4B7BA

Eg5-3
Total Genus 100
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
100
sequence length
348
structure length
329
Chain Sequence
GKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGEREYTWEEVPLDGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENININQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The Mitotic Kinesin Eg5 Overcomes Inhibition to the Phase I/II Clinical Candidate Sb743921 by an Allosteric Resistance Mechanism.
pubmed doi rcsb
molecule tags Cell cycle
source organism Homo sapiens
molecule keywords KINESIN-LIKE PROTEIN KIF11
total genus 100
structure length 329
sequence length 348
ec nomenclature
pdb deposition date 2012-08-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 4b7bA00
3K3BA 2X7CA 5LT3A 3LREA 4FRZA 2G1QA 2GRYA 4PK4A 3DCBA 4H1GA 1LVKA 2UYMA 3X2TA 3K5EA 1VFWA 4A51A 4BXNA 1BR2A 3B6VA 1BG2A 1D0YA 4ZHIA 1D0XA 5GSZA 1VOMA 2KINA 3B6UA 4DBQA 1MMGA 4PJLA 3CJOA 4A28A 4AP0A 2VVGA 1YRSA 2X2RA 1F9UA 1VFVA 3KINA 4AS7A 1F9WA 4A50A 1KK7A 2ZFKA 3GBJA 2GM1A 2HEHA 2Q2YA 4PJJA 5LT0A 4ANJA 2OWMA 1CZ7A 1X88A 1II6A 4E7SA 2UYIA 2MYSA 1MKJA 4PJNA 4PFOA 1D0ZA 3ZFCA 2ZFMA 2X7EA 3PXNA 2Q2ZA 5LT2A 1I5SA 1T5CA 4BBGA 3U06A 4GKRA 4ETPA 1V8JA 2XAEA 1Q0BA 2X51A 4DBRA 3CNZA 1MNEA 1V8KA 4PJMA 3BFNA 5HLEA 3ZCWA 1MMDA 2FL6A 3KARA 4B7BA 2FMEA 1F9VA 2VB6A 4LNUK 1FMVA 3L1CA 1MMNA 1RY6A 2FL2A 1SDMA 2VASA 4E7ZA 2V26A 2IEHA 4Y05A 1BR1A 4ZCAA 4A5YA 3DC4A 3L9HA 4HNAK 3ZFDA 2WOGA 2XT3A 2PG2A 1D1AA 4A1ZA 1VFZA 1I6IA 4PFPA 3WRDA 1N6MA 5LT1A 3KENA 3COBA 1VFXA 3T0QA 1D1CA 1BR4A 1GOJA 1FMWA 3WPNA 4BN2A 2ZFJA 2FKYA 1MMAA 1LKXA 2Y5WA 2NCDA 1D1BA 5LT4A 2Y65A 3HQDA 2ZFLA 2X7DA 3H4SA 1F9TA 4A14A 3NWNA 2ZFIA 4UBFA 1G8XA
chains in the Genus database with same CATH superfamily
3K3BA 2X7CA 5LT3A 3LREA 4FRZA 2G1QA 2GRYA 4PK4A 3DCBA 4H1GA 1LVKA 2UYMA 3X2TA 3K5EA 1VFWA 4A51A 4BXNA 1BR2A 3B6VA 1BG2A 1D0YA 4ZHIA 1D0XA 5GSZA 1VOMA 2KINA 3B6UA 4DBQA 1MMGA 4PJLA 3CJOA 4A28A 4AP0A 2VVGA 1YRSA 2X2RA 1F9UA 1VFVA 3KINA 4AS7A 1F9WA 4A50A 1KK7A 2ZFKA 3GBJA 2GM1A 2HEHA 2Q2YA 4PJJA 5LT0A 4ANJA 2OWMA 1CZ7A 1X88A 1II6A 4E7SA 2UYIA 2MYSA 1MKJA 4PJNA 4PFOA 1D0ZA 3ZFCA 2ZFMA 2X7EA 3PXNA 2Q2ZA 5LT2A 1I5SA 1T5CA 4BBGA 3U06A 4ETPB 4GKRA 4ETPA 1V8JA 2XAEA 1Q0BA 2X51A 4DBRA 3CNZA 1MNEA 1V8KA 4PJMA 3BFNA 5HLEA 3ZCWA 1MMDA 2FL6A 2O0AA 3KARA 4B7BA 2FMEA 1F9VA 2VB6A 4LNUK 1FMVA 3L1CA 1MMNA 1RY6A 2FL2A 1SDMA 2VASA 4E7ZA 2V26A 2IEHA 4Y05A 1BR1A 4ZCAA 4A5YA 3DC4A 3L9HA 4HNAK 3ZFDA 2WOGA 2XT3A 2PG2A 1D1AA 4A1ZA 1VFZA 1I6IA 4PFPA 3WRDA 1N6MA 5LT1A 3KENA 3COBA 1VFXA 3T0QA 1D1CA 1BR4A 1GOJA 4GKQA 1FMWA 3WPNA 4BN2A 2ZFJA 2FKYA 1MMAA 1LKXA 2Y5WA 2NCDA 1D1BA 4GKPA 5LT4A 2Y65A 3HQDA 2ZFLA 2X7DA 3H4SA 1F9TA 4A14A 3NWNA 2ZFIA 4UBFA 1G8XA
chains in the Genus database with same CATH topology
3K3BA 2X7CA 5LT3A 3LREA 4FRZA 2G1QA 2GRYA 4PK4A 3DCBA 4H1GA 1LVKA 2UYMA 3X2TA 3K5EA 1VFWA 4A51A 4BXNA 1BR2A 3B6VA 1BG2A 1D0YA 4ZHIA 1D0XA 5GSZA 1VOMA 2KINA 3B6UA 4DBQA 1MMGA 4PJLA 3CJOA 4A28A 4AP0A 2VVGA 1YRSA 2X2RA 1F9UA 1VFVA 3KINA 4AS7A 1F9WA 4A50A 1KK7A 2ZFKA 3GBJA 2GM1A 2HEHA 2Q2YA 4PJJA 5LT0A 4ANJA 2OWMA 1CZ7A 1X88A 1II6A 4E7SA 2UYIA 2MYSA 1MKJA 4PJNA 4PFOA 1D0ZA 3ZFCA 2ZFMA 2X7EA 3PXNA 2Q2ZA 5LT2A 1I5SA 1T5CA 4BBGA 3U06A 4GKRA 4ETPA 1V8JA 2XAEA 1Q0BA 2X51A 4DBRA 3CNZA 1MNEA 1V8KA 4PJMA 3BFNA 5HLEA 3ZCWA 1MMDA 2FL6A 3KARA 4B7BA 2FMEA 1F9VA 2VB6A 4LNUK 1FMVA 3L1CA 1MMNA 1RY6A 2FL2A 1SDMA 2VASA 4E7ZA 2V26A 2IEHA 4Y05A 1BR1A 4ZCAA 4A5YA 3DC4A 3L9HA 4HNAK 3ZFDA 2WOGA 2XT3A 2PG2A 1D1AA 4A1ZA 1VFZA 1I6IA 4PFPA 3WRDA 1N6MA 5LT1A 3KENA 3COBA 1VFXA 3T0QA 1D1CA 1BR4A 1GOJA 1FMWA 3WPNA 4BN2A 2ZFJA 2FKYA 1MMAA 1LKXA 2Y5WA 2NCDA 1D1BA 5LT4A 2Y65A 3HQDA 2ZFLA 2X7DA 3H4SA 1F9TA 4A14A 3NWNA 2ZFIA 4UBFA 1G8XA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3K3B A;  2X7C A;  5LT3 A;  3LRE A;  4FRZ A;  2G1Q A;  2GRY A;  4PK4 A;  3DCB A;  4H1G A;  1LVK A;  2UYM A;  3X2T A;  3K5E A;  1VFW A;  4A51 A;  4BXN A;  1BR2 A;  3B6V A;  1BG2 A;  1D0Y A;  4ZHI A;  1D0X A;  5GSZ A;  1VOM A;  2KIN A;  3B6U A;  4DBQ A;  1MMG A;  4PJL A;  3CJO A;  4A28 A;  4AP0 A;  2VVG A;  1YRS A;  2X2R A;  1F9U A;  1VFV A;  3KIN A;  4AS7 A;  1F9W A;  4A50 A;  1KK7 A;  2ZFK A;  3GBJ A;  2GM1 A;  2HEH A;  2Q2Y A;  4PJJ A;  5LT0 A;  4ANJ A;  2OWM A;  1CZ7 A;  1X88 A;  1II6 A;  4E7S A;  2UYI A;  2MYS A;  1MKJ A;  4PJN A;  4PFO A;  1D0Z A;  3ZFC A;  2ZFM A;  2X7E A;  3PXN A;  2Q2Z A;  5LT2 A;  1I5S A;  1T5C A;  4BBG A;  3U06 A;  4GKR A;  4ETP A;  1V8J A;  2XAE A;  1Q0B A;  2X51 A;  4DBR A;  3CNZ A;  1MNE A;  1V8K A;  4PJM A;  3BFN A;  5HLE A;  3ZCW A;  1MMD A;  2FL6 A;  3KAR A;  4B7B A;  2FME A;  1F9V A;  2VB6 A;  4LNU K;  1FMV A;  3L1C A;  1MMN A;  1RY6 A;  2FL2 A;  1SDM A;  2VAS A;  4E7Z A;  2V26 A;  2IEH A;  4Y05 A;  1BR1 A;  4ZCA A;  4A5Y A;  3DC4 A;  3L9H A;  4HNA K;  3ZFD A;  2WOG A;  2XT3 A;  2PG2 A;  1D1A A;  4A1Z A;  1VFZ A;  1I6I A;  4PFP A;  3WRD A;  1N6M A;  5LT1 A;  3KEN A;  3COB A;  1VFX A;  3T0Q A;  1D1C A;  1BR4 A;  1GOJ A;  1FMW A;  3WPN A;  4BN2 A;  2ZFJ A;  2FKY A;  1MMA A;  1LKX A;  2Y5W A;  2NCD A;  1D1B A;  5LT4 A;  2Y65 A;  3HQD A;  2ZFL A;  2X7D A;  3H4S A;  1F9T A;  4A14 A;  3NWN A;  2ZFI A;  4UBF A;  1G8X A; 
#chains in the Genus database with same CATH topology
 3K3B A;  2X7C A;  5LT3 A;  3LRE A;  4FRZ A;  2G1Q A;  2GRY A;  4PK4 A;  3DCB A;  4H1G A;  1LVK A;  2UYM A;  3X2T A;  3K5E A;  1VFW A;  4A51 A;  4BXN A;  1BR2 A;  3B6V A;  1BG2 A;  1D0Y A;  4ZHI A;  1D0X A;  5GSZ A;  1VOM A;  2KIN A;  3B6U A;  4DBQ A;  1MMG A;  4PJL A;  3CJO A;  4A28 A;  4AP0 A;  2VVG A;  1YRS A;  2X2R A;  1F9U A;  1VFV A;  3KIN A;  4AS7 A;  1F9W A;  4A50 A;  1KK7 A;  2ZFK A;  3GBJ A;  2GM1 A;  2HEH A;  2Q2Y A;  4PJJ A;  5LT0 A;  4ANJ A;  2OWM A;  1CZ7 A;  1X88 A;  1II6 A;  4E7S A;  2UYI A;  2MYS A;  1MKJ A;  4PJN A;  4PFO A;  1D0Z A;  3ZFC A;  2ZFM A;  2X7E A;  3PXN A;  2Q2Z A;  5LT2 A;  1I5S A;  1T5C A;  4BBG A;  3U06 A;  4ETP B;  4GKR A;  4ETP A;  1V8J A;  2XAE A;  1Q0B A;  2X51 A;  4DBR A;  3CNZ A;  1MNE A;  1V8K A;  4PJM A;  3BFN A;  5HLE A;  3ZCW A;  1MMD A;  2FL6 A;  2O0A A;  3KAR A;  4B7B A;  2FME A;  1F9V A;  2VB6 A;  4LNU K;  1FMV A;  3L1C A;  1MMN A;  1RY6 A;  2FL2 A;  1SDM A;  2VAS A;  4E7Z A;  2V26 A;  2IEH A;  4Y05 A;  1BR1 A;  4ZCA A;  4A5Y A;  3DC4 A;  3L9H A;  4HNA K;  3ZFD A;  2WOG A;  2XT3 A;  2PG2 A;  1D1A A;  4A1Z A;  1VFZ A;  1I6I A;  4PFP A;  3WRD A;  1N6M A;  5LT1 A;  3KEN A;  3COB A;  1VFX A;  3T0Q A;  1D1C A;  1BR4 A;  1GOJ A;  4GKQ A;  1FMW A;  3WPN A;  4BN2 A;  2ZFJ A;  2FKY A;  1MMA A;  1LKX A;  2Y5W A;  2NCD A;  1D1B A;  4GKP A;  5LT4 A;  2Y65 A;  3HQD A;  2ZFL A;  2X7D A;  3H4S A;  1F9T A;  4A14 A;  3NWN A;  2ZFI A;  4UBF A;  1G8X A; 
#chains in the Genus database with same CATH homology
 3K3B A;  2X7C A;  5LT3 A;  3LRE A;  4FRZ A;  2G1Q A;  2GRY A;  4PK4 A;  3DCB A;  4H1G A;  1LVK A;  2UYM A;  3X2T A;  3K5E A;  1VFW A;  4A51 A;  4BXN A;  1BR2 A;  3B6V A;  1BG2 A;  1D0Y A;  4ZHI A;  1D0X A;  5GSZ A;  1VOM A;  2KIN A;  3B6U A;  4DBQ A;  1MMG A;  4PJL A;  3CJO A;  4A28 A;  4AP0 A;  2VVG A;  1YRS A;  2X2R A;  1F9U A;  1VFV A;  3KIN A;  4AS7 A;  1F9W A;  4A50 A;  1KK7 A;  2ZFK A;  3GBJ A;  2GM1 A;  2HEH A;  2Q2Y A;  4PJJ A;  5LT0 A;  4ANJ A;  2OWM A;  1CZ7 A;  1X88 A;  1II6 A;  4E7S A;  2UYI A;  2MYS A;  1MKJ A;  4PJN A;  4PFO A;  1D0Z A;  3ZFC A;  2ZFM A;  2X7E A;  3PXN A;  2Q2Z A;  5LT2 A;  1I5S A;  1T5C A;  4BBG A;  3U06 A;  4GKR A;  4ETP A;  1V8J A;  2XAE A;  1Q0B A;  2X51 A;  4DBR A;  3CNZ A;  1MNE A;  1V8K A;  4PJM A;  3BFN A;  5HLE A;  3ZCW A;  1MMD A;  2FL6 A;  3KAR A;  4B7B A;  2FME A;  1F9V A;  2VB6 A;  4LNU K;  1FMV A;  3L1C A;  1MMN A;  1RY6 A;  2FL2 A;  1SDM A;  2VAS A;  4E7Z A;  2V26 A;  2IEH A;  4Y05 A;  1BR1 A;  4ZCA A;  4A5Y A;  3DC4 A;  3L9H A;  4HNA K;  3ZFD A;  2WOG A;  2XT3 A;  2PG2 A;  1D1A A;  4A1Z A;  1VFZ A;  1I6I A;  4PFP A;  3WRD A;  1N6M A;  5LT1 A;  3KEN A;  3COB A;  1VFX A;  3T0Q A;  1D1C A;  1BR4 A;  1GOJ A;  1FMW A;  3WPN A;  4BN2 A;  2ZFJ A;  2FKY A;  1MMA A;  1LKX A;  2Y5W A;  2NCD A;  1D1B A;  5LT4 A;  2Y65 A;  3HQD A;  2ZFL A;  2X7D A;  3H4S A;  1F9T A;  4A14 A;  3NWN A;  2ZFI A;  4UBF A;  1G8X A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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