4A1ZA

Eg5-1
Total Genus 101
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
101
sequence length
348
structure length
327
Chain Sequence
KNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERYTWEEVPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSEEAGNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords KINESIN-LIKE PROTEIN KIF11
publication title The Mitotic Kinesin Eg5 Overcomes Inhibition to the Phase I/II Clinical Candidate Sb743921 by an Allosteric Resistance Mechanism.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Motor protein
total genus 101
structure length 327
sequence length 348
chains with identical sequence B
ec nomenclature
pdb deposition date 2011-09-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 4a1zA00
2ZFIA 4BBGA 2VASA 4ZHIA 2UYMA 1T5CA 2ZFMA 2PG2A 3ZFDA 1MMGA 4ZCAA 4A28A 2ZFLA 1VOMA 2GM1A 1LVKA 3ZCWA 2OWMA 4B7BA 4H1GA 2X2RA 3DC4A 4A1ZA 2WOGA 1FMVA 1VFXA 4E7SA 2HEHA 2V26A 1CZ7A 1X88A 4DBQA 1N6MA 3HQDA 4PK4A 2FMEA 2ZFKA 3U06A 1I6IA 1D0XA 2XT3A 4A51A 1BR4A 1D1CA 3K5EA 3KARA 2FL6A 5LT4A 1D1AA 4ETPA 1BR1A 3WPNA 2NCDA 3T0QA 4PJJA 3B6VA 1VFWA 1MMAA 1LKXA 1V8JA 3ZFCA 1MMDA 3CJOA 3DCBA 1F9VA 2Y65A 3KENA 4BN2A 5LT2A 3GBJA 4BXNA 2ZFJA 3L1CA 2GRYA 1MKJA 2X51A 2X7EA 1VFVA 1F9UA 1BR2A 2X7CA 4FRZA 4AS7A 4AP0A 4A5YA 1II6A 1Q0BA 5LT3A 2KINA 3LREA 3K3BA 4HNAK 3L9HA 4A50A 1BG2A 4DBRA 2Q2YA 3COBA 2VB6A 1RY6A 4GKRA 3BFNA 1KK7A 1YRSA 1SDMA 2VVGA 3PXNA 3WRDA 3NWNA 3X2TA 2Y5WA 5LT1A 2X7DA 4PFPA 5GSZA 4ANJA 3KINA 1G8XA 5HLEA 4Y05A 4E7ZA 4LNUK 4PFOA 3B6UA 4PJLA 4PJNA 1F9TA 2Q2ZA 2UYIA 2G1QA 1FMWA 1I5SA 1D1BA 2FKYA 5LT0A 3CNZA 2MYSA 4PJMA 1V8KA 2IEHA 4A14A 1MNEA 1MMNA 1D0YA 1F9WA 1D0ZA 1GOJA 2XAEA 4UBFA 1VFZA 2FL2A 3H4SA
chains in the Genus database with same CATH superfamily
2ZFIA 4BBGA 2VASA 4ZHIA 2UYMA 1T5CA 2ZFMA 2PG2A 3ZFDA 1MMGA 4ZCAA 4A28A 2ZFLA 1VOMA 2GM1A 1LVKA 3ZCWA 2OWMA 4B7BA 4H1GA 2X2RA 3DC4A 4A1ZA 2WOGA 1FMVA 1VFXA 4E7SA 2HEHA 2V26A 1CZ7A 1X88A 4DBQA 1N6MA 3HQDA 4PK4A 2FMEA 2ZFKA 3U06A 1I6IA 1D0XA 2XT3A 4A51A 1BR4A 1D1CA 3K5EA 3KARA 2FL6A 5LT4A 1D1AA 4ETPA 1BR1A 3WPNA 2NCDA 3T0QA 4PJJA 3B6VA 1VFWA 1MMAA 1LKXA 1V8JA 3ZFCA 1MMDA 3CJOA 3DCBA 1F9VA 2Y65A 3KENA 4BN2A 5LT2A 3GBJA 4BXNA 2ZFJA 3L1CA 2GRYA 1MKJA 2X51A 2X7EA 1VFVA 1F9UA 1BR2A 4ETPB 2X7CA 4FRZA 4AS7A 4AP0A 4A5YA 1II6A 1Q0BA 5LT3A 2KINA 3LREA 3K3BA 4HNAK 3L9HA 4A50A 1BG2A 4DBRA 2Q2YA 3COBA 2VB6A 1RY6A 4GKRA 3BFNA 1KK7A 1YRSA 4GKQA 1SDMA 2VVGA 3PXNA 4GKPA 3NWNA 3WRDA 3X2TA 2Y5WA 5LT1A 2X7DA 4PFPA 5GSZA 4ANJA 3KINA 1G8XA 5HLEA 4Y05A 4E7ZA 4LNUK 4PFOA 3B6UA 4PJLA 4PJNA 1F9TA 2Q2ZA 2UYIA 2G1QA 1FMWA 1I5SA 1D1BA 2FKYA 5LT0A 3CNZA 2MYSA 4PJMA 1V8KA 2O0AA 2IEHA 4A14A 1MNEA 1MMNA 1D0YA 1F9WA 1D0ZA 1GOJA 2XAEA 4UBFA 1VFZA 2FL2A 3H4SA
chains in the Genus database with same CATH topology
2ZFIA 4BBGA 2VASA 4ZHIA 2UYMA 1T5CA 2ZFMA 2PG2A 3ZFDA 1MMGA 4ZCAA 4A28A 2ZFLA 1VOMA 2GM1A 1LVKA 3ZCWA 2OWMA 4B7BA 4H1GA 2X2RA 3DC4A 4A1ZA 2WOGA 1FMVA 1VFXA 4E7SA 2HEHA 2V26A 1CZ7A 1X88A 4DBQA 1N6MA 3HQDA 4PK4A 2FMEA 2ZFKA 3U06A 1I6IA 1D0XA 2XT3A 4A51A 1BR4A 1D1CA 3K5EA 3KARA 2FL6A 5LT4A 1D1AA 4ETPA 1BR1A 3WPNA 2NCDA 3T0QA 4PJJA 3B6VA 1VFWA 1MMAA 1LKXA 1V8JA 3ZFCA 1MMDA 3CJOA 3DCBA 1F9VA 2Y65A 3KENA 4BN2A 5LT2A 3GBJA 4BXNA 2ZFJA 3L1CA 2GRYA 1MKJA 2X51A 2X7EA 1VFVA 1F9UA 1BR2A 2X7CA 4FRZA 4AS7A 4AP0A 4A5YA 1II6A 1Q0BA 5LT3A 2KINA 3LREA 3K3BA 4HNAK 3L9HA 4A50A 1BG2A 4DBRA 2Q2YA 3COBA 2VB6A 1RY6A 4GKRA 3BFNA 1KK7A 1YRSA 1SDMA 2VVGA 3PXNA 3WRDA 3NWNA 3X2TA 2Y5WA 5LT1A 2X7DA 4PFPA 5GSZA 4ANJA 3KINA 1G8XA 5HLEA 4Y05A 4E7ZA 4LNUK 4PFOA 3B6UA 4PJLA 4PJNA 1F9TA 2Q2ZA 2UYIA 2G1QA 1FMWA 1I5SA 1D1BA 2FKYA 5LT0A 3CNZA 2MYSA 4PJMA 1V8KA 2IEHA 4A14A 1MNEA 1MMNA 1D0YA 1F9WA 1D0ZA 1GOJA 2XAEA 4UBFA 1VFZA 2FL2A 3H4SA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2ZFI A;  4BBG A;  2VAS A;  4ZHI A;  2UYM A;  1T5C A;  2ZFM A;  2PG2 A;  3ZFD A;  1MMG A;  4ZCA A;  4A28 A;  2ZFL A;  1VOM A;  2GM1 A;  1LVK A;  3ZCW A;  2OWM A;  4B7B A;  4H1G A;  2X2R A;  3DC4 A;  4A1Z A;  2WOG A;  1FMV A;  1VFX A;  4E7S A;  2HEH A;  2V26 A;  1CZ7 A;  1X88 A;  4DBQ A;  1N6M A;  3HQD A;  4PK4 A;  2FME A;  2ZFK A;  3U06 A;  1I6I A;  1D0X A;  2XT3 A;  4A51 A;  1BR4 A;  1D1C A;  3K5E A;  3KAR A;  2FL6 A;  5LT4 A;  1D1A A;  4ETP A;  1BR1 A;  3WPN A;  2NCD A;  3T0Q A;  4PJJ A;  3B6V A;  1VFW A;  1MMA A;  1LKX A;  1V8J A;  3ZFC A;  1MMD A;  3CJO A;  3DCB A;  1F9V A;  2Y65 A;  3KEN A;  4BN2 A;  5LT2 A;  3GBJ A;  4BXN A;  2ZFJ A;  3L1C A;  2GRY A;  1MKJ A;  2X51 A;  2X7E A;  1VFV A;  1F9U A;  1BR2 A;  2X7C A;  4FRZ A;  4AS7 A;  4AP0 A;  4A5Y A;  1II6 A;  1Q0B A;  5LT3 A;  2KIN A;  3LRE A;  3K3B A;  4HNA K;  3L9H A;  4A50 A;  1BG2 A;  4DBR A;  2Q2Y A;  3COB A;  2VB6 A;  1RY6 A;  4GKR A;  3BFN A;  1KK7 A;  1YRS A;  1SDM A;  2VVG A;  3PXN A;  3WRD A;  3NWN A;  3X2T A;  2Y5W A;  5LT1 A;  2X7D A;  4PFP A;  5GSZ A;  4ANJ A;  3KIN A;  1G8X A;  5HLE A;  4Y05 A;  4E7Z A;  4LNU K;  4PFO A;  3B6U A;  4PJL A;  4PJN A;  1F9T A;  2Q2Z A;  2UYI A;  2G1Q A;  1FMW A;  1I5S A;  1D1B A;  2FKY A;  5LT0 A;  3CNZ A;  2MYS A;  4PJM A;  1V8K A;  2IEH A;  4A14 A;  1MNE A;  1MMN A;  1D0Y A;  1F9W A;  1D0Z A;  1GOJ A;  2XAE A;  4UBF A;  1VFZ A;  2FL2 A;  3H4S A; 
#chains in the Genus database with same CATH topology
 2ZFI A;  4BBG A;  2VAS A;  4ZHI A;  2UYM A;  1T5C A;  2ZFM A;  2PG2 A;  3ZFD A;  1MMG A;  4ZCA A;  4A28 A;  2ZFL A;  1VOM A;  2GM1 A;  1LVK A;  3ZCW A;  2OWM A;  4B7B A;  4H1G A;  2X2R A;  3DC4 A;  4A1Z A;  2WOG A;  1FMV A;  1VFX A;  4E7S A;  2HEH A;  2V26 A;  1CZ7 A;  1X88 A;  4DBQ A;  1N6M A;  3HQD A;  4PK4 A;  2FME A;  2ZFK A;  3U06 A;  1I6I A;  1D0X A;  2XT3 A;  4A51 A;  1BR4 A;  1D1C A;  3K5E A;  3KAR A;  2FL6 A;  5LT4 A;  1D1A A;  4ETP A;  1BR1 A;  3WPN A;  2NCD A;  3T0Q A;  4PJJ A;  3B6V A;  1VFW A;  1MMA A;  1LKX A;  1V8J A;  3ZFC A;  1MMD A;  3CJO A;  3DCB A;  1F9V A;  2Y65 A;  3KEN A;  4BN2 A;  5LT2 A;  3GBJ A;  4BXN A;  2ZFJ A;  3L1C A;  2GRY A;  1MKJ A;  2X51 A;  2X7E A;  1VFV A;  1F9U A;  1BR2 A;  4ETP B;  2X7C A;  4FRZ A;  4AS7 A;  4AP0 A;  4A5Y A;  1II6 A;  1Q0B A;  5LT3 A;  2KIN A;  3LRE A;  3K3B A;  4HNA K;  3L9H A;  4A50 A;  1BG2 A;  4DBR A;  2Q2Y A;  3COB A;  2VB6 A;  1RY6 A;  4GKR A;  3BFN A;  1KK7 A;  1YRS A;  4GKQ A;  1SDM A;  2VVG A;  3PXN A;  4GKP A;  3NWN A;  3WRD A;  3X2T A;  2Y5W A;  5LT1 A;  2X7D A;  4PFP A;  5GSZ A;  4ANJ A;  3KIN A;  1G8X A;  5HLE A;  4Y05 A;  4E7Z A;  4LNU K;  4PFO A;  3B6U A;  4PJL A;  4PJN A;  1F9T A;  2Q2Z A;  2UYI A;  2G1Q A;  1FMW A;  1I5S A;  1D1B A;  2FKY A;  5LT0 A;  3CNZ A;  2MYS A;  4PJM A;  1V8K A;  2O0A A;  2IEH A;  4A14 A;  1MNE A;  1MMN A;  1D0Y A;  1F9W A;  1D0Z A;  1GOJ A;  2XAE A;  4UBF A;  1VFZ A;  2FL2 A;  3H4S A; 
#chains in the Genus database with same CATH homology
 2ZFI A;  4BBG A;  2VAS A;  4ZHI A;  2UYM A;  1T5C A;  2ZFM A;  2PG2 A;  3ZFD A;  1MMG A;  4ZCA A;  4A28 A;  2ZFL A;  1VOM A;  2GM1 A;  1LVK A;  3ZCW A;  2OWM A;  4B7B A;  4H1G A;  2X2R A;  3DC4 A;  4A1Z A;  2WOG A;  1FMV A;  1VFX A;  4E7S A;  2HEH A;  2V26 A;  1CZ7 A;  1X88 A;  4DBQ A;  1N6M A;  3HQD A;  4PK4 A;  2FME A;  2ZFK A;  3U06 A;  1I6I A;  1D0X A;  2XT3 A;  4A51 A;  1BR4 A;  1D1C A;  3K5E A;  3KAR A;  2FL6 A;  5LT4 A;  1D1A A;  4ETP A;  1BR1 A;  3WPN A;  2NCD A;  3T0Q A;  4PJJ A;  3B6V A;  1VFW A;  1MMA A;  1LKX A;  1V8J A;  3ZFC A;  1MMD A;  3CJO A;  3DCB A;  1F9V A;  2Y65 A;  3KEN A;  4BN2 A;  5LT2 A;  3GBJ A;  4BXN A;  2ZFJ A;  3L1C A;  2GRY A;  1MKJ A;  2X51 A;  2X7E A;  1VFV A;  1F9U A;  1BR2 A;  2X7C A;  4FRZ A;  4AS7 A;  4AP0 A;  4A5Y A;  1II6 A;  1Q0B A;  5LT3 A;  2KIN A;  3LRE A;  3K3B A;  4HNA K;  3L9H A;  4A50 A;  1BG2 A;  4DBR A;  2Q2Y A;  3COB A;  2VB6 A;  1RY6 A;  4GKR A;  3BFN A;  1KK7 A;  1YRS A;  1SDM A;  2VVG A;  3PXN A;  3WRD A;  3NWN A;  3X2T A;  2Y5W A;  5LT1 A;  2X7D A;  4PFP A;  5GSZ A;  4ANJ A;  3KIN A;  1G8X A;  5HLE A;  4Y05 A;  4E7Z A;  4LNU K;  4PFO A;  3B6U A;  4PJL A;  4PJN A;  1F9T A;  2Q2Z A;  2UYI A;  2G1Q A;  1FMW A;  1I5S A;  1D1B A;  2FKY A;  5LT0 A;  3CNZ A;  2MYS A;  4PJM A;  1V8K A;  2IEH A;  4A14 A;  1MNE A;  1MMN A;  1D0Y A;  1F9W A;  1D0Z A;  1GOJ A;  2XAE A;  4UBF A;  1VFZ A;  2FL2 A;  3H4S A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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