3K3BA

Co-crystal structure of the human kinesin eg5 with a novel tetrahydro-beta-carboline
Total Genus 103

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
103
sequence length
349
structure length
335
Chain Sequence
GKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSEAGNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPE
5010015020025030030025020015010050
020406080100Genus Matrix

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
EMPTYTVIb1 (58-61)TIV1 (16-19)TVIII2 (306-309)S1 (19-25)TI10 (310-313)AH1 (30-35)TIV2 (44-47)3H2 (321-323)S3 (49-53)TIV3 (55-58)S4 (63-67)S6 (98-105)TI2 (73-76)TI5 (130-133)AH2 (78-95)AH5 (209-228)TII5 (249-252)TIV6 (121-124)AH3 (111-116)TIV7 (122-125)TI3 (126-129)TI4 (127-130)TII3 (190-193)AH4 (135-150)TI9 (206-209)S7 (153-164)S8 (167-170)S9 (181-186)TI8 (177-180)TI6 (170-173)TI7 (173-176)S10 (194-197)TII2 (187-190)TIV9 (188-191)S11 (202-204)S13 (254-265)O1 (229-231)S12 (235-248)AH7 (315-320)TI11 (311-314)S14 (330-336)TIV10 (325-328)TIV4 (59-62)TIV5 (68-71)S5 (70-72)TII4 (196-199)3H1 (232-234)AH6 (285-304)Updating...
connected with : NaN
molecule tags Motor protein
source organism Homo sapiens
publication title The discovery of tetrahydro-beta-carbolines as inhibitors of the kinesin Eg5.
pubmed doi rcsb
molecule keywords Kinesin-like protein KIF11
total genus 103
structure length 335
sequence length 349
chains with identical sequence B
ec nomenclature
pdb deposition date 2009-10-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 3k3bA00
5LT3A 1FMWA 4H1GA 2PG2A 3L9HA 2WOGA 2NCDA 3WPNA 5HLEA 1F9TA 1V8JA 1N6MA 4PJLA 4ZHIA 3DCBA 3GBJA 2FL6A 3CJOA 2IEHA 4BXNA 5LT0A 2ZFJA 2X7DA 3L1CA 1LKXA 4PJJA 3BFNA 2V26A 2VB6A 4ZCAA 2ZFIA 1BR2A 2MYSA 1MMDA 4Y05A 2ZFLA 1F9UA 5LT1A 5GSZA 1VFZA 3KENA 3CNZA 1BR4A 4ANJA 1D0ZA 2X2RA 1Q0BA 4BBGA 4AS7A 2Y65A 4FRZA 3KARA 1FMVA 4LNUK 1D0YA 1VFXA 4E7SA 1I6IA 1I5SA 4AP0A 4ETPA 4DBRA 1G8XA 4B7BA 1VFVA 4PJMA 3ZFDA 2VASA 1SDMA 3PXNA 1MNEA 4A50A 4BN2A 4A1ZA 2ZFMA 4PJNA 4PFPA 4A5YA 3X2TA 1MMNA 3K5EA 2Y5WA 1V8KA 2VVGA 4A14A 2UYIA 1MKJA 4PFOA 1II6A 3ZFCA 1GOJA 1D0XA 2XT3A 4A51A 5LT4A 2OWMA 1X88A 2FMEA 4PK4A 2GM1A 1F9VA 1RY6A 2UYMA 3NWNA 4E7ZA 1D1CA 2FKYA 2Q2ZA 3ZCWA 1T5CA 5LT2A 3B6UA 3U06A 1YRSA 3DC4A 2XAEA 2X7EA 1F9WA 1MMAA 3KINA 2ZFKA 3HQDA 2KINA 1BG2A 1LVKA 2HEHA 3K3BA 1KK7A 3LREA 2X7CA 3COBA 1CZ7A 3B6VA 2FL2A 4GKRA 1VOMA 4UBFA 4A28A 3WRDA 1MMGA 3H4SA 1D1AA 2X51A 3T0QA 2G1QA 1BR1A 1D1BA 1VFWA 2GRYA 2Q2YA 4DBQA 4HNAK
chains in the Genus database with same CATH superfamily
5LT3A 1FMWA 4H1GA 2PG2A 3L9HA 2WOGA 2NCDA 3WPNA 5HLEA 1F9TA 1V8JA 1N6MA 4PJLA 4ZHIA 3DCBA 3GBJA 2FL6A 3CJOA 2IEHA 4BXNA 5LT0A 2ZFJA 2X7DA 3L1CA 1LKXA 4PJJA 3BFNA 2V26A 2VB6A 4ZCAA 2ZFIA 1BR2A 2MYSA 1MMDA 4Y05A 2ZFLA 1F9UA 5LT1A 5GSZA 1VFZA 3KENA 3CNZA 1BR4A 4ANJA 1D0ZA 2X2RA 1Q0BA 4BBGA 4AS7A 2Y65A 4FRZA 3KARA 1FMVA 4LNUK 1D0YA 1VFXA 4E7SA 1I6IA 1I5SA 4AP0A 4ETPA 4DBRA 1G8XA 4B7BA 1VFVA 4PJMA 3ZFDA 2VASA 1SDMA 3PXNA 1MNEA 4A50A 4BN2A 4A1ZA 2ZFMA 4PJNA 4PFPA 4ETPB 4A5YA 3X2TA 1MMNA 3K5EA 2Y5WA 1V8KA 2VVGA 4A14A 2UYIA 1MKJA 4PFOA 1II6A 3ZFCA 1GOJA 1D0XA 2XT3A 4A51A 4GKPA 5LT4A 2OWMA 1X88A 2FMEA 4PK4A 2GM1A 1F9VA 4GKQA 1RY6A 2UYMA 3NWNA 4E7ZA 1D1CA 2FKYA 2Q2ZA 3ZCWA 1T5CA 5LT2A 3B6UA 3U06A 1YRSA 3DC4A 2XAEA 2X7EA 1F9WA 1MMAA 3KINA 2ZFKA 2O0AA 3HQDA 2KINA 1BG2A 1LVKA 2HEHA 3K3BA 1KK7A 3LREA 2X7CA 3COBA 1CZ7A 3B6VA 2FL2A 4GKRA 1VOMA 4UBFA 4A28A 3WRDA 1MMGA 3H4SA 1D1AA 2X51A 3T0QA 2G1QA 1BR1A 1D1BA 1VFWA 2GRYA 2Q2YA 4DBQA 4HNAK
chains in the Genus database with same CATH topology
5LT3A 1FMWA 4H1GA 2PG2A 3L9HA 2WOGA 2NCDA 3WPNA 5HLEA 1F9TA 1V8JA 1N6MA 4PJLA 4ZHIA 3DCBA 3GBJA 2FL6A 3CJOA 2IEHA 4BXNA 5LT0A 2ZFJA 2X7DA 3L1CA 1LKXA 4PJJA 3BFNA 2V26A 2VB6A 4ZCAA 2ZFIA 1BR2A 2MYSA 1MMDA 4Y05A 2ZFLA 1F9UA 5LT1A 5GSZA 1VFZA 3KENA 3CNZA 1BR4A 4ANJA 1D0ZA 2X2RA 1Q0BA 4BBGA 4AS7A 2Y65A 4FRZA 3KARA 1FMVA 4LNUK 1D0YA 1VFXA 4E7SA 1I6IA 1I5SA 4AP0A 4ETPA 4DBRA 1G8XA 4B7BA 1VFVA 4PJMA 3ZFDA 2VASA 1SDMA 3PXNA 1MNEA 4A50A 4BN2A 4A1ZA 2ZFMA 4PJNA 4PFPA 4A5YA 3X2TA 1MMNA 3K5EA 2Y5WA 1V8KA 2VVGA 4A14A 2UYIA 1MKJA 4PFOA 1II6A 3ZFCA 1GOJA 1D0XA 2XT3A 4A51A 5LT4A 2OWMA 1X88A 2FMEA 4PK4A 2GM1A 1F9VA 1RY6A 2UYMA 3NWNA 4E7ZA 1D1CA 2FKYA 2Q2ZA 3ZCWA 1T5CA 5LT2A 3B6UA 3U06A 1YRSA 3DC4A 2XAEA 2X7EA 1F9WA 1MMAA 3KINA 2ZFKA 3HQDA 2KINA 1BG2A 1LVKA 2HEHA 3K3BA 1KK7A 3LREA 2X7CA 3COBA 1CZ7A 3B6VA 2FL2A 4GKRA 1VOMA 4UBFA 4A28A 3WRDA 1MMGA 3H4SA 1D1AA 2X51A 3T0QA 2G1QA 1BR1A 1D1BA 1VFWA 2GRYA 2Q2YA 4DBQA 4HNAK
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5LT3 A;  1FMW A;  4H1G A;  2PG2 A;  3L9H A;  2WOG A;  2NCD A;  3WPN A;  5HLE A;  1F9T A;  1V8J A;  1N6M A;  4PJL A;  4ZHI A;  3DCB A;  3GBJ A;  2FL6 A;  3CJO A;  2IEH A;  4BXN A;  5LT0 A;  2ZFJ A;  2X7D A;  3L1C A;  1LKX A;  4PJJ A;  3BFN A;  2V26 A;  2VB6 A;  4ZCA A;  2ZFI A;  1BR2 A;  2MYS A;  1MMD A;  4Y05 A;  2ZFL A;  1F9U A;  5LT1 A;  5GSZ A;  1VFZ A;  3KEN A;  3CNZ A;  1BR4 A;  4ANJ A;  1D0Z A;  2X2R A;  1Q0B A;  4BBG A;  4AS7 A;  2Y65 A;  4FRZ A;  3KAR A;  1FMV A;  4LNU K;  1D0Y A;  1VFX A;  4E7S A;  1I6I A;  1I5S A;  4AP0 A;  4ETP A;  4DBR A;  1G8X A;  4B7B A;  1VFV A;  4PJM A;  3ZFD A;  2VAS A;  1SDM A;  3PXN A;  1MNE A;  4A50 A;  4BN2 A;  4A1Z A;  2ZFM A;  4PJN A;  4PFP A;  4A5Y A;  3X2T A;  1MMN A;  3K5E A;  2Y5W A;  1V8K A;  2VVG A;  4A14 A;  2UYI A;  1MKJ A;  4PFO A;  1II6 A;  3ZFC A;  1GOJ A;  1D0X A;  2XT3 A;  4A51 A;  5LT4 A;  2OWM A;  1X88 A;  2FME A;  4PK4 A;  2GM1 A;  1F9V A;  1RY6 A;  2UYM A;  3NWN A;  4E7Z A;  1D1C A;  2FKY A;  2Q2Z A;  3ZCW A;  1T5C A;  5LT2 A;  3B6U A;  3U06 A;  1YRS A;  3DC4 A;  2XAE A;  2X7E A;  1F9W A;  1MMA A;  3KIN A;  2ZFK A;  3HQD A;  2KIN A;  1BG2 A;  1LVK A;  2HEH A;  3K3B A;  1KK7 A;  3LRE A;  2X7C A;  3COB A;  1CZ7 A;  3B6V A;  2FL2 A;  4GKR A;  1VOM A;  4UBF A;  4A28 A;  3WRD A;  1MMG A;  3H4S A;  1D1A A;  2X51 A;  3T0Q A;  2G1Q A;  1BR1 A;  1D1B A;  1VFW A;  2GRY A;  2Q2Y A;  4DBQ A;  4HNA K; 
#chains in the Genus database with same CATH topology
 5LT3 A;  1FMW A;  4H1G A;  2PG2 A;  3L9H A;  2WOG A;  2NCD A;  3WPN A;  5HLE A;  1F9T A;  1V8J A;  1N6M A;  4PJL A;  4ZHI A;  3DCB A;  3GBJ A;  2FL6 A;  3CJO A;  2IEH A;  4BXN A;  5LT0 A;  2ZFJ A;  2X7D A;  3L1C A;  1LKX A;  4PJJ A;  3BFN A;  2V26 A;  2VB6 A;  4ZCA A;  2ZFI A;  1BR2 A;  2MYS A;  1MMD A;  4Y05 A;  2ZFL A;  1F9U A;  5LT1 A;  5GSZ A;  1VFZ A;  3KEN A;  3CNZ A;  1BR4 A;  4ANJ A;  1D0Z A;  2X2R A;  1Q0B A;  4BBG A;  4AS7 A;  2Y65 A;  4FRZ A;  3KAR A;  1FMV A;  4LNU K;  1D0Y A;  1VFX A;  4E7S A;  1I6I A;  1I5S A;  4AP0 A;  4ETP A;  4DBR A;  1G8X A;  4B7B A;  1VFV A;  4PJM A;  3ZFD A;  2VAS A;  1SDM A;  3PXN A;  1MNE A;  4A50 A;  4BN2 A;  4A1Z A;  2ZFM A;  4PJN A;  4PFP A;  4ETP B;  4A5Y A;  3X2T A;  1MMN A;  3K5E A;  2Y5W A;  1V8K A;  2VVG A;  4A14 A;  2UYI A;  1MKJ A;  4PFO A;  1II6 A;  3ZFC A;  1GOJ A;  1D0X A;  2XT3 A;  4A51 A;  4GKP A;  5LT4 A;  2OWM A;  1X88 A;  2FME A;  4PK4 A;  2GM1 A;  1F9V A;  4GKQ A;  1RY6 A;  2UYM A;  3NWN A;  4E7Z A;  1D1C A;  2FKY A;  2Q2Z A;  3ZCW A;  1T5C A;  5LT2 A;  3B6U A;  3U06 A;  1YRS A;  3DC4 A;  2XAE A;  2X7E A;  1F9W A;  1MMA A;  3KIN A;  2ZFK A;  2O0A A;  3HQD A;  2KIN A;  1BG2 A;  1LVK A;  2HEH A;  3K3B A;  1KK7 A;  3LRE A;  2X7C A;  3COB A;  1CZ7 A;  3B6V A;  2FL2 A;  4GKR A;  1VOM A;  4UBF A;  4A28 A;  3WRD A;  1MMG A;  3H4S A;  1D1A A;  2X51 A;  3T0Q A;  2G1Q A;  1BR1 A;  1D1B A;  1VFW A;  2GRY A;  2Q2Y A;  4DBQ A;  4HNA K; 
#chains in the Genus database with same CATH homology
 5LT3 A;  1FMW A;  4H1G A;  2PG2 A;  3L9H A;  2WOG A;  2NCD A;  3WPN A;  5HLE A;  1F9T A;  1V8J A;  1N6M A;  4PJL A;  4ZHI A;  3DCB A;  3GBJ A;  2FL6 A;  3CJO A;  2IEH A;  4BXN A;  5LT0 A;  2ZFJ A;  2X7D A;  3L1C A;  1LKX A;  4PJJ A;  3BFN A;  2V26 A;  2VB6 A;  4ZCA A;  2ZFI A;  1BR2 A;  2MYS A;  1MMD A;  4Y05 A;  2ZFL A;  1F9U A;  5LT1 A;  5GSZ A;  1VFZ A;  3KEN A;  3CNZ A;  1BR4 A;  4ANJ A;  1D0Z A;  2X2R A;  1Q0B A;  4BBG A;  4AS7 A;  2Y65 A;  4FRZ A;  3KAR A;  1FMV A;  4LNU K;  1D0Y A;  1VFX A;  4E7S A;  1I6I A;  1I5S A;  4AP0 A;  4ETP A;  4DBR A;  1G8X A;  4B7B A;  1VFV A;  4PJM A;  3ZFD A;  2VAS A;  1SDM A;  3PXN A;  1MNE A;  4A50 A;  4BN2 A;  4A1Z A;  2ZFM A;  4PJN A;  4PFP A;  4A5Y A;  3X2T A;  1MMN A;  3K5E A;  2Y5W A;  1V8K A;  2VVG A;  4A14 A;  2UYI A;  1MKJ A;  4PFO A;  1II6 A;  3ZFC A;  1GOJ A;  1D0X A;  2XT3 A;  4A51 A;  5LT4 A;  2OWM A;  1X88 A;  2FME A;  4PK4 A;  2GM1 A;  1F9V A;  1RY6 A;  2UYM A;  3NWN A;  4E7Z A;  1D1C A;  2FKY A;  2Q2Z A;  3ZCW A;  1T5C A;  5LT2 A;  3B6U A;  3U06 A;  1YRS A;  3DC4 A;  2XAE A;  2X7E A;  1F9W A;  1MMA A;  3KIN A;  2ZFK A;  3HQD A;  2KIN A;  1BG2 A;  1LVK A;  2HEH A;  3K3B A;  1KK7 A;  3LRE A;  2X7C A;  3COB A;  1CZ7 A;  3B6V A;  2FL2 A;  4GKR A;  1VOM A;  4UBF A;  4A28 A;  3WRD A;  1MMG A;  3H4S A;  1D1A A;  2X51 A;  3T0Q A;  2G1Q A;  1BR1 A;  1D1B A;  1VFW A;  2GRY A;  2Q2Y A;  4DBQ A;  4HNA K; 
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