2G1QA

Crystal structure of ksp in complex with inhibitor 9h
Total Genus 99

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
99
sequence length
345
structure length
330
Chain Sequence
NIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNK

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
S1 (20-25)EMPTYTVIII2 (306-309)AH1 (30-34)S2 (41-44)AH8 (315-320)S3 (49-53)AH3 (111-116)TIV1 (58-61)S4 (63-67)S5 (70-72)TI2 (73-76)TVIII1 (68-71)AH2 (78-95)TI3 (126-129)AH7 (290-304)S12 (236-248)TI7 (310-313)S11 (202-204)S6 (98-104)TII1 (106-109)TIV7 (187-190)TIV2 (120-123)TIV3 (121-124)TI4 (127-130)TI5 (130-133)AH4 (135-147)TIV10 (228-231)3H2 (148-150)S13 (254-265)TIV4 (163-166)S7 (152-164)S9 (181-186)TI6 (177-180)S8 (167-170)TIV5 (170-173)TIV6 (173-176)3H3 (207-209)AH5 (210-227)AH6 (231-234)3H4 (321-323)TI8 (311-314)TIV12 (323-326)TI1 (57-60)3H1 (45-47)TIV11 (249-252)S10 (194-197)TIV9 (190-193)TII2 (196-199)S14 (329-336)Updating...
connected with : NaN
molecule tags Cell cycle
source organism Homo sapiens
publication title Kinesin spindle protein (KSP) inhibitors. Part 4: Structure-based design of 5-alkylamino-3,5-diaryl-4,5-dihydropyrazoles as potent, water-soluble inhibitors of the mitotic kinesin KSP.
pubmed doi rcsb
molecule keywords Kinesin-like protein KIF11
total genus 99
structure length 330
sequence length 345
chains with identical sequence B
ec nomenclature
pdb deposition date 2006-02-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 2g1qA00
3WPNA 4E7ZA 4E7SA 2VB6A 4DBQA 1D0XA 1VOMA 3CNZA 4HNAK 3L9HA 4ZHIA 1D0ZA 1Q0BA 1FMVA 1BG2A 4BN2A 1MNEA 1N6MA 1GOJA 2OWMA 3K5EA 2X7DA 4BBGA 2IEHA 3K3BA 4Y05A 3L1CA 4ETPA 3KENA 3CJOA 3DC4A 5LT3A 2ZFJA 4PJNA 4PK4A 3T0QA 4FRZA 5LT1A 2FMEA 3ZFCA 4GKRA 3WRDA 1BR4A 1F9UA 1MMDA 1FMWA 4B7BA 1CZ7A 2X2RA 1MMAA 3ZCWA 3ZFDA 3DCBA 2GM1A 1D1BA 1SDMA 1VFVA 2ZFMA 1D0YA 3X2TA 1V8KA 4A1ZA 1MKJA 4AS7A 1VFWA 4A5YA 1G8XA 2HEHA 3B6UA 2XAEA 1VFXA 2KINA 1D1CA 1X88A 3BFNA 2X7EA 1YRSA 1F9VA 3PXNA 4BXNA 2FKYA 1V8JA 2Y5WA 2Q2ZA 3KINA 3H4SA 3GBJA 2NCDA 5HLEA 1KK7A 2XT3A 4ZCAA 4A14A 4H1GA 4A51A 3U06A 2WOGA 2ZFIA 1F9WA 3LREA 1T5CA 2FL2A 2MYSA 1F9TA 3B6VA 3NWNA 2VVGA 5GSZA 2X7CA 1BR1A 2PG2A 1BR2A 2ZFKA 2VASA 4ANJA 1I5SA 1MMGA 5LT2A 4PJJA 4PJMA 1VFZA 4UBFA 3COBA 1I6IA 2G1QA 2ZFLA 2UYMA 3HQDA 1LVKA 1D1AA 4PFPA 2FL6A 4PJLA 5LT0A 1MMNA 4DBRA 1LKXA 4A28A 4LNUK 1RY6A 2Q2YA 5LT4A 2GRYA 2V26A 1II6A 4A50A 2X51A 3KARA 4AP0A 2Y65A 4PFOA 2UYIA
chains in the Genus database with same CATH superfamily
3WPNA 4E7ZA 4E7SA 2VB6A 4DBQA 1D0XA 1VOMA 3CNZA 4HNAK 3L9HA 4ZHIA 1D0ZA 1Q0BA 1FMVA 1BG2A 4BN2A 1MNEA 1N6MA 1GOJA 2OWMA 3K5EA 2X7DA 4BBGA 2IEHA 3K3BA 4Y05A 3L1CA 4ETPA 3KENA 3CJOA 3DC4A 5LT3A 2ZFJA 4PJNA 4PK4A 3T0QA 4FRZA 5LT1A 2FMEA 3ZFCA 4GKRA 3WRDA 1BR4A 1F9UA 1MMDA 1FMWA 4B7BA 1CZ7A 2X2RA 1MMAA 3ZCWA 3ZFDA 3DCBA 2GM1A 1D1BA 1SDMA 1VFVA 2ZFMA 1D0YA 3X2TA 1V8KA 4A1ZA 1MKJA 4AS7A 1VFWA 4A5YA 4GKQA 1G8XA 2HEHA 3B6UA 2XAEA 1VFXA 2KINA 1D1CA 1X88A 3BFNA 2X7EA 1YRSA 1F9VA 3PXNA 4BXNA 2FKYA 1V8JA 2Y5WA 2Q2ZA 3KINA 4GKPA 3H4SA 3GBJA 2NCDA 5HLEA 4ETPB 1KK7A 2XT3A 4ZCAA 4A14A 4H1GA 4A51A 3U06A 2WOGA 2ZFIA 1F9WA 3LREA 1T5CA 2FL2A 2MYSA 1F9TA 3B6VA 3NWNA 2VVGA 5GSZA 2X7CA 2O0AA 1BR1A 2PG2A 1BR2A 2ZFKA 2VASA 4ANJA 1I5SA 1MMGA 5LT2A 4PJJA 4PJMA 1VFZA 4UBFA 3COBA 1I6IA 2G1QA 2ZFLA 2UYMA 3HQDA 1LVKA 1D1AA 4PFPA 2FL6A 4PJLA 5LT0A 1MMNA 4DBRA 1LKXA 4A28A 4LNUK 1RY6A 2Q2YA 5LT4A 2GRYA 2V26A 1II6A 4A50A 2X51A 3KARA 4AP0A 2Y65A 4PFOA 2UYIA
chains in the Genus database with same CATH topology
3WPNA 4E7ZA 4E7SA 2VB6A 4DBQA 1D0XA 1VOMA 3CNZA 4HNAK 3L9HA 4ZHIA 1D0ZA 1Q0BA 1FMVA 1BG2A 4BN2A 1MNEA 1N6MA 1GOJA 2OWMA 3K5EA 2X7DA 4BBGA 2IEHA 3K3BA 4Y05A 3L1CA 4ETPA 3KENA 3CJOA 3DC4A 5LT3A 2ZFJA 4PJNA 4PK4A 3T0QA 4FRZA 5LT1A 2FMEA 3ZFCA 4GKRA 3WRDA 1BR4A 1F9UA 1MMDA 1FMWA 4B7BA 1CZ7A 2X2RA 1MMAA 3ZCWA 3ZFDA 3DCBA 2GM1A 1D1BA 1SDMA 1VFVA 2ZFMA 1D0YA 3X2TA 1V8KA 4A1ZA 1MKJA 4AS7A 1VFWA 4A5YA 1G8XA 2HEHA 3B6UA 2XAEA 1VFXA 2KINA 1D1CA 1X88A 3BFNA 2X7EA 1YRSA 1F9VA 3PXNA 4BXNA 2FKYA 1V8JA 2Y5WA 2Q2ZA 3KINA 3H4SA 3GBJA 2NCDA 5HLEA 1KK7A 2XT3A 4ZCAA 4A14A 4H1GA 4A51A 3U06A 2WOGA 2ZFIA 1F9WA 3LREA 1T5CA 2FL2A 2MYSA 1F9TA 3B6VA 3NWNA 2VVGA 5GSZA 2X7CA 1BR1A 2PG2A 1BR2A 2ZFKA 2VASA 4ANJA 1I5SA 1MMGA 5LT2A 4PJJA 4PJMA 1VFZA 4UBFA 3COBA 1I6IA 2G1QA 2ZFLA 2UYMA 3HQDA 1LVKA 1D1AA 4PFPA 2FL6A 4PJLA 5LT0A 1MMNA 4DBRA 1LKXA 4A28A 4LNUK 1RY6A 2Q2YA 5LT4A 2GRYA 2V26A 1II6A 4A50A 2X51A 3KARA 4AP0A 2Y65A 4PFOA 2UYIA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3WPN A;  4E7Z A;  4E7S A;  2VB6 A;  4DBQ A;  1D0X A;  1VOM A;  3CNZ A;  4HNA K;  3L9H A;  4ZHI A;  1D0Z A;  1Q0B A;  1FMV A;  1BG2 A;  4BN2 A;  1MNE A;  1N6M A;  1GOJ A;  2OWM A;  3K5E A;  2X7D A;  4BBG A;  2IEH A;  3K3B A;  4Y05 A;  3L1C A;  4ETP A;  3KEN A;  3CJO A;  3DC4 A;  5LT3 A;  2ZFJ A;  4PJN A;  4PK4 A;  3T0Q A;  4FRZ A;  5LT1 A;  2FME A;  3ZFC A;  4GKR A;  3WRD A;  1BR4 A;  1F9U A;  1MMD A;  1FMW A;  4B7B A;  1CZ7 A;  2X2R A;  1MMA A;  3ZCW A;  3ZFD A;  3DCB A;  2GM1 A;  1D1B A;  1SDM A;  1VFV A;  2ZFM A;  1D0Y A;  3X2T A;  1V8K A;  4A1Z A;  1MKJ A;  4AS7 A;  1VFW A;  4A5Y A;  1G8X A;  2HEH A;  3B6U A;  2XAE A;  1VFX A;  2KIN A;  1D1C A;  1X88 A;  3BFN A;  2X7E A;  1YRS A;  1F9V A;  3PXN A;  4BXN A;  2FKY A;  1V8J A;  2Y5W A;  2Q2Z A;  3KIN A;  3H4S A;  3GBJ A;  2NCD A;  5HLE A;  1KK7 A;  2XT3 A;  4ZCA A;  4A14 A;  4H1G A;  4A51 A;  3U06 A;  2WOG A;  2ZFI A;  1F9W A;  3LRE A;  1T5C A;  2FL2 A;  2MYS A;  1F9T A;  3B6V A;  3NWN A;  2VVG A;  5GSZ A;  2X7C A;  1BR1 A;  2PG2 A;  1BR2 A;  2ZFK A;  2VAS A;  4ANJ A;  1I5S A;  1MMG A;  5LT2 A;  4PJJ A;  4PJM A;  1VFZ A;  4UBF A;  3COB A;  1I6I A;  2G1Q A;  2ZFL A;  2UYM A;  3HQD A;  1LVK A;  1D1A A;  4PFP A;  2FL6 A;  4PJL A;  5LT0 A;  1MMN A;  4DBR A;  1LKX A;  4A28 A;  4LNU K;  1RY6 A;  2Q2Y A;  5LT4 A;  2GRY A;  2V26 A;  1II6 A;  4A50 A;  2X51 A;  3KAR A;  4AP0 A;  2Y65 A;  4PFO A;  2UYI A; 
#chains in the Genus database with same CATH topology
 3WPN A;  4E7Z A;  4E7S A;  2VB6 A;  4DBQ A;  1D0X A;  1VOM A;  3CNZ A;  4HNA K;  3L9H A;  4ZHI A;  1D0Z A;  1Q0B A;  1FMV A;  1BG2 A;  4BN2 A;  1MNE A;  1N6M A;  1GOJ A;  2OWM A;  3K5E A;  2X7D A;  4BBG A;  2IEH A;  3K3B A;  4Y05 A;  3L1C A;  4ETP A;  3KEN A;  3CJO A;  3DC4 A;  5LT3 A;  2ZFJ A;  4PJN A;  4PK4 A;  3T0Q A;  4FRZ A;  5LT1 A;  2FME A;  3ZFC A;  4GKR A;  3WRD A;  1BR4 A;  1F9U A;  1MMD A;  1FMW A;  4B7B A;  1CZ7 A;  2X2R A;  1MMA A;  3ZCW A;  3ZFD A;  3DCB A;  2GM1 A;  1D1B A;  1SDM A;  1VFV A;  2ZFM A;  1D0Y A;  3X2T A;  1V8K A;  4A1Z A;  1MKJ A;  4AS7 A;  1VFW A;  4A5Y A;  4GKQ A;  1G8X A;  2HEH A;  3B6U A;  2XAE A;  1VFX A;  2KIN A;  1D1C A;  1X88 A;  3BFN A;  2X7E A;  1YRS A;  1F9V A;  3PXN A;  4BXN A;  2FKY A;  1V8J A;  2Y5W A;  2Q2Z A;  3KIN A;  4GKP A;  3H4S A;  3GBJ A;  2NCD A;  5HLE A;  4ETP B;  1KK7 A;  2XT3 A;  4ZCA A;  4A14 A;  4H1G A;  4A51 A;  3U06 A;  2WOG A;  2ZFI A;  1F9W A;  3LRE A;  1T5C A;  2FL2 A;  2MYS A;  1F9T A;  3B6V A;  3NWN A;  2VVG A;  5GSZ A;  2X7C A;  2O0A A;  1BR1 A;  2PG2 A;  1BR2 A;  2ZFK A;  2VAS A;  4ANJ A;  1I5S A;  1MMG A;  5LT2 A;  4PJJ A;  4PJM A;  1VFZ A;  4UBF A;  3COB A;  1I6I A;  2G1Q A;  2ZFL A;  2UYM A;  3HQD A;  1LVK A;  1D1A A;  4PFP A;  2FL6 A;  4PJL A;  5LT0 A;  1MMN A;  4DBR A;  1LKX A;  4A28 A;  4LNU K;  1RY6 A;  2Q2Y A;  5LT4 A;  2GRY A;  2V26 A;  1II6 A;  4A50 A;  2X51 A;  3KAR A;  4AP0 A;  2Y65 A;  4PFO A;  2UYI A; 
#chains in the Genus database with same CATH homology
 3WPN A;  4E7Z A;  4E7S A;  2VB6 A;  4DBQ A;  1D0X A;  1VOM A;  3CNZ A;  4HNA K;  3L9H A;  4ZHI A;  1D0Z A;  1Q0B A;  1FMV A;  1BG2 A;  4BN2 A;  1MNE A;  1N6M A;  1GOJ A;  2OWM A;  3K5E A;  2X7D A;  4BBG A;  2IEH A;  3K3B A;  4Y05 A;  3L1C A;  4ETP A;  3KEN A;  3CJO A;  3DC4 A;  5LT3 A;  2ZFJ A;  4PJN A;  4PK4 A;  3T0Q A;  4FRZ A;  5LT1 A;  2FME A;  3ZFC A;  4GKR A;  3WRD A;  1BR4 A;  1F9U A;  1MMD A;  1FMW A;  4B7B A;  1CZ7 A;  2X2R A;  1MMA A;  3ZCW A;  3ZFD A;  3DCB A;  2GM1 A;  1D1B A;  1SDM A;  1VFV A;  2ZFM A;  1D0Y A;  3X2T A;  1V8K A;  4A1Z A;  1MKJ A;  4AS7 A;  1VFW A;  4A5Y A;  1G8X A;  2HEH A;  3B6U A;  2XAE A;  1VFX A;  2KIN A;  1D1C A;  1X88 A;  3BFN A;  2X7E A;  1YRS A;  1F9V A;  3PXN A;  4BXN A;  2FKY A;  1V8J A;  2Y5W A;  2Q2Z A;  3KIN A;  3H4S A;  3GBJ A;  2NCD A;  5HLE A;  1KK7 A;  2XT3 A;  4ZCA A;  4A14 A;  4H1G A;  4A51 A;  3U06 A;  2WOG A;  2ZFI A;  1F9W A;  3LRE A;  1T5C A;  2FL2 A;  2MYS A;  1F9T A;  3B6V A;  3NWN A;  2VVG A;  5GSZ A;  2X7C A;  1BR1 A;  2PG2 A;  1BR2 A;  2ZFK A;  2VAS A;  4ANJ A;  1I5S A;  1MMG A;  5LT2 A;  4PJJ A;  4PJM A;  1VFZ A;  4UBF A;  3COB A;  1I6I A;  2G1Q A;  2ZFL A;  2UYM A;  3HQD A;  1LVK A;  1D1A A;  4PFP A;  2FL6 A;  4PJL A;  5LT0 A;  1MMN A;  4DBR A;  1LKX A;  4A28 A;  4LNU K;  1RY6 A;  2Q2Y A;  5LT4 A;  2GRY A;  2V26 A;  1II6 A;  4A50 A;  2X51 A;  3KAR A;  4AP0 A;  2Y65 A;  4PFO A;  2UYI A; 
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similar chains in the Genus database (?% sequence similarity)
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