1YRSA

Crystal structure of ksp in complex with inhibitor 1
Total Genus 104
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
104
sequence length
345
structure length
330
Chain Sequence
b'NIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNK'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Kinesin-like protein KIF11
publication title Kinesin spindle protein (KSP) inhibitors. Part 1: The discovery of 3,5-diaryl-4,5-dihydropyrazoles as potent and selective inhibitors of the mitotic kinesin KSP
pubmed doi rcsb
source organism Homo sapiens
molecule tags Cell cycle
total genus 104
structure length 330
sequence length 345
chains with identical sequence B
ec nomenclature
pdb deposition date 2005-02-04

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 1yrsA00
4H1GA 3DC4A 1YRSA 4DBQA 1II6A 4DBRA 4A5YA 1MMGA 1D1AA 3CNZA 4LNUK 1VFZA 2UYMA 2FMEA 4A1ZA 4Y05A 4E7ZA 3WPNA 5LT3A 3BFNA 4PFOA 1D1BA 3L9HA 3LREA 3ZCWA 3ZFCA 1I6IA 3B6UA 2VASA 1VOMA 3HQDA 2ZFMA 1VFWA 5LT2A 3K5EA 1BG2A 1D0YA 1KK7A 4PJLA 2G1QA 1FMWA 3KARA 3T0QA 1GOJA 5LT0A 2FL2A 1D0ZA 4ZCAA 4HNAK 2HEHA 2Q2YA 2ZFIA 3PXNA 5LT4A 1LKXA 3CJOA 1G8XA 1RY6A 1VFVA 4A51A 1BR1A 2XAEA 2X51A 2V26A 2Q2ZA 1MMAA 2FKYA 2WOGA 2VVGA 3WRDA 4PK4A 1MMDA 1T5CA 1BR2A 2X2RA 4A28A 3KENA 2MYSA 1BR4A 3DCBA 1D0XA 4A14A 4PFPA 1MMNA 1LVKA 1FMVA 4ANJA 2ZFJA 4AP0A 4AS7A 4PJMA 5LT1A 2ZFLA 2KINA 4B7BA 1V8JA 2XT3A 1F9VA 4GKRA 4E7SA 4A50A 1F9TA 2NCDA 3H4SA 4BXNA 1MNEA 4UBFA 4ETPA 2IEHA 4PJNA 2X7DA 3KINA 1Q0BA 5GSZA 4BBGA 1F9UA 4ZHIA 2PG2A 1MKJA 1N6MA 3NWNA 2Y65A 2X7EA 3ZFDA 2VB6A 3K3BA 1SDMA 1VFXA 2Y5WA 2GM1A 3COBA 1D1CA 1V8KA 3L1CA 1F9WA 2GRYA 3X2TA 3U06A 5HLEA 3B6VA 3GBJA 4PJJA 4FRZA 2X7CA 2ZFKA 2OWMA 1X88A 2UYIA 1CZ7A 1I5SA 2FL6A 4BN2A
chains in the Genus database with same CATH superfamily
4H1GA 3DC4A 1YRSA 4DBQA 1II6A 4DBRA 4A5YA 1MMGA 1D1AA 3CNZA 4LNUK 1VFZA 2UYMA 2FMEA 4A1ZA 4Y05A 4E7ZA 3WPNA 5LT3A 3BFNA 4PFOA 1D1BA 3L9HA 3LREA 3ZCWA 3ZFCA 1I6IA 3B6UA 2VASA 1VOMA 3HQDA 2ZFMA 1VFWA 5LT2A 2O0AA 3K5EA 1BG2A 1D0YA 1KK7A 4PJLA 2G1QA 1FMWA 3KARA 3T0QA 1GOJA 5LT0A 2FL2A 1D0ZA 4ZCAA 4HNAK 2HEHA 2Q2YA 2ZFIA 3PXNA 5LT4A 1LKXA 3CJOA 1G8XA 1RY6A 1VFVA 4GKPA 4A51A 1BR1A 2XAEA 2X51A 2V26A 2Q2ZA 1MMAA 2FKYA 2WOGA 2VVGA 3WRDA 4PK4A 4GKQA 1MMDA 1T5CA 1BR2A 2X2RA 4A28A 3KENA 2MYSA 1BR4A 3DCBA 1D0XA 4A14A 4PFPA 1MMNA 4ETPB 1LVKA 1FMVA 4ANJA 2ZFJA 4AP0A 4AS7A 4PJMA 5LT1A 2ZFLA 2KINA 4B7BA 1V8JA 2XT3A 1F9VA 4GKRA 4E7SA 4A50A 1F9TA 2NCDA 3H4SA 4BXNA 1MNEA 4UBFA 4ETPA 2IEHA 4PJNA 2X7DA 3KINA 1Q0BA 5GSZA 4BBGA 1F9UA 4ZHIA 2PG2A 1MKJA 1N6MA 3NWNA 2Y65A 2X7EA 3ZFDA 2VB6A 3K3BA 1SDMA 1VFXA 2Y5WA 2GM1A 3COBA 1D1CA 1V8KA 3L1CA 1F9WA 2GRYA 3X2TA 3U06A 5HLEA 3B6VA 3GBJA 4PJJA 4FRZA 2X7CA 2ZFKA 2OWMA 1X88A 2UYIA 1CZ7A 1I5SA 2FL6A 4BN2A
chains in the Genus database with same CATH topology
4H1GA 3DC4A 1YRSA 4DBQA 1II6A 4DBRA 4A5YA 1MMGA 1D1AA 3CNZA 4LNUK 1VFZA 2UYMA 2FMEA 4A1ZA 4Y05A 4E7ZA 3WPNA 5LT3A 3BFNA 4PFOA 1D1BA 3L9HA 3LREA 3ZCWA 3ZFCA 1I6IA 3B6UA 2VASA 1VOMA 3HQDA 2ZFMA 1VFWA 5LT2A 3K5EA 1BG2A 1D0YA 1KK7A 4PJLA 2G1QA 1FMWA 3KARA 3T0QA 1GOJA 5LT0A 2FL2A 1D0ZA 4ZCAA 4HNAK 2HEHA 2Q2YA 2ZFIA 3PXNA 5LT4A 1LKXA 3CJOA 1G8XA 1RY6A 1VFVA 4A51A 1BR1A 2XAEA 2X51A 2V26A 2Q2ZA 1MMAA 2FKYA 2WOGA 2VVGA 3WRDA 4PK4A 1MMDA 1T5CA 1BR2A 2X2RA 4A28A 3KENA 2MYSA 1BR4A 3DCBA 1D0XA 4A14A 4PFPA 1MMNA 1LVKA 1FMVA 4ANJA 2ZFJA 4AP0A 4AS7A 4PJMA 5LT1A 2ZFLA 2KINA 4B7BA 1V8JA 2XT3A 1F9VA 4GKRA 4E7SA 4A50A 1F9TA 2NCDA 3H4SA 4BXNA 1MNEA 4UBFA 4ETPA 2IEHA 4PJNA 2X7DA 3KINA 1Q0BA 5GSZA 4BBGA 1F9UA 4ZHIA 2PG2A 1MKJA 1N6MA 3NWNA 2Y65A 2X7EA 3ZFDA 2VB6A 3K3BA 1SDMA 1VFXA 2Y5WA 2GM1A 3COBA 1D1CA 1V8KA 3L1CA 1F9WA 2GRYA 3X2TA 3U06A 5HLEA 3B6VA 3GBJA 4PJJA 4FRZA 2X7CA 2ZFKA 2OWMA 1X88A 2UYIA 1CZ7A 1I5SA 2FL6A 4BN2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4H1G A;  3DC4 A;  1YRS A;  4DBQ A;  1II6 A;  4DBR A;  4A5Y A;  1MMG A;  1D1A A;  3CNZ A;  4LNU K;  1VFZ A;  2UYM A;  2FME A;  4A1Z A;  4Y05 A;  4E7Z A;  3WPN A;  5LT3 A;  3BFN A;  4PFO A;  1D1B A;  3L9H A;  3LRE A;  3ZCW A;  3ZFC A;  1I6I A;  3B6U A;  2VAS A;  1VOM A;  3HQD A;  2ZFM A;  1VFW A;  5LT2 A;  3K5E A;  1BG2 A;  1D0Y A;  1KK7 A;  4PJL A;  2G1Q A;  1FMW A;  3KAR A;  3T0Q A;  1GOJ A;  5LT0 A;  2FL2 A;  1D0Z A;  4ZCA A;  4HNA K;  2HEH A;  2Q2Y A;  2ZFI A;  3PXN A;  5LT4 A;  1LKX A;  3CJO A;  1G8X A;  1RY6 A;  1VFV A;  4A51 A;  1BR1 A;  2XAE A;  2X51 A;  2V26 A;  2Q2Z A;  1MMA A;  2FKY A;  2WOG A;  2VVG A;  3WRD A;  4PK4 A;  1MMD A;  1T5C A;  1BR2 A;  2X2R A;  4A28 A;  3KEN A;  2MYS A;  1BR4 A;  3DCB A;  1D0X A;  4A14 A;  4PFP A;  1MMN A;  1LVK A;  1FMV A;  4ANJ A;  2ZFJ A;  4AP0 A;  4AS7 A;  4PJM A;  5LT1 A;  2ZFL A;  2KIN A;  4B7B A;  1V8J A;  2XT3 A;  1F9V A;  4GKR A;  4E7S A;  4A50 A;  1F9T A;  2NCD A;  3H4S A;  4BXN A;  1MNE A;  4UBF A;  4ETP A;  2IEH A;  4PJN A;  2X7D A;  3KIN A;  1Q0B A;  5GSZ A;  4BBG A;  1F9U A;  4ZHI A;  2PG2 A;  1MKJ A;  1N6M A;  3NWN A;  2Y65 A;  2X7E A;  3ZFD A;  2VB6 A;  3K3B A;  1SDM A;  1VFX A;  2Y5W A;  2GM1 A;  3COB A;  1D1C A;  1V8K A;  3L1C A;  1F9W A;  2GRY A;  3X2T A;  3U06 A;  5HLE A;  3B6V A;  3GBJ A;  4PJJ A;  4FRZ A;  2X7C A;  2ZFK A;  2OWM A;  1X88 A;  2UYI A;  1CZ7 A;  1I5S A;  2FL6 A;  4BN2 A; 
#chains in the Genus database with same CATH topology
 4H1G A;  3DC4 A;  1YRS A;  4DBQ A;  1II6 A;  4DBR A;  4A5Y A;  1MMG A;  1D1A A;  3CNZ A;  4LNU K;  1VFZ A;  2UYM A;  2FME A;  4A1Z A;  4Y05 A;  4E7Z A;  3WPN A;  5LT3 A;  3BFN A;  4PFO A;  1D1B A;  3L9H A;  3LRE A;  3ZCW A;  3ZFC A;  1I6I A;  3B6U A;  2VAS A;  1VOM A;  3HQD A;  2ZFM A;  1VFW A;  5LT2 A;  2O0A A;  3K5E A;  1BG2 A;  1D0Y A;  1KK7 A;  4PJL A;  2G1Q A;  1FMW A;  3KAR A;  3T0Q A;  1GOJ A;  5LT0 A;  2FL2 A;  1D0Z A;  4ZCA A;  4HNA K;  2HEH A;  2Q2Y A;  2ZFI A;  3PXN A;  5LT4 A;  1LKX A;  3CJO A;  1G8X A;  1RY6 A;  1VFV A;  4GKP A;  4A51 A;  1BR1 A;  2XAE A;  2X51 A;  2V26 A;  2Q2Z A;  1MMA A;  2FKY A;  2WOG A;  2VVG A;  3WRD A;  4PK4 A;  4GKQ A;  1MMD A;  1T5C A;  1BR2 A;  2X2R A;  4A28 A;  3KEN A;  2MYS A;  1BR4 A;  3DCB A;  1D0X A;  4A14 A;  4PFP A;  1MMN A;  4ETP B;  1LVK A;  1FMV A;  4ANJ A;  2ZFJ A;  4AP0 A;  4AS7 A;  4PJM A;  5LT1 A;  2ZFL A;  2KIN A;  4B7B A;  1V8J A;  2XT3 A;  1F9V A;  4GKR A;  4E7S A;  4A50 A;  1F9T A;  2NCD A;  3H4S A;  4BXN A;  1MNE A;  4UBF A;  4ETP A;  2IEH A;  4PJN A;  2X7D A;  3KIN A;  1Q0B A;  5GSZ A;  4BBG A;  1F9U A;  4ZHI A;  2PG2 A;  1MKJ A;  1N6M A;  3NWN A;  2Y65 A;  2X7E A;  3ZFD A;  2VB6 A;  3K3B A;  1SDM A;  1VFX A;  2Y5W A;  2GM1 A;  3COB A;  1D1C A;  1V8K A;  3L1C A;  1F9W A;  2GRY A;  3X2T A;  3U06 A;  5HLE A;  3B6V A;  3GBJ A;  4PJJ A;  4FRZ A;  2X7C A;  2ZFK A;  2OWM A;  1X88 A;  2UYI A;  1CZ7 A;  1I5S A;  2FL6 A;  4BN2 A; 
#chains in the Genus database with same CATH homology
 4H1G A;  3DC4 A;  1YRS A;  4DBQ A;  1II6 A;  4DBR A;  4A5Y A;  1MMG A;  1D1A A;  3CNZ A;  4LNU K;  1VFZ A;  2UYM A;  2FME A;  4A1Z A;  4Y05 A;  4E7Z A;  3WPN A;  5LT3 A;  3BFN A;  4PFO A;  1D1B A;  3L9H A;  3LRE A;  3ZCW A;  3ZFC A;  1I6I A;  3B6U A;  2VAS A;  1VOM A;  3HQD A;  2ZFM A;  1VFW A;  5LT2 A;  3K5E A;  1BG2 A;  1D0Y A;  1KK7 A;  4PJL A;  2G1Q A;  1FMW A;  3KAR A;  3T0Q A;  1GOJ A;  5LT0 A;  2FL2 A;  1D0Z A;  4ZCA A;  4HNA K;  2HEH A;  2Q2Y A;  2ZFI A;  3PXN A;  5LT4 A;  1LKX A;  3CJO A;  1G8X A;  1RY6 A;  1VFV A;  4A51 A;  1BR1 A;  2XAE A;  2X51 A;  2V26 A;  2Q2Z A;  1MMA A;  2FKY A;  2WOG A;  2VVG A;  3WRD A;  4PK4 A;  1MMD A;  1T5C A;  1BR2 A;  2X2R A;  4A28 A;  3KEN A;  2MYS A;  1BR4 A;  3DCB A;  1D0X A;  4A14 A;  4PFP A;  1MMN A;  1LVK A;  1FMV A;  4ANJ A;  2ZFJ A;  4AP0 A;  4AS7 A;  4PJM A;  5LT1 A;  2ZFL A;  2KIN A;  4B7B A;  1V8J A;  2XT3 A;  1F9V A;  4GKR A;  4E7S A;  4A50 A;  1F9T A;  2NCD A;  3H4S A;  4BXN A;  1MNE A;  4UBF A;  4ETP A;  2IEH A;  4PJN A;  2X7D A;  3KIN A;  1Q0B A;  5GSZ A;  4BBG A;  1F9U A;  4ZHI A;  2PG2 A;  1MKJ A;  1N6M A;  3NWN A;  2Y65 A;  2X7E A;  3ZFD A;  2VB6 A;  3K3B A;  1SDM A;  1VFX A;  2Y5W A;  2GM1 A;  3COB A;  1D1C A;  1V8K A;  3L1C A;  1F9W A;  2GRY A;  3X2T A;  3U06 A;  5HLE A;  3B6V A;  3GBJ A;  4PJJ A;  4FRZ A;  2X7C A;  2ZFK A;  2OWM A;  1X88 A;  2UYI A;  1CZ7 A;  1I5S A;  2FL6 A;  4BN2 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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