4A1ZA

Eg5-1
Total Genus 101
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
101
sequence length
348
structure length
327
Chain Sequence
KNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERYTWEEVPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSEEAGNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The Mitotic Kinesin Eg5 Overcomes Inhibition to the Phase I/II Clinical Candidate Sb743921 by an Allosteric Resistance Mechanism.
pubmed doi rcsb
molecule tags Motor protein
source organism Homo sapiens
molecule keywords KINESIN-LIKE PROTEIN KIF11
total genus 101
structure length 327
sequence length 348
chains with identical sequence B
ec nomenclature
pdb deposition date 2011-09-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 4a1zA00
5LT2A 2FMEA 2FL2A 4ZCAA 1BR2A 2ZFJA 2PG2A 1VFZA 1MMDA 2X2RA 1G8XA 2IEHA 2Q2ZA 3K5EA 1LVKA 4E7ZA 4DBRA 1F9UA 3CJOA 4PFOA 1CZ7A 4PJNA 1V8KA 2HEHA 3KINA 2VB6A 3PXNA 1D0YA 1KK7A 2GM1A 1VOMA 4PJMA 2XT3A 2OWMA 1MKJA 1MMAA 1T5CA 1D0ZA 3L1CA 4LNUK 3CNZA 3HQDA 1V8JA 1SDMA 1X88A 3K3BA 4A5YA 2NCDA 1FMVA 3GBJA 3BFNA 3ZCWA 5LT3A 4ETPA 4A28A 1Q0BA 1D0XA 1F9WA 2X7EA 5LT0A 1VFVA 1BG2A 4BBGA 1YRSA 3B6UA 5LT1A 4ANJA 3H4SA 3L9HA 1MMNA 4A50A 3T0QA 4B7BA 4E7SA 4H1GA 1F9VA 2XAEA 1I6IA 1BR4A 2UYMA 1N6MA 4GKRA 3ZFCA 4A51A 5GSZA 5LT4A 3KENA 4BN2A 2VASA 4FRZA 4HNAK 4PFPA 4AP0A 3WPNA 3NWNA 5HLEA 3DC4A 4PJJA 2ZFLA 4PK4A 2Q2YA 1MNEA 2Y65A 4AS7A 3U06A 2WOGA 1MMGA 2X7DA 1F9TA 2G1QA 4DBQA 1VFWA 2KINA 2ZFIA 4A14A 1LKXA 2V26A 4PJLA 1GOJA 3COBA 4UBFA 3ZFDA 4Y05A 2FKYA 1II6A 3KARA 1RY6A 3X2TA 1D1AA 1D1BA 3B6VA 2ZFKA 1D1CA 2GRYA 4A1ZA 2Y5WA 2VVGA 2X7CA 2X51A 3LREA 2ZFMA 3WRDA 1FMWA 1BR1A 4ZHIA 4BXNA 1I5SA 1VFXA 3DCBA 2FL6A 2MYSA 2UYIA
chains in the Genus database with same CATH superfamily
5LT2A 2FMEA 2FL2A 4ZCAA 1BR2A 2ZFJA 2PG2A 1VFZA 1MMDA 2X2RA 1G8XA 2IEHA 2Q2ZA 3K5EA 1LVKA 4E7ZA 4DBRA 1F9UA 3CJOA 4PFOA 1CZ7A 4PJNA 1V8KA 2HEHA 3KINA 2VB6A 3PXNA 1D0YA 1KK7A 2GM1A 1VOMA 4PJMA 2XT3A 2OWMA 1MKJA 1MMAA 1T5CA 1D0ZA 3L1CA 4LNUK 3CNZA 3HQDA 4ETPB 1V8JA 1SDMA 1X88A 3K3BA 4A5YA 2O0AA 2NCDA 1FMVA 3GBJA 3BFNA 3ZCWA 5LT3A 4ETPA 4A28A 1Q0BA 1D0XA 1F9WA 2X7EA 5LT0A 1VFVA 1BG2A 4BBGA 1YRSA 3B6UA 5LT1A 4ANJA 3H4SA 3L9HA 1MMNA 4A50A 3T0QA 4B7BA 4E7SA 4H1GA 1F9VA 2XAEA 1I6IA 1BR4A 2UYMA 1N6MA 4GKRA 3ZFCA 4A51A 5GSZA 5LT4A 3KENA 4BN2A 2VASA 4GKPA 4FRZA 4HNAK 4PFPA 4AP0A 3WPNA 3NWNA 5HLEA 3DC4A 4PJJA 2ZFLA 4PK4A 2Q2YA 1MNEA 2Y65A 4AS7A 3U06A 2WOGA 1MMGA 2X7DA 1F9TA 2G1QA 4DBQA 1VFWA 2KINA 2ZFIA 4A14A 1LKXA 2V26A 4PJLA 1GOJA 3COBA 4UBFA 3ZFDA 4Y05A 2FKYA 1II6A 3KARA 1RY6A 3X2TA 1D1AA 1D1BA 3B6VA 2ZFKA 1D1CA 2GRYA 4A1ZA 2Y5WA 2VVGA 2X7CA 2X51A 3LREA 4GKQA 2ZFMA 3WRDA 1FMWA 1BR1A 4ZHIA 4BXNA 1I5SA 1VFXA 3DCBA 2FL6A 2MYSA 2UYIA
chains in the Genus database with same CATH topology
5LT2A 2FMEA 2FL2A 4ZCAA 1BR2A 2ZFJA 2PG2A 1VFZA 1MMDA 2X2RA 1G8XA 2IEHA 2Q2ZA 3K5EA 1LVKA 4E7ZA 4DBRA 1F9UA 3CJOA 4PFOA 1CZ7A 4PJNA 1V8KA 2HEHA 3KINA 2VB6A 3PXNA 1D0YA 1KK7A 2GM1A 1VOMA 4PJMA 2XT3A 2OWMA 1MKJA 1MMAA 1T5CA 1D0ZA 3L1CA 4LNUK 3CNZA 3HQDA 1V8JA 1SDMA 1X88A 3K3BA 4A5YA 2NCDA 1FMVA 3GBJA 3BFNA 3ZCWA 5LT3A 4ETPA 4A28A 1Q0BA 1D0XA 1F9WA 2X7EA 5LT0A 1VFVA 1BG2A 4BBGA 1YRSA 3B6UA 5LT1A 4ANJA 3H4SA 3L9HA 1MMNA 4A50A 3T0QA 4B7BA 4E7SA 4H1GA 1F9VA 2XAEA 1I6IA 1BR4A 2UYMA 1N6MA 4GKRA 3ZFCA 4A51A 5GSZA 5LT4A 3KENA 4BN2A 2VASA 4FRZA 4HNAK 4PFPA 4AP0A 3WPNA 3NWNA 5HLEA 3DC4A 4PJJA 2ZFLA 4PK4A 2Q2YA 1MNEA 2Y65A 4AS7A 3U06A 2WOGA 1MMGA 2X7DA 1F9TA 2G1QA 4DBQA 1VFWA 2KINA 2ZFIA 4A14A 1LKXA 2V26A 4PJLA 1GOJA 3COBA 4UBFA 3ZFDA 4Y05A 2FKYA 1II6A 3KARA 1RY6A 3X2TA 1D1AA 1D1BA 3B6VA 2ZFKA 1D1CA 2GRYA 4A1ZA 2Y5WA 2VVGA 2X7CA 2X51A 3LREA 2ZFMA 3WRDA 1FMWA 1BR1A 4ZHIA 4BXNA 1I5SA 1VFXA 3DCBA 2FL6A 2MYSA 2UYIA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5LT2 A;  2FME A;  2FL2 A;  4ZCA A;  1BR2 A;  2ZFJ A;  2PG2 A;  1VFZ A;  1MMD A;  2X2R A;  1G8X A;  2IEH A;  2Q2Z A;  3K5E A;  1LVK A;  4E7Z A;  4DBR A;  1F9U A;  3CJO A;  4PFO A;  1CZ7 A;  4PJN A;  1V8K A;  2HEH A;  3KIN A;  2VB6 A;  3PXN A;  1D0Y A;  1KK7 A;  2GM1 A;  1VOM A;  4PJM A;  2XT3 A;  2OWM A;  1MKJ A;  1MMA A;  1T5C A;  1D0Z A;  3L1C A;  4LNU K;  3CNZ A;  3HQD A;  1V8J A;  1SDM A;  1X88 A;  3K3B A;  4A5Y A;  2NCD A;  1FMV A;  3GBJ A;  3BFN A;  3ZCW A;  5LT3 A;  4ETP A;  4A28 A;  1Q0B A;  1D0X A;  1F9W A;  2X7E A;  5LT0 A;  1VFV A;  1BG2 A;  4BBG A;  1YRS A;  3B6U A;  5LT1 A;  4ANJ A;  3H4S A;  3L9H A;  1MMN A;  4A50 A;  3T0Q A;  4B7B A;  4E7S A;  4H1G A;  1F9V A;  2XAE A;  1I6I A;  1BR4 A;  2UYM A;  1N6M A;  4GKR A;  3ZFC A;  4A51 A;  5GSZ A;  5LT4 A;  3KEN A;  4BN2 A;  2VAS A;  4FRZ A;  4HNA K;  4PFP A;  4AP0 A;  3WPN A;  3NWN A;  5HLE A;  3DC4 A;  4PJJ A;  2ZFL A;  4PK4 A;  2Q2Y A;  1MNE A;  2Y65 A;  4AS7 A;  3U06 A;  2WOG A;  1MMG A;  2X7D A;  1F9T A;  2G1Q A;  4DBQ A;  1VFW A;  2KIN A;  2ZFI A;  4A14 A;  1LKX A;  2V26 A;  4PJL A;  1GOJ A;  3COB A;  4UBF A;  3ZFD A;  4Y05 A;  2FKY A;  1II6 A;  3KAR A;  1RY6 A;  3X2T A;  1D1A A;  1D1B A;  3B6V A;  2ZFK A;  1D1C A;  2GRY A;  4A1Z A;  2Y5W A;  2VVG A;  2X7C A;  2X51 A;  3LRE A;  2ZFM A;  3WRD A;  1FMW A;  1BR1 A;  4ZHI A;  4BXN A;  1I5S A;  1VFX A;  3DCB A;  2FL6 A;  2MYS A;  2UYI A; 
#chains in the Genus database with same CATH topology
 5LT2 A;  2FME A;  2FL2 A;  4ZCA A;  1BR2 A;  2ZFJ A;  2PG2 A;  1VFZ A;  1MMD A;  2X2R A;  1G8X A;  2IEH A;  2Q2Z A;  3K5E A;  1LVK A;  4E7Z A;  4DBR A;  1F9U A;  3CJO A;  4PFO A;  1CZ7 A;  4PJN A;  1V8K A;  2HEH A;  3KIN A;  2VB6 A;  3PXN A;  1D0Y A;  1KK7 A;  2GM1 A;  1VOM A;  4PJM A;  2XT3 A;  2OWM A;  1MKJ A;  1MMA A;  1T5C A;  1D0Z A;  3L1C A;  4LNU K;  3CNZ A;  3HQD A;  4ETP B;  1V8J A;  1SDM A;  1X88 A;  3K3B A;  4A5Y A;  2O0A A;  2NCD A;  1FMV A;  3GBJ A;  3BFN A;  3ZCW A;  5LT3 A;  4ETP A;  4A28 A;  1Q0B A;  1D0X A;  1F9W A;  2X7E A;  5LT0 A;  1VFV A;  1BG2 A;  4BBG A;  1YRS A;  3B6U A;  5LT1 A;  4ANJ A;  3H4S A;  3L9H A;  1MMN A;  4A50 A;  3T0Q A;  4B7B A;  4E7S A;  4H1G A;  1F9V A;  2XAE A;  1I6I A;  1BR4 A;  2UYM A;  1N6M A;  4GKR A;  3ZFC A;  4A51 A;  5GSZ A;  5LT4 A;  3KEN A;  4BN2 A;  2VAS A;  4GKP A;  4FRZ A;  4HNA K;  4PFP A;  4AP0 A;  3WPN A;  3NWN A;  5HLE A;  3DC4 A;  4PJJ A;  2ZFL A;  4PK4 A;  2Q2Y A;  1MNE A;  2Y65 A;  4AS7 A;  3U06 A;  2WOG A;  1MMG A;  2X7D A;  1F9T A;  2G1Q A;  4DBQ A;  1VFW A;  2KIN A;  2ZFI A;  4A14 A;  1LKX A;  2V26 A;  4PJL A;  1GOJ A;  3COB A;  4UBF A;  3ZFD A;  4Y05 A;  2FKY A;  1II6 A;  3KAR A;  1RY6 A;  3X2T A;  1D1A A;  1D1B A;  3B6V A;  2ZFK A;  1D1C A;  2GRY A;  4A1Z A;  2Y5W A;  2VVG A;  2X7C A;  2X51 A;  3LRE A;  4GKQ A;  2ZFM A;  3WRD A;  1FMW A;  1BR1 A;  4ZHI A;  4BXN A;  1I5S A;  1VFX A;  3DCB A;  2FL6 A;  2MYS A;  2UYI A; 
#chains in the Genus database with same CATH homology
 5LT2 A;  2FME A;  2FL2 A;  4ZCA A;  1BR2 A;  2ZFJ A;  2PG2 A;  1VFZ A;  1MMD A;  2X2R A;  1G8X A;  2IEH A;  2Q2Z A;  3K5E A;  1LVK A;  4E7Z A;  4DBR A;  1F9U A;  3CJO A;  4PFO A;  1CZ7 A;  4PJN A;  1V8K A;  2HEH A;  3KIN A;  2VB6 A;  3PXN A;  1D0Y A;  1KK7 A;  2GM1 A;  1VOM A;  4PJM A;  2XT3 A;  2OWM A;  1MKJ A;  1MMA A;  1T5C A;  1D0Z A;  3L1C A;  4LNU K;  3CNZ A;  3HQD A;  1V8J A;  1SDM A;  1X88 A;  3K3B A;  4A5Y A;  2NCD A;  1FMV A;  3GBJ A;  3BFN A;  3ZCW A;  5LT3 A;  4ETP A;  4A28 A;  1Q0B A;  1D0X A;  1F9W A;  2X7E A;  5LT0 A;  1VFV A;  1BG2 A;  4BBG A;  1YRS A;  3B6U A;  5LT1 A;  4ANJ A;  3H4S A;  3L9H A;  1MMN A;  4A50 A;  3T0Q A;  4B7B A;  4E7S A;  4H1G A;  1F9V A;  2XAE A;  1I6I A;  1BR4 A;  2UYM A;  1N6M A;  4GKR A;  3ZFC A;  4A51 A;  5GSZ A;  5LT4 A;  3KEN A;  4BN2 A;  2VAS A;  4FRZ A;  4HNA K;  4PFP A;  4AP0 A;  3WPN A;  3NWN A;  5HLE A;  3DC4 A;  4PJJ A;  2ZFL A;  4PK4 A;  2Q2Y A;  1MNE A;  2Y65 A;  4AS7 A;  3U06 A;  2WOG A;  1MMG A;  2X7D A;  1F9T A;  2G1Q A;  4DBQ A;  1VFW A;  2KIN A;  2ZFI A;  4A14 A;  1LKX A;  2V26 A;  4PJL A;  1GOJ A;  3COB A;  4UBF A;  3ZFD A;  4Y05 A;  2FKY A;  1II6 A;  3KAR A;  1RY6 A;  3X2T A;  1D1A A;  1D1B A;  3B6V A;  2ZFK A;  1D1C A;  2GRY A;  4A1Z A;  2Y5W A;  2VVG A;  2X7C A;  2X51 A;  3LRE A;  2ZFM A;  3WRD A;  1FMW A;  1BR1 A;  4ZHI A;  4BXN A;  1I5S A;  1VFX A;  3DCB A;  2FL6 A;  2MYS A;  2UYI A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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