3KENA

Human eg5 in complex with s-trityl-l-cysteine
Total Genus 108
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
108
sequence length
349
structure length
333
Chain Sequence
NIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPEVN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Kinesin-like protein KIF11
publication title Allosteric drug discrimination is coupled to mechanochemical changes in the kinesin-5 motor core.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Motor protein
total genus 108
structure length 333
sequence length 349
ec nomenclature
pdb deposition date 2009-10-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 3kenA00
2UYIA 1I6IA 1MMNA 4FRZA 3BFNA 2VB6A 1FMWA 2FMEA 4AP0A 1BR2A 4Y05A 4PFOA 2X51A 1VFVA 2GRYA 1D1AA 3LREA 2ZFLA 4A1ZA 3WRDA 4DBRA 1VFWA 1MMAA 4PJJA 2Y5WA 1D0ZA 1I5SA 4PFPA 2IEHA 3K3BA 2OWMA 2VASA 3KARA 1F9TA 2ZFJA 2NCDA 2G1QA 2MYSA 1MKJA 2X7DA 2VVGA 2Q2YA 3GBJA 4BBGA 1SDMA 1G8XA 2XT3A 1VOMA 1F9VA 5LT4A 4A51A 1MMDA 1Q0BA 1YRSA 5GSZA 2HEHA 1MMGA 4E7ZA 2UYMA 4ANJA 3B6VA 3X2TA 2FL6A 3NWNA 4A5YA 3ZFCA 5LT3A 1BR4A 3U06A 1F9WA 3CJOA 3KINA 4DBQA 3L1CA 2FL2A 2KINA 1V8KA 4ZHIA 4A14A 3HQDA 1BR1A 4BXNA 4ETPA 5LT2A 1BG2A 1RY6A 3KENA 4E7SA 4LNUK 4ZCAA 1N6MA 4UBFA 4HNAK 5LT1A 2V26A 4PJLA 3ZCWA 2ZFIA 3T0QA 4PK4A 1FMVA 2PG2A 3H4SA 1II6A 4BN2A 3ZFDA 2Y65A 4GKRA 3K5EA 2X7EA 3DCBA 5LT0A 3L9HA 2ZFKA 2WOGA 1VFXA 1GOJA 2GM1A 1D0YA 3CNZA 3B6UA 1MNEA 4A28A 1X88A 1F9UA 1T5CA 2Q2ZA 2XAEA 2X7CA 3COBA 1D1BA 2ZFMA 2FKYA 1D1CA 3DC4A 5HLEA 4A50A 4B7BA 4H1GA 1VFZA 3WPNA 1LKXA 4PJNA 2X2RA 4PJMA 1D0XA 1LVKA 3PXNA 1CZ7A 4AS7A 1V8JA 1KK7A
chains in the Genus database with same CATH superfamily
2UYIA 1I6IA 1MMNA 4FRZA 3BFNA 2VB6A 1FMWA 2FMEA 4AP0A 1BR2A 4Y05A 4PFOA 4ETPB 2X51A 1VFVA 2GRYA 1D1AA 3LREA 2ZFLA 4A1ZA 3WRDA 4DBRA 1VFWA 1MMAA 4PJJA 2Y5WA 1D0ZA 1I5SA 4PFPA 2IEHA 3K3BA 4GKPA 2OWMA 2VASA 3KARA 1F9TA 2ZFJA 2NCDA 2G1QA 2MYSA 1MKJA 2X7DA 2VVGA 2Q2YA 3GBJA 4BBGA 1SDMA 1G8XA 2XT3A 1VOMA 1F9VA 5LT4A 4A51A 1MMDA 1Q0BA 1YRSA 5GSZA 2HEHA 1MMGA 2O0AA 4E7ZA 2UYMA 4ANJA 3B6VA 3X2TA 2FL6A 3NWNA 4A5YA 3ZFCA 5LT3A 1BR4A 3U06A 1F9WA 3CJOA 3KINA 4DBQA 3L1CA 2FL2A 2KINA 1V8KA 4ZHIA 4A14A 3HQDA 1BR1A 4BXNA 4ETPA 5LT2A 1BG2A 1RY6A 3KENA 4E7SA 4LNUK 4ZCAA 1N6MA 4UBFA 4HNAK 4GKQA 5LT1A 2V26A 4PJLA 3ZCWA 2ZFIA 3T0QA 4PK4A 1FMVA 2PG2A 3H4SA 1II6A 4BN2A 3ZFDA 2Y65A 4GKRA 3K5EA 2X7EA 3DCBA 5LT0A 3L9HA 2ZFKA 2WOGA 1VFXA 1GOJA 2GM1A 1D0YA 3CNZA 3B6UA 1MNEA 4A28A 1X88A 1F9UA 1T5CA 2Q2ZA 2XAEA 2X7CA 3COBA 1D1BA 2ZFMA 2FKYA 1D1CA 3DC4A 5HLEA 4A50A 4B7BA 4H1GA 1VFZA 3WPNA 1LKXA 4PJNA 2X2RA 4PJMA 1D0XA 1LVKA 3PXNA 1CZ7A 4AS7A 1V8JA 1KK7A
chains in the Genus database with same CATH topology
2UYIA 1I6IA 1MMNA 4FRZA 3BFNA 2VB6A 1FMWA 2FMEA 4AP0A 1BR2A 4Y05A 4PFOA 2X51A 1VFVA 2GRYA 1D1AA 3LREA 2ZFLA 4A1ZA 3WRDA 4DBRA 1VFWA 1MMAA 4PJJA 2Y5WA 1D0ZA 1I5SA 4PFPA 2IEHA 3K3BA 2OWMA 2VASA 3KARA 1F9TA 2ZFJA 2NCDA 2G1QA 2MYSA 1MKJA 2X7DA 2VVGA 2Q2YA 3GBJA 4BBGA 1SDMA 1G8XA 2XT3A 1VOMA 1F9VA 5LT4A 4A51A 1MMDA 1Q0BA 1YRSA 5GSZA 2HEHA 1MMGA 4E7ZA 2UYMA 4ANJA 3B6VA 3X2TA 2FL6A 3NWNA 4A5YA 3ZFCA 5LT3A 1BR4A 3U06A 1F9WA 3CJOA 3KINA 4DBQA 3L1CA 2FL2A 2KINA 1V8KA 4ZHIA 4A14A 3HQDA 1BR1A 4BXNA 4ETPA 5LT2A 1BG2A 1RY6A 3KENA 4E7SA 4LNUK 4ZCAA 1N6MA 4UBFA 4HNAK 5LT1A 2V26A 4PJLA 3ZCWA 2ZFIA 3T0QA 4PK4A 1FMVA 2PG2A 3H4SA 1II6A 4BN2A 3ZFDA 2Y65A 4GKRA 3K5EA 2X7EA 3DCBA 5LT0A 3L9HA 2ZFKA 2WOGA 1VFXA 1GOJA 2GM1A 1D0YA 3CNZA 3B6UA 1MNEA 4A28A 1X88A 1F9UA 1T5CA 2Q2ZA 2XAEA 2X7CA 3COBA 1D1BA 2ZFMA 2FKYA 1D1CA 3DC4A 5HLEA 4A50A 4B7BA 4H1GA 1VFZA 3WPNA 1LKXA 4PJNA 2X2RA 4PJMA 1D0XA 1LVKA 3PXNA 1CZ7A 4AS7A 1V8JA 1KK7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2UYI A;  1I6I A;  1MMN A;  4FRZ A;  3BFN A;  2VB6 A;  1FMW A;  2FME A;  4AP0 A;  1BR2 A;  4Y05 A;  4PFO A;  2X51 A;  1VFV A;  2GRY A;  1D1A A;  3LRE A;  2ZFL A;  4A1Z A;  3WRD A;  4DBR A;  1VFW A;  1MMA A;  4PJJ A;  2Y5W A;  1D0Z A;  1I5S A;  4PFP A;  2IEH A;  3K3B A;  2OWM A;  2VAS A;  3KAR A;  1F9T A;  2ZFJ A;  2NCD A;  2G1Q A;  2MYS A;  1MKJ A;  2X7D A;  2VVG A;  2Q2Y A;  3GBJ A;  4BBG A;  1SDM A;  1G8X A;  2XT3 A;  1VOM A;  1F9V A;  5LT4 A;  4A51 A;  1MMD A;  1Q0B A;  1YRS A;  5GSZ A;  2HEH A;  1MMG A;  4E7Z A;  2UYM A;  4ANJ A;  3B6V A;  3X2T A;  2FL6 A;  3NWN A;  4A5Y A;  3ZFC A;  5LT3 A;  1BR4 A;  3U06 A;  1F9W A;  3CJO A;  3KIN A;  4DBQ A;  3L1C A;  2FL2 A;  2KIN A;  1V8K A;  4ZHI A;  4A14 A;  3HQD A;  1BR1 A;  4BXN A;  4ETP A;  5LT2 A;  1BG2 A;  1RY6 A;  3KEN A;  4E7S A;  4LNU K;  4ZCA A;  1N6M A;  4UBF A;  4HNA K;  5LT1 A;  2V26 A;  4PJL A;  3ZCW A;  2ZFI A;  3T0Q A;  4PK4 A;  1FMV A;  2PG2 A;  3H4S A;  1II6 A;  4BN2 A;  3ZFD A;  2Y65 A;  4GKR A;  3K5E A;  2X7E A;  3DCB A;  5LT0 A;  3L9H A;  2ZFK A;  2WOG A;  1VFX A;  1GOJ A;  2GM1 A;  1D0Y A;  3CNZ A;  3B6U A;  1MNE A;  4A28 A;  1X88 A;  1F9U A;  1T5C A;  2Q2Z A;  2XAE A;  2X7C A;  3COB A;  1D1B A;  2ZFM A;  2FKY A;  1D1C A;  3DC4 A;  5HLE A;  4A50 A;  4B7B A;  4H1G A;  1VFZ A;  3WPN A;  1LKX A;  4PJN A;  2X2R A;  4PJM A;  1D0X A;  1LVK A;  3PXN A;  1CZ7 A;  4AS7 A;  1V8J A;  1KK7 A; 
#chains in the Genus database with same CATH topology
 2UYI A;  1I6I A;  1MMN A;  4FRZ A;  3BFN A;  2VB6 A;  1FMW A;  2FME A;  4AP0 A;  1BR2 A;  4Y05 A;  4PFO A;  4ETP B;  2X51 A;  1VFV A;  2GRY A;  1D1A A;  3LRE A;  2ZFL A;  4A1Z A;  3WRD A;  4DBR A;  1VFW A;  1MMA A;  4PJJ A;  2Y5W A;  1D0Z A;  1I5S A;  4PFP A;  2IEH A;  3K3B A;  4GKP A;  2OWM A;  2VAS A;  3KAR A;  1F9T A;  2ZFJ A;  2NCD A;  2G1Q A;  2MYS A;  1MKJ A;  2X7D A;  2VVG A;  2Q2Y A;  3GBJ A;  4BBG A;  1SDM A;  1G8X A;  2XT3 A;  1VOM A;  1F9V A;  5LT4 A;  4A51 A;  1MMD A;  1Q0B A;  1YRS A;  5GSZ A;  2HEH A;  1MMG A;  2O0A A;  4E7Z A;  2UYM A;  4ANJ A;  3B6V A;  3X2T A;  2FL6 A;  3NWN A;  4A5Y A;  3ZFC A;  5LT3 A;  1BR4 A;  3U06 A;  1F9W A;  3CJO A;  3KIN A;  4DBQ A;  3L1C A;  2FL2 A;  2KIN A;  1V8K A;  4ZHI A;  4A14 A;  3HQD A;  1BR1 A;  4BXN A;  4ETP A;  5LT2 A;  1BG2 A;  1RY6 A;  3KEN A;  4E7S A;  4LNU K;  4ZCA A;  1N6M A;  4UBF A;  4HNA K;  4GKQ A;  5LT1 A;  2V26 A;  4PJL A;  3ZCW A;  2ZFI A;  3T0Q A;  4PK4 A;  1FMV A;  2PG2 A;  3H4S A;  1II6 A;  4BN2 A;  3ZFD A;  2Y65 A;  4GKR A;  3K5E A;  2X7E A;  3DCB A;  5LT0 A;  3L9H A;  2ZFK A;  2WOG A;  1VFX A;  1GOJ A;  2GM1 A;  1D0Y A;  3CNZ A;  3B6U A;  1MNE A;  4A28 A;  1X88 A;  1F9U A;  1T5C A;  2Q2Z A;  2XAE A;  2X7C A;  3COB A;  1D1B A;  2ZFM A;  2FKY A;  1D1C A;  3DC4 A;  5HLE A;  4A50 A;  4B7B A;  4H1G A;  1VFZ A;  3WPN A;  1LKX A;  4PJN A;  2X2R A;  4PJM A;  1D0X A;  1LVK A;  3PXN A;  1CZ7 A;  4AS7 A;  1V8J A;  1KK7 A; 
#chains in the Genus database with same CATH homology
 2UYI A;  1I6I A;  1MMN A;  4FRZ A;  3BFN A;  2VB6 A;  1FMW A;  2FME A;  4AP0 A;  1BR2 A;  4Y05 A;  4PFO A;  2X51 A;  1VFV A;  2GRY A;  1D1A A;  3LRE A;  2ZFL A;  4A1Z A;  3WRD A;  4DBR A;  1VFW A;  1MMA A;  4PJJ A;  2Y5W A;  1D0Z A;  1I5S A;  4PFP A;  2IEH A;  3K3B A;  2OWM A;  2VAS A;  3KAR A;  1F9T A;  2ZFJ A;  2NCD A;  2G1Q A;  2MYS A;  1MKJ A;  2X7D A;  2VVG A;  2Q2Y A;  3GBJ A;  4BBG A;  1SDM A;  1G8X A;  2XT3 A;  1VOM A;  1F9V A;  5LT4 A;  4A51 A;  1MMD A;  1Q0B A;  1YRS A;  5GSZ A;  2HEH A;  1MMG A;  4E7Z A;  2UYM A;  4ANJ A;  3B6V A;  3X2T A;  2FL6 A;  3NWN A;  4A5Y A;  3ZFC A;  5LT3 A;  1BR4 A;  3U06 A;  1F9W A;  3CJO A;  3KIN A;  4DBQ A;  3L1C A;  2FL2 A;  2KIN A;  1V8K A;  4ZHI A;  4A14 A;  3HQD A;  1BR1 A;  4BXN A;  4ETP A;  5LT2 A;  1BG2 A;  1RY6 A;  3KEN A;  4E7S A;  4LNU K;  4ZCA A;  1N6M A;  4UBF A;  4HNA K;  5LT1 A;  2V26 A;  4PJL A;  3ZCW A;  2ZFI A;  3T0Q A;  4PK4 A;  1FMV A;  2PG2 A;  3H4S A;  1II6 A;  4BN2 A;  3ZFD A;  2Y65 A;  4GKR A;  3K5E A;  2X7E A;  3DCB A;  5LT0 A;  3L9H A;  2ZFK A;  2WOG A;  1VFX A;  1GOJ A;  2GM1 A;  1D0Y A;  3CNZ A;  3B6U A;  1MNE A;  4A28 A;  1X88 A;  1F9U A;  1T5C A;  2Q2Z A;  2XAE A;  2X7C A;  3COB A;  1D1B A;  2ZFM A;  2FKY A;  1D1C A;  3DC4 A;  5HLE A;  4A50 A;  4B7B A;  4H1G A;  1VFZ A;  3WPN A;  1LKX A;  4PJN A;  2X2R A;  4PJM A;  1D0X A;  1LVK A;  3PXN A;  1CZ7 A;  4AS7 A;  1V8J A;  1KK7 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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