2X7CA

Crystal structure of human kinesin eg5 in complex with (s)-enastron
Total Genus 104
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
104
sequence length
347
structure length
332
Chain Sequence
NIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Cell cycle
molecule keywords KINESIN-LIKE PROTEIN KIF11
publication title Structural Basis for Inhibition of Eg5 by Dihydropyrimidines: Stereoselectivity of Antimitotic Inhibitors Enastron, Dimethylenastron and Fluorastrol.
pubmed doi rcsb
source organism Homo sapiens
total genus 104
structure length 332
sequence length 347
chains with identical sequence B
ec nomenclature
pdb deposition date 2010-02-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 2x7cA00
3X2TA 2HEHA 4Y05A 1BR4A 4PJJA 3K3BA 4ZHIA 1VOMA 2ZFKA 3NWNA 2XT3A 2IEHA 4H1GA 3KENA 3CJOA 1GOJA 4HNAK 2X7DA 1MMGA 1MMDA 1I5SA 1MKJA 3H4SA 2UYIA 1F9WA 2Y5WA 3WRDA 2X2RA 3B6VA 1T5CA 4UBFA 3BFNA 2ZFJA 2Q2ZA 1VFVA 2FMEA 5LT2A 5LT3A 4A14A 3KARA 2GM1A 1BR1A 1X88A 1V8KA 1Q0BA 4BN2A 3CNZA 4A1ZA 1BG2A 2Q2YA 2KINA 3ZFDA 2G1QA 2PG2A 1SDMA 3GBJA 3KINA 1VFWA 5LT0A 5LT1A 3L9HA 2ZFLA 4PJLA 1N6MA 2GRYA 2V26A 3DCBA 1RY6A 1MMNA 5GSZA 1FMVA 4A28A 4LNUK 3ZFCA 1D0XA 2XAEA 5LT4A 1D1CA 2FKYA 1II6A 3B6UA 1CZ7A 1F9TA 1F9UA 5HLEA 4BBGA 4E7SA 1G8XA 1MMAA 2VASA 2ZFMA 4ETPA 4GKRA 2MYSA 3WPNA 4A50A 1I6IA 1D0YA 2VB6A 1VFZA 2X7CA 2OWMA 3LREA 1D0ZA 1KK7A 2NCDA 1F9VA 4PFOA 4PJNA 4BXNA 4A5YA 3ZCWA 2Y65A 2FL2A 2X7EA 4E7ZA 4DBQA 4B7BA 4ANJA 1MNEA 2FL6A 1LKXA 4PJMA 4PK4A 4A51A 2WOGA 2VVGA 1D1AA 3K5EA 4DBRA 3L1CA 1V8JA 4PFPA 4ZCAA 4AP0A 3PXNA 4AS7A 1LVKA 1BR2A 1YRSA 2UYMA 3U06A 3HQDA 2X51A 3DC4A 4FRZA 3T0QA 1D1BA 3COBA 2ZFIA 1FMWA 1VFXA
chains in the Genus database with same CATH superfamily
3X2TA 2HEHA 4Y05A 1BR4A 4GKPA 3K3BA 4PJJA 4ZHIA 1VOMA 2ZFKA 3NWNA 2XT3A 2IEHA 4H1GA 3KENA 3CJOA 1GOJA 4HNAK 2X7DA 1MMGA 1MMDA 2O0AA 1I5SA 1MKJA 3H4SA 2UYIA 1F9WA 2Y5WA 3WRDA 2X2RA 3B6VA 1T5CA 4UBFA 3BFNA 2ZFJA 2Q2ZA 1VFVA 2FMEA 5LT2A 5LT3A 4A14A 3KARA 2GM1A 1BR1A 1X88A 1V8KA 1Q0BA 4BN2A 3CNZA 4A1ZA 1BG2A 2Q2YA 2KINA 3ZFDA 2G1QA 2PG2A 1SDMA 3GBJA 3KINA 1VFWA 5LT0A 5LT1A 3L9HA 2ZFLA 4PJLA 1N6MA 2GRYA 2V26A 3DCBA 1RY6A 1MMNA 4GKQA 5GSZA 1FMVA 4A28A 4LNUK 3ZFCA 1D0XA 2XAEA 5LT4A 1D1CA 2FKYA 1II6A 3B6UA 1CZ7A 1F9TA 1F9UA 5HLEA 4BBGA 4E7SA 1G8XA 1MMAA 2VASA 2ZFMA 4ETPA 4GKRA 2MYSA 3WPNA 4A50A 1I6IA 1D0YA 2VB6A 1VFZA 2X7CA 2OWMA 3LREA 1D0ZA 1KK7A 2NCDA 1F9VA 4PFOA 4PJNA 4BXNA 4A5YA 3ZCWA 2FL2A 2Y65A 2X7EA 4E7ZA 4DBQA 4B7BA 4ANJA 1MNEA 2FL6A 1LKXA 4PJMA 4PK4A 4A51A 2WOGA 2VVGA 1D1AA 3K5EA 4DBRA 3L1CA 1V8JA 4PFPA 4ZCAA 4AP0A 3PXNA 4AS7A 1LVKA 1BR2A 4ETPB 1YRSA 2UYMA 3U06A 3HQDA 2X51A 3DC4A 4FRZA 3T0QA 1D1BA 3COBA 2ZFIA 1FMWA 1VFXA
chains in the Genus database with same CATH topology
3X2TA 2HEHA 4Y05A 1BR4A 4PJJA 3K3BA 4ZHIA 1VOMA 2ZFKA 3NWNA 2XT3A 2IEHA 4H1GA 3KENA 3CJOA 1GOJA 4HNAK 2X7DA 1MMGA 1MMDA 1I5SA 1MKJA 3H4SA 2UYIA 1F9WA 2Y5WA 3WRDA 2X2RA 3B6VA 1T5CA 4UBFA 3BFNA 2ZFJA 2Q2ZA 1VFVA 2FMEA 5LT2A 5LT3A 4A14A 3KARA 2GM1A 1BR1A 1X88A 1V8KA 1Q0BA 4BN2A 3CNZA 4A1ZA 1BG2A 2Q2YA 2KINA 3ZFDA 2G1QA 2PG2A 1SDMA 3GBJA 3KINA 1VFWA 5LT0A 5LT1A 3L9HA 2ZFLA 4PJLA 1N6MA 2GRYA 2V26A 3DCBA 1RY6A 1MMNA 5GSZA 1FMVA 4A28A 4LNUK 3ZFCA 1D0XA 2XAEA 5LT4A 1D1CA 2FKYA 1II6A 3B6UA 1CZ7A 1F9TA 1F9UA 5HLEA 4BBGA 4E7SA 1G8XA 1MMAA 2VASA 2ZFMA 4ETPA 4GKRA 2MYSA 3WPNA 4A50A 1I6IA 1D0YA 2VB6A 1VFZA 2X7CA 2OWMA 3LREA 1D0ZA 1KK7A 2NCDA 1F9VA 4PFOA 4PJNA 4BXNA 4A5YA 3ZCWA 2Y65A 2FL2A 2X7EA 4E7ZA 4DBQA 4B7BA 4ANJA 1MNEA 2FL6A 1LKXA 4PJMA 4PK4A 4A51A 2WOGA 2VVGA 1D1AA 3K5EA 4DBRA 3L1CA 1V8JA 4PFPA 4ZCAA 4AP0A 3PXNA 4AS7A 1LVKA 1BR2A 1YRSA 2UYMA 3U06A 3HQDA 2X51A 3DC4A 4FRZA 3T0QA 1D1BA 3COBA 2ZFIA 1FMWA 1VFXA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3X2T A;  2HEH A;  4Y05 A;  1BR4 A;  4PJJ A;  3K3B A;  4ZHI A;  1VOM A;  2ZFK A;  3NWN A;  2XT3 A;  2IEH A;  4H1G A;  3KEN A;  3CJO A;  1GOJ A;  4HNA K;  2X7D A;  1MMG A;  1MMD A;  1I5S A;  1MKJ A;  3H4S A;  2UYI A;  1F9W A;  2Y5W A;  3WRD A;  2X2R A;  3B6V A;  1T5C A;  4UBF A;  3BFN A;  2ZFJ A;  2Q2Z A;  1VFV A;  2FME A;  5LT2 A;  5LT3 A;  4A14 A;  3KAR A;  2GM1 A;  1BR1 A;  1X88 A;  1V8K A;  1Q0B A;  4BN2 A;  3CNZ A;  4A1Z A;  1BG2 A;  2Q2Y A;  2KIN A;  3ZFD A;  2G1Q A;  2PG2 A;  1SDM A;  3GBJ A;  3KIN A;  1VFW A;  5LT0 A;  5LT1 A;  3L9H A;  2ZFL A;  4PJL A;  1N6M A;  2GRY A;  2V26 A;  3DCB A;  1RY6 A;  1MMN A;  5GSZ A;  1FMV A;  4A28 A;  4LNU K;  3ZFC A;  1D0X A;  2XAE A;  5LT4 A;  1D1C A;  2FKY A;  1II6 A;  3B6U A;  1CZ7 A;  1F9T A;  1F9U A;  5HLE A;  4BBG A;  4E7S A;  1G8X A;  1MMA A;  2VAS A;  2ZFM A;  4ETP A;  4GKR A;  2MYS A;  3WPN A;  4A50 A;  1I6I A;  1D0Y A;  2VB6 A;  1VFZ A;  2X7C A;  2OWM A;  3LRE A;  1D0Z A;  1KK7 A;  2NCD A;  1F9V A;  4PFO A;  4PJN A;  4BXN A;  4A5Y A;  3ZCW A;  2Y65 A;  2FL2 A;  2X7E A;  4E7Z A;  4DBQ A;  4B7B A;  4ANJ A;  1MNE A;  2FL6 A;  1LKX A;  4PJM A;  4PK4 A;  4A51 A;  2WOG A;  2VVG A;  1D1A A;  3K5E A;  4DBR A;  3L1C A;  1V8J A;  4PFP A;  4ZCA A;  4AP0 A;  3PXN A;  4AS7 A;  1LVK A;  1BR2 A;  1YRS A;  2UYM A;  3U06 A;  3HQD A;  2X51 A;  3DC4 A;  4FRZ A;  3T0Q A;  1D1B A;  3COB A;  2ZFI A;  1FMW A;  1VFX A; 
#chains in the Genus database with same CATH topology
 3X2T A;  2HEH A;  4Y05 A;  1BR4 A;  4GKP A;  3K3B A;  4PJJ A;  4ZHI A;  1VOM A;  2ZFK A;  3NWN A;  2XT3 A;  2IEH A;  4H1G A;  3KEN A;  3CJO A;  1GOJ A;  4HNA K;  2X7D A;  1MMG A;  1MMD A;  2O0A A;  1I5S A;  1MKJ A;  3H4S A;  2UYI A;  1F9W A;  2Y5W A;  3WRD A;  2X2R A;  3B6V A;  1T5C A;  4UBF A;  3BFN A;  2ZFJ A;  2Q2Z A;  1VFV A;  2FME A;  5LT2 A;  5LT3 A;  4A14 A;  3KAR A;  2GM1 A;  1BR1 A;  1X88 A;  1V8K A;  1Q0B A;  4BN2 A;  3CNZ A;  4A1Z A;  1BG2 A;  2Q2Y A;  2KIN A;  3ZFD A;  2G1Q A;  2PG2 A;  1SDM A;  3GBJ A;  3KIN A;  1VFW A;  5LT0 A;  5LT1 A;  3L9H A;  2ZFL A;  4PJL A;  1N6M A;  2GRY A;  2V26 A;  3DCB A;  1RY6 A;  1MMN A;  4GKQ A;  5GSZ A;  1FMV A;  4A28 A;  4LNU K;  3ZFC A;  1D0X A;  2XAE A;  5LT4 A;  1D1C A;  2FKY A;  1II6 A;  3B6U A;  1CZ7 A;  1F9T A;  1F9U A;  5HLE A;  4BBG A;  4E7S A;  1G8X A;  1MMA A;  2VAS A;  2ZFM A;  4ETP A;  4GKR A;  2MYS A;  3WPN A;  4A50 A;  1I6I A;  1D0Y A;  2VB6 A;  1VFZ A;  2X7C A;  2OWM A;  3LRE A;  1D0Z A;  1KK7 A;  2NCD A;  1F9V A;  4PFO A;  4PJN A;  4BXN A;  4A5Y A;  3ZCW A;  2FL2 A;  2Y65 A;  2X7E A;  4E7Z A;  4DBQ A;  4B7B A;  4ANJ A;  1MNE A;  2FL6 A;  1LKX A;  4PJM A;  4PK4 A;  4A51 A;  2WOG A;  2VVG A;  1D1A A;  3K5E A;  4DBR A;  3L1C A;  1V8J A;  4PFP A;  4ZCA A;  4AP0 A;  3PXN A;  4AS7 A;  1LVK A;  1BR2 A;  4ETP B;  1YRS A;  2UYM A;  3U06 A;  3HQD A;  2X51 A;  3DC4 A;  4FRZ A;  3T0Q A;  1D1B A;  3COB A;  2ZFI A;  1FMW A;  1VFX A; 
#chains in the Genus database with same CATH homology
 3X2T A;  2HEH A;  4Y05 A;  1BR4 A;  4PJJ A;  3K3B A;  4ZHI A;  1VOM A;  2ZFK A;  3NWN A;  2XT3 A;  2IEH A;  4H1G A;  3KEN A;  3CJO A;  1GOJ A;  4HNA K;  2X7D A;  1MMG A;  1MMD A;  1I5S A;  1MKJ A;  3H4S A;  2UYI A;  1F9W A;  2Y5W A;  3WRD A;  2X2R A;  3B6V A;  1T5C A;  4UBF A;  3BFN A;  2ZFJ A;  2Q2Z A;  1VFV A;  2FME A;  5LT2 A;  5LT3 A;  4A14 A;  3KAR A;  2GM1 A;  1BR1 A;  1X88 A;  1V8K A;  1Q0B A;  4BN2 A;  3CNZ A;  4A1Z A;  1BG2 A;  2Q2Y A;  2KIN A;  3ZFD A;  2G1Q A;  2PG2 A;  1SDM A;  3GBJ A;  3KIN A;  1VFW A;  5LT0 A;  5LT1 A;  3L9H A;  2ZFL A;  4PJL A;  1N6M A;  2GRY A;  2V26 A;  3DCB A;  1RY6 A;  1MMN A;  5GSZ A;  1FMV A;  4A28 A;  4LNU K;  3ZFC A;  1D0X A;  2XAE A;  5LT4 A;  1D1C A;  2FKY A;  1II6 A;  3B6U A;  1CZ7 A;  1F9T A;  1F9U A;  5HLE A;  4BBG A;  4E7S A;  1G8X A;  1MMA A;  2VAS A;  2ZFM A;  4ETP A;  4GKR A;  2MYS A;  3WPN A;  4A50 A;  1I6I A;  1D0Y A;  2VB6 A;  1VFZ A;  2X7C A;  2OWM A;  3LRE A;  1D0Z A;  1KK7 A;  2NCD A;  1F9V A;  4PFO A;  4PJN A;  4BXN A;  4A5Y A;  3ZCW A;  2Y65 A;  2FL2 A;  2X7E A;  4E7Z A;  4DBQ A;  4B7B A;  4ANJ A;  1MNE A;  2FL6 A;  1LKX A;  4PJM A;  4PK4 A;  4A51 A;  2WOG A;  2VVG A;  1D1A A;  3K5E A;  4DBR A;  3L1C A;  1V8J A;  4PFP A;  4ZCA A;  4AP0 A;  3PXN A;  4AS7 A;  1LVK A;  1BR2 A;  1YRS A;  2UYM A;  3U06 A;  3HQD A;  2X51 A;  3DC4 A;  4FRZ A;  3T0Q A;  1D1B A;  3COB A;  2ZFI A;  1FMW A;  1VFX A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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