2X7CA

Crystal structure of human kinesin eg5 in complex with (s)-enastron
Total Genus 104
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
104
sequence length
347
structure length
332
Chain Sequence
NIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural Basis for Inhibition of Eg5 by Dihydropyrimidines: Stereoselectivity of Antimitotic Inhibitors Enastron, Dimethylenastron and Fluorastrol.
pubmed doi rcsb
molecule keywords KINESIN-LIKE PROTEIN KIF11
molecule tags Cell cycle
source organism Homo sapiens
total genus 104
structure length 332
sequence length 347
chains with identical sequence B
ec nomenclature
pdb deposition date 2010-02-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 2x7cA00
4PK4A 4DBRA 4BXNA 4AP0A 3CNZA 1BR2A 4A14A 1I5SA 4FRZA 3KENA 1D0YA 3BFNA 3PXNA 3HQDA 3LREA 2G1QA 2X7EA 2UYMA 4UBFA 2KINA 2IEHA 3B6VA 2ZFJA 3K3BA 1FMVA 2V26A 2FMEA 1V8JA 5LT1A 1D1AA 2OWMA 1BR1A 1F9UA 3K5EA 2X7DA 1RY6A 4BBGA 1LKXA 1N6MA 4BN2A 3X2TA 2FL6A 2NCDA 5LT3A 1MKJA 1MNEA 3CJOA 4A51A 1Q0BA 1X88A 3GBJA 2MYSA 4PJLA 2FL2A 5LT2A 1F9TA 2ZFIA 1II6A 2Y65A 3L9HA 2XT3A 5LT0A 1BG2A 4A28A 5GSZA 2GRYA 5HLEA 3B6UA 1GOJA 4A50A 1MMNA 4AS7A 4B7BA 1MMGA 4PFPA 4PJNA 2X51A 2X2RA 1MMDA 1G8XA 2Q2YA 4ZHIA 1VFWA 4LNUK 1FMWA 1D1BA 1D1CA 1MMAA 3ZFDA 3DCBA 3COBA 1VOMA 4A5YA 1F9WA 2VB6A 3WPNA 1CZ7A 4E7SA 2ZFKA 2X7CA 3L1CA 1T5CA 1VFZA 1VFXA 1LVKA 2XAEA 2VVGA 4PJJA 2ZFLA 3ZCWA 4ZCAA 3KINA 1D0ZA 3H4SA 1KK7A 2GM1A 1BR4A 3KARA 3T0QA 4DBQA 2VASA 4A1ZA 1V8KA 4Y05A 2HEHA 4PFOA 1F9VA 5LT4A 2PG2A 4ETPA 4HNAK 4E7ZA 4H1GA 2WOGA 4GKRA 3DC4A 1I6IA 2ZFMA 1VFVA 2FKYA 2Q2ZA 2Y5WA 4ANJA 2UYIA 1D0XA 3WRDA 3NWNA 4PJMA 1YRSA 3ZFCA 1SDMA 3U06A
chains in the Genus database with same CATH superfamily
4PK4A 4DBRA 4BXNA 4AP0A 3CNZA 1BR2A 4A14A 1I5SA 4FRZA 3KENA 1D0YA 3BFNA 3PXNA 3HQDA 3LREA 2G1QA 2X7EA 2UYMA 4UBFA 2KINA 2IEHA 3B6VA 2ZFJA 3K3BA 1FMVA 2V26A 2FMEA 2O0AA 1V8JA 5LT1A 1D1AA 2OWMA 1BR1A 1F9UA 3K5EA 2X7DA 1RY6A 4BBGA 1LKXA 1N6MA 4BN2A 3X2TA 2FL6A 2NCDA 5LT3A 1MKJA 1MNEA 3CJOA 4A51A 1Q0BA 1X88A 3GBJA 4GKPA 2MYSA 4PJLA 4ETPB 2FL2A 5LT2A 1F9TA 2ZFIA 1II6A 2Y65A 3L9HA 2XT3A 5LT0A 1BG2A 4GKQA 4A28A 5GSZA 2GRYA 5HLEA 3B6UA 1GOJA 4A50A 1MMNA 4AS7A 4B7BA 1MMGA 4PFPA 4PJNA 2X51A 2X2RA 1MMDA 1G8XA 2Q2YA 4ZHIA 1VFWA 4LNUK 1FMWA 1D1BA 1D1CA 1MMAA 3ZFDA 3DCBA 3COBA 1VOMA 4A5YA 1F9WA 2VB6A 3WPNA 1CZ7A 4E7SA 2ZFKA 2X7CA 3L1CA 1T5CA 1VFZA 1VFXA 1LVKA 2XAEA 2VVGA 4PJJA 2ZFLA 3ZCWA 4ZCAA 3KINA 1D0ZA 3H4SA 1KK7A 2GM1A 1BR4A 3KARA 3T0QA 4DBQA 2VASA 4A1ZA 1V8KA 4Y05A 2HEHA 4PFOA 1F9VA 5LT4A 2PG2A 4ETPA 4HNAK 4E7ZA 4H1GA 2WOGA 4GKRA 3DC4A 1I6IA 2ZFMA 1VFVA 2FKYA 2Q2ZA 2Y5WA 4ANJA 2UYIA 1D0XA 3WRDA 3NWNA 4PJMA 1YRSA 3ZFCA 1SDMA 3U06A
chains in the Genus database with same CATH topology
4PK4A 4DBRA 4BXNA 4AP0A 3CNZA 1BR2A 4A14A 1I5SA 4FRZA 3KENA 1D0YA 3BFNA 3PXNA 3HQDA 3LREA 2G1QA 2X7EA 2UYMA 4UBFA 2KINA 2IEHA 3B6VA 2ZFJA 3K3BA 1FMVA 2V26A 2FMEA 1V8JA 5LT1A 1D1AA 2OWMA 1BR1A 1F9UA 3K5EA 2X7DA 1RY6A 4BBGA 1LKXA 1N6MA 4BN2A 3X2TA 2FL6A 2NCDA 5LT3A 1MKJA 1MNEA 3CJOA 4A51A 1Q0BA 1X88A 3GBJA 2MYSA 4PJLA 2FL2A 5LT2A 1F9TA 2ZFIA 1II6A 2Y65A 3L9HA 2XT3A 5LT0A 1BG2A 4A28A 5GSZA 2GRYA 5HLEA 3B6UA 1GOJA 4A50A 1MMNA 4AS7A 4B7BA 1MMGA 4PFPA 4PJNA 2X51A 2X2RA 1MMDA 1G8XA 2Q2YA 4ZHIA 1VFWA 4LNUK 1FMWA 1D1BA 1D1CA 1MMAA 3ZFDA 3DCBA 3COBA 1VOMA 4A5YA 1F9WA 2VB6A 3WPNA 1CZ7A 4E7SA 2ZFKA 2X7CA 3L1CA 1T5CA 1VFZA 1VFXA 1LVKA 2XAEA 2VVGA 4PJJA 2ZFLA 3ZCWA 4ZCAA 3KINA 1D0ZA 3H4SA 1KK7A 2GM1A 1BR4A 3KARA 3T0QA 4DBQA 2VASA 4A1ZA 1V8KA 4Y05A 2HEHA 4PFOA 1F9VA 5LT4A 2PG2A 4ETPA 4HNAK 4E7ZA 4H1GA 2WOGA 4GKRA 3DC4A 1I6IA 2ZFMA 1VFVA 2FKYA 2Q2ZA 2Y5WA 4ANJA 2UYIA 1D0XA 3WRDA 3NWNA 4PJMA 1YRSA 3ZFCA 1SDMA 3U06A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4PK4 A;  4DBR A;  4BXN A;  4AP0 A;  3CNZ A;  1BR2 A;  4A14 A;  1I5S A;  4FRZ A;  3KEN A;  1D0Y A;  3BFN A;  3PXN A;  3HQD A;  3LRE A;  2G1Q A;  2X7E A;  2UYM A;  4UBF A;  2KIN A;  2IEH A;  3B6V A;  2ZFJ A;  3K3B A;  1FMV A;  2V26 A;  2FME A;  1V8J A;  5LT1 A;  1D1A A;  2OWM A;  1BR1 A;  1F9U A;  3K5E A;  2X7D A;  1RY6 A;  4BBG A;  1LKX A;  1N6M A;  4BN2 A;  3X2T A;  2FL6 A;  2NCD A;  5LT3 A;  1MKJ A;  1MNE A;  3CJO A;  4A51 A;  1Q0B A;  1X88 A;  3GBJ A;  2MYS A;  4PJL A;  2FL2 A;  5LT2 A;  1F9T A;  2ZFI A;  1II6 A;  2Y65 A;  3L9H A;  2XT3 A;  5LT0 A;  1BG2 A;  4A28 A;  5GSZ A;  2GRY A;  5HLE A;  3B6U A;  1GOJ A;  4A50 A;  1MMN A;  4AS7 A;  4B7B A;  1MMG A;  4PFP A;  4PJN A;  2X51 A;  2X2R A;  1MMD A;  1G8X A;  2Q2Y A;  4ZHI A;  1VFW A;  4LNU K;  1FMW A;  1D1B A;  1D1C A;  1MMA A;  3ZFD A;  3DCB A;  3COB A;  1VOM A;  4A5Y A;  1F9W A;  2VB6 A;  3WPN A;  1CZ7 A;  4E7S A;  2ZFK A;  2X7C A;  3L1C A;  1T5C A;  1VFZ A;  1VFX A;  1LVK A;  2XAE A;  2VVG A;  4PJJ A;  2ZFL A;  3ZCW A;  4ZCA A;  3KIN A;  1D0Z A;  3H4S A;  1KK7 A;  2GM1 A;  1BR4 A;  3KAR A;  3T0Q A;  4DBQ A;  2VAS A;  4A1Z A;  1V8K A;  4Y05 A;  2HEH A;  4PFO A;  1F9V A;  5LT4 A;  2PG2 A;  4ETP A;  4HNA K;  4E7Z A;  4H1G A;  2WOG A;  4GKR A;  3DC4 A;  1I6I A;  2ZFM A;  1VFV A;  2FKY A;  2Q2Z A;  2Y5W A;  4ANJ A;  2UYI A;  1D0X A;  3WRD A;  3NWN A;  4PJM A;  1YRS A;  3ZFC A;  1SDM A;  3U06 A; 
#chains in the Genus database with same CATH topology
 4PK4 A;  4DBR A;  4BXN A;  4AP0 A;  3CNZ A;  1BR2 A;  4A14 A;  1I5S A;  4FRZ A;  3KEN A;  1D0Y A;  3BFN A;  3PXN A;  3HQD A;  3LRE A;  2G1Q A;  2X7E A;  2UYM A;  4UBF A;  2KIN A;  2IEH A;  3B6V A;  2ZFJ A;  3K3B A;  1FMV A;  2V26 A;  2FME A;  2O0A A;  1V8J A;  5LT1 A;  1D1A A;  2OWM A;  1BR1 A;  1F9U A;  3K5E A;  2X7D A;  1RY6 A;  4BBG A;  1LKX A;  1N6M A;  4BN2 A;  3X2T A;  2FL6 A;  2NCD A;  5LT3 A;  1MKJ A;  1MNE A;  3CJO A;  4A51 A;  1Q0B A;  1X88 A;  3GBJ A;  4GKP A;  2MYS A;  4PJL A;  4ETP B;  2FL2 A;  5LT2 A;  1F9T A;  2ZFI A;  1II6 A;  2Y65 A;  3L9H A;  2XT3 A;  5LT0 A;  1BG2 A;  4GKQ A;  4A28 A;  5GSZ A;  2GRY A;  5HLE A;  3B6U A;  1GOJ A;  4A50 A;  1MMN A;  4AS7 A;  4B7B A;  1MMG A;  4PFP A;  4PJN A;  2X51 A;  2X2R A;  1MMD A;  1G8X A;  2Q2Y A;  4ZHI A;  1VFW A;  4LNU K;  1FMW A;  1D1B A;  1D1C A;  1MMA A;  3ZFD A;  3DCB A;  3COB A;  1VOM A;  4A5Y A;  1F9W A;  2VB6 A;  3WPN A;  1CZ7 A;  4E7S A;  2ZFK A;  2X7C A;  3L1C A;  1T5C A;  1VFZ A;  1VFX A;  1LVK A;  2XAE A;  2VVG A;  4PJJ A;  2ZFL A;  3ZCW A;  4ZCA A;  3KIN A;  1D0Z A;  3H4S A;  1KK7 A;  2GM1 A;  1BR4 A;  3KAR A;  3T0Q A;  4DBQ A;  2VAS A;  4A1Z A;  1V8K A;  4Y05 A;  2HEH A;  4PFO A;  1F9V A;  5LT4 A;  2PG2 A;  4ETP A;  4HNA K;  4E7Z A;  4H1G A;  2WOG A;  4GKR A;  3DC4 A;  1I6I A;  2ZFM A;  1VFV A;  2FKY A;  2Q2Z A;  2Y5W A;  4ANJ A;  2UYI A;  1D0X A;  3WRD A;  3NWN A;  4PJM A;  1YRS A;  3ZFC A;  1SDM A;  3U06 A; 
#chains in the Genus database with same CATH homology
 4PK4 A;  4DBR A;  4BXN A;  4AP0 A;  3CNZ A;  1BR2 A;  4A14 A;  1I5S A;  4FRZ A;  3KEN A;  1D0Y A;  3BFN A;  3PXN A;  3HQD A;  3LRE A;  2G1Q A;  2X7E A;  2UYM A;  4UBF A;  2KIN A;  2IEH A;  3B6V A;  2ZFJ A;  3K3B A;  1FMV A;  2V26 A;  2FME A;  1V8J A;  5LT1 A;  1D1A A;  2OWM A;  1BR1 A;  1F9U A;  3K5E A;  2X7D A;  1RY6 A;  4BBG A;  1LKX A;  1N6M A;  4BN2 A;  3X2T A;  2FL6 A;  2NCD A;  5LT3 A;  1MKJ A;  1MNE A;  3CJO A;  4A51 A;  1Q0B A;  1X88 A;  3GBJ A;  2MYS A;  4PJL A;  2FL2 A;  5LT2 A;  1F9T A;  2ZFI A;  1II6 A;  2Y65 A;  3L9H A;  2XT3 A;  5LT0 A;  1BG2 A;  4A28 A;  5GSZ A;  2GRY A;  5HLE A;  3B6U A;  1GOJ A;  4A50 A;  1MMN A;  4AS7 A;  4B7B A;  1MMG A;  4PFP A;  4PJN A;  2X51 A;  2X2R A;  1MMD A;  1G8X A;  2Q2Y A;  4ZHI A;  1VFW A;  4LNU K;  1FMW A;  1D1B A;  1D1C A;  1MMA A;  3ZFD A;  3DCB A;  3COB A;  1VOM A;  4A5Y A;  1F9W A;  2VB6 A;  3WPN A;  1CZ7 A;  4E7S A;  2ZFK A;  2X7C A;  3L1C A;  1T5C A;  1VFZ A;  1VFX A;  1LVK A;  2XAE A;  2VVG A;  4PJJ A;  2ZFL A;  3ZCW A;  4ZCA A;  3KIN A;  1D0Z A;  3H4S A;  1KK7 A;  2GM1 A;  1BR4 A;  3KAR A;  3T0Q A;  4DBQ A;  2VAS A;  4A1Z A;  1V8K A;  4Y05 A;  2HEH A;  4PFO A;  1F9V A;  5LT4 A;  2PG2 A;  4ETP A;  4HNA K;  4E7Z A;  4H1G A;  2WOG A;  4GKR A;  3DC4 A;  1I6I A;  2ZFM A;  1VFV A;  2FKY A;  2Q2Z A;  2Y5W A;  4ANJ A;  2UYI A;  1D0X A;  3WRD A;  3NWN A;  4PJM A;  1YRS A;  3ZFC A;  1SDM A;  3U06 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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