2X7CA

Crystal structure of human kinesin eg5 in complex with (s)-enastron
Total Genus 104
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
104
sequence length
347
structure length
332
Chain Sequence
NIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Cell cycle
source organism Homo sapiens
publication title Structural Basis for Inhibition of Eg5 by Dihydropyrimidines: Stereoselectivity of Antimitotic Inhibitors Enastron, Dimethylenastron and Fluorastrol.
pubmed doi rcsb
molecule keywords KINESIN-LIKE PROTEIN KIF11
total genus 104
structure length 332
sequence length 347
chains with identical sequence B
ec nomenclature
pdb deposition date 2010-02-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 2x7cA00
1MMAA 3HQDA 1D0YA 1V8JA 4H1GA 3PXNA 3BFNA 2X2RA 2ZFKA 4ZCAA 3ZFCA 1YRSA 3B6VA 1N6MA 4BBGA 5LT1A 4E7SA 4PJLA 2ZFIA 1MMNA 4PJMA 2VB6A 3DCBA 5LT3A 2FMEA 4FRZA 1VOMA 1BR1A 2GM1A 1D1BA 4PK4A 1CZ7A 1II6A 1MKJA 1MMGA 2OWMA 2X7CA 1F9VA 4DBQA 2UYIA 3WRDA 1F9UA 2V26A 2IEHA 1VFZA 4A51A 2HEHA 2XAEA 3KARA 3X2TA 2KINA 3CJOA 5LT0A 4BXNA 4DBRA 4PJJA 1D1CA 1G8XA 1RY6A 1FMWA 1SDMA 5GSZA 3L9HA 4Y05A 1I6IA 2GRYA 4PJNA 1MNEA 1X88A 2VASA 1V8KA 3T0QA 4GKRA 4LNUK 4ZHIA 2G1QA 2XT3A 1LKXA 2VVGA 3ZCWA 1BG2A 5LT4A 1Q0BA 4E7ZA 1F9TA 4BN2A 1D0ZA 4AP0A 1T5CA 2PG2A 3LREA 1FMVA 2UYMA 1D1AA 3U06A 1BR4A 2X51A 1D0XA 2ZFLA 3ZFDA 1I5SA 2FKYA 2X7DA 4UBFA 3COBA 4A28A 4ANJA 1F9WA 2FL6A 4PFOA 3H4SA 3CNZA 4ETPA 2X7EA 4AS7A 2Y5WA 1VFXA 4A50A 1VFVA 1GOJA 2Q2ZA 3L1CA 2NCDA 2ZFMA 1LVKA 4A14A 2Q2YA 3KENA 4PFPA 1KK7A 3GBJA 4HNAK 3K5EA 2ZFJA 3NWNA 1BR2A 1VFWA 2Y65A 3B6UA 4A5YA 4A1ZA 2MYSA 3DC4A 3KINA 3K3BA 4B7BA 2FL2A 1MMDA 3WPNA 5HLEA 2WOGA 5LT2A
chains in the Genus database with same CATH superfamily
1MMAA 3HQDA 1D0YA 1V8JA 4H1GA 3PXNA 3BFNA 2X2RA 2ZFKA 4ZCAA 3ZFCA 1YRSA 3B6VA 1N6MA 4BBGA 5LT1A 4E7SA 4PJLA 2ZFIA 1MMNA 4PJMA 2VB6A 3DCBA 5LT3A 2FMEA 4FRZA 1VOMA 1BR1A 2GM1A 1D1BA 4PK4A 1CZ7A 1II6A 1MKJA 1MMGA 2OWMA 2X7CA 1F9VA 4DBQA 2UYIA 3WRDA 1F9UA 2V26A 2IEHA 1VFZA 4A51A 2HEHA 2XAEA 3KARA 3X2TA 2KINA 3CJOA 5LT0A 4BXNA 4DBRA 4GKQA 4PJJA 1D1CA 1G8XA 1RY6A 1FMWA 1SDMA 5GSZA 3L9HA 4Y05A 1I6IA 2GRYA 4GKPA 4PJNA 1MNEA 1X88A 2VASA 1V8KA 3T0QA 4GKRA 4LNUK 4ZHIA 2G1QA 2XT3A 1LKXA 2VVGA 3ZCWA 1BG2A 5LT4A 1Q0BA 4E7ZA 1F9TA 4BN2A 1D0ZA 4AP0A 1T5CA 2PG2A 3LREA 1FMVA 2UYMA 1D1AA 3U06A 1BR4A 2X51A 1D0XA 2O0AA 2ZFLA 3ZFDA 1I5SA 2FKYA 2X7DA 4UBFA 3COBA 4A28A 4ANJA 1F9WA 2FL6A 4PFOA 3H4SA 3CNZA 4ETPA 2X7EA 4AS7A 2Y5WA 1VFXA 4A50A 1VFVA 1GOJA 2Q2ZA 3L1CA 2NCDA 2ZFMA 1LVKA 4A14A 2Q2YA 3KENA 4PFPA 1KK7A 3GBJA 4HNAK 3K5EA 2ZFJA 4ETPB 3NWNA 1BR2A 1VFWA 2Y65A 3B6UA 4A5YA 4A1ZA 2MYSA 3DC4A 3KINA 3K3BA 4B7BA 2FL2A 1MMDA 3WPNA 5HLEA 2WOGA 5LT2A
chains in the Genus database with same CATH topology
1MMAA 3HQDA 1D0YA 1V8JA 4H1GA 3PXNA 3BFNA 2X2RA 2ZFKA 4ZCAA 3ZFCA 1YRSA 3B6VA 1N6MA 4BBGA 5LT1A 4E7SA 4PJLA 2ZFIA 1MMNA 4PJMA 2VB6A 3DCBA 5LT3A 2FMEA 4FRZA 1VOMA 1BR1A 2GM1A 1D1BA 4PK4A 1CZ7A 1II6A 1MKJA 1MMGA 2OWMA 2X7CA 1F9VA 4DBQA 2UYIA 3WRDA 1F9UA 2V26A 2IEHA 1VFZA 4A51A 2HEHA 2XAEA 3KARA 3X2TA 2KINA 3CJOA 5LT0A 4BXNA 4DBRA 4PJJA 1D1CA 1G8XA 1RY6A 1FMWA 1SDMA 5GSZA 3L9HA 4Y05A 1I6IA 2GRYA 4PJNA 1MNEA 1X88A 2VASA 1V8KA 3T0QA 4GKRA 4LNUK 4ZHIA 2G1QA 2XT3A 1LKXA 2VVGA 3ZCWA 1BG2A 5LT4A 1Q0BA 4E7ZA 1F9TA 4BN2A 1D0ZA 4AP0A 1T5CA 2PG2A 3LREA 1FMVA 2UYMA 1D1AA 3U06A 1BR4A 2X51A 1D0XA 2ZFLA 3ZFDA 1I5SA 2FKYA 2X7DA 4UBFA 3COBA 4A28A 4ANJA 1F9WA 2FL6A 4PFOA 3H4SA 3CNZA 4ETPA 2X7EA 4AS7A 2Y5WA 1VFXA 4A50A 1VFVA 1GOJA 2Q2ZA 3L1CA 2NCDA 2ZFMA 1LVKA 4A14A 2Q2YA 3KENA 4PFPA 1KK7A 3GBJA 4HNAK 3K5EA 2ZFJA 3NWNA 1BR2A 1VFWA 2Y65A 3B6UA 4A5YA 4A1ZA 2MYSA 3DC4A 3KINA 3K3BA 4B7BA 2FL2A 1MMDA 3WPNA 5HLEA 2WOGA 5LT2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1MMA A;  3HQD A;  1D0Y A;  1V8J A;  4H1G A;  3PXN A;  3BFN A;  2X2R A;  2ZFK A;  4ZCA A;  3ZFC A;  1YRS A;  3B6V A;  1N6M A;  4BBG A;  5LT1 A;  4E7S A;  4PJL A;  2ZFI A;  1MMN A;  4PJM A;  2VB6 A;  3DCB A;  5LT3 A;  2FME A;  4FRZ A;  1VOM A;  1BR1 A;  2GM1 A;  1D1B A;  4PK4 A;  1CZ7 A;  1II6 A;  1MKJ A;  1MMG A;  2OWM A;  2X7C A;  1F9V A;  4DBQ A;  2UYI A;  3WRD A;  1F9U A;  2V26 A;  2IEH A;  1VFZ A;  4A51 A;  2HEH A;  2XAE A;  3KAR A;  3X2T A;  2KIN A;  3CJO A;  5LT0 A;  4BXN A;  4DBR A;  4PJJ A;  1D1C A;  1G8X A;  1RY6 A;  1FMW A;  1SDM A;  5GSZ A;  3L9H A;  4Y05 A;  1I6I A;  2GRY A;  4PJN A;  1MNE A;  1X88 A;  2VAS A;  1V8K A;  3T0Q A;  4GKR A;  4LNU K;  4ZHI A;  2G1Q A;  2XT3 A;  1LKX A;  2VVG A;  3ZCW A;  1BG2 A;  5LT4 A;  1Q0B A;  4E7Z A;  1F9T A;  4BN2 A;  1D0Z A;  4AP0 A;  1T5C A;  2PG2 A;  3LRE A;  1FMV A;  2UYM A;  1D1A A;  3U06 A;  1BR4 A;  2X51 A;  1D0X A;  2ZFL A;  3ZFD A;  1I5S A;  2FKY A;  2X7D A;  4UBF A;  3COB A;  4A28 A;  4ANJ A;  1F9W A;  2FL6 A;  4PFO A;  3H4S A;  3CNZ A;  4ETP A;  2X7E A;  4AS7 A;  2Y5W A;  1VFX A;  4A50 A;  1VFV A;  1GOJ A;  2Q2Z A;  3L1C A;  2NCD A;  2ZFM A;  1LVK A;  4A14 A;  2Q2Y A;  3KEN A;  4PFP A;  1KK7 A;  3GBJ A;  4HNA K;  3K5E A;  2ZFJ A;  3NWN A;  1BR2 A;  1VFW A;  2Y65 A;  3B6U A;  4A5Y A;  4A1Z A;  2MYS A;  3DC4 A;  3KIN A;  3K3B A;  4B7B A;  2FL2 A;  1MMD A;  3WPN A;  5HLE A;  2WOG A;  5LT2 A; 
#chains in the Genus database with same CATH topology
 1MMA A;  3HQD A;  1D0Y A;  1V8J A;  4H1G A;  3PXN A;  3BFN A;  2X2R A;  2ZFK A;  4ZCA A;  3ZFC A;  1YRS A;  3B6V A;  1N6M A;  4BBG A;  5LT1 A;  4E7S A;  4PJL A;  2ZFI A;  1MMN A;  4PJM A;  2VB6 A;  3DCB A;  5LT3 A;  2FME A;  4FRZ A;  1VOM A;  1BR1 A;  2GM1 A;  1D1B A;  4PK4 A;  1CZ7 A;  1II6 A;  1MKJ A;  1MMG A;  2OWM A;  2X7C A;  1F9V A;  4DBQ A;  2UYI A;  3WRD A;  1F9U A;  2V26 A;  2IEH A;  1VFZ A;  4A51 A;  2HEH A;  2XAE A;  3KAR A;  3X2T A;  2KIN A;  3CJO A;  5LT0 A;  4BXN A;  4DBR A;  4GKQ A;  4PJJ A;  1D1C A;  1G8X A;  1RY6 A;  1FMW A;  1SDM A;  5GSZ A;  3L9H A;  4Y05 A;  1I6I A;  2GRY A;  4GKP A;  4PJN A;  1MNE A;  1X88 A;  2VAS A;  1V8K A;  3T0Q A;  4GKR A;  4LNU K;  4ZHI A;  2G1Q A;  2XT3 A;  1LKX A;  2VVG A;  3ZCW A;  1BG2 A;  5LT4 A;  1Q0B A;  4E7Z A;  1F9T A;  4BN2 A;  1D0Z A;  4AP0 A;  1T5C A;  2PG2 A;  3LRE A;  1FMV A;  2UYM A;  1D1A A;  3U06 A;  1BR4 A;  2X51 A;  1D0X A;  2O0A A;  2ZFL A;  3ZFD A;  1I5S A;  2FKY A;  2X7D A;  4UBF A;  3COB A;  4A28 A;  4ANJ A;  1F9W A;  2FL6 A;  4PFO A;  3H4S A;  3CNZ A;  4ETP A;  2X7E A;  4AS7 A;  2Y5W A;  1VFX A;  4A50 A;  1VFV A;  1GOJ A;  2Q2Z A;  3L1C A;  2NCD A;  2ZFM A;  1LVK A;  4A14 A;  2Q2Y A;  3KEN A;  4PFP A;  1KK7 A;  3GBJ A;  4HNA K;  3K5E A;  2ZFJ A;  4ETP B;  3NWN A;  1BR2 A;  1VFW A;  2Y65 A;  3B6U A;  4A5Y A;  4A1Z A;  2MYS A;  3DC4 A;  3KIN A;  3K3B A;  4B7B A;  2FL2 A;  1MMD A;  3WPN A;  5HLE A;  2WOG A;  5LT2 A; 
#chains in the Genus database with same CATH homology
 1MMA A;  3HQD A;  1D0Y A;  1V8J A;  4H1G A;  3PXN A;  3BFN A;  2X2R A;  2ZFK A;  4ZCA A;  3ZFC A;  1YRS A;  3B6V A;  1N6M A;  4BBG A;  5LT1 A;  4E7S A;  4PJL A;  2ZFI A;  1MMN A;  4PJM A;  2VB6 A;  3DCB A;  5LT3 A;  2FME A;  4FRZ A;  1VOM A;  1BR1 A;  2GM1 A;  1D1B A;  4PK4 A;  1CZ7 A;  1II6 A;  1MKJ A;  1MMG A;  2OWM A;  2X7C A;  1F9V A;  4DBQ A;  2UYI A;  3WRD A;  1F9U A;  2V26 A;  2IEH A;  1VFZ A;  4A51 A;  2HEH A;  2XAE A;  3KAR A;  3X2T A;  2KIN A;  3CJO A;  5LT0 A;  4BXN A;  4DBR A;  4PJJ A;  1D1C A;  1G8X A;  1RY6 A;  1FMW A;  1SDM A;  5GSZ A;  3L9H A;  4Y05 A;  1I6I A;  2GRY A;  4PJN A;  1MNE A;  1X88 A;  2VAS A;  1V8K A;  3T0Q A;  4GKR A;  4LNU K;  4ZHI A;  2G1Q A;  2XT3 A;  1LKX A;  2VVG A;  3ZCW A;  1BG2 A;  5LT4 A;  1Q0B A;  4E7Z A;  1F9T A;  4BN2 A;  1D0Z A;  4AP0 A;  1T5C A;  2PG2 A;  3LRE A;  1FMV A;  2UYM A;  1D1A A;  3U06 A;  1BR4 A;  2X51 A;  1D0X A;  2ZFL A;  3ZFD A;  1I5S A;  2FKY A;  2X7D A;  4UBF A;  3COB A;  4A28 A;  4ANJ A;  1F9W A;  2FL6 A;  4PFO A;  3H4S A;  3CNZ A;  4ETP A;  2X7E A;  4AS7 A;  2Y5W A;  1VFX A;  4A50 A;  1VFV A;  1GOJ A;  2Q2Z A;  3L1C A;  2NCD A;  2ZFM A;  1LVK A;  4A14 A;  2Q2Y A;  3KEN A;  4PFP A;  1KK7 A;  3GBJ A;  4HNA K;  3K5E A;  2ZFJ A;  3NWN A;  1BR2 A;  1VFW A;  2Y65 A;  3B6U A;  4A5Y A;  4A1Z A;  2MYS A;  3DC4 A;  3KIN A;  3K3B A;  4B7B A;  2FL2 A;  1MMD A;  3WPN A;  5HLE A;  2WOG A;  5LT2 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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