2X7DA

Crystal structure of human kinesin eg5 in complex with (s)-dimethylenastron
Total Genus 106
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
106
sequence length
350
structure length
335
Chain Sequence
KNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPEVN
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title Structural Basis for Inhibition of Eg5 by Dihydropyrimidines: Stereoselectivity of Antimitotic Inhibitors Enastron, Dimethylenastron and Fluorastrol.
pubmed doi rcsb
molecule keywords KINESIN-LIKE PROTEIN KIF11
molecule tags Cell cycle
source organism Homo sapiens
total genus 106
structure length 335
sequence length 350
chains with identical sequence B
ec nomenclature
pdb deposition date 2010-02-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 2x7dA00
4ETPA 1N6MA 5LT3A 1F9UA 1I5SA 4BBGA 5GSZA 1I6IA 1V8JA 4FRZA 1D0YA 1VFXA 3ZFCA 1BR4A 1KK7A 4UBFA 2Y65A 5LT0A 3ZCWA 2MYSA 4E7SA 3WPNA 2FKYA 2GM1A 1F9VA 3PXNA 4PJMA 1GOJA 1CZ7A 1MMDA 3LREA 4ZHIA 2UYIA 2GRYA 1VOMA 5LT4A 1D1BA 4PK4A 4A51A 5HLEA 1Q0BA 1FMWA 4A1ZA 3L9HA 2V26A 1D1CA 4PJLA 1V8KA 2X2RA 1II6A 2ZFMA 1MMAA 3KARA 3B6VA 2VASA 1FMVA 3U06A 4BXNA 3KENA 3HQDA 4B7BA 3T0QA 1D1AA 1G8XA 2FMEA 4HNAK 2KINA 2X7DA 2ZFLA 4PJNA 2ZFJA 4PFOA 4DBRA 1VFVA 1BR1A 3K5EA 2UYMA 4PJJA 4BN2A 4AP0A 3ZFDA 1MKJA 2NCDA 4AS7A 3B6UA 3KINA 2IEHA 1D0ZA 2VB6A 1MMNA 1SDMA 1D0XA 2Y5WA 2X7CA 3CNZA 4LNUK 4ZCAA 3DCBA 5LT1A 1RY6A 1F9TA 3CJOA 2X7EA 1MNEA 2FL2A 2G1QA 1BR2A 4H1GA 2VVGA 1YRSA 3NWNA 3L1CA 2HEHA 2ZFIA 3H4SA 1BG2A 3DC4A 3K3BA 2OWMA 1F9WA 4A50A 4A14A 4A28A 2X51A 4PFPA 2PG2A 3COBA 3BFNA 4E7ZA 1T5CA 2XAEA 1LVKA 4A5YA 4ANJA 1VFZA 1MMGA 4DBQA 4Y05A 1X88A 3WRDA 3X2TA 4GKRA 2ZFKA 2WOGA 3GBJA 2FL6A 1VFWA 5LT2A 2Q2YA 2XT3A 2Q2ZA 1LKXA
chains in the Genus database with same CATH superfamily
4ETPA 1N6MA 5LT3A 1F9UA 1I5SA 4BBGA 5GSZA 1I6IA 1V8JA 4ETPB 4FRZA 1D0YA 1VFXA 3ZFCA 1BR4A 1KK7A 4UBFA 2Y65A 5LT0A 3ZCWA 2MYSA 4E7SA 3WPNA 2FKYA 2GM1A 1F9VA 3PXNA 4PJMA 1GOJA 1CZ7A 1MMDA 3LREA 4ZHIA 2UYIA 2GRYA 1VOMA 5LT4A 1D1BA 4PK4A 4A51A 5HLEA 1Q0BA 1FMWA 4A1ZA 3L9HA 2V26A 1D1CA 4PJLA 1V8KA 2X2RA 1II6A 2ZFMA 1MMAA 3KARA 3B6VA 2VASA 1FMVA 3U06A 4BXNA 3KENA 3HQDA 4B7BA 3T0QA 1D1AA 1G8XA 2FMEA 4HNAK 2KINA 2X7DA 2ZFLA 4PJNA 2ZFJA 4PFOA 4DBRA 1VFVA 1BR1A 3K5EA 2UYMA 4PJJA 4BN2A 4AP0A 3ZFDA 1MKJA 2NCDA 4AS7A 3B6UA 3KINA 2IEHA 1D0ZA 2VB6A 1MMNA 1SDMA 1D0XA 2Y5WA 2X7CA 3CNZA 4GKQA 4LNUK 4ZCAA 3DCBA 5LT1A 1RY6A 1F9TA 3CJOA 2X7EA 1MNEA 2FL2A 2G1QA 1BR2A 4H1GA 2VVGA 1YRSA 2O0AA 3NWNA 3L1CA 2HEHA 2ZFIA 3H4SA 1BG2A 3DC4A 3K3BA 2OWMA 1F9WA 4A50A 4A14A 4A28A 2X51A 4PFPA 2PG2A 3COBA 3BFNA 4E7ZA 1T5CA 2XAEA 1LVKA 4A5YA 4ANJA 1VFZA 1MMGA 4DBQA 4Y05A 1X88A 3WRDA 3X2TA 4GKRA 2ZFKA 2WOGA 3GBJA 2FL6A 1VFWA 5LT2A 2Q2YA 4GKPA 2XT3A 2Q2ZA 1LKXA
chains in the Genus database with same CATH topology
4ETPA 1N6MA 5LT3A 1F9UA 1I5SA 4BBGA 5GSZA 1I6IA 1V8JA 4FRZA 1D0YA 1VFXA 3ZFCA 1BR4A 1KK7A 4UBFA 2Y65A 5LT0A 3ZCWA 2MYSA 4E7SA 3WPNA 2FKYA 2GM1A 1F9VA 3PXNA 4PJMA 1GOJA 1CZ7A 1MMDA 3LREA 4ZHIA 2UYIA 2GRYA 1VOMA 5LT4A 1D1BA 4PK4A 4A51A 5HLEA 1Q0BA 1FMWA 4A1ZA 3L9HA 2V26A 1D1CA 4PJLA 1V8KA 2X2RA 1II6A 2ZFMA 1MMAA 3KARA 3B6VA 2VASA 1FMVA 3U06A 4BXNA 3KENA 3HQDA 4B7BA 3T0QA 1D1AA 1G8XA 2FMEA 4HNAK 2KINA 2X7DA 2ZFLA 4PJNA 2ZFJA 4PFOA 4DBRA 1VFVA 1BR1A 3K5EA 2UYMA 4PJJA 4BN2A 4AP0A 3ZFDA 1MKJA 2NCDA 4AS7A 3B6UA 3KINA 2IEHA 1D0ZA 2VB6A 1MMNA 1SDMA 1D0XA 2Y5WA 2X7CA 3CNZA 4LNUK 4ZCAA 3DCBA 5LT1A 1RY6A 1F9TA 3CJOA 2X7EA 1MNEA 2FL2A 2G1QA 1BR2A 4H1GA 2VVGA 1YRSA 3NWNA 3L1CA 2HEHA 2ZFIA 3H4SA 1BG2A 3DC4A 3K3BA 2OWMA 1F9WA 4A50A 4A14A 4A28A 2X51A 4PFPA 2PG2A 3COBA 3BFNA 4E7ZA 1T5CA 2XAEA 1LVKA 4A5YA 4ANJA 1VFZA 1MMGA 4DBQA 4Y05A 1X88A 3WRDA 3X2TA 4GKRA 2ZFKA 2WOGA 3GBJA 2FL6A 1VFWA 5LT2A 2Q2YA 2XT3A 2Q2ZA 1LKXA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4ETP A;  1N6M A;  5LT3 A;  1F9U A;  1I5S A;  4BBG A;  5GSZ A;  1I6I A;  1V8J A;  4FRZ A;  1D0Y A;  1VFX A;  3ZFC A;  1BR4 A;  1KK7 A;  4UBF A;  2Y65 A;  5LT0 A;  3ZCW A;  2MYS A;  4E7S A;  3WPN A;  2FKY A;  2GM1 A;  1F9V A;  3PXN A;  4PJM A;  1GOJ A;  1CZ7 A;  1MMD A;  3LRE A;  4ZHI A;  2UYI A;  2GRY A;  1VOM A;  5LT4 A;  1D1B A;  4PK4 A;  4A51 A;  5HLE A;  1Q0B A;  1FMW A;  4A1Z A;  3L9H A;  2V26 A;  1D1C A;  4PJL A;  1V8K A;  2X2R A;  1II6 A;  2ZFM A;  1MMA A;  3KAR A;  3B6V A;  2VAS A;  1FMV A;  3U06 A;  4BXN A;  3KEN A;  3HQD A;  4B7B A;  3T0Q A;  1D1A A;  1G8X A;  2FME A;  4HNA K;  2KIN A;  2X7D A;  2ZFL A;  4PJN A;  2ZFJ A;  4PFO A;  4DBR A;  1VFV A;  1BR1 A;  3K5E A;  2UYM A;  4PJJ A;  4BN2 A;  4AP0 A;  3ZFD A;  1MKJ A;  2NCD A;  4AS7 A;  3B6U A;  3KIN A;  2IEH A;  1D0Z A;  2VB6 A;  1MMN A;  1SDM A;  1D0X A;  2Y5W A;  2X7C A;  3CNZ A;  4LNU K;  4ZCA A;  3DCB A;  5LT1 A;  1RY6 A;  1F9T A;  3CJO A;  2X7E A;  1MNE A;  2FL2 A;  2G1Q A;  1BR2 A;  4H1G A;  2VVG A;  1YRS A;  3NWN A;  3L1C A;  2HEH A;  2ZFI A;  3H4S A;  1BG2 A;  3DC4 A;  3K3B A;  2OWM A;  1F9W A;  4A50 A;  4A14 A;  4A28 A;  2X51 A;  4PFP A;  2PG2 A;  3COB A;  3BFN A;  4E7Z A;  1T5C A;  2XAE A;  1LVK A;  4A5Y A;  4ANJ A;  1VFZ A;  1MMG A;  4DBQ A;  4Y05 A;  1X88 A;  3WRD A;  3X2T A;  4GKR A;  2ZFK A;  2WOG A;  3GBJ A;  2FL6 A;  1VFW A;  5LT2 A;  2Q2Y A;  2XT3 A;  2Q2Z A;  1LKX A; 
#chains in the Genus database with same CATH topology
 4ETP A;  1N6M A;  5LT3 A;  1F9U A;  1I5S A;  4BBG A;  5GSZ A;  1I6I A;  1V8J A;  4ETP B;  4FRZ A;  1D0Y A;  1VFX A;  3ZFC A;  1BR4 A;  1KK7 A;  4UBF A;  2Y65 A;  5LT0 A;  3ZCW A;  2MYS A;  4E7S A;  3WPN A;  2FKY A;  2GM1 A;  1F9V A;  3PXN A;  4PJM A;  1GOJ A;  1CZ7 A;  1MMD A;  3LRE A;  4ZHI A;  2UYI A;  2GRY A;  1VOM A;  5LT4 A;  1D1B A;  4PK4 A;  4A51 A;  5HLE A;  1Q0B A;  1FMW A;  4A1Z A;  3L9H A;  2V26 A;  1D1C A;  4PJL A;  1V8K A;  2X2R A;  1II6 A;  2ZFM A;  1MMA A;  3KAR A;  3B6V A;  2VAS A;  1FMV A;  3U06 A;  4BXN A;  3KEN A;  3HQD A;  4B7B A;  3T0Q A;  1D1A A;  1G8X A;  2FME A;  4HNA K;  2KIN A;  2X7D A;  2ZFL A;  4PJN A;  2ZFJ A;  4PFO A;  4DBR A;  1VFV A;  1BR1 A;  3K5E A;  2UYM A;  4PJJ A;  4BN2 A;  4AP0 A;  3ZFD A;  1MKJ A;  2NCD A;  4AS7 A;  3B6U A;  3KIN A;  2IEH A;  1D0Z A;  2VB6 A;  1MMN A;  1SDM A;  1D0X A;  2Y5W A;  2X7C A;  3CNZ A;  4GKQ A;  4LNU K;  4ZCA A;  3DCB A;  5LT1 A;  1RY6 A;  1F9T A;  3CJO A;  2X7E A;  1MNE A;  2FL2 A;  2G1Q A;  1BR2 A;  4H1G A;  2VVG A;  1YRS A;  2O0A A;  3NWN A;  3L1C A;  2HEH A;  2ZFI A;  3H4S A;  1BG2 A;  3DC4 A;  3K3B A;  2OWM A;  1F9W A;  4A50 A;  4A14 A;  4A28 A;  2X51 A;  4PFP A;  2PG2 A;  3COB A;  3BFN A;  4E7Z A;  1T5C A;  2XAE A;  1LVK A;  4A5Y A;  4ANJ A;  1VFZ A;  1MMG A;  4DBQ A;  4Y05 A;  1X88 A;  3WRD A;  3X2T A;  4GKR A;  2ZFK A;  2WOG A;  3GBJ A;  2FL6 A;  1VFW A;  5LT2 A;  2Q2Y A;  4GKP A;  2XT3 A;  2Q2Z A;  1LKX A; 
#chains in the Genus database with same CATH homology
 4ETP A;  1N6M A;  5LT3 A;  1F9U A;  1I5S A;  4BBG A;  5GSZ A;  1I6I A;  1V8J A;  4FRZ A;  1D0Y A;  1VFX A;  3ZFC A;  1BR4 A;  1KK7 A;  4UBF A;  2Y65 A;  5LT0 A;  3ZCW A;  2MYS A;  4E7S A;  3WPN A;  2FKY A;  2GM1 A;  1F9V A;  3PXN A;  4PJM A;  1GOJ A;  1CZ7 A;  1MMD A;  3LRE A;  4ZHI A;  2UYI A;  2GRY A;  1VOM A;  5LT4 A;  1D1B A;  4PK4 A;  4A51 A;  5HLE A;  1Q0B A;  1FMW A;  4A1Z A;  3L9H A;  2V26 A;  1D1C A;  4PJL A;  1V8K A;  2X2R A;  1II6 A;  2ZFM A;  1MMA A;  3KAR A;  3B6V A;  2VAS A;  1FMV A;  3U06 A;  4BXN A;  3KEN A;  3HQD A;  4B7B A;  3T0Q A;  1D1A A;  1G8X A;  2FME A;  4HNA K;  2KIN A;  2X7D A;  2ZFL A;  4PJN A;  2ZFJ A;  4PFO A;  4DBR A;  1VFV A;  1BR1 A;  3K5E A;  2UYM A;  4PJJ A;  4BN2 A;  4AP0 A;  3ZFD A;  1MKJ A;  2NCD A;  4AS7 A;  3B6U A;  3KIN A;  2IEH A;  1D0Z A;  2VB6 A;  1MMN A;  1SDM A;  1D0X A;  2Y5W A;  2X7C A;  3CNZ A;  4LNU K;  4ZCA A;  3DCB A;  5LT1 A;  1RY6 A;  1F9T A;  3CJO A;  2X7E A;  1MNE A;  2FL2 A;  2G1Q A;  1BR2 A;  4H1G A;  2VVG A;  1YRS A;  3NWN A;  3L1C A;  2HEH A;  2ZFI A;  3H4S A;  1BG2 A;  3DC4 A;  3K3B A;  2OWM A;  1F9W A;  4A50 A;  4A14 A;  4A28 A;  2X51 A;  4PFP A;  2PG2 A;  3COB A;  3BFN A;  4E7Z A;  1T5C A;  2XAE A;  1LVK A;  4A5Y A;  4ANJ A;  1VFZ A;  1MMG A;  4DBQ A;  4Y05 A;  1X88 A;  3WRD A;  3X2T A;  4GKR A;  2ZFK A;  2WOG A;  3GBJ A;  2FL6 A;  1VFW A;  5LT2 A;  2Q2Y A;  2XT3 A;  2Q2Z A;  1LKX A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...