1V8J | Genus

Total Genus 99

Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	99
sequence length	363
structure length	337
Chain Sequence	PNWEFARMIKEFRVTMECSPLTPIEEHRICVCVRKRPLNKQELAKKEIDVISVPSKCLLLVHEPKLKVDLTKYLENQAFCFDFAFDETASNEVVYRFTARPLVQTIFEGGKATCFAYGQTGSGKTHTMGGDQNASKGIYAMASRDVFLLKNQPRYRNLNLEVYVTFFEIYNGKVFDLLNKKAKLRVLEDSRQQVQVVGLQEYLVTCADDVIKMINMGSACRTSGNSNSSRSHACFQILLRTKGRLHGKFSLVDLAGNERRQTRMEGAEINKSLLALKECIRALGQFRESKLTQVLRDSFIGENSRTCMIAMISPGISSCEYTLNTLRYADRVKELSH

Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

loadScript /static/js/j2s/core/package.js

loadScript /static/js/j2s/core/corejmol.z.js

loadScript /static/js/j2s/core/corescript.z.js

JSmol exec jmolApplet0 start applet null

Jmol JavaScript applet jmolApplet0__696571373251119__ initializing

Jmol getValue debug null

Jmol getValue logLevel null

Jmol getValue allowjavascript null

AppletRegistry.checkIn(jmolApplet0__696571373251119__)

vwrOptions:

{ "name":"jmolApplet0","applet":true,"documentBase":"https://genus.fuw.edu.pl/view/1V8J/A/","platform":"J.awtjs2d.Platform","fullName":"jmolApplet0__696571373251119__","codePath":"https:/static/js/j2s/","display":"jmolApplet0_canvas2d","signedApplet":"true","appletReadyCallback":"Jmol._readyCallback","statusListener":"[J.appletjs.Jmol object]","syncId":"696571373251119","bgcolor":"white" }

setting document base to "https://genus.fuw.edu.pl/view/1V8J/A/"

Jmol Version: 14.29.13 2018-04-17 17:17

java.vendor: Java2Script (HTML5)

java.version: 2018-01-28 23:38:52 (JSmol/j2s)

os.name: Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)

Access: ALL

memory: 0.0/0.0

processors available: 1

useCommandThread: false

appletId:jmolApplet0 (signed)

Jmol getValue emulate null

defaults = "Jmol"

Jmol getValue boxbgcolor null

Jmol getValue bgcolor white

backgroundColor = "white"

Jmol getValue ANIMFRAMECallback null

Jmol getValue APPLETREADYCallback Jmol._readyCallback

APPLETREADYCallback = "Jmol._readyCallback"

callback set for APPLETREADYCallback Jmol._readyCallback APPLETREADY

Jmol getValue ATOMMOVEDCallback null

Jmol getValue AUDIOCallback null

Jmol getValue CLICKCallback null

Jmol getValue DRAGDROPCallback null

Jmol getValue ECHOCallback null

Jmol getValue ERRORCallback null

Jmol getValue EVALCallback null

Jmol getValue HOVERCallback null

Jmol getValue IMAGECallback null

Jmol getValue LOADSTRUCTCallback null

Jmol getValue MEASURECallback null

Jmol getValue MESSAGECallback null

Jmol getValue MINIMIZATIONCallback null

Jmol getValue SERVICECallback null

Jmol getValue PICKCallback null

Jmol getValue RESIZECallback null

Jmol getValue SCRIPTCallback null

Jmol getValue SYNCCallback null

Jmol getValue STRUCTUREMODIFIEDCallback null

Jmol getValue doTranslate null

language=en_US

Jmol getValue popupMenu null

Jmol getValue script null

Jmol getValue loadInline null

Jmol getValue load null

Jmol applet jmolApplet0__696571373251119__ ready

script 1 started

platformSpeed = 8

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Structural protein
source organism	Mus musculus
publication title	A common mechanism for microtubule destabilizers-M type kinesins stabilize curling of the protofilament using the class-specific neck and loops. pubmed doi rcsb
molecule keywords	Kinesin-like protein KIF2C
total genus	99
structure length	337
sequence length	363
ec nomenclature
pdb deposition date	2004-01-09

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00225	Kinesin	Kinesin motor domain

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
3.40.850.10	Alpha Beta	3-Layer(aba) Sandwich	Kinesin	Kinesin motor domain	1v8jA00

2ZFLA 2FMEA 4BBGA 2FL2A 2FL6A 4BN2A 1VFXA 1VFVA 2X7EA 1BR4A 3B6UA 3K5EA 1MKJA 4PJNA 2G1QA 2Y5WA 5LT0A 3LREA 4AS7A 1I6IA 4A51A 2V26A 1LKXA 4ZCAA 1YRSA 1D1AA 4E7ZA 1MMDA 1KK7A 3PXNA 4A14A 3GBJA 2WOGA 5LT2A 3ZCWA 1N6MA 3B6VA 1T5CA 5LT1A 4PJLA 1F9TA 1G8XA 1LVKA 1SDMA 1MMAA 1MMGA 2KINA 3WPNA 3U06A 1V8KA 2Q2ZA 3L1CA 4B7BA 2X7DA 3BFNA 1CZ7A 2MYSA 1D0XA 4BXNA 2X51A 3DCBA 1D0YA 3ZFCA 3T0QA 4ANJA 4HNAK 1MNEA 2VASA 3ZFDA 2X2RA 4GKRA 2XAEA 2HEHA 2NCDA 4PK4A 2UYIA 4A50A 2PG2A 2XT3A 4ETPA 1D1CA 1FMWA 2VB6A 3KINA 1MMNA 1F9UA 1F9VA 2ZFKA 2X7CA 4PFPA 1Q0BA 3DC4A 1FMVA 2ZFJA 1X88A 4DBRA 1V8JA 1VFZA 4PJMA 2IEHA 2UYMA 4A1ZA 2ZFIA 3L9HA 1RY6A 1D1BA 3HQDA 4H1GA 4E7SA 3X2TA 2GRYA 2OWMA 4A5YA 4FRZA 1BG2A 1F9WA 4AP0A 3CNZA 5GSZA 1BR1A 2FKYA 4DBQA 5LT4A 4A28A 2Q2YA 3COBA 4LNUK 4UBFA 5HLEA 1VOMA 3H4SA 3K3BA 4Y05A 5LT3A 2ZFMA 3CJOA 3KENA 2GM1A 4PJJA 4PFOA 1BR2A 3WRDA 3KARA 2Y65A 4ZHIA 1II6A 1D0ZA 1GOJA 1I5SA 2VVGA 3NWNA 1VFWA
chains in the Genus database with same CATH superfamily

2ZFLA 2FMEA 4BBGA 2FL2A 2FL6A 4BN2A 1VFXA 1VFVA 2X7EA 1BR4A 3B6UA 3K5EA 1MKJA 4PJNA 2G1QA 2Y5WA 5LT0A 3LREA 4AS7A 1I6IA 4A51A 2V26A 1LKXA 4ZCAA 1YRSA 1D1AA 4GKQA 4E7ZA 1MMDA 1KK7A 3PXNA 4A14A 3GBJA 2WOGA 4GKPA 5LT2A 3ZCWA 1N6MA 3B6VA 1T5CA 5LT1A 4PJLA 1F9TA 1G8XA 1LVKA 1SDMA 1MMAA 1MMGA 2KINA 3WPNA 4ETPB 3U06A 1V8KA 2Q2ZA 3L1CA 4B7BA 2X7DA 3BFNA 1CZ7A 2MYSA 1D0XA 4BXNA 2X51A 3DCBA 1D0YA 3ZFCA 3T0QA 4ANJA 4HNAK 1MNEA 2VASA 3ZFDA 2X2RA 4GKRA 2XAEA 2HEHA 2NCDA 4PK4A 2UYIA 4A50A 2PG2A 2XT3A 4ETPA 1D1CA 1FMWA 2VB6A 3KINA 1MMNA 1F9UA 1F9VA 2ZFKA 2X7CA 4PFPA 1Q0BA 3DC4A 1FMVA 2ZFJA 1X88A 4DBRA 1V8JA 1VFZA 4PJMA 2IEHA 2UYMA 4A1ZA 2ZFIA 3L9HA 1RY6A 1D1BA 3HQDA 4H1GA 4E7SA 3X2TA 2GRYA 2OWMA 4A5YA 4FRZA 1BG2A 1F9WA 4AP0A 3CNZA 5GSZA 1BR1A 2FKYA 4DBQA 5LT4A 4A28A 2Q2YA 3COBA 4LNUK 4UBFA 5HLEA 1VOMA 3H4SA 3K3BA 4Y05A 5LT3A 2ZFMA 3CJOA 3KENA 2GM1A 4PJJA 4PFOA 1BR2A 2O0AA 3WRDA 3KARA 2Y65A 4ZHIA 1II6A 1D0ZA 1GOJA 1I5SA 2VVGA 3NWNA 1VFWA
chains in the Genus database with same CATH topology

#chains in the Genus database with same CATH superfamily
 2ZFL A;  2FME A;  4BBG A;  2FL2 A;  2FL6 A;  4BN2 A;  1VFX A;  1VFV A;  2X7E A;  1BR4 A;  3B6U A;  3K5E A;  1MKJ A;  4PJN A;  2G1Q A;  2Y5W A;  5LT0 A;  3LRE A;  4AS7 A;  1I6I A;  4A51 A;  2V26 A;  1LKX A;  4ZCA A;  1YRS A;  1D1A A;  4E7Z A;  1MMD A;  1KK7 A;  3PXN A;  4A14 A;  3GBJ A;  2WOG A;  5LT2 A;  3ZCW A;  1N6M A;  3B6V A;  1T5C A;  5LT1 A;  4PJL A;  1F9T A;  1G8X A;  1LVK A;  1SDM A;  1MMA A;  1MMG A;  2KIN A;  3WPN A;  3U06 A;  1V8K A;  2Q2Z A;  3L1C A;  4B7B A;  2X7D A;  3BFN A;  1CZ7 A;  2MYS A;  1D0X A;  4BXN A;  2X51 A;  3DCB A;  1D0Y A;  3ZFC A;  3T0Q A;  4ANJ A;  4HNA K;  1MNE A;  2VAS A;  3ZFD A;  2X2R A;  4GKR A;  2XAE A;  2HEH A;  2NCD A;  4PK4 A;  2UYI A;  4A50 A;  2PG2 A;  2XT3 A;  4ETP A;  1D1C A;  1FMW A;  2VB6 A;  3KIN A;  1MMN A;  1F9U A;  1F9V A;  2ZFK A;  2X7C A;  4PFP A;  1Q0B A;  3DC4 A;  1FMV A;  2ZFJ A;  1X88 A;  4DBR A;  1V8J A;  1VFZ A;  4PJM A;  2IEH A;  2UYM A;  4A1Z A;  2ZFI A;  3L9H A;  1RY6 A;  1D1B A;  3HQD A;  4H1G A;  4E7S A;  3X2T A;  2GRY A;  2OWM A;  4A5Y A;  4FRZ A;  1BG2 A;  1F9W A;  4AP0 A;  3CNZ A;  5GSZ A;  1BR1 A;  2FKY A;  4DBQ A;  5LT4 A;  4A28 A;  2Q2Y A;  3COB A;  4LNU K;  4UBF A;  5HLE A;  1VOM A;  3H4S A;  3K3B A;  4Y05 A;  5LT3 A;  2ZFM A;  3CJO A;  3KEN A;  2GM1 A;  4PJJ A;  4PFO A;  1BR2 A;  3WRD A;  3KAR A;  2Y65 A;  4ZHI A;  1II6 A;  1D0Z A;  1GOJ A;  1I5S A;  2VVG A;  3NWN A;  1VFW A; 
#chains in the Genus database with same CATH topology
 2ZFL A;  2FME A;  4BBG A;  2FL2 A;  2FL6 A;  4BN2 A;  1VFX A;  1VFV A;  2X7E A;  1BR4 A;  3B6U A;  3K5E A;  1MKJ A;  4PJN A;  2G1Q A;  2Y5W A;  5LT0 A;  3LRE A;  4AS7 A;  1I6I A;  4A51 A;  2V26 A;  1LKX A;  4ZCA A;  1YRS A;  1D1A A;  4GKQ A;  4E7Z A;  1MMD A;  1KK7 A;  3PXN A;  4A14 A;  3GBJ A;  2WOG A;  4GKP A;  5LT2 A;  3ZCW A;  1N6M A;  3B6V A;  1T5C A;  5LT1 A;  4PJL A;  1F9T A;  1G8X A;  1LVK A;  1SDM A;  1MMA A;  1MMG A;  2KIN A;  3WPN A;  4ETP B;  3U06 A;  1V8K A;  2Q2Z A;  3L1C A;  4B7B A;  2X7D A;  3BFN A;  1CZ7 A;  2MYS A;  1D0X A;  4BXN A;  2X51 A;  3DCB A;  1D0Y A;  3ZFC A;  3T0Q A;  4ANJ A;  4HNA K;  1MNE A;  2VAS A;  3ZFD A;  2X2R A;  4GKR A;  2XAE A;  2HEH A;  2NCD A;  4PK4 A;  2UYI A;  4A50 A;  2PG2 A;  2XT3 A;  4ETP A;  1D1C A;  1FMW A;  2VB6 A;  3KIN A;  1MMN A;  1F9U A;  1F9V A;  2ZFK A;  2X7C A;  4PFP A;  1Q0B A;  3DC4 A;  1FMV A;  2ZFJ A;  1X88 A;  4DBR A;  1V8J A;  1VFZ A;  4PJM A;  2IEH A;  2UYM A;  4A1Z A;  2ZFI A;  3L9H A;  1RY6 A;  1D1B A;  3HQD A;  4H1G A;  4E7S A;  3X2T A;  2GRY A;  2OWM A;  4A5Y A;  4FRZ A;  1BG2 A;  1F9W A;  4AP0 A;  3CNZ A;  5GSZ A;  1BR1 A;  2FKY A;  4DBQ A;  5LT4 A;  4A28 A;  2Q2Y A;  3COB A;  4LNU K;  4UBF A;  5HLE A;  1VOM A;  3H4S A;  3K3B A;  4Y05 A;  5LT3 A;  2ZFM A;  3CJO A;  3KEN A;  2GM1 A;  4PJJ A;  4PFO A;  1BR2 A;  2O0A A;  3WRD A;  3KAR A;  2Y65 A;  4ZHI A;  1II6 A;  1D0Z A;  1GOJ A;  1I5S A;  2VVG A;  3NWN A;  1VFW A; 
#chains in the Genus database with same CATH homology
 2ZFL A;  2FME A;  4BBG A;  2FL2 A;  2FL6 A;  4BN2 A;  1VFX A;  1VFV A;  2X7E A;  1BR4 A;  3B6U A;  3K5E A;  1MKJ A;  4PJN A;  2G1Q A;  2Y5W A;  5LT0 A;  3LRE A;  4AS7 A;  1I6I A;  4A51 A;  2V26 A;  1LKX A;  4ZCA A;  1YRS A;  1D1A A;  4E7Z A;  1MMD A;  1KK7 A;  3PXN A;  4A14 A;  3GBJ A;  2WOG A;  5LT2 A;  3ZCW A;  1N6M A;  3B6V A;  1T5C A;  5LT1 A;  4PJL A;  1F9T A;  1G8X A;  1LVK A;  1SDM A;  1MMA A;  1MMG A;  2KIN A;  3WPN A;  3U06 A;  1V8K A;  2Q2Z A;  3L1C A;  4B7B A;  2X7D A;  3BFN A;  1CZ7 A;  2MYS A;  1D0X A;  4BXN A;  2X51 A;  3DCB A;  1D0Y A;  3ZFC A;  3T0Q A;  4ANJ A;  4HNA K;  1MNE A;  2VAS A;  3ZFD A;  2X2R A;  4GKR A;  2XAE A;  2HEH A;  2NCD A;  4PK4 A;  2UYI A;  4A50 A;  2PG2 A;  2XT3 A;  4ETP A;  1D1C A;  1FMW A;  2VB6 A;  3KIN A;  1MMN A;  1F9U A;  1F9V A;  2ZFK A;  2X7C A;  4PFP A;  1Q0B A;  3DC4 A;  1FMV A;  2ZFJ A;  1X88 A;  4DBR A;  1V8J A;  1VFZ A;  4PJM A;  2IEH A;  2UYM A;  4A1Z A;  2ZFI A;  3L9H A;  1RY6 A;  1D1B A;  3HQD A;  4H1G A;  4E7S A;  3X2T A;  2GRY A;  2OWM A;  4A5Y A;  4FRZ A;  1BG2 A;  1F9W A;  4AP0 A;  3CNZ A;  5GSZ A;  1BR1 A;  2FKY A;  4DBQ A;  5LT4 A;  4A28 A;  2Q2Y A;  3COB A;  4LNU K;  4UBF A;  5HLE A;  1VOM A;  3H4S A;  3K3B A;  4Y05 A;  5LT3 A;  2ZFM A;  3CJO A;  3KEN A;  2GM1 A;  4PJJ A;  4PFO A;  1BR2 A;  3WRD A;  3KAR A;  2Y65 A;  4ZHI A;  1II6 A;  1D0Z A;  1GOJ A;  1I5S A;  2VVG A;  3NWN A;  1VFW A;

...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)

...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...

1V8JA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations