2XAEA

Crystal structure of human kinesin eg5 in complex with (r)-2-amino-3-((s)-2-methyl-1,1-diphenylbutylthio)propanoic acid
Total Genus 104
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
104
sequence length
348
structure length
328
Chain Sequence
KNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKEEELVKIGKLNLVDLAGSENNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure-Activity Relationship and Multidrug Resistance Study of New S-Trityl-L-Cysteine Derivatives as Inhibitors of Eg5.
pubmed doi rcsb
molecule keywords KINESIN-LIKE PROTEIN KIF11
molecule tags Cell cycle
source organism Homo sapiens
total genus 104
structure length 328
sequence length 348
chains with identical sequence B, C
ec nomenclature
pdb deposition date 2010-03-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 2xaeA00
1MMAA 1VFXA 4A51A 1D0YA 3L1CA 2OWMA 3U06A 2GM1A 3KARA 2Y65A 1Q0BA 4BXNA 2HEHA 4FRZA 3T0QA 2X51A 3DCBA 1D1AA 4PJLA 1KK7A 4ANJA 2X7DA 1D1BA 2ZFJA 1F9TA 3X2TA 2Q2YA 3K3BA 1D1CA 2NCDA 1SDMA 5HLEA 1BG2A 1GOJA 1MKJA 1II6A 4PJNA 2UYIA 2VVGA 1BR1A 1X88A 2ZFKA 3PXNA 2IEHA 1YRSA 2Q2ZA 2X7EA 2FL2A 1D0ZA 1BR2A 4DBRA 3GBJA 4ZCAA 1D0XA 5GSZA 2VASA 1VFWA 1FMWA 2ZFMA 1I5SA 2GRYA 2VB6A 5LT4A 3COBA 2Y5WA 1V8JA 4A5YA 1LVKA 4E7SA 4ETPA 4PK4A 2ZFLA 4Y05A 4A1ZA 4PJMA 1VOMA 1MMNA 1LKXA 1F9WA 4A14A 2FKYA 3KINA 3H4SA 2FMEA 1MMDA 3HQDA 2WOGA 4LNUK 2UYMA 3K5EA 3L9HA 4ZHIA 1FMVA 3KENA 3WRDA 2MYSA 3CNZA 5LT1A 1BR4A 4UBFA 4AS7A 4PJJA 3B6VA 1F9UA 1V8KA 3DC4A 4BN2A 2FL6A 1MNEA 3WPNA 2ZFIA 4A28A 3NWNA 4GKRA 4DBQA 4PFPA 4B7BA 3ZFCA 4PFOA 5LT3A 4E7ZA 2X7CA 1I6IA 1G8XA 3BFNA 2G1QA 5LT0A 1VFZA 5LT2A 4H1GA 1CZ7A 2KINA 2X2RA 3LREA 4AP0A 1N6MA 2XT3A 1RY6A 2V26A 4HNAK 4A50A 2PG2A 4BBGA 3B6UA 1MMGA 1T5CA 1VFVA 3ZFDA 2XAEA 3ZCWA 1F9VA 3CJOA
chains in the Genus database with same CATH superfamily
1MMAA 1VFXA 4A51A 1D0YA 3L1CA 2OWMA 3U06A 2GM1A 3KARA 2Y65A 1Q0BA 4BXNA 2HEHA 4FRZA 3T0QA 2X51A 3DCBA 1D1AA 4PJLA 1KK7A 4ANJA 2X7DA 1D1BA 2ZFJA 1F9TA 3X2TA 2O0AA 2Q2YA 3K3BA 1D1CA 2NCDA 1SDMA 5HLEA 1BG2A 1GOJA 1MKJA 1II6A 4PJNA 2UYIA 2VVGA 1BR1A 1X88A 2ZFKA 3PXNA 2IEHA 1YRSA 2Q2ZA 2X7EA 2FL2A 4GKPA 1D0ZA 1BR2A 4DBRA 3GBJA 4ZCAA 1D0XA 5GSZA 2VASA 1VFWA 1FMWA 2ZFMA 1I5SA 2GRYA 2VB6A 5LT4A 3COBA 2Y5WA 1V8JA 4A5YA 1LVKA 4E7SA 4ETPA 4PK4A 2ZFLA 4Y05A 4A1ZA 4PJMA 1VOMA 1MMNA 1LKXA 1F9WA 4A14A 2FKYA 3KINA 3H4SA 2FMEA 1MMDA 3HQDA 2WOGA 4LNUK 2UYMA 3K5EA 3L9HA 4ZHIA 1FMVA 3KENA 3WRDA 2MYSA 3CNZA 5LT1A 1BR4A 4UBFA 4AS7A 4PJJA 3B6VA 1F9UA 1V8KA 3DC4A 4BN2A 4ETPB 2FL6A 1MNEA 3WPNA 2ZFIA 4A28A 3NWNA 4GKRA 4DBQA 4GKQA 4PFPA 4B7BA 3ZFCA 4PFOA 5LT3A 4E7ZA 2X7CA 1I6IA 1G8XA 3BFNA 2G1QA 5LT0A 1VFZA 5LT2A 4H1GA 1CZ7A 2KINA 2X2RA 3LREA 4AP0A 1N6MA 2XT3A 1RY6A 2V26A 4HNAK 4A50A 2PG2A 4BBGA 3B6UA 1MMGA 1T5CA 1VFVA 3ZFDA 2XAEA 3ZCWA 1F9VA 3CJOA
chains in the Genus database with same CATH topology
1MMAA 1VFXA 4A51A 1D0YA 3L1CA 2OWMA 3U06A 2GM1A 3KARA 2Y65A 1Q0BA 4BXNA 2HEHA 4FRZA 3T0QA 2X51A 3DCBA 1D1AA 4PJLA 1KK7A 4ANJA 2X7DA 1D1BA 2ZFJA 1F9TA 3X2TA 2Q2YA 3K3BA 1D1CA 2NCDA 1SDMA 5HLEA 1BG2A 1GOJA 1MKJA 1II6A 4PJNA 2UYIA 2VVGA 1BR1A 1X88A 2ZFKA 3PXNA 2IEHA 1YRSA 2Q2ZA 2X7EA 2FL2A 1D0ZA 1BR2A 4DBRA 3GBJA 4ZCAA 1D0XA 5GSZA 2VASA 1VFWA 1FMWA 2ZFMA 1I5SA 2GRYA 2VB6A 5LT4A 3COBA 2Y5WA 1V8JA 4A5YA 1LVKA 4E7SA 4ETPA 4PK4A 2ZFLA 4Y05A 4A1ZA 4PJMA 1VOMA 1MMNA 1LKXA 1F9WA 4A14A 2FKYA 3KINA 3H4SA 2FMEA 1MMDA 3HQDA 2WOGA 4LNUK 2UYMA 3K5EA 3L9HA 4ZHIA 1FMVA 3KENA 3WRDA 2MYSA 3CNZA 5LT1A 1BR4A 4UBFA 4AS7A 4PJJA 3B6VA 1F9UA 1V8KA 3DC4A 4BN2A 2FL6A 1MNEA 3WPNA 2ZFIA 4A28A 3NWNA 4GKRA 4DBQA 4PFPA 4B7BA 3ZFCA 4PFOA 5LT3A 4E7ZA 2X7CA 1I6IA 1G8XA 3BFNA 2G1QA 5LT0A 1VFZA 5LT2A 4H1GA 1CZ7A 2KINA 2X2RA 3LREA 4AP0A 1N6MA 2XT3A 1RY6A 2V26A 4HNAK 4A50A 2PG2A 4BBGA 3B6UA 1MMGA 1T5CA 1VFVA 3ZFDA 2XAEA 3ZCWA 1F9VA 3CJOA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1MMA A;  1VFX A;  4A51 A;  1D0Y A;  3L1C A;  2OWM A;  3U06 A;  2GM1 A;  3KAR A;  2Y65 A;  1Q0B A;  4BXN A;  2HEH A;  4FRZ A;  3T0Q A;  2X51 A;  3DCB A;  1D1A A;  4PJL A;  1KK7 A;  4ANJ A;  2X7D A;  1D1B A;  2ZFJ A;  1F9T A;  3X2T A;  2Q2Y A;  3K3B A;  1D1C A;  2NCD A;  1SDM A;  5HLE A;  1BG2 A;  1GOJ A;  1MKJ A;  1II6 A;  4PJN A;  2UYI A;  2VVG A;  1BR1 A;  1X88 A;  2ZFK A;  3PXN A;  2IEH A;  1YRS A;  2Q2Z A;  2X7E A;  2FL2 A;  1D0Z A;  1BR2 A;  4DBR A;  3GBJ A;  4ZCA A;  1D0X A;  5GSZ A;  2VAS A;  1VFW A;  1FMW A;  2ZFM A;  1I5S A;  2GRY A;  2VB6 A;  5LT4 A;  3COB A;  2Y5W A;  1V8J A;  4A5Y A;  1LVK A;  4E7S A;  4ETP A;  4PK4 A;  2ZFL A;  4Y05 A;  4A1Z A;  4PJM A;  1VOM A;  1MMN A;  1LKX A;  1F9W A;  4A14 A;  2FKY A;  3KIN A;  3H4S A;  2FME A;  1MMD A;  3HQD A;  2WOG A;  4LNU K;  2UYM A;  3K5E A;  3L9H A;  4ZHI A;  1FMV A;  3KEN A;  3WRD A;  2MYS A;  3CNZ A;  5LT1 A;  1BR4 A;  4UBF A;  4AS7 A;  4PJJ A;  3B6V A;  1F9U A;  1V8K A;  3DC4 A;  4BN2 A;  2FL6 A;  1MNE A;  3WPN A;  2ZFI A;  4A28 A;  3NWN A;  4GKR A;  4DBQ A;  4PFP A;  4B7B A;  3ZFC A;  4PFO A;  5LT3 A;  4E7Z A;  2X7C A;  1I6I A;  1G8X A;  3BFN A;  2G1Q A;  5LT0 A;  1VFZ A;  5LT2 A;  4H1G A;  1CZ7 A;  2KIN A;  2X2R A;  3LRE A;  4AP0 A;  1N6M A;  2XT3 A;  1RY6 A;  2V26 A;  4HNA K;  4A50 A;  2PG2 A;  4BBG A;  3B6U A;  1MMG A;  1T5C A;  1VFV A;  3ZFD A;  2XAE A;  3ZCW A;  1F9V A;  3CJO A; 
#chains in the Genus database with same CATH topology
 1MMA A;  1VFX A;  4A51 A;  1D0Y A;  3L1C A;  2OWM A;  3U06 A;  2GM1 A;  3KAR A;  2Y65 A;  1Q0B A;  4BXN A;  2HEH A;  4FRZ A;  3T0Q A;  2X51 A;  3DCB A;  1D1A A;  4PJL A;  1KK7 A;  4ANJ A;  2X7D A;  1D1B A;  2ZFJ A;  1F9T A;  3X2T A;  2O0A A;  2Q2Y A;  3K3B A;  1D1C A;  2NCD A;  1SDM A;  5HLE A;  1BG2 A;  1GOJ A;  1MKJ A;  1II6 A;  4PJN A;  2UYI A;  2VVG A;  1BR1 A;  1X88 A;  2ZFK A;  3PXN A;  2IEH A;  1YRS A;  2Q2Z A;  2X7E A;  2FL2 A;  4GKP A;  1D0Z A;  1BR2 A;  4DBR A;  3GBJ A;  4ZCA A;  1D0X A;  5GSZ A;  2VAS A;  1VFW A;  1FMW A;  2ZFM A;  1I5S A;  2GRY A;  2VB6 A;  5LT4 A;  3COB A;  2Y5W A;  1V8J A;  4A5Y A;  1LVK A;  4E7S A;  4ETP A;  4PK4 A;  2ZFL A;  4Y05 A;  4A1Z A;  4PJM A;  1VOM A;  1MMN A;  1LKX A;  1F9W A;  4A14 A;  2FKY A;  3KIN A;  3H4S A;  2FME A;  1MMD A;  3HQD A;  2WOG A;  4LNU K;  2UYM A;  3K5E A;  3L9H A;  4ZHI A;  1FMV A;  3KEN A;  3WRD A;  2MYS A;  3CNZ A;  5LT1 A;  1BR4 A;  4UBF A;  4AS7 A;  4PJJ A;  3B6V A;  1F9U A;  1V8K A;  3DC4 A;  4BN2 A;  4ETP B;  2FL6 A;  1MNE A;  3WPN A;  2ZFI A;  4A28 A;  3NWN A;  4GKR A;  4DBQ A;  4GKQ A;  4PFP A;  4B7B A;  3ZFC A;  4PFO A;  5LT3 A;  4E7Z A;  2X7C A;  1I6I A;  1G8X A;  3BFN A;  2G1Q A;  5LT0 A;  1VFZ A;  5LT2 A;  4H1G A;  1CZ7 A;  2KIN A;  2X2R A;  3LRE A;  4AP0 A;  1N6M A;  2XT3 A;  1RY6 A;  2V26 A;  4HNA K;  4A50 A;  2PG2 A;  4BBG A;  3B6U A;  1MMG A;  1T5C A;  1VFV A;  3ZFD A;  2XAE A;  3ZCW A;  1F9V A;  3CJO A; 
#chains in the Genus database with same CATH homology
 1MMA A;  1VFX A;  4A51 A;  1D0Y A;  3L1C A;  2OWM A;  3U06 A;  2GM1 A;  3KAR A;  2Y65 A;  1Q0B A;  4BXN A;  2HEH A;  4FRZ A;  3T0Q A;  2X51 A;  3DCB A;  1D1A A;  4PJL A;  1KK7 A;  4ANJ A;  2X7D A;  1D1B A;  2ZFJ A;  1F9T A;  3X2T A;  2Q2Y A;  3K3B A;  1D1C A;  2NCD A;  1SDM A;  5HLE A;  1BG2 A;  1GOJ A;  1MKJ A;  1II6 A;  4PJN A;  2UYI A;  2VVG A;  1BR1 A;  1X88 A;  2ZFK A;  3PXN A;  2IEH A;  1YRS A;  2Q2Z A;  2X7E A;  2FL2 A;  1D0Z A;  1BR2 A;  4DBR A;  3GBJ A;  4ZCA A;  1D0X A;  5GSZ A;  2VAS A;  1VFW A;  1FMW A;  2ZFM A;  1I5S A;  2GRY A;  2VB6 A;  5LT4 A;  3COB A;  2Y5W A;  1V8J A;  4A5Y A;  1LVK A;  4E7S A;  4ETP A;  4PK4 A;  2ZFL A;  4Y05 A;  4A1Z A;  4PJM A;  1VOM A;  1MMN A;  1LKX A;  1F9W A;  4A14 A;  2FKY A;  3KIN A;  3H4S A;  2FME A;  1MMD A;  3HQD A;  2WOG A;  4LNU K;  2UYM A;  3K5E A;  3L9H A;  4ZHI A;  1FMV A;  3KEN A;  3WRD A;  2MYS A;  3CNZ A;  5LT1 A;  1BR4 A;  4UBF A;  4AS7 A;  4PJJ A;  3B6V A;  1F9U A;  1V8K A;  3DC4 A;  4BN2 A;  2FL6 A;  1MNE A;  3WPN A;  2ZFI A;  4A28 A;  3NWN A;  4GKR A;  4DBQ A;  4PFP A;  4B7B A;  3ZFC A;  4PFO A;  5LT3 A;  4E7Z A;  2X7C A;  1I6I A;  1G8X A;  3BFN A;  2G1Q A;  5LT0 A;  1VFZ A;  5LT2 A;  4H1G A;  1CZ7 A;  2KIN A;  2X2R A;  3LRE A;  4AP0 A;  1N6M A;  2XT3 A;  1RY6 A;  2V26 A;  4HNA K;  4A50 A;  2PG2 A;  4BBG A;  3B6U A;  1MMG A;  1T5C A;  1VFV A;  3ZFD A;  2XAE A;  3ZCW A;  1F9V A;  3CJO A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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