4A50A

Crystal structure of human kinesin eg5 in complex with 2-amino-5-(3-methylphenyl)-5,5-diphenylpentanoic acid
Total Genus 108
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
108
sequence length
350
structure length
336
Chain Sequence
KNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENININQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPEVN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords KINESIN-LIKE PROTEIN KIF11
publication title Triphenylbutanamines: Kinesin Spindle Protein Inhibitors with in Vivo Antitumor Activity.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Cell cycle
total genus 108
structure length 336
sequence length 350
ec nomenclature
pdb deposition date 2011-10-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 4a50A00
2GRYA 2Q2YA 2PG2A 3LREA 2OWMA 3COBA 1I6IA 2MYSA 3ZCWA 4E7SA 1N6MA 2ZFLA 4A51A 1LKXA 1D0ZA 4LNUK 2IEHA 4BN2A 1SDMA 2FMEA 3K5EA 3DC4A 2FL6A 3K3BA 2X51A 1BR2A 4BXNA 1D1CA 4H1GA 1VFWA 1G8XA 3PXNA 1II6A 4E7ZA 1V8JA 4ZHIA 3X2TA 3CNZA 1F9UA 4GKRA 1GOJA 3WPNA 3KENA 4UBFA 2UYIA 1T5CA 1VFVA 4ZCAA 1I5SA 4ETPA 2ZFMA 2XAEA 4A5YA 2VB6A 4HNAK 2VASA 1F9TA 2VVGA 2G1QA 4PJMA 1CZ7A 4A28A 5GSZA 4PJJA 3L1CA 2ZFIA 2WOGA 1Q0BA 2HEHA 1MMNA 4A1ZA 4B7BA 2ZFJA 3B6UA 4FRZA 4AS7A 1VOMA 1KK7A 2GM1A 3ZFDA 3CJOA 2X2RA 3ZFCA 2UYMA 1D1BA 5LT2A 1MMAA 1MMDA 1RY6A 4A14A 2FKYA 4ANJA 1MNEA 1MKJA 1D0XA 1FMWA 2XT3A 3NWNA 4PFOA 1VFXA 3U06A 3H4SA 3DCBA 2NCDA 5LT1A 4DBRA 2KINA 1D0YA 1X88A 3GBJA 4DBQA 5LT4A 4PJNA 2Y5WA 1YRSA 2X7DA 2X7EA 3L9HA 2Y65A 1D1AA 3B6VA 1BR1A 4BBGA 3KARA 2ZFKA 3HQDA 3KINA 4PFPA 1F9WA 1V8KA 5LT3A 1LVKA 1F9VA 4Y05A 3T0QA 4PJLA 1VFZA 3WRDA 2FL2A 4PK4A 1BG2A 1FMVA 1MMGA 3BFNA 2Q2ZA 4A50A 4AP0A 5LT0A 1BR4A 2V26A 5HLEA 2X7CA
chains in the Genus database with same CATH superfamily
2GRYA 2Q2YA 2PG2A 4ETPB 3LREA 2O0AA 2OWMA 4GKQA 3COBA 1I6IA 2MYSA 3ZCWA 4E7SA 1N6MA 2ZFLA 4A51A 1LKXA 1D0ZA 4LNUK 2IEHA 4BN2A 1SDMA 2FMEA 3K5EA 3DC4A 4GKPA 2FL6A 3K3BA 2X51A 1BR2A 4BXNA 1D1CA 4H1GA 1VFWA 1G8XA 3PXNA 1II6A 4E7ZA 1V8JA 4ZHIA 3X2TA 3CNZA 1F9UA 4GKRA 1GOJA 3WPNA 3KENA 4UBFA 2UYIA 1T5CA 1VFVA 4ZCAA 1I5SA 4ETPA 2ZFMA 2XAEA 4A5YA 2VB6A 4HNAK 2VASA 1F9TA 2VVGA 2G1QA 4PJMA 1CZ7A 4A28A 5GSZA 4PJJA 3L1CA 2ZFIA 2WOGA 1Q0BA 2HEHA 1MMNA 4A1ZA 4B7BA 2ZFJA 3B6UA 4FRZA 4AS7A 1VOMA 1KK7A 2GM1A 3ZFDA 3CJOA 2X2RA 3ZFCA 2UYMA 1D1BA 5LT2A 1MMAA 1MMDA 1RY6A 4A14A 2FKYA 4ANJA 1MNEA 1MKJA 1D0XA 1FMWA 2XT3A 3NWNA 4PFOA 1VFXA 3U06A 3H4SA 3DCBA 2NCDA 5LT1A 4DBRA 2KINA 1D0YA 1X88A 3GBJA 4DBQA 5LT4A 4PJNA 2Y5WA 1YRSA 2X7DA 2X7EA 3L9HA 2Y65A 1D1AA 3B6VA 1BR1A 4BBGA 3KARA 2ZFKA 3HQDA 3KINA 4PFPA 1F9WA 1V8KA 5LT3A 1LVKA 1F9VA 4Y05A 3T0QA 4PJLA 1VFZA 3WRDA 2FL2A 4PK4A 1BG2A 1FMVA 1MMGA 3BFNA 2Q2ZA 4A50A 4AP0A 5LT0A 1BR4A 2V26A 5HLEA 2X7CA
chains in the Genus database with same CATH topology
2GRYA 2Q2YA 2PG2A 3LREA 2OWMA 3COBA 1I6IA 2MYSA 3ZCWA 4E7SA 1N6MA 2ZFLA 4A51A 1LKXA 1D0ZA 4LNUK 2IEHA 4BN2A 1SDMA 2FMEA 3K5EA 3DC4A 2FL6A 3K3BA 2X51A 1BR2A 4BXNA 1D1CA 4H1GA 1VFWA 1G8XA 3PXNA 1II6A 4E7ZA 1V8JA 4ZHIA 3X2TA 3CNZA 1F9UA 4GKRA 1GOJA 3WPNA 3KENA 4UBFA 2UYIA 1T5CA 1VFVA 4ZCAA 1I5SA 4ETPA 2ZFMA 2XAEA 4A5YA 2VB6A 4HNAK 2VASA 1F9TA 2VVGA 2G1QA 4PJMA 1CZ7A 4A28A 5GSZA 4PJJA 3L1CA 2ZFIA 2WOGA 1Q0BA 2HEHA 1MMNA 4A1ZA 4B7BA 2ZFJA 3B6UA 4FRZA 4AS7A 1VOMA 1KK7A 2GM1A 3ZFDA 3CJOA 2X2RA 3ZFCA 2UYMA 1D1BA 5LT2A 1MMAA 1MMDA 1RY6A 4A14A 2FKYA 4ANJA 1MNEA 1MKJA 1D0XA 1FMWA 2XT3A 3NWNA 4PFOA 1VFXA 3U06A 3H4SA 3DCBA 2NCDA 5LT1A 4DBRA 2KINA 1D0YA 1X88A 3GBJA 4DBQA 5LT4A 4PJNA 2Y5WA 1YRSA 2X7DA 2X7EA 3L9HA 2Y65A 1D1AA 3B6VA 1BR1A 4BBGA 3KARA 2ZFKA 3HQDA 3KINA 4PFPA 1F9WA 1V8KA 5LT3A 1LVKA 1F9VA 4Y05A 3T0QA 4PJLA 1VFZA 3WRDA 2FL2A 4PK4A 1BG2A 1FMVA 1MMGA 3BFNA 2Q2ZA 4A50A 4AP0A 5LT0A 1BR4A 2V26A 5HLEA 2X7CA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2GRY A;  2Q2Y A;  2PG2 A;  3LRE A;  2OWM A;  3COB A;  1I6I A;  2MYS A;  3ZCW A;  4E7S A;  1N6M A;  2ZFL A;  4A51 A;  1LKX A;  1D0Z A;  4LNU K;  2IEH A;  4BN2 A;  1SDM A;  2FME A;  3K5E A;  3DC4 A;  2FL6 A;  3K3B A;  2X51 A;  1BR2 A;  4BXN A;  1D1C A;  4H1G A;  1VFW A;  1G8X A;  3PXN A;  1II6 A;  4E7Z A;  1V8J A;  4ZHI A;  3X2T A;  3CNZ A;  1F9U A;  4GKR A;  1GOJ A;  3WPN A;  3KEN A;  4UBF A;  2UYI A;  1T5C A;  1VFV A;  4ZCA A;  1I5S A;  4ETP A;  2ZFM A;  2XAE A;  4A5Y A;  2VB6 A;  4HNA K;  2VAS A;  1F9T A;  2VVG A;  2G1Q A;  4PJM A;  1CZ7 A;  4A28 A;  5GSZ A;  4PJJ A;  3L1C A;  2ZFI A;  2WOG A;  1Q0B A;  2HEH A;  1MMN A;  4A1Z A;  4B7B A;  2ZFJ A;  3B6U A;  4FRZ A;  4AS7 A;  1VOM A;  1KK7 A;  2GM1 A;  3ZFD A;  3CJO A;  2X2R A;  3ZFC A;  2UYM A;  1D1B A;  5LT2 A;  1MMA A;  1MMD A;  1RY6 A;  4A14 A;  2FKY A;  4ANJ A;  1MNE A;  1MKJ A;  1D0X A;  1FMW A;  2XT3 A;  3NWN A;  4PFO A;  1VFX A;  3U06 A;  3H4S A;  3DCB A;  2NCD A;  5LT1 A;  4DBR A;  2KIN A;  1D0Y A;  1X88 A;  3GBJ A;  4DBQ A;  5LT4 A;  4PJN A;  2Y5W A;  1YRS A;  2X7D A;  2X7E A;  3L9H A;  2Y65 A;  1D1A A;  3B6V A;  1BR1 A;  4BBG A;  3KAR A;  2ZFK A;  3HQD A;  3KIN A;  4PFP A;  1F9W A;  1V8K A;  5LT3 A;  1LVK A;  1F9V A;  4Y05 A;  3T0Q A;  4PJL A;  1VFZ A;  3WRD A;  2FL2 A;  4PK4 A;  1BG2 A;  1FMV A;  1MMG A;  3BFN A;  2Q2Z A;  4A50 A;  4AP0 A;  5LT0 A;  1BR4 A;  2V26 A;  5HLE A;  2X7C A; 
#chains in the Genus database with same CATH topology
 2GRY A;  2Q2Y A;  2PG2 A;  4ETP B;  3LRE A;  2O0A A;  2OWM A;  4GKQ A;  3COB A;  1I6I A;  2MYS A;  3ZCW A;  4E7S A;  1N6M A;  2ZFL A;  4A51 A;  1LKX A;  1D0Z A;  4LNU K;  2IEH A;  4BN2 A;  1SDM A;  2FME A;  3K5E A;  3DC4 A;  4GKP A;  2FL6 A;  3K3B A;  2X51 A;  1BR2 A;  4BXN A;  1D1C A;  4H1G A;  1VFW A;  1G8X A;  3PXN A;  1II6 A;  4E7Z A;  1V8J A;  4ZHI A;  3X2T A;  3CNZ A;  1F9U A;  4GKR A;  1GOJ A;  3WPN A;  3KEN A;  4UBF A;  2UYI A;  1T5C A;  1VFV A;  4ZCA A;  1I5S A;  4ETP A;  2ZFM A;  2XAE A;  4A5Y A;  2VB6 A;  4HNA K;  2VAS A;  1F9T A;  2VVG A;  2G1Q A;  4PJM A;  1CZ7 A;  4A28 A;  5GSZ A;  4PJJ A;  3L1C A;  2ZFI A;  2WOG A;  1Q0B A;  2HEH A;  1MMN A;  4A1Z A;  4B7B A;  2ZFJ A;  3B6U A;  4FRZ A;  4AS7 A;  1VOM A;  1KK7 A;  2GM1 A;  3ZFD A;  3CJO A;  2X2R A;  3ZFC A;  2UYM A;  1D1B A;  5LT2 A;  1MMA A;  1MMD A;  1RY6 A;  4A14 A;  2FKY A;  4ANJ A;  1MNE A;  1MKJ A;  1D0X A;  1FMW A;  2XT3 A;  3NWN A;  4PFO A;  1VFX A;  3U06 A;  3H4S A;  3DCB A;  2NCD A;  5LT1 A;  4DBR A;  2KIN A;  1D0Y A;  1X88 A;  3GBJ A;  4DBQ A;  5LT4 A;  4PJN A;  2Y5W A;  1YRS A;  2X7D A;  2X7E A;  3L9H A;  2Y65 A;  1D1A A;  3B6V A;  1BR1 A;  4BBG A;  3KAR A;  2ZFK A;  3HQD A;  3KIN A;  4PFP A;  1F9W A;  1V8K A;  5LT3 A;  1LVK A;  1F9V A;  4Y05 A;  3T0Q A;  4PJL A;  1VFZ A;  3WRD A;  2FL2 A;  4PK4 A;  1BG2 A;  1FMV A;  1MMG A;  3BFN A;  2Q2Z A;  4A50 A;  4AP0 A;  5LT0 A;  1BR4 A;  2V26 A;  5HLE A;  2X7C A; 
#chains in the Genus database with same CATH homology
 2GRY A;  2Q2Y A;  2PG2 A;  3LRE A;  2OWM A;  3COB A;  1I6I A;  2MYS A;  3ZCW A;  4E7S A;  1N6M A;  2ZFL A;  4A51 A;  1LKX A;  1D0Z A;  4LNU K;  2IEH A;  4BN2 A;  1SDM A;  2FME A;  3K5E A;  3DC4 A;  2FL6 A;  3K3B A;  2X51 A;  1BR2 A;  4BXN A;  1D1C A;  4H1G A;  1VFW A;  1G8X A;  3PXN A;  1II6 A;  4E7Z A;  1V8J A;  4ZHI A;  3X2T A;  3CNZ A;  1F9U A;  4GKR A;  1GOJ A;  3WPN A;  3KEN A;  4UBF A;  2UYI A;  1T5C A;  1VFV A;  4ZCA A;  1I5S A;  4ETP A;  2ZFM A;  2XAE A;  4A5Y A;  2VB6 A;  4HNA K;  2VAS A;  1F9T A;  2VVG A;  2G1Q A;  4PJM A;  1CZ7 A;  4A28 A;  5GSZ A;  4PJJ A;  3L1C A;  2ZFI A;  2WOG A;  1Q0B A;  2HEH A;  1MMN A;  4A1Z A;  4B7B A;  2ZFJ A;  3B6U A;  4FRZ A;  4AS7 A;  1VOM A;  1KK7 A;  2GM1 A;  3ZFD A;  3CJO A;  2X2R A;  3ZFC A;  2UYM A;  1D1B A;  5LT2 A;  1MMA A;  1MMD A;  1RY6 A;  4A14 A;  2FKY A;  4ANJ A;  1MNE A;  1MKJ A;  1D0X A;  1FMW A;  2XT3 A;  3NWN A;  4PFO A;  1VFX A;  3U06 A;  3H4S A;  3DCB A;  2NCD A;  5LT1 A;  4DBR A;  2KIN A;  1D0Y A;  1X88 A;  3GBJ A;  4DBQ A;  5LT4 A;  4PJN A;  2Y5W A;  1YRS A;  2X7D A;  2X7E A;  3L9H A;  2Y65 A;  1D1A A;  3B6V A;  1BR1 A;  4BBG A;  3KAR A;  2ZFK A;  3HQD A;  3KIN A;  4PFP A;  1F9W A;  1V8K A;  5LT3 A;  1LVK A;  1F9V A;  4Y05 A;  3T0Q A;  4PJL A;  1VFZ A;  3WRD A;  2FL2 A;  4PK4 A;  1BG2 A;  1FMV A;  1MMG A;  3BFN A;  2Q2Z A;  4A50 A;  4AP0 A;  5LT0 A;  1BR4 A;  2V26 A;  5HLE A;  2X7C A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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