4B7BA

Eg5-3
Total Genus 100
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
100
sequence length
348
structure length
329
Chain Sequence
GKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGEREYTWEEVPLDGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENININQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords KINESIN-LIKE PROTEIN KIF11
publication title The Mitotic Kinesin Eg5 Overcomes Inhibition to the Phase I/II Clinical Candidate Sb743921 by an Allosteric Resistance Mechanism.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Cell cycle
total genus 100
structure length 329
sequence length 348
ec nomenclature
pdb deposition date 2012-08-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 4b7bA00
2Y5WA 2FKYA 1MKJA 3WRDA 2FMEA 3CNZA 1SDMA 1T5CA 2ZFJA 5HLEA 1D1CA 1MMAA 4GKRA 1MMGA 4PK4A 4DBQA 1V8JA 4Y05A 1VFXA 2IEHA 3DCBA 1N6MA 2UYIA 2VB6A 2VVGA 3LREA 4B7BA 3KINA 2GRYA 3X2TA 4E7SA 1BR4A 2VASA 3L9HA 3PXNA 4AP0A 4LNUK 1MNEA 1D1BA 4DBRA 2ZFKA 1VOMA 1CZ7A 1GOJA 4ZHIA 4PJJA 2V26A 4BBGA 2WOGA 2ZFLA 4PJMA 5LT4A 2X51A 3BFNA 3H4SA 1F9TA 1VFWA 2X7EA 4A5YA 5LT0A 1I6IA 2XAEA 3U06A 1BG2A 4AS7A 3GBJA 4A51A 4FRZA 4PFOA 4BN2A 2FL6A 1D0YA 3WPNA 2X2RA 5LT2A 1VFVA 3B6UA 4HNAK 2X7CA 4H1GA 1LKXA 2X7DA 1Q0BA 2Q2YA 1YRSA 2Y65A 1D0ZA 1FMWA 3T0QA 3COBA 1RY6A 4UBFA 2MYSA 3CJOA 4E7ZA 4A50A 2HEHA 3ZFDA 1G8XA 2Q2ZA 4PJLA 2KINA 4A1ZA 1D1AA 4PFPA 2XT3A 1II6A 1BR1A 1X88A 2FL2A 1MMDA 2UYMA 1F9VA 1MMNA 2G1QA 2ZFIA 3ZCWA 3KENA 1F9UA 5GSZA 1KK7A 1BR2A 3DC4A 1VFZA 1FMVA 2NCDA 2OWMA 1D0XA 3L1CA 3ZFCA 4BXNA 5LT3A 3KARA 4A14A 3B6VA 5LT1A 3K3BA 3NWNA 2ZFMA 1V8KA 4ZCAA 1LVKA 4ANJA 4A28A 3HQDA 1I5SA 1F9WA 4ETPA 2GM1A 2PG2A 3K5EA 4PJNA
chains in the Genus database with same CATH superfamily
2Y5WA 2FKYA 1MKJA 3WRDA 2FMEA 3CNZA 1SDMA 1T5CA 2ZFJA 5HLEA 1D1CA 1MMAA 4GKRA 1MMGA 4PK4A 4DBQA 1V8JA 4Y05A 1VFXA 2IEHA 3DCBA 1N6MA 2UYIA 2VB6A 2VVGA 3LREA 4B7BA 3KINA 2GRYA 3X2TA 4E7SA 1BR4A 2VASA 3L9HA 3PXNA 4AP0A 4LNUK 1MNEA 1D1BA 4DBRA 2ZFKA 4GKPA 1VOMA 1CZ7A 1GOJA 4ZHIA 4PJJA 2V26A 4BBGA 2WOGA 2ZFLA 4PJMA 5LT4A 2X51A 3BFNA 3H4SA 1F9TA 1VFWA 2X7EA 4A5YA 5LT0A 1I6IA 2XAEA 3U06A 1BG2A 4AS7A 3GBJA 4A51A 4FRZA 4PFOA 4BN2A 2FL6A 1D0YA 3WPNA 2X2RA 5LT2A 1VFVA 3B6UA 4HNAK 2X7CA 4H1GA 1LKXA 2X7DA 1Q0BA 2Q2YA 1YRSA 2Y65A 1D0ZA 1FMWA 3T0QA 3COBA 1RY6A 4UBFA 2MYSA 3CJOA 4E7ZA 4A50A 2HEHA 3ZFDA 1G8XA 2Q2ZA 4PJLA 2KINA 4A1ZA 1D1AA 4PFPA 2XT3A 4GKQA 1II6A 1BR1A 1X88A 2FL2A 1MMDA 2UYMA 1F9VA 1MMNA 2G1QA 2ZFIA 3ZCWA 3KENA 1F9UA 5GSZA 1KK7A 1BR2A 3DC4A 1VFZA 1FMVA 2NCDA 2OWMA 1D0XA 2O0AA 3L1CA 3ZFCA 4BXNA 5LT3A 3KARA 4A14A 3B6VA 5LT1A 3K3BA 3NWNA 2ZFMA 1V8KA 4ZCAA 1LVKA 4ANJA 4A28A 3HQDA 4ETPB 1I5SA 1F9WA 4ETPA 2GM1A 2PG2A 3K5EA 4PJNA
chains in the Genus database with same CATH topology
2Y5WA 2FKYA 1MKJA 3WRDA 2FMEA 3CNZA 1SDMA 1T5CA 2ZFJA 5HLEA 1D1CA 1MMAA 4GKRA 1MMGA 4PK4A 4DBQA 1V8JA 4Y05A 1VFXA 2IEHA 3DCBA 1N6MA 2UYIA 2VB6A 2VVGA 3LREA 4B7BA 3KINA 2GRYA 3X2TA 4E7SA 1BR4A 2VASA 3L9HA 3PXNA 4AP0A 4LNUK 1MNEA 1D1BA 4DBRA 2ZFKA 1VOMA 1CZ7A 1GOJA 4ZHIA 4PJJA 2V26A 4BBGA 2WOGA 2ZFLA 4PJMA 5LT4A 2X51A 3BFNA 3H4SA 1F9TA 1VFWA 2X7EA 4A5YA 5LT0A 1I6IA 2XAEA 3U06A 1BG2A 4AS7A 3GBJA 4A51A 4FRZA 4PFOA 4BN2A 2FL6A 1D0YA 3WPNA 2X2RA 5LT2A 1VFVA 3B6UA 4HNAK 2X7CA 4H1GA 1LKXA 2X7DA 1Q0BA 2Q2YA 1YRSA 2Y65A 1D0ZA 1FMWA 3T0QA 3COBA 1RY6A 4UBFA 2MYSA 3CJOA 4E7ZA 4A50A 2HEHA 3ZFDA 1G8XA 2Q2ZA 4PJLA 2KINA 4A1ZA 1D1AA 4PFPA 2XT3A 1II6A 1BR1A 1X88A 2FL2A 1MMDA 2UYMA 1F9VA 1MMNA 2G1QA 2ZFIA 3ZCWA 3KENA 1F9UA 5GSZA 1KK7A 1BR2A 3DC4A 1VFZA 1FMVA 2NCDA 2OWMA 1D0XA 3L1CA 3ZFCA 4BXNA 5LT3A 3KARA 4A14A 3B6VA 5LT1A 3K3BA 3NWNA 2ZFMA 1V8KA 4ZCAA 1LVKA 4ANJA 4A28A 3HQDA 1I5SA 1F9WA 4ETPA 2GM1A 2PG2A 3K5EA 4PJNA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2Y5W A;  2FKY A;  1MKJ A;  3WRD A;  2FME A;  3CNZ A;  1SDM A;  1T5C A;  2ZFJ A;  5HLE A;  1D1C A;  1MMA A;  4GKR A;  1MMG A;  4PK4 A;  4DBQ A;  1V8J A;  4Y05 A;  1VFX A;  2IEH A;  3DCB A;  1N6M A;  2UYI A;  2VB6 A;  2VVG A;  3LRE A;  4B7B A;  3KIN A;  2GRY A;  3X2T A;  4E7S A;  1BR4 A;  2VAS A;  3L9H A;  3PXN A;  4AP0 A;  4LNU K;  1MNE A;  1D1B A;  4DBR A;  2ZFK A;  1VOM A;  1CZ7 A;  1GOJ A;  4ZHI A;  4PJJ A;  2V26 A;  4BBG A;  2WOG A;  2ZFL A;  4PJM A;  5LT4 A;  2X51 A;  3BFN A;  3H4S A;  1F9T A;  1VFW A;  2X7E A;  4A5Y A;  5LT0 A;  1I6I A;  2XAE A;  3U06 A;  1BG2 A;  4AS7 A;  3GBJ A;  4A51 A;  4FRZ A;  4PFO A;  4BN2 A;  2FL6 A;  1D0Y A;  3WPN A;  2X2R A;  5LT2 A;  1VFV A;  3B6U A;  4HNA K;  2X7C A;  4H1G A;  1LKX A;  2X7D A;  1Q0B A;  2Q2Y A;  1YRS A;  2Y65 A;  1D0Z A;  1FMW A;  3T0Q A;  3COB A;  1RY6 A;  4UBF A;  2MYS A;  3CJO A;  4E7Z A;  4A50 A;  2HEH A;  3ZFD A;  1G8X A;  2Q2Z A;  4PJL A;  2KIN A;  4A1Z A;  1D1A A;  4PFP A;  2XT3 A;  1II6 A;  1BR1 A;  1X88 A;  2FL2 A;  1MMD A;  2UYM A;  1F9V A;  1MMN A;  2G1Q A;  2ZFI A;  3ZCW A;  3KEN A;  1F9U A;  5GSZ A;  1KK7 A;  1BR2 A;  3DC4 A;  1VFZ A;  1FMV A;  2NCD A;  2OWM A;  1D0X A;  3L1C A;  3ZFC A;  4BXN A;  5LT3 A;  3KAR A;  4A14 A;  3B6V A;  5LT1 A;  3K3B A;  3NWN A;  2ZFM A;  1V8K A;  4ZCA A;  1LVK A;  4ANJ A;  4A28 A;  3HQD A;  1I5S A;  1F9W A;  4ETP A;  2GM1 A;  2PG2 A;  3K5E A;  4PJN A; 
#chains in the Genus database with same CATH topology
 2Y5W A;  2FKY A;  1MKJ A;  3WRD A;  2FME A;  3CNZ A;  1SDM A;  1T5C A;  2ZFJ A;  5HLE A;  1D1C A;  1MMA A;  4GKR A;  1MMG A;  4PK4 A;  4DBQ A;  1V8J A;  4Y05 A;  1VFX A;  2IEH A;  3DCB A;  1N6M A;  2UYI A;  2VB6 A;  2VVG A;  3LRE A;  4B7B A;  3KIN A;  2GRY A;  3X2T A;  4E7S A;  1BR4 A;  2VAS A;  3L9H A;  3PXN A;  4AP0 A;  4LNU K;  1MNE A;  1D1B A;  4DBR A;  2ZFK A;  4GKP A;  1VOM A;  1CZ7 A;  1GOJ A;  4ZHI A;  4PJJ A;  2V26 A;  4BBG A;  2WOG A;  2ZFL A;  4PJM A;  5LT4 A;  2X51 A;  3BFN A;  3H4S A;  1F9T A;  1VFW A;  2X7E A;  4A5Y A;  5LT0 A;  1I6I A;  2XAE A;  3U06 A;  1BG2 A;  4AS7 A;  3GBJ A;  4A51 A;  4FRZ A;  4PFO A;  4BN2 A;  2FL6 A;  1D0Y A;  3WPN A;  2X2R A;  5LT2 A;  1VFV A;  3B6U A;  4HNA K;  2X7C A;  4H1G A;  1LKX A;  2X7D A;  1Q0B A;  2Q2Y A;  1YRS A;  2Y65 A;  1D0Z A;  1FMW A;  3T0Q A;  3COB A;  1RY6 A;  4UBF A;  2MYS A;  3CJO A;  4E7Z A;  4A50 A;  2HEH A;  3ZFD A;  1G8X A;  2Q2Z A;  4PJL A;  2KIN A;  4A1Z A;  1D1A A;  4PFP A;  2XT3 A;  4GKQ A;  1II6 A;  1BR1 A;  1X88 A;  2FL2 A;  1MMD A;  2UYM A;  1F9V A;  1MMN A;  2G1Q A;  2ZFI A;  3ZCW A;  3KEN A;  1F9U A;  5GSZ A;  1KK7 A;  1BR2 A;  3DC4 A;  1VFZ A;  1FMV A;  2NCD A;  2OWM A;  1D0X A;  2O0A A;  3L1C A;  3ZFC A;  4BXN A;  5LT3 A;  3KAR A;  4A14 A;  3B6V A;  5LT1 A;  3K3B A;  3NWN A;  2ZFM A;  1V8K A;  4ZCA A;  1LVK A;  4ANJ A;  4A28 A;  3HQD A;  4ETP B;  1I5S A;  1F9W A;  4ETP A;  2GM1 A;  2PG2 A;  3K5E A;  4PJN A; 
#chains in the Genus database with same CATH homology
 2Y5W A;  2FKY A;  1MKJ A;  3WRD A;  2FME A;  3CNZ A;  1SDM A;  1T5C A;  2ZFJ A;  5HLE A;  1D1C A;  1MMA A;  4GKR A;  1MMG A;  4PK4 A;  4DBQ A;  1V8J A;  4Y05 A;  1VFX A;  2IEH A;  3DCB A;  1N6M A;  2UYI A;  2VB6 A;  2VVG A;  3LRE A;  4B7B A;  3KIN A;  2GRY A;  3X2T A;  4E7S A;  1BR4 A;  2VAS A;  3L9H A;  3PXN A;  4AP0 A;  4LNU K;  1MNE A;  1D1B A;  4DBR A;  2ZFK A;  1VOM A;  1CZ7 A;  1GOJ A;  4ZHI A;  4PJJ A;  2V26 A;  4BBG A;  2WOG A;  2ZFL A;  4PJM A;  5LT4 A;  2X51 A;  3BFN A;  3H4S A;  1F9T A;  1VFW A;  2X7E A;  4A5Y A;  5LT0 A;  1I6I A;  2XAE A;  3U06 A;  1BG2 A;  4AS7 A;  3GBJ A;  4A51 A;  4FRZ A;  4PFO A;  4BN2 A;  2FL6 A;  1D0Y A;  3WPN A;  2X2R A;  5LT2 A;  1VFV A;  3B6U A;  4HNA K;  2X7C A;  4H1G A;  1LKX A;  2X7D A;  1Q0B A;  2Q2Y A;  1YRS A;  2Y65 A;  1D0Z A;  1FMW A;  3T0Q A;  3COB A;  1RY6 A;  4UBF A;  2MYS A;  3CJO A;  4E7Z A;  4A50 A;  2HEH A;  3ZFD A;  1G8X A;  2Q2Z A;  4PJL A;  2KIN A;  4A1Z A;  1D1A A;  4PFP A;  2XT3 A;  1II6 A;  1BR1 A;  1X88 A;  2FL2 A;  1MMD A;  2UYM A;  1F9V A;  1MMN A;  2G1Q A;  2ZFI A;  3ZCW A;  3KEN A;  1F9U A;  5GSZ A;  1KK7 A;  1BR2 A;  3DC4 A;  1VFZ A;  1FMV A;  2NCD A;  2OWM A;  1D0X A;  3L1C A;  3ZFC A;  4BXN A;  5LT3 A;  3KAR A;  4A14 A;  3B6V A;  5LT1 A;  3K3B A;  3NWN A;  2ZFM A;  1V8K A;  4ZCA A;  1LVK A;  4ANJ A;  4A28 A;  3HQD A;  1I5S A;  1F9W A;  4ETP A;  2GM1 A;  2PG2 A;  3K5E A;  4PJN A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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