2X7EA

Crystal structure of human kinesin eg5 in complex with (r)-fluorastrol
Total Genus 104
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
104
sequence length
348
structure length
333
Chain Sequence
KNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural Basis for Inhibition of Eg5 by Dihydropyrimidines: Stereoselectivity of Antimitotic Inhibitors Enastron, Dimethylenastron and Fluorastrol.
pubmed doi rcsb
molecule keywords KINESIN-LIKE PROTEIN KIF11
molecule tags Cell cycle
source organism Homo sapiens
total genus 104
structure length 333
sequence length 348
chains with identical sequence B
ec nomenclature
pdb deposition date 2010-02-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 2x7eA00
3NWNA 1VFWA 1F9UA 2FL6A 2ZFJA 3KINA 4LNUK 3T0QA 3ZFCA 2UYMA 1D1BA 1VOMA 5HLEA 1I6IA 1D0XA 1F9WA 1F9VA 4AP0A 2GM1A 4B7BA 2ZFMA 4PJMA 2FL2A 3ZCWA 2ZFKA 4PFPA 3BFNA 2G1QA 3L1CA 1MKJA 2NCDA 3COBA 4A50A 4BBGA 3CJOA 3WPNA 5LT1A 2X51A 1MNEA 3HQDA 1II6A 2X7EA 1LKXA 1VFXA 2GRYA 1MMGA 1RY6A 4ZHIA 1T5CA 3H4SA 1KK7A 1VFZA 4AS7A 2VVGA 3ZFDA 5LT3A 2X2RA 4A5YA 5LT0A 1G8XA 3DCBA 2UYIA 1LVKA 1CZ7A 3X2TA 4E7SA 4PJLA 4BXNA 3B6VA 1BR1A 2KINA 3DC4A 3L9HA 1YRSA 2WOGA 2FKYA 1FMVA 3WRDA 3LREA 1BR4A 3KARA 4ANJA 2Q2ZA 4GKRA 1V8KA 5LT4A 3PXNA 4Y05A 4A14A 5GSZA 1I5SA 1MMDA 2Y5WA 3K3BA 1D1AA 2X7DA 2XT3A 2HEHA 4E7ZA 1D1CA 2X7CA 2FMEA 3U06A 2ZFLA 1BR2A 4A1ZA 2Q2YA 3B6UA 2VASA 3GBJA 1Q0BA 4PJNA 4UBFA 2MYSA 4HNAK 4FRZA 4PK4A 1VFVA 5LT2A 1MMAA 1FMWA 1D0YA 1D0ZA 4ZCAA 1N6MA 2XAEA 1SDMA 4ETPA 2OWMA 1X88A 1MMNA 4H1GA 4PJJA 2Y65A 1BG2A 4BN2A 1GOJA 3CNZA 4A28A 3KENA 3K5EA 1V8JA 4DBQA 4DBRA 1F9TA 2V26A 2PG2A 2ZFIA 2VB6A 2IEHA 4PFOA 4A51A
chains in the Genus database with same CATH superfamily
3NWNA 1VFWA 1F9UA 2FL6A 2ZFJA 3KINA 4LNUK 3T0QA 3ZFCA 2UYMA 1D1BA 1VOMA 5HLEA 1I6IA 1D0XA 1F9WA 1F9VA 4AP0A 2GM1A 4B7BA 2ZFMA 4PJMA 2FL2A 3ZCWA 2ZFKA 4PFPA 3BFNA 2G1QA 3L1CA 1MKJA 2NCDA 3COBA 4A50A 4BBGA 3CJOA 3WPNA 5LT1A 2X51A 1MNEA 3HQDA 1II6A 2X7EA 1LKXA 1VFXA 2GRYA 1MMGA 1RY6A 4ZHIA 1T5CA 3H4SA 1KK7A 1VFZA 4AS7A 2VVGA 3ZFDA 5LT3A 2X2RA 4A5YA 5LT0A 2O0AA 1G8XA 3DCBA 4ETPB 2UYIA 1LVKA 1CZ7A 3X2TA 4E7SA 4PJLA 4BXNA 3B6VA 1BR1A 2KINA 3DC4A 3L9HA 1YRSA 2WOGA 2FKYA 4GKQA 1FMVA 3WRDA 3LREA 1BR4A 3KARA 4ANJA 2Q2ZA 4GKRA 1V8KA 5LT4A 3PXNA 4Y05A 4A14A 5GSZA 1I5SA 1MMDA 2Y5WA 3K3BA 1D1AA 2X7DA 2XT3A 2HEHA 4E7ZA 1D1CA 2X7CA 2FMEA 3U06A 2ZFLA 1BR2A 4A1ZA 2Q2YA 3B6UA 2VASA 3GBJA 1Q0BA 4PJNA 4UBFA 2MYSA 4HNAK 4FRZA 4PK4A 1VFVA 5LT2A 1MMAA 1FMWA 1D0YA 1D0ZA 4ZCAA 1N6MA 2XAEA 1SDMA 4ETPA 2OWMA 1X88A 1MMNA 4H1GA 4PJJA 2Y65A 1BG2A 4BN2A 4GKPA 1GOJA 3CNZA 4A28A 3KENA 3K5EA 1V8JA 4DBQA 4DBRA 1F9TA 2V26A 2PG2A 2ZFIA 2VB6A 2IEHA 4PFOA 4A51A
chains in the Genus database with same CATH topology
3NWNA 1VFWA 1F9UA 2FL6A 2ZFJA 3KINA 4LNUK 3T0QA 3ZFCA 2UYMA 1D1BA 1VOMA 5HLEA 1I6IA 1D0XA 1F9WA 1F9VA 4AP0A 2GM1A 4B7BA 2ZFMA 4PJMA 2FL2A 3ZCWA 2ZFKA 4PFPA 3BFNA 2G1QA 3L1CA 1MKJA 2NCDA 3COBA 4A50A 4BBGA 3CJOA 3WPNA 5LT1A 2X51A 1MNEA 3HQDA 1II6A 2X7EA 1LKXA 1VFXA 2GRYA 1MMGA 1RY6A 4ZHIA 1T5CA 3H4SA 1KK7A 1VFZA 4AS7A 2VVGA 3ZFDA 5LT3A 2X2RA 4A5YA 5LT0A 1G8XA 3DCBA 2UYIA 1LVKA 1CZ7A 3X2TA 4E7SA 4PJLA 4BXNA 3B6VA 1BR1A 2KINA 3DC4A 3L9HA 1YRSA 2WOGA 2FKYA 1FMVA 3WRDA 3LREA 1BR4A 3KARA 4ANJA 2Q2ZA 4GKRA 1V8KA 5LT4A 3PXNA 4Y05A 4A14A 5GSZA 1I5SA 1MMDA 2Y5WA 3K3BA 1D1AA 2X7DA 2XT3A 2HEHA 4E7ZA 1D1CA 2X7CA 2FMEA 3U06A 2ZFLA 1BR2A 4A1ZA 2Q2YA 3B6UA 2VASA 3GBJA 1Q0BA 4PJNA 4UBFA 2MYSA 4HNAK 4FRZA 4PK4A 1VFVA 5LT2A 1MMAA 1FMWA 1D0YA 1D0ZA 4ZCAA 1N6MA 2XAEA 1SDMA 4ETPA 2OWMA 1X88A 1MMNA 4H1GA 4PJJA 2Y65A 1BG2A 4BN2A 1GOJA 3CNZA 4A28A 3KENA 3K5EA 1V8JA 4DBQA 4DBRA 1F9TA 2V26A 2PG2A 2ZFIA 2VB6A 2IEHA 4PFOA 4A51A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3NWN A;  1VFW A;  1F9U A;  2FL6 A;  2ZFJ A;  3KIN A;  4LNU K;  3T0Q A;  3ZFC A;  2UYM A;  1D1B A;  1VOM A;  5HLE A;  1I6I A;  1D0X A;  1F9W A;  1F9V A;  4AP0 A;  2GM1 A;  4B7B A;  2ZFM A;  4PJM A;  2FL2 A;  3ZCW A;  2ZFK A;  4PFP A;  3BFN A;  2G1Q A;  3L1C A;  1MKJ A;  2NCD A;  3COB A;  4A50 A;  4BBG A;  3CJO A;  3WPN A;  5LT1 A;  2X51 A;  1MNE A;  3HQD A;  1II6 A;  2X7E A;  1LKX A;  1VFX A;  2GRY A;  1MMG A;  1RY6 A;  4ZHI A;  1T5C A;  3H4S A;  1KK7 A;  1VFZ A;  4AS7 A;  2VVG A;  3ZFD A;  5LT3 A;  2X2R A;  4A5Y A;  5LT0 A;  1G8X A;  3DCB A;  2UYI A;  1LVK A;  1CZ7 A;  3X2T A;  4E7S A;  4PJL A;  4BXN A;  3B6V A;  1BR1 A;  2KIN A;  3DC4 A;  3L9H A;  1YRS A;  2WOG A;  2FKY A;  1FMV A;  3WRD A;  3LRE A;  1BR4 A;  3KAR A;  4ANJ A;  2Q2Z A;  4GKR A;  1V8K A;  5LT4 A;  3PXN A;  4Y05 A;  4A14 A;  5GSZ A;  1I5S A;  1MMD A;  2Y5W A;  3K3B A;  1D1A A;  2X7D A;  2XT3 A;  2HEH A;  4E7Z A;  1D1C A;  2X7C A;  2FME A;  3U06 A;  2ZFL A;  1BR2 A;  4A1Z A;  2Q2Y A;  3B6U A;  2VAS A;  3GBJ A;  1Q0B A;  4PJN A;  4UBF A;  2MYS A;  4HNA K;  4FRZ A;  4PK4 A;  1VFV A;  5LT2 A;  1MMA A;  1FMW A;  1D0Y A;  1D0Z A;  4ZCA A;  1N6M A;  2XAE A;  1SDM A;  4ETP A;  2OWM A;  1X88 A;  1MMN A;  4H1G A;  4PJJ A;  2Y65 A;  1BG2 A;  4BN2 A;  1GOJ A;  3CNZ A;  4A28 A;  3KEN A;  3K5E A;  1V8J A;  4DBQ A;  4DBR A;  1F9T A;  2V26 A;  2PG2 A;  2ZFI A;  2VB6 A;  2IEH A;  4PFO A;  4A51 A; 
#chains in the Genus database with same CATH topology
 3NWN A;  1VFW A;  1F9U A;  2FL6 A;  2ZFJ A;  3KIN A;  4LNU K;  3T0Q A;  3ZFC A;  2UYM A;  1D1B A;  1VOM A;  5HLE A;  1I6I A;  1D0X A;  1F9W A;  1F9V A;  4AP0 A;  2GM1 A;  4B7B A;  2ZFM A;  4PJM A;  2FL2 A;  3ZCW A;  2ZFK A;  4PFP A;  3BFN A;  2G1Q A;  3L1C A;  1MKJ A;  2NCD A;  3COB A;  4A50 A;  4BBG A;  3CJO A;  3WPN A;  5LT1 A;  2X51 A;  1MNE A;  3HQD A;  1II6 A;  2X7E A;  1LKX A;  1VFX A;  2GRY A;  1MMG A;  1RY6 A;  4ZHI A;  1T5C A;  3H4S A;  1KK7 A;  1VFZ A;  4AS7 A;  2VVG A;  3ZFD A;  5LT3 A;  2X2R A;  4A5Y A;  5LT0 A;  2O0A A;  1G8X A;  3DCB A;  4ETP B;  2UYI A;  1LVK A;  1CZ7 A;  3X2T A;  4E7S A;  4PJL A;  4BXN A;  3B6V A;  1BR1 A;  2KIN A;  3DC4 A;  3L9H A;  1YRS A;  2WOG A;  2FKY A;  4GKQ A;  1FMV A;  3WRD A;  3LRE A;  1BR4 A;  3KAR A;  4ANJ A;  2Q2Z A;  4GKR A;  1V8K A;  5LT4 A;  3PXN A;  4Y05 A;  4A14 A;  5GSZ A;  1I5S A;  1MMD A;  2Y5W A;  3K3B A;  1D1A A;  2X7D A;  2XT3 A;  2HEH A;  4E7Z A;  1D1C A;  2X7C A;  2FME A;  3U06 A;  2ZFL A;  1BR2 A;  4A1Z A;  2Q2Y A;  3B6U A;  2VAS A;  3GBJ A;  1Q0B A;  4PJN A;  4UBF A;  2MYS A;  4HNA K;  4FRZ A;  4PK4 A;  1VFV A;  5LT2 A;  1MMA A;  1FMW A;  1D0Y A;  1D0Z A;  4ZCA A;  1N6M A;  2XAE A;  1SDM A;  4ETP A;  2OWM A;  1X88 A;  1MMN A;  4H1G A;  4PJJ A;  2Y65 A;  1BG2 A;  4BN2 A;  4GKP A;  1GOJ A;  3CNZ A;  4A28 A;  3KEN A;  3K5E A;  1V8J A;  4DBQ A;  4DBR A;  1F9T A;  2V26 A;  2PG2 A;  2ZFI A;  2VB6 A;  2IEH A;  4PFO A;  4A51 A; 
#chains in the Genus database with same CATH homology
 3NWN A;  1VFW A;  1F9U A;  2FL6 A;  2ZFJ A;  3KIN A;  4LNU K;  3T0Q A;  3ZFC A;  2UYM A;  1D1B A;  1VOM A;  5HLE A;  1I6I A;  1D0X A;  1F9W A;  1F9V A;  4AP0 A;  2GM1 A;  4B7B A;  2ZFM A;  4PJM A;  2FL2 A;  3ZCW A;  2ZFK A;  4PFP A;  3BFN A;  2G1Q A;  3L1C A;  1MKJ A;  2NCD A;  3COB A;  4A50 A;  4BBG A;  3CJO A;  3WPN A;  5LT1 A;  2X51 A;  1MNE A;  3HQD A;  1II6 A;  2X7E A;  1LKX A;  1VFX A;  2GRY A;  1MMG A;  1RY6 A;  4ZHI A;  1T5C A;  3H4S A;  1KK7 A;  1VFZ A;  4AS7 A;  2VVG A;  3ZFD A;  5LT3 A;  2X2R A;  4A5Y A;  5LT0 A;  1G8X A;  3DCB A;  2UYI A;  1LVK A;  1CZ7 A;  3X2T A;  4E7S A;  4PJL A;  4BXN A;  3B6V A;  1BR1 A;  2KIN A;  3DC4 A;  3L9H A;  1YRS A;  2WOG A;  2FKY A;  1FMV A;  3WRD A;  3LRE A;  1BR4 A;  3KAR A;  4ANJ A;  2Q2Z A;  4GKR A;  1V8K A;  5LT4 A;  3PXN A;  4Y05 A;  4A14 A;  5GSZ A;  1I5S A;  1MMD A;  2Y5W A;  3K3B A;  1D1A A;  2X7D A;  2XT3 A;  2HEH A;  4E7Z A;  1D1C A;  2X7C A;  2FME A;  3U06 A;  2ZFL A;  1BR2 A;  4A1Z A;  2Q2Y A;  3B6U A;  2VAS A;  3GBJ A;  1Q0B A;  4PJN A;  4UBF A;  2MYS A;  4HNA K;  4FRZ A;  4PK4 A;  1VFV A;  5LT2 A;  1MMA A;  1FMW A;  1D0Y A;  1D0Z A;  4ZCA A;  1N6M A;  2XAE A;  1SDM A;  4ETP A;  2OWM A;  1X88 A;  1MMN A;  4H1G A;  4PJJ A;  2Y65 A;  1BG2 A;  4BN2 A;  1GOJ A;  3CNZ A;  4A28 A;  3KEN A;  3K5E A;  1V8J A;  4DBQ A;  4DBR A;  1F9T A;  2V26 A;  2PG2 A;  2ZFI A;  2VB6 A;  2IEH A;  4PFO A;  4A51 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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