1X88A

Human eg5 motor domain bound to mg-adp and monastrol
Total Genus 109
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
109
sequence length
347
structure length
332
Chain Sequence
NIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural Basis of Eg5 Inhibition by Monastrol
rcsb
molecule tags Cell cycle
source organism Homo sapiens
molecule keywords Kinesin-like protein KIF11
total genus 109
structure length 332
sequence length 347
chains with identical sequence B
ec nomenclature
pdb deposition date 2004-08-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 1x88A00
1F9VA 2ZFJA 3LREA 5LT4A 3K5EA 4A28A 2GM1A 4PK4A 2NCDA 2Y65A 3U06A 2HEHA 1CZ7A 2X7DA 4PJMA 4A1ZA 2G1QA 2ZFMA 4DBRA 1MMDA 4UBFA 1GOJA 1D0ZA 2MYSA 1D1AA 2OWMA 1X88A 3NWNA 3L9HA 4BBGA 4HNAK 3ZFDA 4ANJA 2UYIA 3KENA 2FL6A 4GKRA 1BR2A 4B7BA 5GSZA 3WRDA 2XAEA 1N6MA 1VOMA 2WOGA 3CJOA 3PXNA 3KINA 1BR4A 2VB6A 3KARA 4PJJA 1T5CA 1V8JA 1VFZA 3GBJA 2IEHA 1RY6A 2KINA 3K3BA 1BR1A 2FL2A 4Y05A 4PFOA 1F9UA 1FMWA 4BXNA 3ZCWA 3T0QA 2X51A 4FRZA 4ZHIA 1FMVA 5LT0A 1KK7A 5HLEA 2X7EA 1D0YA 1D1BA 3DCBA 1YRSA 4PJNA 1V8KA 5LT2A 1MMGA 2Q2ZA 1I6IA 4PFPA 2GRYA 4A14A 2ZFIA 2UYMA 1BG2A 2VVGA 3X2TA 4A51A 4BN2A 3HQDA 4A50A 3B6UA 1D1CA 1SDMA 4E7ZA 3DC4A 4H1GA 1Q0BA 2ZFLA 3COBA 4AS7A 4DBQA 5LT3A 3L1CA 2X7CA 4AP0A 3BFNA 1LVKA 3ZFCA 1II6A 2PG2A 4PJLA 2VASA 1VFXA 1MMAA 1F9WA 1MNEA 2FKYA 3WPNA 2Q2YA 1G8XA 3B6VA 5LT1A 2V26A 2ZFKA 4LNUK 4ZCAA 2X2RA 1VFWA 4ETPA 1F9TA 4A5YA 1VFVA 3CNZA 2FMEA 3H4SA 1MMNA 1I5SA 2Y5WA 1D0XA 1MKJA 1LKXA 4E7SA 2XT3A
chains in the Genus database with same CATH superfamily
1F9VA 2ZFJA 3LREA 5LT4A 3K5EA 4A28A 2GM1A 4PK4A 2NCDA 2Y65A 3U06A 2HEHA 1CZ7A 2X7DA 4PJMA 4A1ZA 2G1QA 2ZFMA 4DBRA 1MMDA 4UBFA 1GOJA 1D0ZA 2MYSA 1D1AA 2OWMA 1X88A 3NWNA 3L9HA 4BBGA 4HNAK 3ZFDA 4ANJA 2UYIA 3KENA 2FL6A 4GKRA 1BR2A 4B7BA 5GSZA 3WRDA 2XAEA 1N6MA 1VOMA 2WOGA 3CJOA 3PXNA 3KINA 1BR4A 2VB6A 3KARA 4PJJA 1T5CA 1V8JA 1VFZA 3GBJA 2IEHA 1RY6A 2KINA 3K3BA 1BR1A 2FL2A 4Y05A 4PFOA 1F9UA 1FMWA 4BXNA 3ZCWA 3T0QA 2X51A 4FRZA 4ZHIA 1FMVA 5LT0A 1KK7A 5HLEA 4ETPB 2X7EA 1D0YA 1D1BA 3DCBA 1YRSA 4PJNA 1V8KA 5LT2A 1MMGA 2Q2ZA 1I6IA 4PFPA 2GRYA 4A14A 2ZFIA 2UYMA 1BG2A 2VVGA 3X2TA 4A51A 4BN2A 3HQDA 4A50A 3B6UA 1D1CA 1SDMA 4GKQA 4E7ZA 2O0AA 3DC4A 4H1GA 1Q0BA 2ZFLA 3COBA 4AS7A 4DBQA 5LT3A 3L1CA 2X7CA 4AP0A 3BFNA 1LVKA 3ZFCA 1II6A 2PG2A 4PJLA 2VASA 1VFXA 1MMAA 1F9WA 1MNEA 2FKYA 3WPNA 2Q2YA 1G8XA 3B6VA 5LT1A 2V26A 2ZFKA 4LNUK 4ZCAA 2X2RA 1VFWA 4ETPA 1F9TA 4A5YA 1VFVA 3CNZA 2FMEA 3H4SA 1MMNA 4GKPA 1I5SA 2Y5WA 1D0XA 1MKJA 1LKXA 4E7SA 2XT3A
chains in the Genus database with same CATH topology
1F9VA 2ZFJA 3LREA 5LT4A 3K5EA 4A28A 2GM1A 4PK4A 2NCDA 2Y65A 3U06A 2HEHA 1CZ7A 2X7DA 4PJMA 4A1ZA 2G1QA 2ZFMA 4DBRA 1MMDA 4UBFA 1GOJA 1D0ZA 2MYSA 1D1AA 2OWMA 1X88A 3NWNA 3L9HA 4BBGA 4HNAK 3ZFDA 4ANJA 2UYIA 3KENA 2FL6A 4GKRA 1BR2A 4B7BA 5GSZA 3WRDA 2XAEA 1N6MA 1VOMA 2WOGA 3CJOA 3PXNA 3KINA 1BR4A 2VB6A 3KARA 4PJJA 1T5CA 1V8JA 1VFZA 3GBJA 2IEHA 1RY6A 2KINA 3K3BA 1BR1A 2FL2A 4Y05A 4PFOA 1F9UA 1FMWA 4BXNA 3ZCWA 3T0QA 2X51A 4FRZA 4ZHIA 1FMVA 5LT0A 1KK7A 5HLEA 2X7EA 1D0YA 1D1BA 3DCBA 1YRSA 4PJNA 1V8KA 5LT2A 1MMGA 2Q2ZA 1I6IA 4PFPA 2GRYA 4A14A 2ZFIA 2UYMA 1BG2A 2VVGA 3X2TA 4A51A 4BN2A 3HQDA 4A50A 3B6UA 1D1CA 1SDMA 4E7ZA 3DC4A 4H1GA 1Q0BA 2ZFLA 3COBA 4AS7A 4DBQA 5LT3A 3L1CA 2X7CA 4AP0A 3BFNA 1LVKA 3ZFCA 1II6A 2PG2A 4PJLA 2VASA 1VFXA 1MMAA 1F9WA 1MNEA 2FKYA 3WPNA 2Q2YA 1G8XA 3B6VA 5LT1A 2V26A 2ZFKA 4LNUK 4ZCAA 2X2RA 1VFWA 4ETPA 1F9TA 4A5YA 1VFVA 3CNZA 2FMEA 3H4SA 1MMNA 1I5SA 2Y5WA 1D0XA 1MKJA 1LKXA 4E7SA 2XT3A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1F9V A;  2ZFJ A;  3LRE A;  5LT4 A;  3K5E A;  4A28 A;  2GM1 A;  4PK4 A;  2NCD A;  2Y65 A;  3U06 A;  2HEH A;  1CZ7 A;  2X7D A;  4PJM A;  4A1Z A;  2G1Q A;  2ZFM A;  4DBR A;  1MMD A;  4UBF A;  1GOJ A;  1D0Z A;  2MYS A;  1D1A A;  2OWM A;  1X88 A;  3NWN A;  3L9H A;  4BBG A;  4HNA K;  3ZFD A;  4ANJ A;  2UYI A;  3KEN A;  2FL6 A;  4GKR A;  1BR2 A;  4B7B A;  5GSZ A;  3WRD A;  2XAE A;  1N6M A;  1VOM A;  2WOG A;  3CJO A;  3PXN A;  3KIN A;  1BR4 A;  2VB6 A;  3KAR A;  4PJJ A;  1T5C A;  1V8J A;  1VFZ A;  3GBJ A;  2IEH A;  1RY6 A;  2KIN A;  3K3B A;  1BR1 A;  2FL2 A;  4Y05 A;  4PFO A;  1F9U A;  1FMW A;  4BXN A;  3ZCW A;  3T0Q A;  2X51 A;  4FRZ A;  4ZHI A;  1FMV A;  5LT0 A;  1KK7 A;  5HLE A;  2X7E A;  1D0Y A;  1D1B A;  3DCB A;  1YRS A;  4PJN A;  1V8K A;  5LT2 A;  1MMG A;  2Q2Z A;  1I6I A;  4PFP A;  2GRY A;  4A14 A;  2ZFI A;  2UYM A;  1BG2 A;  2VVG A;  3X2T A;  4A51 A;  4BN2 A;  3HQD A;  4A50 A;  3B6U A;  1D1C A;  1SDM A;  4E7Z A;  3DC4 A;  4H1G A;  1Q0B A;  2ZFL A;  3COB A;  4AS7 A;  4DBQ A;  5LT3 A;  3L1C A;  2X7C A;  4AP0 A;  3BFN A;  1LVK A;  3ZFC A;  1II6 A;  2PG2 A;  4PJL A;  2VAS A;  1VFX A;  1MMA A;  1F9W A;  1MNE A;  2FKY A;  3WPN A;  2Q2Y A;  1G8X A;  3B6V A;  5LT1 A;  2V26 A;  2ZFK A;  4LNU K;  4ZCA A;  2X2R A;  1VFW A;  4ETP A;  1F9T A;  4A5Y A;  1VFV A;  3CNZ A;  2FME A;  3H4S A;  1MMN A;  1I5S A;  2Y5W A;  1D0X A;  1MKJ A;  1LKX A;  4E7S A;  2XT3 A; 
#chains in the Genus database with same CATH topology
 1F9V A;  2ZFJ A;  3LRE A;  5LT4 A;  3K5E A;  4A28 A;  2GM1 A;  4PK4 A;  2NCD A;  2Y65 A;  3U06 A;  2HEH A;  1CZ7 A;  2X7D A;  4PJM A;  4A1Z A;  2G1Q A;  2ZFM A;  4DBR A;  1MMD A;  4UBF A;  1GOJ A;  1D0Z A;  2MYS A;  1D1A A;  2OWM A;  1X88 A;  3NWN A;  3L9H A;  4BBG A;  4HNA K;  3ZFD A;  4ANJ A;  2UYI A;  3KEN A;  2FL6 A;  4GKR A;  1BR2 A;  4B7B A;  5GSZ A;  3WRD A;  2XAE A;  1N6M A;  1VOM A;  2WOG A;  3CJO A;  3PXN A;  3KIN A;  1BR4 A;  2VB6 A;  3KAR A;  4PJJ A;  1T5C A;  1V8J A;  1VFZ A;  3GBJ A;  2IEH A;  1RY6 A;  2KIN A;  3K3B A;  1BR1 A;  2FL2 A;  4Y05 A;  4PFO A;  1F9U A;  1FMW A;  4BXN A;  3ZCW A;  3T0Q A;  2X51 A;  4FRZ A;  4ZHI A;  1FMV A;  5LT0 A;  1KK7 A;  5HLE A;  4ETP B;  2X7E A;  1D0Y A;  1D1B A;  3DCB A;  1YRS A;  4PJN A;  1V8K A;  5LT2 A;  1MMG A;  2Q2Z A;  1I6I A;  4PFP A;  2GRY A;  4A14 A;  2ZFI A;  2UYM A;  1BG2 A;  2VVG A;  3X2T A;  4A51 A;  4BN2 A;  3HQD A;  4A50 A;  3B6U A;  1D1C A;  1SDM A;  4GKQ A;  4E7Z A;  2O0A A;  3DC4 A;  4H1G A;  1Q0B A;  2ZFL A;  3COB A;  4AS7 A;  4DBQ A;  5LT3 A;  3L1C A;  2X7C A;  4AP0 A;  3BFN A;  1LVK A;  3ZFC A;  1II6 A;  2PG2 A;  4PJL A;  2VAS A;  1VFX A;  1MMA A;  1F9W A;  1MNE A;  2FKY A;  3WPN A;  2Q2Y A;  1G8X A;  3B6V A;  5LT1 A;  2V26 A;  2ZFK A;  4LNU K;  4ZCA A;  2X2R A;  1VFW A;  4ETP A;  1F9T A;  4A5Y A;  1VFV A;  3CNZ A;  2FME A;  3H4S A;  1MMN A;  4GKP A;  1I5S A;  2Y5W A;  1D0X A;  1MKJ A;  1LKX A;  4E7S A;  2XT3 A; 
#chains in the Genus database with same CATH homology
 1F9V A;  2ZFJ A;  3LRE A;  5LT4 A;  3K5E A;  4A28 A;  2GM1 A;  4PK4 A;  2NCD A;  2Y65 A;  3U06 A;  2HEH A;  1CZ7 A;  2X7D A;  4PJM A;  4A1Z A;  2G1Q A;  2ZFM A;  4DBR A;  1MMD A;  4UBF A;  1GOJ A;  1D0Z A;  2MYS A;  1D1A A;  2OWM A;  1X88 A;  3NWN A;  3L9H A;  4BBG A;  4HNA K;  3ZFD A;  4ANJ A;  2UYI A;  3KEN A;  2FL6 A;  4GKR A;  1BR2 A;  4B7B A;  5GSZ A;  3WRD A;  2XAE A;  1N6M A;  1VOM A;  2WOG A;  3CJO A;  3PXN A;  3KIN A;  1BR4 A;  2VB6 A;  3KAR A;  4PJJ A;  1T5C A;  1V8J A;  1VFZ A;  3GBJ A;  2IEH A;  1RY6 A;  2KIN A;  3K3B A;  1BR1 A;  2FL2 A;  4Y05 A;  4PFO A;  1F9U A;  1FMW A;  4BXN A;  3ZCW A;  3T0Q A;  2X51 A;  4FRZ A;  4ZHI A;  1FMV A;  5LT0 A;  1KK7 A;  5HLE A;  2X7E A;  1D0Y A;  1D1B A;  3DCB A;  1YRS A;  4PJN A;  1V8K A;  5LT2 A;  1MMG A;  2Q2Z A;  1I6I A;  4PFP A;  2GRY A;  4A14 A;  2ZFI A;  2UYM A;  1BG2 A;  2VVG A;  3X2T A;  4A51 A;  4BN2 A;  3HQD A;  4A50 A;  3B6U A;  1D1C A;  1SDM A;  4E7Z A;  3DC4 A;  4H1G A;  1Q0B A;  2ZFL A;  3COB A;  4AS7 A;  4DBQ A;  5LT3 A;  3L1C A;  2X7C A;  4AP0 A;  3BFN A;  1LVK A;  3ZFC A;  1II6 A;  2PG2 A;  4PJL A;  2VAS A;  1VFX A;  1MMA A;  1F9W A;  1MNE A;  2FKY A;  3WPN A;  2Q2Y A;  1G8X A;  3B6V A;  5LT1 A;  2V26 A;  2ZFK A;  4LNU K;  4ZCA A;  2X2R A;  1VFW A;  4ETP A;  1F9T A;  4A5Y A;  1VFV A;  3CNZ A;  2FME A;  3H4S A;  1MMN A;  1I5S A;  2Y5W A;  1D0X A;  1MKJ A;  1LKX A;  4E7S A;  2XT3 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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