2UYMA

Crystal structure of ksp in complex with adp and thiophene containing inhibitor 37
Total Genus 102

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
102
sequence length
347
structure length
331
Chain Sequence
GKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
EMPTYS15 (329-336)TIV2 (58-61)S2 (20-25)TVIII1 (306-309)AH1 (30-35)S4 (49-53)3H1 (45-47)AH8 (315-320)TIV10 (323-326)TIV1 (57-60)S5 (63-67)S7 (98-104)TI1 (73-76)AH2 (78-95)S13 (236-246)TI6 (310-313)O1 (255-257)TIV9 (249-252)AH3 (111-116)S11 (194-197)TI5 (190-193)TII2 (120-123)TIV4 (121-124)3H2 (127-129)TI2 (130-133)AH4 (135-149)AH6 (231-234)TIV8 (228-231)S10 (181-186)S8 (153-164)S9 (167-170)TIV5 (163-166)TI3 (177-180)TIV6 (170-173)TIV7 (173-176)TI4 (187-190)3H3 (207-209)AH5 (210-227)S14 (257-265)TI7 (311-314)S1 (17-18)TIV3 (68-71)S6 (70-72)TII3 (196-199)S12 (202-204)AH7 (290-304)3H4 (321-323)Updating...
connected with : NaN
publication title Synthesis and Sar of Thiophene Containing Kinesin Spindle Protein (Ksp) Inhibitors.
pubmed doi rcsb
molecule tags Cell cycle
source organism Homo sapiens
molecule keywords KINESIN-LIKE PROTEIN KIF11
total genus 102
structure length 331
sequence length 347
chains with identical sequence B
ec nomenclature
pdb deposition date 2007-04-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 2uymA00
2HEHA 1LVKA 2X7CA 3L9HA 4A5YA 1T5CA 1Q0BA 4UBFA 1BG2A 4BBGA 1LKXA 4ZCAA 2KINA 1BR1A 2VB6A 4HNAK 2FMEA 2X7DA 2FL2A 2GM1A 2ZFJA 4PJMA 2XT3A 4PK4A 1FMVA 1II6A 1VFVA 1BR4A 1GOJA 4A51A 2VVGA 5LT3A 4FRZA 1D0XA 2XAEA 3PXNA 2ZFLA 1YRSA 3WRDA 4A50A 1KK7A 1MMNA 3KINA 4E7SA 2WOGA 3CJOA 1F9WA 2IEHA 2FL6A 3U06A 1VFWA 2UYIA 3LREA 3ZCWA 3WPNA 2ZFIA 4DBRA 4ZHIA 1VFZA 3B6VA 4PJLA 4ETPA 4AS7A 4ANJA 2X7EA 2OWMA 3H4SA 1D1AA 2Q2YA 1SDMA 5HLEA 5LT1A 3K5EA 3T0QA 1N6MA 3K3BA 3B6UA 3KENA 4GKRA 5GSZA 4BXNA 2ZFMA 1V8JA 2ZFKA 1VFXA 1F9VA 2Q2ZA 3BFNA 2PG2A 4PJJA 1MMGA 3CNZA 3X2TA 1I5SA 4PJNA 1V8KA 2NCDA 2Y65A 1MKJA 3ZFCA 1F9UA 1X88A 4LNUK 4A14A 3DC4A 2MYSA 4DBQA 3COBA 1G8XA 3ZFDA 2Y5WA 2V26A 3GBJA 4AP0A 1MMAA 4BN2A 1FMWA 2FKYA 4H1GA 4PFOA 1D1CA 2GRYA 3KARA 4B7BA 4Y05A 1D0ZA 4PFPA 3L1CA 1BR2A 3NWNA 2UYMA 4E7ZA 1CZ7A 1D1BA 3DCBA 1D0YA 4A28A 2X51A 4A1ZA 5LT4A 5LT2A 1MNEA 1VOMA 2VASA 5LT0A 1RY6A 1MMDA 2X2RA 1F9TA 1I6IA 3HQDA 2G1QA
chains in the Genus database with same CATH superfamily
2HEHA 1LVKA 2X7CA 3L9HA 4A5YA 1T5CA 1Q0BA 4UBFA 1BG2A 4BBGA 1LKXA 4ZCAA 2KINA 1BR1A 2VB6A 4HNAK 2FMEA 2X7DA 2FL2A 2GM1A 2ZFJA 4PJMA 2XT3A 4GKQA 4PK4A 1FMVA 1II6A 1VFVA 1BR4A 1GOJA 4A51A 2VVGA 5LT3A 4FRZA 1D0XA 2XAEA 3PXNA 2ZFLA 1YRSA 3WRDA 4A50A 1KK7A 1MMNA 2O0AA 3KINA 4E7SA 2WOGA 3CJOA 1F9WA 2IEHA 2FL6A 3U06A 1VFWA 2UYIA 3LREA 3ZCWA 3WPNA 2ZFIA 4DBRA 4ZHIA 1VFZA 3B6VA 4PJLA 4ETPA 4AS7A 4ANJA 2X7EA 2OWMA 3H4SA 1D1AA 2Q2YA 1SDMA 5HLEA 5LT1A 3K5EA 3T0QA 4GKPA 1N6MA 3K3BA 3B6UA 3KENA 4GKRA 5GSZA 4BXNA 2ZFMA 1V8JA 2ZFKA 1VFXA 1F9VA 2Q2ZA 3BFNA 2PG2A 4PJJA 1MMGA 3CNZA 3X2TA 1I5SA 4PJNA 1V8KA 2NCDA 2Y65A 1MKJA 3ZFCA 1F9UA 1X88A 4LNUK 4A14A 3DC4A 2MYSA 4DBQA 3COBA 1G8XA 3ZFDA 2Y5WA 2V26A 3GBJA 4AP0A 1MMAA 4BN2A 1FMWA 2FKYA 4H1GA 4PFOA 1D1CA 2GRYA 3KARA 4B7BA 4Y05A 1D0ZA 4PFPA 3L1CA 1BR2A 3NWNA 2UYMA 4E7ZA 1CZ7A 1D1BA 3DCBA 1D0YA 4A28A 2X51A 4A1ZA 5LT4A 5LT2A 1MNEA 1VOMA 2VASA 5LT0A 1RY6A 1MMDA 2X2RA 4ETPB 1F9TA 1I6IA 3HQDA 2G1QA
chains in the Genus database with same CATH topology
2HEHA 1LVKA 2X7CA 3L9HA 4A5YA 1T5CA 1Q0BA 4UBFA 1BG2A 4BBGA 1LKXA 4ZCAA 2KINA 1BR1A 2VB6A 4HNAK 2FMEA 2X7DA 2FL2A 2GM1A 2ZFJA 4PJMA 2XT3A 4PK4A 1FMVA 1II6A 1VFVA 1BR4A 1GOJA 4A51A 2VVGA 5LT3A 4FRZA 1D0XA 2XAEA 3PXNA 2ZFLA 1YRSA 3WRDA 4A50A 1KK7A 1MMNA 3KINA 4E7SA 2WOGA 3CJOA 1F9WA 2IEHA 2FL6A 3U06A 1VFWA 2UYIA 3LREA 3ZCWA 3WPNA 2ZFIA 4DBRA 4ZHIA 1VFZA 3B6VA 4PJLA 4ETPA 4AS7A 4ANJA 2X7EA 2OWMA 3H4SA 1D1AA 2Q2YA 1SDMA 5HLEA 5LT1A 3K5EA 3T0QA 1N6MA 3K3BA 3B6UA 3KENA 4GKRA 5GSZA 4BXNA 2ZFMA 1V8JA 2ZFKA 1VFXA 1F9VA 2Q2ZA 3BFNA 2PG2A 4PJJA 1MMGA 3CNZA 3X2TA 1I5SA 4PJNA 1V8KA 2NCDA 2Y65A 1MKJA 3ZFCA 1F9UA 1X88A 4LNUK 4A14A 3DC4A 2MYSA 4DBQA 3COBA 1G8XA 3ZFDA 2Y5WA 2V26A 3GBJA 4AP0A 1MMAA 4BN2A 1FMWA 2FKYA 4H1GA 4PFOA 1D1CA 2GRYA 3KARA 4B7BA 4Y05A 1D0ZA 4PFPA 3L1CA 1BR2A 3NWNA 2UYMA 4E7ZA 1CZ7A 1D1BA 3DCBA 1D0YA 4A28A 2X51A 4A1ZA 5LT4A 5LT2A 1MNEA 1VOMA 2VASA 5LT0A 1RY6A 1MMDA 2X2RA 1F9TA 1I6IA 3HQDA 2G1QA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2HEH A;  1LVK A;  2X7C A;  3L9H A;  4A5Y A;  1T5C A;  1Q0B A;  4UBF A;  1BG2 A;  4BBG A;  1LKX A;  4ZCA A;  2KIN A;  1BR1 A;  2VB6 A;  4HNA K;  2FME A;  2X7D A;  2FL2 A;  2GM1 A;  2ZFJ A;  4PJM A;  2XT3 A;  4PK4 A;  1FMV A;  1II6 A;  1VFV A;  1BR4 A;  1GOJ A;  4A51 A;  2VVG A;  5LT3 A;  4FRZ A;  1D0X A;  2XAE A;  3PXN A;  2ZFL A;  1YRS A;  3WRD A;  4A50 A;  1KK7 A;  1MMN A;  3KIN A;  4E7S A;  2WOG A;  3CJO A;  1F9W A;  2IEH A;  2FL6 A;  3U06 A;  1VFW A;  2UYI A;  3LRE A;  3ZCW A;  3WPN A;  2ZFI A;  4DBR A;  4ZHI A;  1VFZ A;  3B6V A;  4PJL A;  4ETP A;  4AS7 A;  4ANJ A;  2X7E A;  2OWM A;  3H4S A;  1D1A A;  2Q2Y A;  1SDM A;  5HLE A;  5LT1 A;  3K5E A;  3T0Q A;  1N6M A;  3K3B A;  3B6U A;  3KEN A;  4GKR A;  5GSZ A;  4BXN A;  2ZFM A;  1V8J A;  2ZFK A;  1VFX A;  1F9V A;  2Q2Z A;  3BFN A;  2PG2 A;  4PJJ A;  1MMG A;  3CNZ A;  3X2T A;  1I5S A;  4PJN A;  1V8K A;  2NCD A;  2Y65 A;  1MKJ A;  3ZFC A;  1F9U A;  1X88 A;  4LNU K;  4A14 A;  3DC4 A;  2MYS A;  4DBQ A;  3COB A;  1G8X A;  3ZFD A;  2Y5W A;  2V26 A;  3GBJ A;  4AP0 A;  1MMA A;  4BN2 A;  1FMW A;  2FKY A;  4H1G A;  4PFO A;  1D1C A;  2GRY A;  3KAR A;  4B7B A;  4Y05 A;  1D0Z A;  4PFP A;  3L1C A;  1BR2 A;  3NWN A;  2UYM A;  4E7Z A;  1CZ7 A;  1D1B A;  3DCB A;  1D0Y A;  4A28 A;  2X51 A;  4A1Z A;  5LT4 A;  5LT2 A;  1MNE A;  1VOM A;  2VAS A;  5LT0 A;  1RY6 A;  1MMD A;  2X2R A;  1F9T A;  1I6I A;  3HQD A;  2G1Q A; 
#chains in the Genus database with same CATH topology
 2HEH A;  1LVK A;  2X7C A;  3L9H A;  4A5Y A;  1T5C A;  1Q0B A;  4UBF A;  1BG2 A;  4BBG A;  1LKX A;  4ZCA A;  2KIN A;  1BR1 A;  2VB6 A;  4HNA K;  2FME A;  2X7D A;  2FL2 A;  2GM1 A;  2ZFJ A;  4PJM A;  2XT3 A;  4GKQ A;  4PK4 A;  1FMV A;  1II6 A;  1VFV A;  1BR4 A;  1GOJ A;  4A51 A;  2VVG A;  5LT3 A;  4FRZ A;  1D0X A;  2XAE A;  3PXN A;  2ZFL A;  1YRS A;  3WRD A;  4A50 A;  1KK7 A;  1MMN A;  2O0A A;  3KIN A;  4E7S A;  2WOG A;  3CJO A;  1F9W A;  2IEH A;  2FL6 A;  3U06 A;  1VFW A;  2UYI A;  3LRE A;  3ZCW A;  3WPN A;  2ZFI A;  4DBR A;  4ZHI A;  1VFZ A;  3B6V A;  4PJL A;  4ETP A;  4AS7 A;  4ANJ A;  2X7E A;  2OWM A;  3H4S A;  1D1A A;  2Q2Y A;  1SDM A;  5HLE A;  5LT1 A;  3K5E A;  3T0Q A;  4GKP A;  1N6M A;  3K3B A;  3B6U A;  3KEN A;  4GKR A;  5GSZ A;  4BXN A;  2ZFM A;  1V8J A;  2ZFK A;  1VFX A;  1F9V A;  2Q2Z A;  3BFN A;  2PG2 A;  4PJJ A;  1MMG A;  3CNZ A;  3X2T A;  1I5S A;  4PJN A;  1V8K A;  2NCD A;  2Y65 A;  1MKJ A;  3ZFC A;  1F9U A;  1X88 A;  4LNU K;  4A14 A;  3DC4 A;  2MYS A;  4DBQ A;  3COB A;  1G8X A;  3ZFD A;  2Y5W A;  2V26 A;  3GBJ A;  4AP0 A;  1MMA A;  4BN2 A;  1FMW A;  2FKY A;  4H1G A;  4PFO A;  1D1C A;  2GRY A;  3KAR A;  4B7B A;  4Y05 A;  1D0Z A;  4PFP A;  3L1C A;  1BR2 A;  3NWN A;  2UYM A;  4E7Z A;  1CZ7 A;  1D1B A;  3DCB A;  1D0Y A;  4A28 A;  2X51 A;  4A1Z A;  5LT4 A;  5LT2 A;  1MNE A;  1VOM A;  2VAS A;  5LT0 A;  1RY6 A;  1MMD A;  2X2R A;  4ETP B;  1F9T A;  1I6I A;  3HQD A;  2G1Q A; 
#chains in the Genus database with same CATH homology
 2HEH A;  1LVK A;  2X7C A;  3L9H A;  4A5Y A;  1T5C A;  1Q0B A;  4UBF A;  1BG2 A;  4BBG A;  1LKX A;  4ZCA A;  2KIN A;  1BR1 A;  2VB6 A;  4HNA K;  2FME A;  2X7D A;  2FL2 A;  2GM1 A;  2ZFJ A;  4PJM A;  2XT3 A;  4PK4 A;  1FMV A;  1II6 A;  1VFV A;  1BR4 A;  1GOJ A;  4A51 A;  2VVG A;  5LT3 A;  4FRZ A;  1D0X A;  2XAE A;  3PXN A;  2ZFL A;  1YRS A;  3WRD A;  4A50 A;  1KK7 A;  1MMN A;  3KIN A;  4E7S A;  2WOG A;  3CJO A;  1F9W A;  2IEH A;  2FL6 A;  3U06 A;  1VFW A;  2UYI A;  3LRE A;  3ZCW A;  3WPN A;  2ZFI A;  4DBR A;  4ZHI A;  1VFZ A;  3B6V A;  4PJL A;  4ETP A;  4AS7 A;  4ANJ A;  2X7E A;  2OWM A;  3H4S A;  1D1A A;  2Q2Y A;  1SDM A;  5HLE A;  5LT1 A;  3K5E A;  3T0Q A;  1N6M A;  3K3B A;  3B6U A;  3KEN A;  4GKR A;  5GSZ A;  4BXN A;  2ZFM A;  1V8J A;  2ZFK A;  1VFX A;  1F9V A;  2Q2Z A;  3BFN A;  2PG2 A;  4PJJ A;  1MMG A;  3CNZ A;  3X2T A;  1I5S A;  4PJN A;  1V8K A;  2NCD A;  2Y65 A;  1MKJ A;  3ZFC A;  1F9U A;  1X88 A;  4LNU K;  4A14 A;  3DC4 A;  2MYS A;  4DBQ A;  3COB A;  1G8X A;  3ZFD A;  2Y5W A;  2V26 A;  3GBJ A;  4AP0 A;  1MMA A;  4BN2 A;  1FMW A;  2FKY A;  4H1G A;  4PFO A;  1D1C A;  2GRY A;  3KAR A;  4B7B A;  4Y05 A;  1D0Z A;  4PFP A;  3L1C A;  1BR2 A;  3NWN A;  2UYM A;  4E7Z A;  1CZ7 A;  1D1B A;  3DCB A;  1D0Y A;  4A28 A;  2X51 A;  4A1Z A;  5LT4 A;  5LT2 A;  1MNE A;  1VOM A;  2VAS A;  5LT0 A;  1RY6 A;  1MMD A;  2X2R A;  1F9T A;  1I6I A;  3HQD A;  2G1Q A; 
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