2X2RA

Crystal structure of human kinesin eg5 in complex with (r)-2-amino-3-((4-chlorophenyl)diphenylmethylthio)propanoic acid
Total Genus 111
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
111
sequence length
349
structure length
331
Chain Sequence
KNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPEV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure-Activity Relationship and Multidrug Resistance Study of New S-Trityl-L-Cysteine Derivatives as Inhibitors of Eg5.
pubmed doi rcsb
molecule keywords KINESIN-LIKE PROTEIN KIF11
molecule tags Cell cycle
source organism Homo sapiens
total genus 111
structure length 331
sequence length 349
chains with identical sequence B, C
ec nomenclature
pdb deposition date 2010-01-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 2x2rA00
1KK7A 1BR4A 2FL2A 5LT3A 1I6IA 4PJNA 1MMAA 1RY6A 1X88A 3CNZA 3LREA 4PFOA 1F9TA 2WOGA 3KENA 4E7ZA 2GM1A 3KINA 1BR2A 5GSZA 2ZFLA 4PJJA 3ZCWA 4LNUK 2Q2ZA 3GBJA 2Y65A 2VB6A 4A1ZA 2ZFMA 4BBGA 4A51A 5LT4A 1II6A 2XAEA 3HQDA 1LVKA 1VFXA 1MKJA 2HEHA 3WRDA 1VOMA 1FMVA 2X7EA 1D0YA 1I5SA 2Q2YA 2KINA 2FMEA 4ETPA 1MMGA 1BG2A 1F9UA 1VFVA 2X7DA 1VFZA 1FMWA 1V8KA 4PJMA 3L9HA 3BFNA 3H4SA 2ZFJA 4FRZA 2UYIA 3NWNA 4AS7A 2VVGA 2OWMA 5LT0A 4A50A 1BR1A 1MNEA 2X7CA 4PJLA 2X51A 4ZCAA 1D1AA 2PG2A 3X2TA 1D1CA 2ZFKA 2Y5WA 1Q0BA 4PFPA 1T5CA 2FL6A 4ANJA 1D0ZA 2G1QA 4DBRA 3DC4A 3WPNA 3U06A 1F9VA 1VFWA 3KARA 4UBFA 2MYSA 5LT2A 2ZFIA 2VASA 3COBA 2V26A 4H1GA 1F9WA 1V8JA 5LT1A 2X2RA 4GKRA 2GRYA 3B6VA 1D1BA 3ZFDA 4E7SA 4AP0A 3ZFCA 1GOJA 3CJOA 4A5YA 1G8XA 4BXNA 3L1CA 1MMDA 4DBQA 4HNAK 2UYMA 1CZ7A 4A28A 3PXNA 1SDMA 1YRSA 3B6UA 4Y05A 4B7BA 4PK4A 3DCBA 3K3BA 3T0QA 1D0XA 2IEHA 2XT3A 1MMNA 2NCDA 3K5EA 4A14A 1LKXA 1N6MA 5HLEA 4BN2A 4ZHIA 2FKYA
chains in the Genus database with same CATH superfamily
1KK7A 1BR4A 2FL2A 5LT3A 1I6IA 4PJNA 1MMAA 1RY6A 1X88A 3CNZA 3LREA 4PFOA 1F9TA 2WOGA 3KENA 4E7ZA 2GM1A 3KINA 1BR2A 5GSZA 2ZFLA 4PJJA 3ZCWA 4LNUK 2Q2ZA 3GBJA 2Y65A 2VB6A 4A1ZA 2ZFMA 4BBGA 4A51A 5LT4A 1II6A 2XAEA 3HQDA 1LVKA 1VFXA 1MKJA 2HEHA 3WRDA 1VOMA 1FMVA 2X7EA 1D0YA 1I5SA 2Q2YA 2KINA 2FMEA 4ETPA 1MMGA 4GKPA 1BG2A 1F9UA 1VFVA 2X7DA 1VFZA 1FMWA 1V8KA 4PJMA 3L9HA 3BFNA 3H4SA 2ZFJA 4FRZA 2UYIA 3NWNA 4AS7A 2VVGA 2OWMA 5LT0A 4A50A 1BR1A 1MNEA 2X7CA 4PJLA 2X51A 4ZCAA 1D1AA 2PG2A 3X2TA 1D1CA 2ZFKA 2Y5WA 1Q0BA 4PFPA 1T5CA 2FL6A 4ANJA 1D0ZA 4ETPB 2G1QA 4DBRA 3DC4A 3WPNA 3U06A 1F9VA 1VFWA 3KARA 4UBFA 2MYSA 5LT2A 2ZFIA 2VASA 3COBA 2V26A 4H1GA 1F9WA 1V8JA 5LT1A 2X2RA 4GKRA 2GRYA 3B6VA 1D1BA 3ZFDA 4E7SA 4AP0A 3ZFCA 1GOJA 3CJOA 4A5YA 1G8XA 4BXNA 3L1CA 1MMDA 4DBQA 4HNAK 2UYMA 1CZ7A 4A28A 3PXNA 1SDMA 1YRSA 4GKQA 3B6UA 4Y05A 4B7BA 4PK4A 3DCBA 3K3BA 3T0QA 1D0XA 2IEHA 2XT3A 1MMNA 2NCDA 3K5EA 4A14A 1LKXA 1N6MA 5HLEA 4BN2A 4ZHIA 2O0AA 2FKYA
chains in the Genus database with same CATH topology
1KK7A 1BR4A 2FL2A 5LT3A 1I6IA 4PJNA 1MMAA 1RY6A 1X88A 3CNZA 3LREA 4PFOA 1F9TA 2WOGA 3KENA 4E7ZA 2GM1A 3KINA 1BR2A 5GSZA 2ZFLA 4PJJA 3ZCWA 4LNUK 2Q2ZA 3GBJA 2Y65A 2VB6A 4A1ZA 2ZFMA 4BBGA 4A51A 5LT4A 1II6A 2XAEA 3HQDA 1LVKA 1VFXA 1MKJA 2HEHA 3WRDA 1VOMA 1FMVA 2X7EA 1D0YA 1I5SA 2Q2YA 2KINA 2FMEA 4ETPA 1MMGA 1BG2A 1F9UA 1VFVA 2X7DA 1VFZA 1FMWA 1V8KA 4PJMA 3L9HA 3BFNA 3H4SA 2ZFJA 4FRZA 2UYIA 3NWNA 4AS7A 2VVGA 2OWMA 5LT0A 4A50A 1BR1A 1MNEA 2X7CA 4PJLA 2X51A 4ZCAA 1D1AA 2PG2A 3X2TA 1D1CA 2ZFKA 2Y5WA 1Q0BA 4PFPA 1T5CA 2FL6A 4ANJA 1D0ZA 2G1QA 4DBRA 3DC4A 3WPNA 3U06A 1F9VA 1VFWA 3KARA 4UBFA 2MYSA 5LT2A 2ZFIA 2VASA 3COBA 2V26A 4H1GA 1F9WA 1V8JA 5LT1A 2X2RA 4GKRA 2GRYA 3B6VA 1D1BA 3ZFDA 4E7SA 4AP0A 3ZFCA 1GOJA 3CJOA 4A5YA 1G8XA 4BXNA 3L1CA 1MMDA 4DBQA 4HNAK 2UYMA 1CZ7A 4A28A 3PXNA 1SDMA 1YRSA 3B6UA 4Y05A 4B7BA 4PK4A 3DCBA 3K3BA 3T0QA 1D0XA 2IEHA 2XT3A 1MMNA 2NCDA 3K5EA 4A14A 1LKXA 1N6MA 5HLEA 4BN2A 4ZHIA 2FKYA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1KK7 A;  1BR4 A;  2FL2 A;  5LT3 A;  1I6I A;  4PJN A;  1MMA A;  1RY6 A;  1X88 A;  3CNZ A;  3LRE A;  4PFO A;  1F9T A;  2WOG A;  3KEN A;  4E7Z A;  2GM1 A;  3KIN A;  1BR2 A;  5GSZ A;  2ZFL A;  4PJJ A;  3ZCW A;  4LNU K;  2Q2Z A;  3GBJ A;  2Y65 A;  2VB6 A;  4A1Z A;  2ZFM A;  4BBG A;  4A51 A;  5LT4 A;  1II6 A;  2XAE A;  3HQD A;  1LVK A;  1VFX A;  1MKJ A;  2HEH A;  3WRD A;  1VOM A;  1FMV A;  2X7E A;  1D0Y A;  1I5S A;  2Q2Y A;  2KIN A;  2FME A;  4ETP A;  1MMG A;  1BG2 A;  1F9U A;  1VFV A;  2X7D A;  1VFZ A;  1FMW A;  1V8K A;  4PJM A;  3L9H A;  3BFN A;  3H4S A;  2ZFJ A;  4FRZ A;  2UYI A;  3NWN A;  4AS7 A;  2VVG A;  2OWM A;  5LT0 A;  4A50 A;  1BR1 A;  1MNE A;  2X7C A;  4PJL A;  2X51 A;  4ZCA A;  1D1A A;  2PG2 A;  3X2T A;  1D1C A;  2ZFK A;  2Y5W A;  1Q0B A;  4PFP A;  1T5C A;  2FL6 A;  4ANJ A;  1D0Z A;  2G1Q A;  4DBR A;  3DC4 A;  3WPN A;  3U06 A;  1F9V A;  1VFW A;  3KAR A;  4UBF A;  2MYS A;  5LT2 A;  2ZFI A;  2VAS A;  3COB A;  2V26 A;  4H1G A;  1F9W A;  1V8J A;  5LT1 A;  2X2R A;  4GKR A;  2GRY A;  3B6V A;  1D1B A;  3ZFD A;  4E7S A;  4AP0 A;  3ZFC A;  1GOJ A;  3CJO A;  4A5Y A;  1G8X A;  4BXN A;  3L1C A;  1MMD A;  4DBQ A;  4HNA K;  2UYM A;  1CZ7 A;  4A28 A;  3PXN A;  1SDM A;  1YRS A;  3B6U A;  4Y05 A;  4B7B A;  4PK4 A;  3DCB A;  3K3B A;  3T0Q A;  1D0X A;  2IEH A;  2XT3 A;  1MMN A;  2NCD A;  3K5E A;  4A14 A;  1LKX A;  1N6M A;  5HLE A;  4BN2 A;  4ZHI A;  2FKY A; 
#chains in the Genus database with same CATH topology
 1KK7 A;  1BR4 A;  2FL2 A;  5LT3 A;  1I6I A;  4PJN A;  1MMA A;  1RY6 A;  1X88 A;  3CNZ A;  3LRE A;  4PFO A;  1F9T A;  2WOG A;  3KEN A;  4E7Z A;  2GM1 A;  3KIN A;  1BR2 A;  5GSZ A;  2ZFL A;  4PJJ A;  3ZCW A;  4LNU K;  2Q2Z A;  3GBJ A;  2Y65 A;  2VB6 A;  4A1Z A;  2ZFM A;  4BBG A;  4A51 A;  5LT4 A;  1II6 A;  2XAE A;  3HQD A;  1LVK A;  1VFX A;  1MKJ A;  2HEH A;  3WRD A;  1VOM A;  1FMV A;  2X7E A;  1D0Y A;  1I5S A;  2Q2Y A;  2KIN A;  2FME A;  4ETP A;  1MMG A;  4GKP A;  1BG2 A;  1F9U A;  1VFV A;  2X7D A;  1VFZ A;  1FMW A;  1V8K A;  4PJM A;  3L9H A;  3BFN A;  3H4S A;  2ZFJ A;  4FRZ A;  2UYI A;  3NWN A;  4AS7 A;  2VVG A;  2OWM A;  5LT0 A;  4A50 A;  1BR1 A;  1MNE A;  2X7C A;  4PJL A;  2X51 A;  4ZCA A;  1D1A A;  2PG2 A;  3X2T A;  1D1C A;  2ZFK A;  2Y5W A;  1Q0B A;  4PFP A;  1T5C A;  2FL6 A;  4ANJ A;  1D0Z A;  4ETP B;  2G1Q A;  4DBR A;  3DC4 A;  3WPN A;  3U06 A;  1F9V A;  1VFW A;  3KAR A;  4UBF A;  2MYS A;  5LT2 A;  2ZFI A;  2VAS A;  3COB A;  2V26 A;  4H1G A;  1F9W A;  1V8J A;  5LT1 A;  2X2R A;  4GKR A;  2GRY A;  3B6V A;  1D1B A;  3ZFD A;  4E7S A;  4AP0 A;  3ZFC A;  1GOJ A;  3CJO A;  4A5Y A;  1G8X A;  4BXN A;  3L1C A;  1MMD A;  4DBQ A;  4HNA K;  2UYM A;  1CZ7 A;  4A28 A;  3PXN A;  1SDM A;  1YRS A;  4GKQ A;  3B6U A;  4Y05 A;  4B7B A;  4PK4 A;  3DCB A;  3K3B A;  3T0Q A;  1D0X A;  2IEH A;  2XT3 A;  1MMN A;  2NCD A;  3K5E A;  4A14 A;  1LKX A;  1N6M A;  5HLE A;  4BN2 A;  4ZHI A;  2O0A A;  2FKY A; 
#chains in the Genus database with same CATH homology
 1KK7 A;  1BR4 A;  2FL2 A;  5LT3 A;  1I6I A;  4PJN A;  1MMA A;  1RY6 A;  1X88 A;  3CNZ A;  3LRE A;  4PFO A;  1F9T A;  2WOG A;  3KEN A;  4E7Z A;  2GM1 A;  3KIN A;  1BR2 A;  5GSZ A;  2ZFL A;  4PJJ A;  3ZCW A;  4LNU K;  2Q2Z A;  3GBJ A;  2Y65 A;  2VB6 A;  4A1Z A;  2ZFM A;  4BBG A;  4A51 A;  5LT4 A;  1II6 A;  2XAE A;  3HQD A;  1LVK A;  1VFX A;  1MKJ A;  2HEH A;  3WRD A;  1VOM A;  1FMV A;  2X7E A;  1D0Y A;  1I5S A;  2Q2Y A;  2KIN A;  2FME A;  4ETP A;  1MMG A;  1BG2 A;  1F9U A;  1VFV A;  2X7D A;  1VFZ A;  1FMW A;  1V8K A;  4PJM A;  3L9H A;  3BFN A;  3H4S A;  2ZFJ A;  4FRZ A;  2UYI A;  3NWN A;  4AS7 A;  2VVG A;  2OWM A;  5LT0 A;  4A50 A;  1BR1 A;  1MNE A;  2X7C A;  4PJL A;  2X51 A;  4ZCA A;  1D1A A;  2PG2 A;  3X2T A;  1D1C A;  2ZFK A;  2Y5W A;  1Q0B A;  4PFP A;  1T5C A;  2FL6 A;  4ANJ A;  1D0Z A;  2G1Q A;  4DBR A;  3DC4 A;  3WPN A;  3U06 A;  1F9V A;  1VFW A;  3KAR A;  4UBF A;  2MYS A;  5LT2 A;  2ZFI A;  2VAS A;  3COB A;  2V26 A;  4H1G A;  1F9W A;  1V8J A;  5LT1 A;  2X2R A;  4GKR A;  2GRY A;  3B6V A;  1D1B A;  3ZFD A;  4E7S A;  4AP0 A;  3ZFC A;  1GOJ A;  3CJO A;  4A5Y A;  1G8X A;  4BXN A;  3L1C A;  1MMD A;  4DBQ A;  4HNA K;  2UYM A;  1CZ7 A;  4A28 A;  3PXN A;  1SDM A;  1YRS A;  3B6U A;  4Y05 A;  4B7B A;  4PK4 A;  3DCB A;  3K3B A;  3T0Q A;  1D0X A;  2IEH A;  2XT3 A;  1MMN A;  2NCD A;  3K5E A;  4A14 A;  1LKX A;  1N6M A;  5HLE A;  4BN2 A;  4ZHI A;  2FKY A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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