1FMWA 4H1GA 1VOMA 3WRDA 3PXNA 2ZFLA 1D1CA 3ZCWA 4PJMA 3K5EA 1F9TA 3COBA 1VFVA 4ZCAA 2IEHA 3ZFCA 1D0XA 5LT4A 4A51A 2V26A 2Q2ZA 4A1ZA 4E7ZA 1D0ZA 4BN2A 4DBRA 2ZFIA 3B6UA 4AS7A 2KINA 4GKRA 1MMAA 2X51A 3X2TA 1BR1A 3LREA 4AP0A 3K3BA 2WOGA 1BR4A 5LT0A 1D1AA 1FMVA 1VFWA 4FRZA 1N6MA 3CNZA 5LT1A 3DCBA 3NWNA 2UYIA 4ZHIA 3L1CA 4A5YA 2X7CA 1F9WA 4HNAK 5LT3A 2Q2YA 4E7SA 1F9VA 2VASA 4A28A 4A14A 3KARA 2FKYA 5GSZA 2MYSA 1V8JA 4PJNA 3L9HA 5HLEA 2O0AA 1MNEA 1D1BA 1I5SA 3T0QA 3CJOA 2Y65A 1T5CA 4BXNA 2FL6A 1F9UA 2XT3A 1VFZA 2HEHA 5LT2A 1MMDA 2UYMA 1D0YA 3WPNA 4A50A 2XAEA 2NCDA 3GBJA 2G1QA 4DBQA 4Y05A 3H4SA 2ZFJA 1LKXA 4PFPA 4UBFA 4LNUK 1X88A 4ETPA 2VB6A 1V8KA 2X2RA 2VVGA 2Y5WA 4PFOA 4BBGA 3HQDA 4B7BA 1I6IA 1RY6A 2FL2A 1BG2A 1CZ7A 3DC4A 3KINA 3KENA 3U06A 4PJJA 4GKPA 1MMGA 1GOJA 1G8XA 1II6A 1MKJA 2GRYA 2PG2A 4GKQA 2OWMA 4PJLA 2ZFMA 2X7DA 3ZFDA 4PK4A 1BR2A 1SDMA 2ZFKA 4ETPB 1Q0BA 1MMNA 4ANJA
chains in the Genus database with same CATH topology
1YRSA 3BFNA 2X7EA 3B6VA 1VFXA 1LVKA 1KK7A 2FMEA 2GM1A 1FMWA 4H1GA 1VOMA 3WRDA 3PXNA 2ZFLA 1D1CA 3ZCWA 4PJMA 3K5EA 1F9TA 3COBA 1VFVA 4ZCAA 2IEHA 3ZFCA 1D0XA 5LT4A 4A51A 2V26A 2Q2ZA 4A1ZA 4E7ZA 1D0ZA 4BN2A 4DBRA 2ZFIA 3B6UA 4AS7A 2KINA 4GKRA 1MMAA 2X51A 3X2TA 1BR1A 3LREA 4AP0A 3K3BA 2WOGA 1BR4A 5LT0A 1D1AA 1FMVA 1VFWA 4FRZA 1N6MA 3CNZA 5LT1A 3DCBA 3NWNA 2UYIA 4ZHIA 3L1CA 4A5YA 2X7CA 1F9WA 4HNAK 5LT3A 2Q2YA 4E7SA 1F9VA 2VASA 4A28A 4A14A 3KARA 2FKYA 5GSZA 2MYSA 1V8JA 4PJNA 3L9HA 5HLEA 1MNEA 1D1BA 1I5SA 3T0QA 3CJOA 2Y65A 1T5CA 4BXNA 2FL6A 1F9UA 2XT3A 1VFZA 2HEHA 5LT2A 1MMDA 2UYMA 1D0YA 3WPNA 4A50A 2XAEA 2NCDA 3GBJA 2G1QA 4DBQA 4Y05A 3H4SA 2ZFJA 1LKXA 4PFPA 4UBFA 4LNUK 1X88A 4ETPA 2VB6A 1V8KA 2X2RA 2VVGA 2Y5WA 4PFOA 4BBGA 3HQDA 4B7BA 1I6IA 1RY6A 2FL2A 1BG2A 1CZ7A 3DC4A 3KINA 3KENA 3U06A 4PJJA 1MMGA 1GOJA 1G8XA 1II6A 1MKJA 2GRYA 2PG2A 2OWMA 4PJLA 2ZFMA 2X7DA 3ZFDA 4PK4A 1BR2A 1SDMA 2ZFKA 1Q0BA 1MMNA 4ANJA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1YRS A;  3BFN A;  2X7E A;  3B6V A;  1VFX A;  1LVK A;  1KK7 A;  2FME A;  2GM1 A;  1FMW A;  4H1G A;  1VOM A;  3WRD A;  3PXN A;  2ZFL A;  1D1C A;  3ZCW A;  4PJM A;  3K5E A;  1F9T A;  3COB A;  1VFV A;  4ZCA A;  2IEH A;  3ZFC A;  1D0X A;  5LT4 A;  4A51 A;  2V26 A;  2Q2Z A;  4A1Z A;  4E7Z A;  1D0Z A;  4BN2 A;  4DBR A;  2ZFI A;  3B6U A;  4AS7 A;  2KIN A;  4GKR A;  1MMA A;  2X51 A;  3X2T A;  1BR1 A;  3LRE A;  4AP0 A;  3K3B A;  2WOG A;  1BR4 A;  5LT0 A;  1D1A A;  1FMV A;  1VFW A;  4FRZ A;  1N6M A;  3CNZ A;  5LT1 A;  3DCB A;  3NWN A;  2UYI A;  4ZHI A;  3L1C A;  4A5Y A;  2X7C A;  1F9W A;  4HNA K;  5LT3 A;  2Q2Y A;  4E7S A;  1F9V A;  2VAS A;  4A28 A;  4A14 A;  3KAR A;  2FKY A;  5GSZ A;  2MYS A;  1V8J A;  4PJN A;  3L9H A;  5HLE A;  1MNE A;  1D1B A;  1I5S A;  3T0Q A;  3CJO A;  2Y65 A;  1T5C A;  4BXN A;  2FL6 A;  1F9U A;  2XT3 A;  1VFZ A;  2HEH A;  5LT2 A;  1MMD A;  2UYM A;  1D0Y A;  3WPN A;  4A50 A;  2XAE A;  2NCD A;  3GBJ A;  2G1Q A;  4DBQ A;  4Y05 A;  3H4S A;  2ZFJ A;  1LKX A;  4PFP A;  4UBF A;  4LNU K;  1X88 A;  4ETP A;  2VB6 A;  1V8K A;  2X2R A;  2VVG A;  2Y5W A;  4PFO A;  4BBG A;  3HQD A;  4B7B A;  1I6I A;  1RY6 A;  2FL2 A;  1BG2 A;  1CZ7 A;  3DC4 A;  3KIN A;  3KEN A;  3U06 A;  4PJJ A;  1MMG A;  1GOJ A;  1G8X A;  1II6 A;  1MKJ A;  2GRY A;  2PG2 A;  2OWM A;  4PJL A;  2ZFM A;  2X7D A;  3ZFD A;  4PK4 A;  1BR2 A;  1SDM A;  2ZFK A;  1Q0B A;  1MMN A;  4ANJ A; 
#chains in the Genus database with same CATH topology
 1YRS A;  3BFN A;  2X7E A;  3B6V A;  1VFX A;  1LVK A;  1KK7 A;  2FME A;  2GM1 A;  1FMW A;  4H1G A;  1VOM A;  3WRD A;  3PXN A;  2ZFL A;  1D1C A;  3ZCW A;  4PJM A;  3K5E A;  1F9T A;  3COB A;  1VFV A;  4ZCA A;  2IEH A;  3ZFC A;  1D0X A;  5LT4 A;  4A51 A;  2V26 A;  2Q2Z A;  4A1Z A;  4E7Z A;  1D0Z A;  4BN2 A;  4DBR A;  2ZFI A;  3B6U A;  4AS7 A;  2KIN A;  4GKR A;  1MMA A;  2X51 A;  3X2T A;  1BR1 A;  3LRE A;  4AP0 A;  3K3B A;  2WOG A;  1BR4 A;  5LT0 A;  1D1A A;  1FMV A;  1VFW A;  4FRZ A;  1N6M A;  3CNZ A;  5LT1 A;  3DCB A;  3NWN A;  2UYI A;  4ZHI A;  3L1C A;  4A5Y A;  2X7C A;  1F9W A;  4HNA K;  5LT3 A;  2Q2Y A;  4E7S A;  1F9V A;  2VAS A;  4A28 A;  4A14 A;  3KAR A;  2FKY A;  5GSZ A;  2MYS A;  1V8J A;  4PJN A;  3L9H A;  5HLE A;  2O0A A;  1MNE A;  1D1B A;  1I5S A;  3T0Q A;  3CJO A;  2Y65 A;  1T5C A;  4BXN A;  2FL6 A;  1F9U A;  2XT3 A;  1VFZ A;  2HEH A;  5LT2 A;  1MMD A;  2UYM A;  1D0Y A;  3WPN A;  4A50 A;  2XAE A;  2NCD A;  3GBJ A;  2G1Q A;  4DBQ A;  4Y05 A;  3H4S A;  2ZFJ A;  1LKX A;  4PFP A;  4UBF A;  4LNU K;  1X88 A;  4ETP A;  2VB6 A;  1V8K A;  2X2R A;  2VVG A;  2Y5W A;  4PFO A;  4BBG A;  3HQD A;  4B7B A;  1I6I A;  1RY6 A;  2FL2 A;  1BG2 A;  1CZ7 A;  3DC4 A;  3KIN A;  3KEN A;  3U06 A;  4PJJ A;  4GKP A;  1MMG A;  1GOJ A;  1G8X A;  1II6 A;  1MKJ A;  2GRY A;  2PG2 A;  4GKQ A;  2OWM A;  4PJL A;  2ZFM A;  2X7D A;  3ZFD A;  4PK4 A;  1BR2 A;  1SDM A;  2ZFK A;  4ETP B;  1Q0B A;  1MMN A;  4ANJ A; 
#chains in the Genus database with same CATH homology
 1YRS A;  3BFN A;  2X7E A;  3B6V A;  1VFX A;  1LVK A;  1KK7 A;  2FME A;  2GM1 A;  1FMW A;  4H1G A;  1VOM A;  3WRD A;  3PXN A;  2ZFL A;  1D1C A;  3ZCW A;  4PJM A;  3K5E A;  1F9T A;  3COB A;  1VFV A;  4ZCA A;  2IEH A;  3ZFC A;  1D0X A;  5LT4 A;  4A51 A;  2V26 A;  2Q2Z A;  4A1Z A;  4E7Z A;  1D0Z A;  4BN2 A;  4DBR A;  2ZFI A;  3B6U A;  4AS7 A;  2KIN A;  4GKR A;  1MMA A;  2X51 A;  3X2T A;  1BR1 A;  3LRE A;  4AP0 A;  3K3B A;  2WOG A;  1BR4 A;  5LT0 A;  1D1A A;  1FMV A;  1VFW A;  4FRZ A;  1N6M A;  3CNZ A;  5LT1 A;  3DCB A;  3NWN A;  2UYI A;  4ZHI A;  3L1C A;  4A5Y A;  2X7C A;  1F9W A;  4HNA K;  5LT3 A;  2Q2Y A;  4E7S A;  1F9V A;  2VAS A;  4A28 A;  4A14 A;  3KAR A;  2FKY A;  5GSZ A;  2MYS A;  1V8J A;  4PJN A;  3L9H A;  5HLE A;  1MNE A;  1D1B A;  1I5S A;  3T0Q A;  3CJO A;  2Y65 A;  1T5C A;  4BXN A;  2FL6 A;  1F9U A;  2XT3 A;  1VFZ A;  2HEH A;  5LT2 A;  1MMD A;  2UYM A;  1D0Y A;  3WPN A;  4A50 A;  2XAE A;  2NCD A;  3GBJ A;  2G1Q A;  4DBQ A;  4Y05 A;  3H4S A;  2ZFJ A;  1LKX A;  4PFP A;  4UBF A;  4LNU K;  1X88 A;  4ETP A;  2VB6 A;  1V8K A;  2X2R A;  2VVG A;  2Y5W A;  4PFO A;  4BBG A;  3HQD A;  4B7B A;  1I6I A;  1RY6 A;  2FL2 A;  1BG2 A;  1CZ7 A;  3DC4 A;  3KIN A;  3KEN A;  3U06 A;  4PJJ A;  1MMG A;  1GOJ A;  1G8X A;  1II6 A;  1MKJ A;  2GRY A;  2PG2 A;  2OWM A;  4PJL A;  2ZFM A;  2X7D A;  3ZFD A;  4PK4 A;  1BR2 A;  1SDM A;  2ZFK A;  1Q0B A;  1MMN A;  4ANJ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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