2IEHA

Crystal structure of human kinesin eg5 in complex with (r)-mon97, a new monastrol-based inhibitor that binds as (r)-enantiomer
Total Genus 106
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
106
sequence length
350
structure length
334
Chain Sequence
KGKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of human Eg5 in complex with a new monastrol-based inhibitor bound in the R configuration.
pubmed doi rcsb
molecule keywords Kinesin-like protein KIF11
molecule tags Hydrolase
source organism Homo sapiens
total genus 106
structure length 334
sequence length 350
chains with identical sequence B
ec nomenclature ec 3.6.4.4: Transferred entry: 5.6.1.3.
pdb deposition date 2006-09-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 2iehA00
1FMWA 2UYMA 3KENA 1CZ7A 4DBRA 4ETPA 3L9HA 4PJNA 3COBA 3BFNA 3CJOA 1D1AA 1LVKA 1X88A 2ZFKA 1I6IA 4HNAK 5HLEA 3KARA 1D0YA 4ZCAA 3X2TA 4A50A 2FL2A 4BBGA 4ZHIA 1D0ZA 2Y5WA 2GRYA 3B6VA 4FRZA 1RY6A 3U06A 5LT0A 4GKRA 2X7EA 4A1ZA 2ZFMA 2X2RA 3K3BA 3B6UA 1D0XA 2HEHA 5GSZA 1D1CA 1KK7A 1F9UA 1VFVA 3ZCWA 1F9WA 3ZFCA 4BN2A 3WPNA 2XT3A 4B7BA 2VVGA 4PK4A 1LKXA 2Q2YA 1MNEA 2MYSA 2ZFLA 4PJJA 3CNZA 1T5CA 2GM1A 4UBFA 4H1GA 2G1QA 3DCBA 5LT4A 1BR1A 1D1BA 4A14A 4LNUK 4Y05A 2WOGA 4A28A 1I5SA 2X51A 1MMDA 2VB6A 4PFOA 2UYIA 4DBQA 4E7ZA 3K5EA 1BG2A 1SDMA 1II6A 2KINA 1F9VA 3T0QA 1V8KA 1YRSA 2Y65A 4PJMA 3NWNA 3LREA 1Q0BA 3HQDA 3DC4A 1G8XA 1MKJA 4AP0A 4AS7A 1BR2A 2V26A 2VASA 4E7SA 2X7DA 1MMAA 2ZFIA 4PFPA 5LT1A 4BXNA 3ZFDA 1N6MA 1VFWA 2ZFJA 2FL6A 1VOMA 2Q2ZA 2XAEA 1GOJA 2NCDA 1MMGA 5LT3A 1MMNA 4ANJA 1VFXA 2FMEA 2FKYA 4A5YA 2X7CA 3WRDA 3GBJA 2PG2A 1V8JA 1BR4A 3H4SA 3KINA 1F9TA 5LT2A 1VFZA 3L1CA 2OWMA 3PXNA 4PJLA 4A51A 2IEHA 1FMVA
chains in the Genus database with same CATH superfamily
1FMWA 2UYMA 3KENA 1CZ7A 4DBRA 4ETPA 3L9HA 4PJNA 3COBA 3BFNA 3CJOA 1D1AA 1LVKA 1X88A 4ETPB 2ZFKA 1I6IA 4HNAK 5HLEA 3KARA 1D0YA 4ZCAA 3X2TA 4A50A 2FL2A 4BBGA 4ZHIA 1D0ZA 2Y5WA 2GRYA 3B6VA 4FRZA 1RY6A 3U06A 5LT0A 4GKRA 2X7EA 4A1ZA 2ZFMA 2X2RA 3K3BA 3B6UA 1D0XA 2HEHA 5GSZA 1D1CA 1KK7A 1F9UA 1VFVA 3ZCWA 1F9WA 3ZFCA 4BN2A 3WPNA 2XT3A 4B7BA 2VVGA 4PK4A 4GKQA 1LKXA 2Q2YA 1MNEA 2MYSA 2ZFLA 4PJJA 3CNZA 1T5CA 2GM1A 4UBFA 4H1GA 2G1QA 3DCBA 5LT4A 1BR1A 1D1BA 4A14A 4LNUK 4Y05A 2O0AA 4GKPA 2WOGA 4A28A 1I5SA 2X51A 1MMDA 2VB6A 4PFOA 2UYIA 4DBQA 4E7ZA 3K5EA 1BG2A 1SDMA 1II6A 2KINA 1F9VA 3T0QA 1V8KA 1YRSA 2Y65A 4PJMA 3NWNA 3LREA 1Q0BA 3HQDA 3DC4A 1G8XA 1MKJA 4AP0A 4AS7A 1BR2A 2V26A 2VASA 4E7SA 2X7DA 1MMAA 2ZFIA 4PFPA 5LT1A 4BXNA 3ZFDA 1N6MA 1VFWA 2ZFJA 2FL6A 1VOMA 2Q2ZA 2XAEA 1GOJA 2NCDA 1MMGA 5LT3A 1MMNA 4ANJA 1VFXA 2FMEA 2FKYA 4A5YA 2X7CA 3WRDA 3GBJA 2PG2A 1V8JA 1BR4A 3H4SA 3KINA 1F9TA 5LT2A 1VFZA 3L1CA 2OWMA 3PXNA 4PJLA 4A51A 2IEHA 1FMVA
chains in the Genus database with same CATH topology
1FMWA 2UYMA 3KENA 1CZ7A 4DBRA 4ETPA 3L9HA 4PJNA 3COBA 3BFNA 3CJOA 1D1AA 1LVKA 1X88A 2ZFKA 1I6IA 4HNAK 5HLEA 3KARA 1D0YA 4ZCAA 3X2TA 4A50A 2FL2A 4BBGA 4ZHIA 1D0ZA 2Y5WA 2GRYA 3B6VA 4FRZA 1RY6A 3U06A 5LT0A 4GKRA 2X7EA 4A1ZA 2ZFMA 2X2RA 3K3BA 3B6UA 1D0XA 2HEHA 5GSZA 1D1CA 1KK7A 1F9UA 1VFVA 3ZCWA 1F9WA 3ZFCA 4BN2A 3WPNA 2XT3A 4B7BA 2VVGA 4PK4A 1LKXA 2Q2YA 1MNEA 2MYSA 2ZFLA 4PJJA 3CNZA 1T5CA 2GM1A 4UBFA 4H1GA 2G1QA 3DCBA 5LT4A 1BR1A 1D1BA 4A14A 4LNUK 4Y05A 2WOGA 4A28A 1I5SA 2X51A 1MMDA 2VB6A 4PFOA 2UYIA 4DBQA 4E7ZA 3K5EA 1BG2A 1SDMA 1II6A 2KINA 1F9VA 3T0QA 1V8KA 1YRSA 2Y65A 4PJMA 3NWNA 3LREA 1Q0BA 3HQDA 3DC4A 1G8XA 1MKJA 4AP0A 4AS7A 1BR2A 2V26A 2VASA 4E7SA 2X7DA 1MMAA 2ZFIA 4PFPA 5LT1A 4BXNA 3ZFDA 1N6MA 1VFWA 2ZFJA 2FL6A 1VOMA 2Q2ZA 2XAEA 1GOJA 2NCDA 1MMGA 5LT3A 1MMNA 4ANJA 1VFXA 2FMEA 2FKYA 4A5YA 2X7CA 3WRDA 3GBJA 2PG2A 1V8JA 1BR4A 3H4SA 3KINA 1F9TA 5LT2A 1VFZA 3L1CA 2OWMA 3PXNA 4PJLA 4A51A 2IEHA 1FMVA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1FMW A;  2UYM A;  3KEN A;  1CZ7 A;  4DBR A;  4ETP A;  3L9H A;  4PJN A;  3COB A;  3BFN A;  3CJO A;  1D1A A;  1LVK A;  1X88 A;  2ZFK A;  1I6I A;  4HNA K;  5HLE A;  3KAR A;  1D0Y A;  4ZCA A;  3X2T A;  4A50 A;  2FL2 A;  4BBG A;  4ZHI A;  1D0Z A;  2Y5W A;  2GRY A;  3B6V A;  4FRZ A;  1RY6 A;  3U06 A;  5LT0 A;  4GKR A;  2X7E A;  4A1Z A;  2ZFM A;  2X2R A;  3K3B A;  3B6U A;  1D0X A;  2HEH A;  5GSZ A;  1D1C A;  1KK7 A;  1F9U A;  1VFV A;  3ZCW A;  1F9W A;  3ZFC A;  4BN2 A;  3WPN A;  2XT3 A;  4B7B A;  2VVG A;  4PK4 A;  1LKX A;  2Q2Y A;  1MNE A;  2MYS A;  2ZFL A;  4PJJ A;  3CNZ A;  1T5C A;  2GM1 A;  4UBF A;  4H1G A;  2G1Q A;  3DCB A;  5LT4 A;  1BR1 A;  1D1B A;  4A14 A;  4LNU K;  4Y05 A;  2WOG A;  4A28 A;  1I5S A;  2X51 A;  1MMD A;  2VB6 A;  4PFO A;  2UYI A;  4DBQ A;  4E7Z A;  3K5E A;  1BG2 A;  1SDM A;  1II6 A;  2KIN A;  1F9V A;  3T0Q A;  1V8K A;  1YRS A;  2Y65 A;  4PJM A;  3NWN A;  3LRE A;  1Q0B A;  3HQD A;  3DC4 A;  1G8X A;  1MKJ A;  4AP0 A;  4AS7 A;  1BR2 A;  2V26 A;  2VAS A;  4E7S A;  2X7D A;  1MMA A;  2ZFI A;  4PFP A;  5LT1 A;  4BXN A;  3ZFD A;  1N6M A;  1VFW A;  2ZFJ A;  2FL6 A;  1VOM A;  2Q2Z A;  2XAE A;  1GOJ A;  2NCD A;  1MMG A;  5LT3 A;  1MMN A;  4ANJ A;  1VFX A;  2FME A;  2FKY A;  4A5Y A;  2X7C A;  3WRD A;  3GBJ A;  2PG2 A;  1V8J A;  1BR4 A;  3H4S A;  3KIN A;  1F9T A;  5LT2 A;  1VFZ A;  3L1C A;  2OWM A;  3PXN A;  4PJL A;  4A51 A;  2IEH A;  1FMV A; 
#chains in the Genus database with same CATH topology
 1FMW A;  2UYM A;  3KEN A;  1CZ7 A;  4DBR A;  4ETP A;  3L9H A;  4PJN A;  3COB A;  3BFN A;  3CJO A;  1D1A A;  1LVK A;  1X88 A;  4ETP B;  2ZFK A;  1I6I A;  4HNA K;  5HLE A;  3KAR A;  1D0Y A;  4ZCA A;  3X2T A;  4A50 A;  2FL2 A;  4BBG A;  4ZHI A;  1D0Z A;  2Y5W A;  2GRY A;  3B6V A;  4FRZ A;  1RY6 A;  3U06 A;  5LT0 A;  4GKR A;  2X7E A;  4A1Z A;  2ZFM A;  2X2R A;  3K3B A;  3B6U A;  1D0X A;  2HEH A;  5GSZ A;  1D1C A;  1KK7 A;  1F9U A;  1VFV A;  3ZCW A;  1F9W A;  3ZFC A;  4BN2 A;  3WPN A;  2XT3 A;  4B7B A;  2VVG A;  4PK4 A;  4GKQ A;  1LKX A;  2Q2Y A;  1MNE A;  2MYS A;  2ZFL A;  4PJJ A;  3CNZ A;  1T5C A;  2GM1 A;  4UBF A;  4H1G A;  2G1Q A;  3DCB A;  5LT4 A;  1BR1 A;  1D1B A;  4A14 A;  4LNU K;  4Y05 A;  2O0A A;  4GKP A;  2WOG A;  4A28 A;  1I5S A;  2X51 A;  1MMD A;  2VB6 A;  4PFO A;  2UYI A;  4DBQ A;  4E7Z A;  3K5E A;  1BG2 A;  1SDM A;  1II6 A;  2KIN A;  1F9V A;  3T0Q A;  1V8K A;  1YRS A;  2Y65 A;  4PJM A;  3NWN A;  3LRE A;  1Q0B A;  3HQD A;  3DC4 A;  1G8X A;  1MKJ A;  4AP0 A;  4AS7 A;  1BR2 A;  2V26 A;  2VAS A;  4E7S A;  2X7D A;  1MMA A;  2ZFI A;  4PFP A;  5LT1 A;  4BXN A;  3ZFD A;  1N6M A;  1VFW A;  2ZFJ A;  2FL6 A;  1VOM A;  2Q2Z A;  2XAE A;  1GOJ A;  2NCD A;  1MMG A;  5LT3 A;  1MMN A;  4ANJ A;  1VFX A;  2FME A;  2FKY A;  4A5Y A;  2X7C A;  3WRD A;  3GBJ A;  2PG2 A;  1V8J A;  1BR4 A;  3H4S A;  3KIN A;  1F9T A;  5LT2 A;  1VFZ A;  3L1C A;  2OWM A;  3PXN A;  4PJL A;  4A51 A;  2IEH A;  1FMV A; 
#chains in the Genus database with same CATH homology
 1FMW A;  2UYM A;  3KEN A;  1CZ7 A;  4DBR A;  4ETP A;  3L9H A;  4PJN A;  3COB A;  3BFN A;  3CJO A;  1D1A A;  1LVK A;  1X88 A;  2ZFK A;  1I6I A;  4HNA K;  5HLE A;  3KAR A;  1D0Y A;  4ZCA A;  3X2T A;  4A50 A;  2FL2 A;  4BBG A;  4ZHI A;  1D0Z A;  2Y5W A;  2GRY A;  3B6V A;  4FRZ A;  1RY6 A;  3U06 A;  5LT0 A;  4GKR A;  2X7E A;  4A1Z A;  2ZFM A;  2X2R A;  3K3B A;  3B6U A;  1D0X A;  2HEH A;  5GSZ A;  1D1C A;  1KK7 A;  1F9U A;  1VFV A;  3ZCW A;  1F9W A;  3ZFC A;  4BN2 A;  3WPN A;  2XT3 A;  4B7B A;  2VVG A;  4PK4 A;  1LKX A;  2Q2Y A;  1MNE A;  2MYS A;  2ZFL A;  4PJJ A;  3CNZ A;  1T5C A;  2GM1 A;  4UBF A;  4H1G A;  2G1Q A;  3DCB A;  5LT4 A;  1BR1 A;  1D1B A;  4A14 A;  4LNU K;  4Y05 A;  2WOG A;  4A28 A;  1I5S A;  2X51 A;  1MMD A;  2VB6 A;  4PFO A;  2UYI A;  4DBQ A;  4E7Z A;  3K5E A;  1BG2 A;  1SDM A;  1II6 A;  2KIN A;  1F9V A;  3T0Q A;  1V8K A;  1YRS A;  2Y65 A;  4PJM A;  3NWN A;  3LRE A;  1Q0B A;  3HQD A;  3DC4 A;  1G8X A;  1MKJ A;  4AP0 A;  4AS7 A;  1BR2 A;  2V26 A;  2VAS A;  4E7S A;  2X7D A;  1MMA A;  2ZFI A;  4PFP A;  5LT1 A;  4BXN A;  3ZFD A;  1N6M A;  1VFW A;  2ZFJ A;  2FL6 A;  1VOM A;  2Q2Z A;  2XAE A;  1GOJ A;  2NCD A;  1MMG A;  5LT3 A;  1MMN A;  4ANJ A;  1VFX A;  2FME A;  2FKY A;  4A5Y A;  2X7C A;  3WRD A;  3GBJ A;  2PG2 A;  1V8J A;  1BR4 A;  3H4S A;  3KIN A;  1F9T A;  5LT2 A;  1VFZ A;  3L1C A;  2OWM A;  3PXN A;  4PJL A;  4A51 A;  2IEH A;  1FMV A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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