2X7DA

Crystal structure of human kinesin eg5 in complex with (s)-dimethylenastron
Total Genus 106

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
106
sequence length
350
structure length
335
Chain Sequence
KNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPEVN
5010015020025030030025020015010050
020406080100Genus Matrix

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
EMPTYS14 (329-336)TII'1 (57-60)S1 (20-25)AH1 (30-35)TIV1 (44-47)TI1 (45-48)S2 (41-44)AH7 (315-320)S3 (49-55)TIV8 (323-326)AH3 (111-116)S4 (62-67)TI2 (73-76)AH6 (290-304)AH2 (78-95)TI8 (249-252)S13 (254-265)S6 (98-104)TII2 (120-123)TII1 (106-109)S10 (194-197)TI7 (190-193)TIV3 (121-124)3H1 (127-129)TI3 (130-133)AH4 (135-147)TI6 (187-190)S9 (183-186)AH5 (210-227)TIV4 (147-150)TIV5 (163-166)S7 (152-164)S8 (167-170)TI5 (177-180)TIV6 (170-173)TI4 (173-176)3H2 (207-209)S12 (236-248)TIV7 (228-231)3H3 (231-233)TI10 (311-314)TIV2 (68-71)S5 (70-72)TII3 (196-199)S11 (202-204)TI9 (310-313)3H4 (321-323)Updating...
connected with : NaN
molecule tags Cell cycle
source organism Homo sapiens
publication title Structural Basis for Inhibition of Eg5 by Dihydropyrimidines: Stereoselectivity of Antimitotic Inhibitors Enastron, Dimethylenastron and Fluorastrol.
pubmed doi rcsb
molecule keywords KINESIN-LIKE PROTEIN KIF11
total genus 106
structure length 335
sequence length 350
chains with identical sequence B
ec nomenclature
pdb deposition date 2010-02-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 2x7dA00
1I6IA 2Q2YA 4PJNA 1N6MA 1D1AA 2VB6A 1FMVA 2UYIA 2Q2ZA 3B6VA 4ZHIA 1VFXA 3WPNA 2ZFKA 4UBFA 2X7EA 1VFWA 4DBQA 3PXNA 2OWMA 3H4SA 3U06A 5LT4A 2GM1A 1LVKA 4ETPA 4E7ZA 3BFNA 2Y5WA 2ZFLA 1VFZA 4ANJA 2V26A 1II6A 3DCBA 5LT2A 1KK7A 4A51A 4HNAK 1F9VA 4B7BA 4PK4A 2X7CA 4A50A 2NCDA 3LREA 4H1GA 2MYSA 3CNZA 1Q0BA 3KENA 2UYMA 3KINA 1D1BA 1MMDA 3WRDA 4AP0A 4PJMA 4A1ZA 5LT0A 4FRZA 4E7SA 3X2TA 3HQDA 4BXNA 1BR4A 2FMEA 5LT1A 4ZCAA 3K3BA 4BN2A 1V8JA 3DC4A 3KARA 2X2RA 1T5CA 1CZ7A 1MKJA 1YRSA 2FL6A 3COBA 1RY6A 1BR1A 2FL2A 4Y05A 1X88A 4BBGA 3T0QA 1GOJA 2X7DA 4PJLA 1D0XA 1F9WA 2IEHA 3ZFDA 4DBRA 1VFVA 1MNEA 2ZFJA 5HLEA 4A28A 2XT3A 1D1CA 4A14A 2X51A 4AS7A 3CJOA 5GSZA 2XAEA 4PFPA 1I5SA 4PFOA 4A5YA 2FKYA 2VVGA 1MMGA 1G8XA 2KINA 1D0ZA 1FMWA 3L1CA 2Y65A 2G1QA 1D0YA 3GBJA 4PJJA 1LKXA 2WOGA 3K5EA 1V8KA 3ZCWA 1F9TA 5LT3A 1MMNA 2HEHA 2PG2A 3ZFCA 1F9UA 1BG2A 1BR2A 1VOMA 4GKRA 3NWNA 2VASA 2ZFIA 2ZFMA 3B6UA 1MMAA 1SDMA 4LNUK 3L9HA 2GRYA
chains in the Genus database with same CATH superfamily
1I6IA 2O0AA 2Q2YA 1N6MA 4PJNA 1D1AA 2VB6A 1FMVA 2UYIA 2Q2ZA 3B6VA 4ZHIA 1VFXA 3WPNA 2ZFKA 4UBFA 2X7EA 1VFWA 4DBQA 3PXNA 2OWMA 3H4SA 4GKPA 3U06A 5LT4A 2GM1A 1LVKA 4ETPA 4E7ZA 3BFNA 2Y5WA 2ZFLA 1VFZA 4ANJA 2V26A 1II6A 3DCBA 5LT2A 1KK7A 4A51A 4HNAK 1F9VA 4B7BA 4PK4A 2X7CA 4A50A 2NCDA 3LREA 4H1GA 2MYSA 3CNZA 1Q0BA 3KENA 2UYMA 3KINA 1D1BA 1MMDA 3WRDA 4AP0A 4PJMA 4A1ZA 5LT0A 4GKQA 4FRZA 4E7SA 3X2TA 3HQDA 4BXNA 1BR4A 2FMEA 5LT1A 4ZCAA 3K3BA 4BN2A 1V8JA 3DC4A 3KARA 2X2RA 1T5CA 1CZ7A 1MKJA 1YRSA 2FL6A 3COBA 1RY6A 1BR1A 2FL2A 4Y05A 1X88A 4BBGA 3T0QA 1GOJA 2X7DA 4PJLA 1D0XA 1F9WA 2IEHA 3ZFDA 4DBRA 1VFVA 1MNEA 2ZFJA 5HLEA 4A28A 2XT3A 1D1CA 4A14A 2X51A 4AS7A 3CJOA 5GSZA 2XAEA 4PFPA 1I5SA 4PFOA 4A5YA 2FKYA 2VVGA 1MMGA 1G8XA 2KINA 1D0ZA 1FMWA 3L1CA 2Y65A 2G1QA 1D0YA 3GBJA 4PJJA 1LKXA 2WOGA 3K5EA 1V8KA 3ZCWA 1F9TA 5LT3A 1MMNA 2HEHA 2PG2A 3ZFCA 4ETPB 1F9UA 1BG2A 1BR2A 1VOMA 4GKRA 3NWNA 2VASA 2ZFIA 2ZFMA 3B6UA 1MMAA 1SDMA 4LNUK 3L9HA 2GRYA
chains in the Genus database with same CATH topology
1I6IA 2Q2YA 4PJNA 1N6MA 1D1AA 2VB6A 1FMVA 2UYIA 2Q2ZA 3B6VA 4ZHIA 1VFXA 3WPNA 2ZFKA 4UBFA 2X7EA 1VFWA 4DBQA 3PXNA 2OWMA 3H4SA 3U06A 5LT4A 2GM1A 1LVKA 4ETPA 4E7ZA 3BFNA 2Y5WA 2ZFLA 1VFZA 4ANJA 2V26A 1II6A 3DCBA 5LT2A 1KK7A 4A51A 4HNAK 1F9VA 4B7BA 4PK4A 2X7CA 4A50A 2NCDA 3LREA 4H1GA 2MYSA 3CNZA 1Q0BA 3KENA 2UYMA 3KINA 1D1BA 1MMDA 3WRDA 4AP0A 4PJMA 4A1ZA 5LT0A 4FRZA 4E7SA 3X2TA 3HQDA 4BXNA 1BR4A 2FMEA 5LT1A 4ZCAA 3K3BA 4BN2A 1V8JA 3DC4A 3KARA 2X2RA 1T5CA 1CZ7A 1MKJA 1YRSA 2FL6A 3COBA 1RY6A 1BR1A 2FL2A 4Y05A 1X88A 4BBGA 3T0QA 1GOJA 2X7DA 4PJLA 1D0XA 1F9WA 2IEHA 3ZFDA 4DBRA 1VFVA 1MNEA 2ZFJA 5HLEA 4A28A 2XT3A 1D1CA 4A14A 2X51A 4AS7A 3CJOA 5GSZA 2XAEA 4PFPA 1I5SA 4PFOA 4A5YA 2FKYA 2VVGA 1MMGA 1G8XA 2KINA 1D0ZA 1FMWA 3L1CA 2Y65A 2G1QA 1D0YA 3GBJA 4PJJA 1LKXA 2WOGA 3K5EA 1V8KA 3ZCWA 1F9TA 5LT3A 1MMNA 2HEHA 2PG2A 3ZFCA 1F9UA 1BG2A 1BR2A 1VOMA 4GKRA 3NWNA 2VASA 2ZFIA 2ZFMA 3B6UA 1MMAA 1SDMA 4LNUK 3L9HA 2GRYA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1I6I A;  2Q2Y A;  4PJN A;  1N6M A;  1D1A A;  2VB6 A;  1FMV A;  2UYI A;  2Q2Z A;  3B6V A;  4ZHI A;  1VFX A;  3WPN A;  2ZFK A;  4UBF A;  2X7E A;  1VFW A;  4DBQ A;  3PXN A;  2OWM A;  3H4S A;  3U06 A;  5LT4 A;  2GM1 A;  1LVK A;  4ETP A;  4E7Z A;  3BFN A;  2Y5W A;  2ZFL A;  1VFZ A;  4ANJ A;  2V26 A;  1II6 A;  3DCB A;  5LT2 A;  1KK7 A;  4A51 A;  4HNA K;  1F9V A;  4B7B A;  4PK4 A;  2X7C A;  4A50 A;  2NCD A;  3LRE A;  4H1G A;  2MYS A;  3CNZ A;  1Q0B A;  3KEN A;  2UYM A;  3KIN A;  1D1B A;  1MMD A;  3WRD A;  4AP0 A;  4PJM A;  4A1Z A;  5LT0 A;  4FRZ A;  4E7S A;  3X2T A;  3HQD A;  4BXN A;  1BR4 A;  2FME A;  5LT1 A;  4ZCA A;  3K3B A;  4BN2 A;  1V8J A;  3DC4 A;  3KAR A;  2X2R A;  1T5C A;  1CZ7 A;  1MKJ A;  1YRS A;  2FL6 A;  3COB A;  1RY6 A;  1BR1 A;  2FL2 A;  4Y05 A;  1X88 A;  4BBG A;  3T0Q A;  1GOJ A;  2X7D A;  4PJL A;  1D0X A;  1F9W A;  2IEH A;  3ZFD A;  4DBR A;  1VFV A;  1MNE A;  2ZFJ A;  5HLE A;  4A28 A;  2XT3 A;  1D1C A;  4A14 A;  2X51 A;  4AS7 A;  3CJO A;  5GSZ A;  2XAE A;  4PFP A;  1I5S A;  4PFO A;  4A5Y A;  2FKY A;  2VVG A;  1MMG A;  1G8X A;  2KIN A;  1D0Z A;  1FMW A;  3L1C A;  2Y65 A;  2G1Q A;  1D0Y A;  3GBJ A;  4PJJ A;  1LKX A;  2WOG A;  3K5E A;  1V8K A;  3ZCW A;  1F9T A;  5LT3 A;  1MMN A;  2HEH A;  2PG2 A;  3ZFC A;  1F9U A;  1BG2 A;  1BR2 A;  1VOM A;  4GKR A;  3NWN A;  2VAS A;  2ZFI A;  2ZFM A;  3B6U A;  1MMA A;  1SDM A;  4LNU K;  3L9H A;  2GRY A; 
#chains in the Genus database with same CATH topology
 1I6I A;  2O0A A;  2Q2Y A;  1N6M A;  4PJN A;  1D1A A;  2VB6 A;  1FMV A;  2UYI A;  2Q2Z A;  3B6V A;  4ZHI A;  1VFX A;  3WPN A;  2ZFK A;  4UBF A;  2X7E A;  1VFW A;  4DBQ A;  3PXN A;  2OWM A;  3H4S A;  4GKP A;  3U06 A;  5LT4 A;  2GM1 A;  1LVK A;  4ETP A;  4E7Z A;  3BFN A;  2Y5W A;  2ZFL A;  1VFZ A;  4ANJ A;  2V26 A;  1II6 A;  3DCB A;  5LT2 A;  1KK7 A;  4A51 A;  4HNA K;  1F9V A;  4B7B A;  4PK4 A;  2X7C A;  4A50 A;  2NCD A;  3LRE A;  4H1G A;  2MYS A;  3CNZ A;  1Q0B A;  3KEN A;  2UYM A;  3KIN A;  1D1B A;  1MMD A;  3WRD A;  4AP0 A;  4PJM A;  4A1Z A;  5LT0 A;  4GKQ A;  4FRZ A;  4E7S A;  3X2T A;  3HQD A;  4BXN A;  1BR4 A;  2FME A;  5LT1 A;  4ZCA A;  3K3B A;  4BN2 A;  1V8J A;  3DC4 A;  3KAR A;  2X2R A;  1T5C A;  1CZ7 A;  1MKJ A;  1YRS A;  2FL6 A;  3COB A;  1RY6 A;  1BR1 A;  2FL2 A;  4Y05 A;  1X88 A;  4BBG A;  3T0Q A;  1GOJ A;  2X7D A;  4PJL A;  1D0X A;  1F9W A;  2IEH A;  3ZFD A;  4DBR A;  1VFV A;  1MNE A;  2ZFJ A;  5HLE A;  4A28 A;  2XT3 A;  1D1C A;  4A14 A;  2X51 A;  4AS7 A;  3CJO A;  5GSZ A;  2XAE A;  4PFP A;  1I5S A;  4PFO A;  4A5Y A;  2FKY A;  2VVG A;  1MMG A;  1G8X A;  2KIN A;  1D0Z A;  1FMW A;  3L1C A;  2Y65 A;  2G1Q A;  1D0Y A;  3GBJ A;  4PJJ A;  1LKX A;  2WOG A;  3K5E A;  1V8K A;  3ZCW A;  1F9T A;  5LT3 A;  1MMN A;  2HEH A;  2PG2 A;  3ZFC A;  4ETP B;  1F9U A;  1BG2 A;  1BR2 A;  1VOM A;  4GKR A;  3NWN A;  2VAS A;  2ZFI A;  2ZFM A;  3B6U A;  1MMA A;  1SDM A;  4LNU K;  3L9H A;  2GRY A; 
#chains in the Genus database with same CATH homology
 1I6I A;  2Q2Y A;  4PJN A;  1N6M A;  1D1A A;  2VB6 A;  1FMV A;  2UYI A;  2Q2Z A;  3B6V A;  4ZHI A;  1VFX A;  3WPN A;  2ZFK A;  4UBF A;  2X7E A;  1VFW A;  4DBQ A;  3PXN A;  2OWM A;  3H4S A;  3U06 A;  5LT4 A;  2GM1 A;  1LVK A;  4ETP A;  4E7Z A;  3BFN A;  2Y5W A;  2ZFL A;  1VFZ A;  4ANJ A;  2V26 A;  1II6 A;  3DCB A;  5LT2 A;  1KK7 A;  4A51 A;  4HNA K;  1F9V A;  4B7B A;  4PK4 A;  2X7C A;  4A50 A;  2NCD A;  3LRE A;  4H1G A;  2MYS A;  3CNZ A;  1Q0B A;  3KEN A;  2UYM A;  3KIN A;  1D1B A;  1MMD A;  3WRD A;  4AP0 A;  4PJM A;  4A1Z A;  5LT0 A;  4FRZ A;  4E7S A;  3X2T A;  3HQD A;  4BXN A;  1BR4 A;  2FME A;  5LT1 A;  4ZCA A;  3K3B A;  4BN2 A;  1V8J A;  3DC4 A;  3KAR A;  2X2R A;  1T5C A;  1CZ7 A;  1MKJ A;  1YRS A;  2FL6 A;  3COB A;  1RY6 A;  1BR1 A;  2FL2 A;  4Y05 A;  1X88 A;  4BBG A;  3T0Q A;  1GOJ A;  2X7D A;  4PJL A;  1D0X A;  1F9W A;  2IEH A;  3ZFD A;  4DBR A;  1VFV A;  1MNE A;  2ZFJ A;  5HLE A;  4A28 A;  2XT3 A;  1D1C A;  4A14 A;  2X51 A;  4AS7 A;  3CJO A;  5GSZ A;  2XAE A;  4PFP A;  1I5S A;  4PFO A;  4A5Y A;  2FKY A;  2VVG A;  1MMG A;  1G8X A;  2KIN A;  1D0Z A;  1FMW A;  3L1C A;  2Y65 A;  2G1Q A;  1D0Y A;  3GBJ A;  4PJJ A;  1LKX A;  2WOG A;  3K5E A;  1V8K A;  3ZCW A;  1F9T A;  5LT3 A;  1MMN A;  2HEH A;  2PG2 A;  3ZFC A;  1F9U A;  1BG2 A;  1BR2 A;  1VOM A;  4GKR A;  3NWN A;  2VAS A;  2ZFI A;  2ZFM A;  3B6U A;  1MMA A;  1SDM A;  4LNU K;  3L9H A;  2GRY A; 
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similar chains in the Genus database (?% sequence similarity)
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