2FMEA

Crystal structure of the mitotic kinesin eg5 (ksp) in complex with mg-adp and (r)-4-(3-hydroxyphenyl)-n,n,7,8-tetramethyl-3,4-dihydroisoquinoline-2(1h)-carboxamide
Total Genus 101
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
101
sequence length
346
structure length
320
Chain Sequence
KNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKVKIGKLNLVDLAGSENIGRINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Cell cycle
molecule keywords Kinesin-like protein KIF11
publication title Inhibitors of human mitotic kinesin Eg5: Characterization of the 4-phenyl-tetrahydroisoquinoline lead series
pubmed doi rcsb
source organism Homo sapiens
total genus 101
structure length 320
sequence length 346
chains with identical sequence B
ec nomenclature
pdb deposition date 2006-01-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 2fmeA00
1VFXA 4A14A 1VFWA 3ZFDA 3CJOA 1MNEA 2MYSA 4PJMA 3DCBA 3PXNA 2X7DA 1F9UA 2X51A 2KINA 3BFNA 4PJNA 3B6UA 3NWNA 1MMAA 1LKXA 1T5CA 1MMGA 1GOJA 1LVKA 2FL2A 4BXNA 4BBGA 4LNUK 2FL6A 2Q2ZA 2VB6A 5HLEA 1VFVA 3K3BA 1D0YA 3WRDA 3ZCWA 1F9TA 2UYMA 2X7CA 3KINA 3ZFCA 4H1GA 3WPNA 1FMWA 3KENA 2FKYA 5LT0A 1D0XA 3KARA 1RY6A 4A1ZA 4BN2A 1CZ7A 1I6IA 1II6A 3K5EA 1D0ZA 2XAEA 3HQDA 4ETPA 5GSZA 2VVGA 2ZFIA 4PK4A 2HEHA 2OWMA 1Q0BA 4ZHIA 2NCDA 2FMEA 3U06A 2Q2YA 3T0QA 4AP0A 1V8JA 1G8XA 1KK7A 1X88A 1YRSA 2GRYA 1N6MA 4FRZA 1VFZA 4E7SA 2GM1A 2V26A 1MKJA 4PJLA 1I5SA 2XT3A 1BG2A 4A5YA 4Y05A 5LT1A 2UYIA 2ZFLA 3B6VA 4E7ZA 5LT3A 4GKRA 5LT4A 3X2TA 2ZFKA 1F9VA 2IEHA 2X7EA 2ZFJA 4AS7A 1BR4A 1D1AA 2Y65A 3L1CA 4PJJA 4ZCAA 2X2RA 4DBQA 3L9HA 4DBRA 4UBFA 1V8KA 1VOMA 2Y5WA 2ZFMA 4PFPA 1D1CA 3GBJA 1MMDA 3H4SA 1SDMA 3LREA 2PG2A 4A51A 1BR1A 4A50A 1MMNA 4ANJA 5LT2A 3DC4A 4HNAK 3CNZA 3COBA 1F9WA 2G1QA 4PFOA 4B7BA 4A28A 2WOGA 1BR2A 2VASA 1FMVA 1D1BA
chains in the Genus database with same CATH superfamily
1VFXA 4A14A 1VFWA 3ZFDA 3CJOA 1MNEA 2MYSA 4PJMA 3DCBA 3PXNA 2X7DA 1F9UA 2X51A 2KINA 3BFNA 4PJNA 3B6UA 3NWNA 1MMAA 1LKXA 1T5CA 1MMGA 1GOJA 1LVKA 2FL2A 4BXNA 4BBGA 4LNUK 2FL6A 2Q2ZA 2VB6A 5HLEA 1VFVA 3K3BA 1D0YA 3WRDA 3ZCWA 1F9TA 2UYMA 2X7CA 3KINA 3ZFCA 4H1GA 3WPNA 1FMWA 3KENA 2FKYA 5LT0A 1D0XA 3KARA 1RY6A 4A1ZA 4BN2A 1CZ7A 1I6IA 1II6A 3K5EA 1D0ZA 2XAEA 3HQDA 4ETPA 5GSZA 2VVGA 2ZFIA 4PK4A 2HEHA 2OWMA 1Q0BA 4ZHIA 2NCDA 4ETPB 2FMEA 3U06A 2Q2YA 3T0QA 4AP0A 1V8JA 1G8XA 1KK7A 1X88A 1YRSA 2GRYA 1N6MA 4FRZA 1VFZA 4E7SA 2GM1A 2O0AA 2V26A 1MKJA 4PJLA 1I5SA 2XT3A 1BG2A 4A5YA 4Y05A 5LT1A 2UYIA 2ZFLA 3B6VA 4E7ZA 5LT3A 4GKRA 5LT4A 3X2TA 2ZFKA 1F9VA 2IEHA 2X7EA 2ZFJA 4GKQA 4AS7A 1BR4A 1D1AA 2Y65A 3L1CA 4PJJA 4ZCAA 2X2RA 4DBQA 3L9HA 4DBRA 4UBFA 4GKPA 1V8KA 1VOMA 2Y5WA 2ZFMA 4PFPA 1D1CA 3GBJA 1MMDA 3H4SA 1SDMA 3LREA 2PG2A 4A51A 1BR1A 4A50A 1MMNA 4ANJA 5LT2A 3DC4A 4HNAK 3CNZA 3COBA 1F9WA 2G1QA 4PFOA 4B7BA 4A28A 2WOGA 1BR2A 2VASA 1FMVA 1D1BA
chains in the Genus database with same CATH topology
1VFXA 4A14A 1VFWA 3ZFDA 3CJOA 1MNEA 2MYSA 4PJMA 3DCBA 3PXNA 2X7DA 1F9UA 2X51A 2KINA 3BFNA 4PJNA 3B6UA 3NWNA 1MMAA 1LKXA 1T5CA 1MMGA 1GOJA 1LVKA 2FL2A 4BXNA 4BBGA 4LNUK 2FL6A 2Q2ZA 2VB6A 5HLEA 1VFVA 3K3BA 1D0YA 3WRDA 3ZCWA 1F9TA 2UYMA 2X7CA 3KINA 3ZFCA 4H1GA 3WPNA 1FMWA 3KENA 2FKYA 5LT0A 1D0XA 3KARA 1RY6A 4A1ZA 4BN2A 1CZ7A 1I6IA 1II6A 3K5EA 1D0ZA 2XAEA 3HQDA 4ETPA 5GSZA 2VVGA 2ZFIA 4PK4A 2HEHA 2OWMA 1Q0BA 4ZHIA 2NCDA 2FMEA 3U06A 2Q2YA 3T0QA 4AP0A 1V8JA 1G8XA 1KK7A 1X88A 1YRSA 2GRYA 1N6MA 4FRZA 1VFZA 4E7SA 2GM1A 2V26A 1MKJA 4PJLA 1I5SA 2XT3A 1BG2A 4A5YA 4Y05A 5LT1A 2UYIA 2ZFLA 3B6VA 4E7ZA 5LT3A 4GKRA 5LT4A 3X2TA 2ZFKA 1F9VA 2IEHA 2X7EA 2ZFJA 4AS7A 1BR4A 1D1AA 2Y65A 3L1CA 4PJJA 4ZCAA 2X2RA 4DBQA 3L9HA 4DBRA 4UBFA 1V8KA 1VOMA 2Y5WA 2ZFMA 4PFPA 1D1CA 3GBJA 1MMDA 3H4SA 1SDMA 3LREA 2PG2A 4A51A 1BR1A 4A50A 1MMNA 4ANJA 5LT2A 3DC4A 4HNAK 3CNZA 3COBA 1F9WA 2G1QA 4PFOA 4B7BA 4A28A 2WOGA 1BR2A 2VASA 1FMVA 1D1BA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1VFX A;  4A14 A;  1VFW A;  3ZFD A;  3CJO A;  1MNE A;  2MYS A;  4PJM A;  3DCB A;  3PXN A;  2X7D A;  1F9U A;  2X51 A;  2KIN A;  3BFN A;  4PJN A;  3B6U A;  3NWN A;  1MMA A;  1LKX A;  1T5C A;  1MMG A;  1GOJ A;  1LVK A;  2FL2 A;  4BXN A;  4BBG A;  4LNU K;  2FL6 A;  2Q2Z A;  2VB6 A;  5HLE A;  1VFV A;  3K3B A;  1D0Y A;  3WRD A;  3ZCW A;  1F9T A;  2UYM A;  2X7C A;  3KIN A;  3ZFC A;  4H1G A;  3WPN A;  1FMW A;  3KEN A;  2FKY A;  5LT0 A;  1D0X A;  3KAR A;  1RY6 A;  4A1Z A;  4BN2 A;  1CZ7 A;  1I6I A;  1II6 A;  3K5E A;  1D0Z A;  2XAE A;  3HQD A;  4ETP A;  5GSZ A;  2VVG A;  2ZFI A;  4PK4 A;  2HEH A;  2OWM A;  1Q0B A;  4ZHI A;  2NCD A;  2FME A;  3U06 A;  2Q2Y A;  3T0Q A;  4AP0 A;  1V8J A;  1G8X A;  1KK7 A;  1X88 A;  1YRS A;  2GRY A;  1N6M A;  4FRZ A;  1VFZ A;  4E7S A;  2GM1 A;  2V26 A;  1MKJ A;  4PJL A;  1I5S A;  2XT3 A;  1BG2 A;  4A5Y A;  4Y05 A;  5LT1 A;  2UYI A;  2ZFL A;  3B6V A;  4E7Z A;  5LT3 A;  4GKR A;  5LT4 A;  3X2T A;  2ZFK A;  1F9V A;  2IEH A;  2X7E A;  2ZFJ A;  4AS7 A;  1BR4 A;  1D1A A;  2Y65 A;  3L1C A;  4PJJ A;  4ZCA A;  2X2R A;  4DBQ A;  3L9H A;  4DBR A;  4UBF A;  1V8K A;  1VOM A;  2Y5W A;  2ZFM A;  4PFP A;  1D1C A;  3GBJ A;  1MMD A;  3H4S A;  1SDM A;  3LRE A;  2PG2 A;  4A51 A;  1BR1 A;  4A50 A;  1MMN A;  4ANJ A;  5LT2 A;  3DC4 A;  4HNA K;  3CNZ A;  3COB A;  1F9W A;  2G1Q A;  4PFO A;  4B7B A;  4A28 A;  2WOG A;  1BR2 A;  2VAS A;  1FMV A;  1D1B A; 
#chains in the Genus database with same CATH topology
 1VFX A;  4A14 A;  1VFW A;  3ZFD A;  3CJO A;  1MNE A;  2MYS A;  4PJM A;  3DCB A;  3PXN A;  2X7D A;  1F9U A;  2X51 A;  2KIN A;  3BFN A;  4PJN A;  3B6U A;  3NWN A;  1MMA A;  1LKX A;  1T5C A;  1MMG A;  1GOJ A;  1LVK A;  2FL2 A;  4BXN A;  4BBG A;  4LNU K;  2FL6 A;  2Q2Z A;  2VB6 A;  5HLE A;  1VFV A;  3K3B A;  1D0Y A;  3WRD A;  3ZCW A;  1F9T A;  2UYM A;  2X7C A;  3KIN A;  3ZFC A;  4H1G A;  3WPN A;  1FMW A;  3KEN A;  2FKY A;  5LT0 A;  1D0X A;  3KAR A;  1RY6 A;  4A1Z A;  4BN2 A;  1CZ7 A;  1I6I A;  1II6 A;  3K5E A;  1D0Z A;  2XAE A;  3HQD A;  4ETP A;  5GSZ A;  2VVG A;  2ZFI A;  4PK4 A;  2HEH A;  2OWM A;  1Q0B A;  4ZHI A;  2NCD A;  4ETP B;  2FME A;  3U06 A;  2Q2Y A;  3T0Q A;  4AP0 A;  1V8J A;  1G8X A;  1KK7 A;  1X88 A;  1YRS A;  2GRY A;  1N6M A;  4FRZ A;  1VFZ A;  4E7S A;  2GM1 A;  2O0A A;  2V26 A;  1MKJ A;  4PJL A;  1I5S A;  2XT3 A;  1BG2 A;  4A5Y A;  4Y05 A;  5LT1 A;  2UYI A;  2ZFL A;  3B6V A;  4E7Z A;  5LT3 A;  4GKR A;  5LT4 A;  3X2T A;  2ZFK A;  1F9V A;  2IEH A;  2X7E A;  2ZFJ A;  4GKQ A;  4AS7 A;  1BR4 A;  1D1A A;  2Y65 A;  3L1C A;  4PJJ A;  4ZCA A;  2X2R A;  4DBQ A;  3L9H A;  4DBR A;  4UBF A;  4GKP A;  1V8K A;  1VOM A;  2Y5W A;  2ZFM A;  4PFP A;  1D1C A;  3GBJ A;  1MMD A;  3H4S A;  1SDM A;  3LRE A;  2PG2 A;  4A51 A;  1BR1 A;  4A50 A;  1MMN A;  4ANJ A;  5LT2 A;  3DC4 A;  4HNA K;  3CNZ A;  3COB A;  1F9W A;  2G1Q A;  4PFO A;  4B7B A;  4A28 A;  2WOG A;  1BR2 A;  2VAS A;  1FMV A;  1D1B A; 
#chains in the Genus database with same CATH homology
 1VFX A;  4A14 A;  1VFW A;  3ZFD A;  3CJO A;  1MNE A;  2MYS A;  4PJM A;  3DCB A;  3PXN A;  2X7D A;  1F9U A;  2X51 A;  2KIN A;  3BFN A;  4PJN A;  3B6U A;  3NWN A;  1MMA A;  1LKX A;  1T5C A;  1MMG A;  1GOJ A;  1LVK A;  2FL2 A;  4BXN A;  4BBG A;  4LNU K;  2FL6 A;  2Q2Z A;  2VB6 A;  5HLE A;  1VFV A;  3K3B A;  1D0Y A;  3WRD A;  3ZCW A;  1F9T A;  2UYM A;  2X7C A;  3KIN A;  3ZFC A;  4H1G A;  3WPN A;  1FMW A;  3KEN A;  2FKY A;  5LT0 A;  1D0X A;  3KAR A;  1RY6 A;  4A1Z A;  4BN2 A;  1CZ7 A;  1I6I A;  1II6 A;  3K5E A;  1D0Z A;  2XAE A;  3HQD A;  4ETP A;  5GSZ A;  2VVG A;  2ZFI A;  4PK4 A;  2HEH A;  2OWM A;  1Q0B A;  4ZHI A;  2NCD A;  2FME A;  3U06 A;  2Q2Y A;  3T0Q A;  4AP0 A;  1V8J A;  1G8X A;  1KK7 A;  1X88 A;  1YRS A;  2GRY A;  1N6M A;  4FRZ A;  1VFZ A;  4E7S A;  2GM1 A;  2V26 A;  1MKJ A;  4PJL A;  1I5S A;  2XT3 A;  1BG2 A;  4A5Y A;  4Y05 A;  5LT1 A;  2UYI A;  2ZFL A;  3B6V A;  4E7Z A;  5LT3 A;  4GKR A;  5LT4 A;  3X2T A;  2ZFK A;  1F9V A;  2IEH A;  2X7E A;  2ZFJ A;  4AS7 A;  1BR4 A;  1D1A A;  2Y65 A;  3L1C A;  4PJJ A;  4ZCA A;  2X2R A;  4DBQ A;  3L9H A;  4DBR A;  4UBF A;  1V8K A;  1VOM A;  2Y5W A;  2ZFM A;  4PFP A;  1D1C A;  3GBJ A;  1MMD A;  3H4S A;  1SDM A;  3LRE A;  2PG2 A;  4A51 A;  1BR1 A;  4A50 A;  1MMN A;  4ANJ A;  5LT2 A;  3DC4 A;  4HNA K;  3CNZ A;  3COB A;  1F9W A;  2G1Q A;  4PFO A;  4B7B A;  4A28 A;  2WOG A;  1BR2 A;  2VAS A;  1FMV A;  1D1B A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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