4B7BA

Eg5-3
Total Genus 100
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
100
sequence length
348
structure length
329
Chain Sequence
b'GKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGEREYTWEEVPLDGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENININQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKP'
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
molecule keywords KINESIN-LIKE PROTEIN KIF11
publication title The Mitotic Kinesin Eg5 Overcomes Inhibition to the Phase I/II Clinical Candidate Sb743921 by an Allosteric Resistance Mechanism.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Cell cycle
total genus 100
structure length 329
sequence length 348
ec nomenclature
pdb deposition date 2012-08-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 4b7bA00
2XAEA 1Q0BA 2UYIA 2X7EA 1FMWA 1SDMA 3WPNA 3B6UA 1MNEA 3U06A 4AP0A 1D1BA 3DCBA 4PFPA 5LT1A 3H4SA 1GOJA 5LT0A 2VVGA 4A50A 3B6VA 4PJNA 1VOMA 2ZFMA 1F9WA 1MMNA 2ZFKA 2FKYA 2X2RA 2FL2A 4DBQA 4B7BA 2X7DA 5HLEA 3ZFDA 1F9TA 3KINA 3X2TA 1LVKA 4AS7A 4ZHIA 4PJMA 4H1GA 3T0QA 2FL6A 4PJJA 4UBFA 1D0XA 2Q2ZA 1BR2A 1BR4A 1FMVA 1VFZA 2XT3A 3BFNA 1I6IA 2NCDA 3ZCWA 1D0ZA 2ZFJA 2ZFIA 1D1CA 5LT2A 2G1QA 2UYMA 1BG2A 2X7CA 2Q2YA 2VASA 4DBRA 4E7SA 1G8XA 4BBGA 2WOGA 4A5YA 1D1AA 4PK4A 4PJLA 3WRDA 4A14A 1YRSA 1RY6A 3GBJA 4PFOA 1D0YA 3COBA 4FRZA 5LT3A 1N6MA 3PXNA 1BR1A 3L9HA 4E7ZA 4BN2A 1MMDA 1I5SA 3NWNA 3LREA 1F9UA 1VFVA 2PG2A 2KINA 4A28A 1T5CA 1KK7A 4LNUK 5LT4A 4ETPA 2HEHA 5GSZA 4Y05A 3DC4A 3CNZA 1F9VA 1MKJA 2FMEA 2Y5WA 4BXNA 3K5EA 1LKXA 1X88A 2GM1A 4A1ZA 3K3BA 4GKRA 2ZFLA 4ZCAA 3ZFCA 1VFXA 1V8JA 2OWMA 2V26A 1VFWA 2Y65A 2GRYA 3L1CA 1CZ7A 1MMGA 4A51A 1MMAA 3HQDA 2IEHA 4HNAK 1II6A 2X51A 3KARA 4ANJA 2MYSA 3CJOA 3KENA 1V8KA 2VB6A
chains in the Genus database with same CATH superfamily
2XAEA 1Q0BA 2UYIA 2X7EA 1FMWA 1SDMA 3WPNA 3B6UA 1MNEA 3U06A 4AP0A 1D1BA 3DCBA 4PFPA 5LT1A 3H4SA 1GOJA 5LT0A 2VVGA 4A50A 3B6VA 4PJNA 1VOMA 2ZFMA 1F9WA 1MMNA 2ZFKA 4GKPA 2FKYA 2X2RA 2FL2A 4DBQA 4B7BA 2X7DA 5HLEA 3ZFDA 1F9TA 3KINA 3X2TA 1LVKA 4AS7A 4ZHIA 4PJMA 4H1GA 3T0QA 2FL6A 4PJJA 4UBFA 1D0XA 2Q2ZA 1BR2A 1BR4A 1FMVA 4ETPB 1VFZA 2XT3A 3BFNA 1I6IA 2NCDA 3ZCWA 1D0ZA 2ZFJA 2ZFIA 1D1CA 5LT2A 2G1QA 2UYMA 1BG2A 2X7CA 2Q2YA 2VASA 4DBRA 4E7SA 1G8XA 4BBGA 2WOGA 4GKQA 4A5YA 1D1AA 4PK4A 4PJLA 3WRDA 4A14A 1YRSA 1RY6A 3GBJA 4PFOA 1D0YA 3COBA 4FRZA 5LT3A 1N6MA 3PXNA 1BR1A 3L9HA 4E7ZA 4BN2A 1MMDA 1I5SA 3NWNA 3LREA 1F9UA 1VFVA 2PG2A 2KINA 4A28A 1T5CA 1KK7A 4LNUK 5LT4A 4ETPA 2HEHA 5GSZA 4Y05A 3DC4A 3CNZA 1F9VA 1MKJA 2FMEA 2Y5WA 4BXNA 3K5EA 1LKXA 1X88A 2GM1A 4A1ZA 3K3BA 4GKRA 2ZFLA 4ZCAA 3ZFCA 1VFXA 1V8JA 2OWMA 2V26A 1VFWA 2Y65A 2GRYA 3L1CA 1CZ7A 1MMGA 4A51A 1MMAA 3HQDA 2IEHA 4HNAK 1II6A 2X51A 3KARA 4ANJA 2MYSA 3CJOA 3KENA 1V8KA 2VB6A 2O0AA
chains in the Genus database with same CATH topology
2XAEA 1Q0BA 2UYIA 2X7EA 1FMWA 1SDMA 3WPNA 3B6UA 1MNEA 3U06A 4AP0A 1D1BA 3DCBA 4PFPA 5LT1A 3H4SA 1GOJA 5LT0A 2VVGA 4A50A 3B6VA 4PJNA 1VOMA 2ZFMA 1F9WA 1MMNA 2ZFKA 2FKYA 2X2RA 2FL2A 4DBQA 4B7BA 2X7DA 5HLEA 3ZFDA 1F9TA 3KINA 3X2TA 1LVKA 4AS7A 4ZHIA 4PJMA 4H1GA 3T0QA 2FL6A 4PJJA 4UBFA 1D0XA 2Q2ZA 1BR2A 1BR4A 1FMVA 1VFZA 2XT3A 3BFNA 1I6IA 2NCDA 3ZCWA 1D0ZA 2ZFJA 2ZFIA 1D1CA 5LT2A 2G1QA 2UYMA 1BG2A 2X7CA 2Q2YA 2VASA 4DBRA 4E7SA 1G8XA 4BBGA 2WOGA 4A5YA 1D1AA 4PK4A 4PJLA 3WRDA 4A14A 1YRSA 1RY6A 3GBJA 4PFOA 1D0YA 3COBA 4FRZA 5LT3A 1N6MA 3PXNA 1BR1A 3L9HA 4E7ZA 4BN2A 1MMDA 1I5SA 3NWNA 3LREA 1F9UA 1VFVA 2PG2A 2KINA 4A28A 1T5CA 1KK7A 4LNUK 5LT4A 4ETPA 2HEHA 5GSZA 4Y05A 3DC4A 3CNZA 1F9VA 1MKJA 2FMEA 2Y5WA 4BXNA 3K5EA 1LKXA 1X88A 2GM1A 4A1ZA 3K3BA 4GKRA 2ZFLA 4ZCAA 3ZFCA 1VFXA 1V8JA 2OWMA 2V26A 1VFWA 2Y65A 2GRYA 3L1CA 1CZ7A 1MMGA 4A51A 1MMAA 3HQDA 2IEHA 4HNAK 1II6A 2X51A 3KARA 4ANJA 2MYSA 3CJOA 3KENA 1V8KA 2VB6A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2XAE A;  1Q0B A;  2UYI A;  2X7E A;  1FMW A;  1SDM A;  3WPN A;  3B6U A;  1MNE A;  3U06 A;  4AP0 A;  1D1B A;  3DCB A;  4PFP A;  5LT1 A;  3H4S A;  1GOJ A;  5LT0 A;  2VVG A;  4A50 A;  3B6V A;  4PJN A;  1VOM A;  2ZFM A;  1F9W A;  1MMN A;  2ZFK A;  2FKY A;  2X2R A;  2FL2 A;  4DBQ A;  4B7B A;  2X7D A;  5HLE A;  3ZFD A;  1F9T A;  3KIN A;  3X2T A;  1LVK A;  4AS7 A;  4ZHI A;  4PJM A;  4H1G A;  3T0Q A;  2FL6 A;  4PJJ A;  4UBF A;  1D0X A;  2Q2Z A;  1BR2 A;  1BR4 A;  1FMV A;  1VFZ A;  2XT3 A;  3BFN A;  1I6I A;  2NCD A;  3ZCW A;  1D0Z A;  2ZFJ A;  2ZFI A;  1D1C A;  5LT2 A;  2G1Q A;  2UYM A;  1BG2 A;  2X7C A;  2Q2Y A;  2VAS A;  4DBR A;  4E7S A;  1G8X A;  4BBG A;  2WOG A;  4A5Y A;  1D1A A;  4PK4 A;  4PJL A;  3WRD A;  4A14 A;  1YRS A;  1RY6 A;  3GBJ A;  4PFO A;  1D0Y A;  3COB A;  4FRZ A;  5LT3 A;  1N6M A;  3PXN A;  1BR1 A;  3L9H A;  4E7Z A;  4BN2 A;  1MMD A;  1I5S A;  3NWN A;  3LRE A;  1F9U A;  1VFV A;  2PG2 A;  2KIN A;  4A28 A;  1T5C A;  1KK7 A;  4LNU K;  5LT4 A;  4ETP A;  2HEH A;  5GSZ A;  4Y05 A;  3DC4 A;  3CNZ A;  1F9V A;  1MKJ A;  2FME A;  2Y5W A;  4BXN A;  3K5E A;  1LKX A;  1X88 A;  2GM1 A;  4A1Z A;  3K3B A;  4GKR A;  2ZFL A;  4ZCA A;  3ZFC A;  1VFX A;  1V8J A;  2OWM A;  2V26 A;  1VFW A;  2Y65 A;  2GRY A;  3L1C A;  1CZ7 A;  1MMG A;  4A51 A;  1MMA A;  3HQD A;  2IEH A;  4HNA K;  1II6 A;  2X51 A;  3KAR A;  4ANJ A;  2MYS A;  3CJO A;  3KEN A;  1V8K A;  2VB6 A; 
#chains in the Genus database with same CATH topology
 2XAE A;  1Q0B A;  2UYI A;  2X7E A;  1FMW A;  1SDM A;  3WPN A;  3B6U A;  1MNE A;  3U06 A;  4AP0 A;  1D1B A;  3DCB A;  4PFP A;  5LT1 A;  3H4S A;  1GOJ A;  5LT0 A;  2VVG A;  4A50 A;  3B6V A;  4PJN A;  1VOM A;  2ZFM A;  1F9W A;  1MMN A;  2ZFK A;  4GKP A;  2FKY A;  2X2R A;  2FL2 A;  4DBQ A;  4B7B A;  2X7D A;  5HLE A;  3ZFD A;  1F9T A;  3KIN A;  3X2T A;  1LVK A;  4AS7 A;  4ZHI A;  4PJM A;  4H1G A;  3T0Q A;  2FL6 A;  4PJJ A;  4UBF A;  1D0X A;  2Q2Z A;  1BR2 A;  1BR4 A;  1FMV A;  4ETP B;  1VFZ A;  2XT3 A;  3BFN A;  1I6I A;  2NCD A;  3ZCW A;  1D0Z A;  2ZFJ A;  2ZFI A;  1D1C A;  5LT2 A;  2G1Q A;  2UYM A;  1BG2 A;  2X7C A;  2Q2Y A;  2VAS A;  4DBR A;  4E7S A;  1G8X A;  4BBG A;  2WOG A;  4GKQ A;  4A5Y A;  1D1A A;  4PK4 A;  4PJL A;  3WRD A;  4A14 A;  1YRS A;  1RY6 A;  3GBJ A;  4PFO A;  1D0Y A;  3COB A;  4FRZ A;  5LT3 A;  1N6M A;  3PXN A;  1BR1 A;  3L9H A;  4E7Z A;  4BN2 A;  1MMD A;  1I5S A;  3NWN A;  3LRE A;  1F9U A;  1VFV A;  2PG2 A;  2KIN A;  4A28 A;  1T5C A;  1KK7 A;  4LNU K;  5LT4 A;  4ETP A;  2HEH A;  5GSZ A;  4Y05 A;  3DC4 A;  3CNZ A;  1F9V A;  1MKJ A;  2FME A;  2Y5W A;  4BXN A;  3K5E A;  1LKX A;  1X88 A;  2GM1 A;  4A1Z A;  3K3B A;  4GKR A;  2ZFL A;  4ZCA A;  3ZFC A;  1VFX A;  1V8J A;  2OWM A;  2V26 A;  1VFW A;  2Y65 A;  2GRY A;  3L1C A;  1CZ7 A;  1MMG A;  4A51 A;  1MMA A;  3HQD A;  2IEH A;  4HNA K;  1II6 A;  2X51 A;  3KAR A;  4ANJ A;  2MYS A;  3CJO A;  3KEN A;  1V8K A;  2VB6 A;  2O0A A; 
#chains in the Genus database with same CATH homology
 2XAE A;  1Q0B A;  2UYI A;  2X7E A;  1FMW A;  1SDM A;  3WPN A;  3B6U A;  1MNE A;  3U06 A;  4AP0 A;  1D1B A;  3DCB A;  4PFP A;  5LT1 A;  3H4S A;  1GOJ A;  5LT0 A;  2VVG A;  4A50 A;  3B6V A;  4PJN A;  1VOM A;  2ZFM A;  1F9W A;  1MMN A;  2ZFK A;  2FKY A;  2X2R A;  2FL2 A;  4DBQ A;  4B7B A;  2X7D A;  5HLE A;  3ZFD A;  1F9T A;  3KIN A;  3X2T A;  1LVK A;  4AS7 A;  4ZHI A;  4PJM A;  4H1G A;  3T0Q A;  2FL6 A;  4PJJ A;  4UBF A;  1D0X A;  2Q2Z A;  1BR2 A;  1BR4 A;  1FMV A;  1VFZ A;  2XT3 A;  3BFN A;  1I6I A;  2NCD A;  3ZCW A;  1D0Z A;  2ZFJ A;  2ZFI A;  1D1C A;  5LT2 A;  2G1Q A;  2UYM A;  1BG2 A;  2X7C A;  2Q2Y A;  2VAS A;  4DBR A;  4E7S A;  1G8X A;  4BBG A;  2WOG A;  4A5Y A;  1D1A A;  4PK4 A;  4PJL A;  3WRD A;  4A14 A;  1YRS A;  1RY6 A;  3GBJ A;  4PFO A;  1D0Y A;  3COB A;  4FRZ A;  5LT3 A;  1N6M A;  3PXN A;  1BR1 A;  3L9H A;  4E7Z A;  4BN2 A;  1MMD A;  1I5S A;  3NWN A;  3LRE A;  1F9U A;  1VFV A;  2PG2 A;  2KIN A;  4A28 A;  1T5C A;  1KK7 A;  4LNU K;  5LT4 A;  4ETP A;  2HEH A;  5GSZ A;  4Y05 A;  3DC4 A;  3CNZ A;  1F9V A;  1MKJ A;  2FME A;  2Y5W A;  4BXN A;  3K5E A;  1LKX A;  1X88 A;  2GM1 A;  4A1Z A;  3K3B A;  4GKR A;  2ZFL A;  4ZCA A;  3ZFC A;  1VFX A;  1V8J A;  2OWM A;  2V26 A;  1VFW A;  2Y65 A;  2GRY A;  3L1C A;  1CZ7 A;  1MMG A;  4A51 A;  1MMA A;  3HQD A;  2IEH A;  4HNA K;  1II6 A;  2X51 A;  3KAR A;  4ANJ A;  2MYS A;  3CJO A;  3KEN A;  1V8K A;  2VB6 A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...