2X7CA

Crystal structure of human kinesin eg5 in complex with (s)-enastron
Total Genus 104
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
104
sequence length
347
structure length
332
Chain Sequence
NIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords KINESIN-LIKE PROTEIN KIF11
publication title Structural Basis for Inhibition of Eg5 by Dihydropyrimidines: Stereoselectivity of Antimitotic Inhibitors Enastron, Dimethylenastron and Fluorastrol.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Cell cycle
total genus 104
structure length 332
sequence length 347
chains with identical sequence B
ec nomenclature
pdb deposition date 2010-02-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 2x7cA00
2WOGA 4B7BA 4E7ZA 3CJOA 4PFPA 1BR4A 4BBGA 1F9VA 1N6MA 2X51A 4A28A 1YRSA 3WRDA 4ZHIA 1MMNA 1MMDA 1F9WA 1GOJA 1CZ7A 2FMEA 2G1QA 4PFOA 3NWNA 1BG2A 1D1CA 3BFNA 2ZFMA 4AP0A 3K5EA 1G8XA 4ANJA 5LT3A 4DBRA 4H1GA 2XT3A 2X2RA 1I5SA 3T0QA 4AS7A 2VB6A 2KINA 3WPNA 1T5CA 1FMVA 2V26A 4GKRA 2HEHA 2Y65A 1I6IA 3U06A 1F9UA 1VFZA 3L9HA 4ZCAA 3B6UA 4FRZA 3X2TA 4PK4A 2Y5WA 1VFXA 3KENA 5LT4A 4PJMA 1D0XA 3KINA 2ZFIA 2FL6A 1Q0BA 3L1CA 3HQDA 3ZCWA 2X7CA 1D0ZA 1VOMA 4Y05A 1VFWA 1D1AA 1FMWA 2X7EA 1V8JA 4ETPA 1KK7A 3COBA 3ZFCA 1V8KA 1MNEA 2MYSA 2ZFLA 2UYMA 2FKYA 2ZFKA 1BR1A 1F9TA 1LVKA 4PJLA 4A50A 2IEHA 2ZFJA 3K3BA 5HLEA 1BR2A 1MMGA 1D0YA 1RY6A 1MKJA 2GRYA 4E7SA 2VVGA 3KARA 3ZFDA 4LNUK 5LT0A 4DBQA 2FL2A 3PXNA 3LREA 4A1ZA 2Q2YA 1D1BA 5LT1A 1X88A 4A14A 4PJNA 2X7DA 4PJJA 3DCBA 3CNZA 2OWMA 3GBJA 5GSZA 4UBFA 2GM1A 2Q2ZA 1SDMA 2NCDA 4BXNA 1LKXA 2VASA 5LT2A 1II6A 3B6VA 4A51A 2PG2A 4A5YA 4HNAK 1MMAA 1VFVA 4BN2A 3DC4A 2XAEA 3H4SA 2UYIA
chains in the Genus database with same CATH superfamily
2WOGA 4B7BA 4E7ZA 3CJOA 4PFPA 1BR4A 4BBGA 1F9VA 1N6MA 2X51A 4A28A 1YRSA 3WRDA 4ZHIA 1MMNA 1MMDA 1F9WA 1GOJA 1CZ7A 2FMEA 2G1QA 4PFOA 3NWNA 1BG2A 1D1CA 3BFNA 2ZFMA 4AP0A 3K5EA 1G8XA 4ANJA 5LT3A 4DBRA 4H1GA 2XT3A 2X2RA 1I5SA 3T0QA 4AS7A 2VB6A 2KINA 3WPNA 1T5CA 1FMVA 2V26A 4GKRA 2HEHA 4ETPB 2Y65A 1I6IA 3U06A 1F9UA 1VFZA 3L9HA 4ZCAA 3B6UA 2O0AA 4FRZA 3X2TA 4PK4A 2Y5WA 1VFXA 3KENA 5LT4A 4PJMA 1D0XA 3KINA 2ZFIA 2FL6A 1Q0BA 3L1CA 3HQDA 3ZCWA 2X7CA 1D0ZA 1VOMA 4Y05A 1VFWA 1D1AA 1FMWA 2X7EA 1V8JA 4ETPA 1KK7A 3COBA 3ZFCA 1V8KA 1MNEA 2MYSA 2ZFLA 2UYMA 2FKYA 2ZFKA 1BR1A 1F9TA 1LVKA 4PJLA 4A50A 2IEHA 2ZFJA 3K3BA 5HLEA 1BR2A 1MMGA 1D0YA 1RY6A 4GKQA 1MKJA 2GRYA 4E7SA 2VVGA 3KARA 3ZFDA 4LNUK 5LT0A 4DBQA 2FL2A 3PXNA 3LREA 4A1ZA 2Q2YA 1D1BA 5LT1A 1X88A 4A14A 4PJNA 2X7DA 4PJJA 3DCBA 3CNZA 2OWMA 3GBJA 5GSZA 4UBFA 2GM1A 2Q2ZA 1SDMA 2NCDA 4BXNA 1LKXA 2VASA 5LT2A 1II6A 3B6VA 4A51A 2PG2A 4A5YA 4HNAK 1MMAA 1VFVA 4BN2A 3DC4A 2XAEA 4GKPA 3H4SA 2UYIA
chains in the Genus database with same CATH topology
2WOGA 4B7BA 4E7ZA 3CJOA 4PFPA 1BR4A 4BBGA 1F9VA 1N6MA 2X51A 4A28A 1YRSA 3WRDA 4ZHIA 1MMNA 1MMDA 1F9WA 1GOJA 1CZ7A 2FMEA 2G1QA 4PFOA 3NWNA 1BG2A 1D1CA 3BFNA 2ZFMA 4AP0A 3K5EA 1G8XA 4ANJA 5LT3A 4DBRA 4H1GA 2XT3A 2X2RA 1I5SA 3T0QA 4AS7A 2VB6A 2KINA 3WPNA 1T5CA 1FMVA 2V26A 4GKRA 2HEHA 2Y65A 1I6IA 3U06A 1F9UA 1VFZA 3L9HA 4ZCAA 3B6UA 4FRZA 3X2TA 4PK4A 2Y5WA 1VFXA 3KENA 5LT4A 4PJMA 1D0XA 3KINA 2ZFIA 2FL6A 1Q0BA 3L1CA 3HQDA 3ZCWA 2X7CA 1D0ZA 1VOMA 4Y05A 1VFWA 1D1AA 1FMWA 2X7EA 1V8JA 4ETPA 1KK7A 3COBA 3ZFCA 1V8KA 1MNEA 2MYSA 2ZFLA 2UYMA 2FKYA 2ZFKA 1BR1A 1F9TA 1LVKA 4PJLA 4A50A 2IEHA 2ZFJA 3K3BA 5HLEA 1BR2A 1MMGA 1D0YA 1RY6A 1MKJA 2GRYA 4E7SA 2VVGA 3KARA 3ZFDA 4LNUK 5LT0A 4DBQA 2FL2A 3PXNA 3LREA 4A1ZA 2Q2YA 1D1BA 5LT1A 1X88A 4A14A 4PJNA 2X7DA 4PJJA 3DCBA 3CNZA 2OWMA 3GBJA 5GSZA 4UBFA 2GM1A 2Q2ZA 1SDMA 2NCDA 4BXNA 1LKXA 2VASA 5LT2A 1II6A 3B6VA 4A51A 2PG2A 4A5YA 4HNAK 1MMAA 1VFVA 4BN2A 3DC4A 2XAEA 3H4SA 2UYIA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2WOG A;  4B7B A;  4E7Z A;  3CJO A;  4PFP A;  1BR4 A;  4BBG A;  1F9V A;  1N6M A;  2X51 A;  4A28 A;  1YRS A;  3WRD A;  4ZHI A;  1MMN A;  1MMD A;  1F9W A;  1GOJ A;  1CZ7 A;  2FME A;  2G1Q A;  4PFO A;  3NWN A;  1BG2 A;  1D1C A;  3BFN A;  2ZFM A;  4AP0 A;  3K5E A;  1G8X A;  4ANJ A;  5LT3 A;  4DBR A;  4H1G A;  2XT3 A;  2X2R A;  1I5S A;  3T0Q A;  4AS7 A;  2VB6 A;  2KIN A;  3WPN A;  1T5C A;  1FMV A;  2V26 A;  4GKR A;  2HEH A;  2Y65 A;  1I6I A;  3U06 A;  1F9U A;  1VFZ A;  3L9H A;  4ZCA A;  3B6U A;  4FRZ A;  3X2T A;  4PK4 A;  2Y5W A;  1VFX A;  3KEN A;  5LT4 A;  4PJM A;  1D0X A;  3KIN A;  2ZFI A;  2FL6 A;  1Q0B A;  3L1C A;  3HQD A;  3ZCW A;  2X7C A;  1D0Z A;  1VOM A;  4Y05 A;  1VFW A;  1D1A A;  1FMW A;  2X7E A;  1V8J A;  4ETP A;  1KK7 A;  3COB A;  3ZFC A;  1V8K A;  1MNE A;  2MYS A;  2ZFL A;  2UYM A;  2FKY A;  2ZFK A;  1BR1 A;  1F9T A;  1LVK A;  4PJL A;  4A50 A;  2IEH A;  2ZFJ A;  3K3B A;  5HLE A;  1BR2 A;  1MMG A;  1D0Y A;  1RY6 A;  1MKJ A;  2GRY A;  4E7S A;  2VVG A;  3KAR A;  3ZFD A;  4LNU K;  5LT0 A;  4DBQ A;  2FL2 A;  3PXN A;  3LRE A;  4A1Z A;  2Q2Y A;  1D1B A;  5LT1 A;  1X88 A;  4A14 A;  4PJN A;  2X7D A;  4PJJ A;  3DCB A;  3CNZ A;  2OWM A;  3GBJ A;  5GSZ A;  4UBF A;  2GM1 A;  2Q2Z A;  1SDM A;  2NCD A;  4BXN A;  1LKX A;  2VAS A;  5LT2 A;  1II6 A;  3B6V A;  4A51 A;  2PG2 A;  4A5Y A;  4HNA K;  1MMA A;  1VFV A;  4BN2 A;  3DC4 A;  2XAE A;  3H4S A;  2UYI A; 
#chains in the Genus database with same CATH topology
 2WOG A;  4B7B A;  4E7Z A;  3CJO A;  4PFP A;  1BR4 A;  4BBG A;  1F9V A;  1N6M A;  2X51 A;  4A28 A;  1YRS A;  3WRD A;  4ZHI A;  1MMN A;  1MMD A;  1F9W A;  1GOJ A;  1CZ7 A;  2FME A;  2G1Q A;  4PFO A;  3NWN A;  1BG2 A;  1D1C A;  3BFN A;  2ZFM A;  4AP0 A;  3K5E A;  1G8X A;  4ANJ A;  5LT3 A;  4DBR A;  4H1G A;  2XT3 A;  2X2R A;  1I5S A;  3T0Q A;  4AS7 A;  2VB6 A;  2KIN A;  3WPN A;  1T5C A;  1FMV A;  2V26 A;  4GKR A;  2HEH A;  4ETP B;  2Y65 A;  1I6I A;  3U06 A;  1F9U A;  1VFZ A;  3L9H A;  4ZCA A;  3B6U A;  2O0A A;  4FRZ A;  3X2T A;  4PK4 A;  2Y5W A;  1VFX A;  3KEN A;  5LT4 A;  4PJM A;  1D0X A;  3KIN A;  2ZFI A;  2FL6 A;  1Q0B A;  3L1C A;  3HQD A;  3ZCW A;  2X7C A;  1D0Z A;  1VOM A;  4Y05 A;  1VFW A;  1D1A A;  1FMW A;  2X7E A;  1V8J A;  4ETP A;  1KK7 A;  3COB A;  3ZFC A;  1V8K A;  1MNE A;  2MYS A;  2ZFL A;  2UYM A;  2FKY A;  2ZFK A;  1BR1 A;  1F9T A;  1LVK A;  4PJL A;  4A50 A;  2IEH A;  2ZFJ A;  3K3B A;  5HLE A;  1BR2 A;  1MMG A;  1D0Y A;  1RY6 A;  4GKQ A;  1MKJ A;  2GRY A;  4E7S A;  2VVG A;  3KAR A;  3ZFD A;  4LNU K;  5LT0 A;  4DBQ A;  2FL2 A;  3PXN A;  3LRE A;  4A1Z A;  2Q2Y A;  1D1B A;  5LT1 A;  1X88 A;  4A14 A;  4PJN A;  2X7D A;  4PJJ A;  3DCB A;  3CNZ A;  2OWM A;  3GBJ A;  5GSZ A;  4UBF A;  2GM1 A;  2Q2Z A;  1SDM A;  2NCD A;  4BXN A;  1LKX A;  2VAS A;  5LT2 A;  1II6 A;  3B6V A;  4A51 A;  2PG2 A;  4A5Y A;  4HNA K;  1MMA A;  1VFV A;  4BN2 A;  3DC4 A;  2XAE A;  4GKP A;  3H4S A;  2UYI A; 
#chains in the Genus database with same CATH homology
 2WOG A;  4B7B A;  4E7Z A;  3CJO A;  4PFP A;  1BR4 A;  4BBG A;  1F9V A;  1N6M A;  2X51 A;  4A28 A;  1YRS A;  3WRD A;  4ZHI A;  1MMN A;  1MMD A;  1F9W A;  1GOJ A;  1CZ7 A;  2FME A;  2G1Q A;  4PFO A;  3NWN A;  1BG2 A;  1D1C A;  3BFN A;  2ZFM A;  4AP0 A;  3K5E A;  1G8X A;  4ANJ A;  5LT3 A;  4DBR A;  4H1G A;  2XT3 A;  2X2R A;  1I5S A;  3T0Q A;  4AS7 A;  2VB6 A;  2KIN A;  3WPN A;  1T5C A;  1FMV A;  2V26 A;  4GKR A;  2HEH A;  2Y65 A;  1I6I A;  3U06 A;  1F9U A;  1VFZ A;  3L9H A;  4ZCA A;  3B6U A;  4FRZ A;  3X2T A;  4PK4 A;  2Y5W A;  1VFX A;  3KEN A;  5LT4 A;  4PJM A;  1D0X A;  3KIN A;  2ZFI A;  2FL6 A;  1Q0B A;  3L1C A;  3HQD A;  3ZCW A;  2X7C A;  1D0Z A;  1VOM A;  4Y05 A;  1VFW A;  1D1A A;  1FMW A;  2X7E A;  1V8J A;  4ETP A;  1KK7 A;  3COB A;  3ZFC A;  1V8K A;  1MNE A;  2MYS A;  2ZFL A;  2UYM A;  2FKY A;  2ZFK A;  1BR1 A;  1F9T A;  1LVK A;  4PJL A;  4A50 A;  2IEH A;  2ZFJ A;  3K3B A;  5HLE A;  1BR2 A;  1MMG A;  1D0Y A;  1RY6 A;  1MKJ A;  2GRY A;  4E7S A;  2VVG A;  3KAR A;  3ZFD A;  4LNU K;  5LT0 A;  4DBQ A;  2FL2 A;  3PXN A;  3LRE A;  4A1Z A;  2Q2Y A;  1D1B A;  5LT1 A;  1X88 A;  4A14 A;  4PJN A;  2X7D A;  4PJJ A;  3DCB A;  3CNZ A;  2OWM A;  3GBJ A;  5GSZ A;  4UBF A;  2GM1 A;  2Q2Z A;  1SDM A;  2NCD A;  4BXN A;  1LKX A;  2VAS A;  5LT2 A;  1II6 A;  3B6V A;  4A51 A;  2PG2 A;  4A5Y A;  4HNA K;  1MMA A;  1VFV A;  4BN2 A;  3DC4 A;  2XAE A;  3H4S A;  2UYI A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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