3L9HA

X-ray structure of mitotic kinesin-5 (ksp, kif11, eg5)in complex with the hexahydro-2h-pyrano[3,2-c]quinoline emd 534085
Total Genus 106

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
106
sequence length
347
structure length
331
Chain Sequence
GKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNK
5010015020025030030025020015010050
020406080100Genus Matrix

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
EMPTYS15 (329-336)AH1 (30-34)S4 (49-56)3H1 (45-47)S3 (41-44)AH8 (315-320)TIV10 (323-326)S5 (61-67)TI1 (57-60)S7 (98-105)TI2 (73-76)TI5 (130-133)AH2 (78-95)TI9 (310-313)TI8 (249-252)S11 (194-197)AH3 (111-116)TIV3 (120-123)TIV4 (121-124)TI3 (126-129)TI4 (127-130)AH4 (135-149)AH6 (231-234)TIV9 (228-231)S10 (181-186)S8 (153-164)S9 (167-170)TI6 (177-180)TIV6 (170-173)TIV7 (173-176)TIV8 (187-190)TI7 (190-193)TII2 (196-199)AH5 (210-227)S14 (254-265)TI10 (311-314)TVIII1 (306-309)S2 (20-25)TIV2 (68-71)S6 (70-72)TIV5 (163-166)AH7 (290-304)S12 (202-204)3H2 (207-209)S13 (236-248)3H3 (321-323)S1 (17-18)Updating...
connected with : NaN
molecule tags Motor protein
source organism Homo sapiens
publication title The discovery and optimization of hexahydro-2H-pyrano[3,2-c]quinolines (HHPQs) as potent and selective inhibitors of the mitotic kinesin-5.
pubmed doi rcsb
molecule keywords Kinesin-like protein KIF11
total genus 106
structure length 331
sequence length 347
chains with identical sequence B
ec nomenclature
pdb deposition date 2010-01-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 3l9hA00
2ZFIA 3NWNA 1Q0BA 1I5SA 3K3BA 1VOMA 1VFWA 2VASA 2Q2YA 2NCDA 1F9VA 2X2RA 4PJJA 4E7ZA 1KK7A 1F9WA 4DBQA 1I6IA 4B7BA 1T5CA 1N6MA 4PFPA 2PG2A 1YRSA 3L1CA 4ANJA 1D0XA 3BFNA 1G8XA 2G1QA 3HQDA 4DBRA 4FRZA 4HNAK 1MNEA 3KINA 4ZHIA 2V26A 1D0YA 1VFVA 1D1BA 3DCBA 2ZFMA 2OWMA 1F9TA 4BN2A 1MKJA 1V8JA 3U06A 1MMNA 5HLEA 3ZCWA 3B6UA 2FL6A 5GSZA 4H1GA 3GBJA 1FMWA 3ZFCA 2WOGA 2X51A 2Y5WA 3DC4A 4PK4A 3T0QA 1GOJA 4AS7A 1LVKA 4A5YA 2Q2ZA 1BR2A 1II6A 2VB6A 2Y65A 3B6VA 4E7SA 2ZFLA 2MYSA 2HEHA 1D1AA 4ZCAA 2KINA 2FL2A 2FKYA 3L9HA 1LKXA 3X2TA 2IEHA 3COBA 2VVGA 1X88A 5LT2A 1VFXA 4A51A 4ETPA 4A1ZA 1MMGA 3WPNA 1D0ZA 1VFZA 1D1CA 4A50A 1RY6A 1SDMA 1F9UA 1MMAA 4A14A 2UYIA 2XT3A 2FMEA 3KARA 3CNZA 2XAEA 2X7CA 5LT1A 2GRYA 5LT0A 2UYMA 5LT3A 2ZFKA 1BR1A 3H4SA 4AP0A 3PXNA 1V8KA 4PJLA 4A28A 4BBGA 2ZFJA 1MMDA 4UBFA 4PJMA 2GM1A 4LNUK 3K5EA 1FMVA 4Y05A 3KENA 3CJOA 1CZ7A 2X7EA 1BR4A 3LREA 5LT4A 4BXNA 2X7DA 1BG2A 3WRDA 4GKRA 4PJNA 3ZFDA 4PFOA
chains in the Genus database with same CATH superfamily
2ZFIA 3NWNA 1Q0BA 1I5SA 3K3BA 2O0AA 1VOMA 1VFWA 2VASA 2Q2YA 2NCDA 1F9VA 2X2RA 4PJJA 4E7ZA 1KK7A 1F9WA 4DBQA 1I6IA 4B7BA 1T5CA 1N6MA 4PFPA 2PG2A 1YRSA 3L1CA 4ANJA 1D0XA 3BFNA 1G8XA 2G1QA 3HQDA 4DBRA 4FRZA 4HNAK 1MNEA 3KINA 4ZHIA 2V26A 1D0YA 4GKQA 1VFVA 1D1BA 3DCBA 2ZFMA 2OWMA 1F9TA 4BN2A 1MKJA 1V8JA 3U06A 1MMNA 5HLEA 3ZCWA 3B6UA 2FL6A 5GSZA 4H1GA 3GBJA 1FMWA 3ZFCA 2WOGA 2X51A 2Y5WA 3DC4A 4PK4A 3T0QA 1GOJA 4AS7A 1LVKA 4A5YA 2Q2ZA 1BR2A 1II6A 2VB6A 2Y65A 3B6VA 4E7SA 2ZFLA 2MYSA 4ETPB 2HEHA 1D1AA 4ZCAA 2KINA 2FL2A 2FKYA 3L9HA 1LKXA 3X2TA 2IEHA 3COBA 2VVGA 1X88A 5LT2A 1VFXA 4A51A 4ETPA 4A1ZA 1MMGA 3WPNA 1D0ZA 1VFZA 1D1CA 4GKPA 4A50A 1RY6A 1SDMA 1F9UA 1MMAA 4A14A 2UYIA 2XT3A 2FMEA 3KARA 3CNZA 2XAEA 2X7CA 5LT1A 2GRYA 5LT0A 2UYMA 5LT3A 2ZFKA 1BR1A 3H4SA 4AP0A 3PXNA 1V8KA 4PJLA 4A28A 4BBGA 2ZFJA 1MMDA 4UBFA 4PJMA 2GM1A 4LNUK 3K5EA 1FMVA 4Y05A 3KENA 3CJOA 1CZ7A 2X7EA 1BR4A 3LREA 5LT4A 4BXNA 2X7DA 1BG2A 3WRDA 4GKRA 4PJNA 3ZFDA 4PFOA
chains in the Genus database with same CATH topology
2ZFIA 3NWNA 1Q0BA 1I5SA 3K3BA 1VOMA 1VFWA 2VASA 2Q2YA 2NCDA 1F9VA 2X2RA 4PJJA 4E7ZA 1KK7A 1F9WA 4DBQA 1I6IA 4B7BA 1T5CA 1N6MA 4PFPA 2PG2A 1YRSA 3L1CA 4ANJA 1D0XA 3BFNA 1G8XA 2G1QA 3HQDA 4DBRA 4FRZA 4HNAK 1MNEA 3KINA 4ZHIA 2V26A 1D0YA 1VFVA 1D1BA 3DCBA 2ZFMA 2OWMA 1F9TA 4BN2A 1MKJA 1V8JA 3U06A 1MMNA 5HLEA 3ZCWA 3B6UA 2FL6A 5GSZA 4H1GA 3GBJA 1FMWA 3ZFCA 2WOGA 2X51A 2Y5WA 3DC4A 4PK4A 3T0QA 1GOJA 4AS7A 1LVKA 4A5YA 2Q2ZA 1BR2A 1II6A 2VB6A 2Y65A 3B6VA 4E7SA 2ZFLA 2MYSA 2HEHA 1D1AA 4ZCAA 2KINA 2FL2A 2FKYA 3L9HA 1LKXA 3X2TA 2IEHA 3COBA 2VVGA 1X88A 5LT2A 1VFXA 4A51A 4ETPA 4A1ZA 1MMGA 3WPNA 1D0ZA 1VFZA 1D1CA 4A50A 1RY6A 1SDMA 1F9UA 1MMAA 4A14A 2UYIA 2XT3A 2FMEA 3KARA 3CNZA 2XAEA 2X7CA 5LT1A 2GRYA 5LT0A 2UYMA 5LT3A 2ZFKA 1BR1A 3H4SA 4AP0A 3PXNA 1V8KA 4PJLA 4A28A 4BBGA 2ZFJA 1MMDA 4UBFA 4PJMA 2GM1A 4LNUK 3K5EA 1FMVA 4Y05A 3KENA 3CJOA 1CZ7A 2X7EA 1BR4A 3LREA 5LT4A 4BXNA 2X7DA 1BG2A 3WRDA 4GKRA 4PJNA 3ZFDA 4PFOA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2ZFI A;  3NWN A;  1Q0B A;  1I5S A;  3K3B A;  1VOM A;  1VFW A;  2VAS A;  2Q2Y A;  2NCD A;  1F9V A;  2X2R A;  4PJJ A;  4E7Z A;  1KK7 A;  1F9W A;  4DBQ A;  1I6I A;  4B7B A;  1T5C A;  1N6M A;  4PFP A;  2PG2 A;  1YRS A;  3L1C A;  4ANJ A;  1D0X A;  3BFN A;  1G8X A;  2G1Q A;  3HQD A;  4DBR A;  4FRZ A;  4HNA K;  1MNE A;  3KIN A;  4ZHI A;  2V26 A;  1D0Y A;  1VFV A;  1D1B A;  3DCB A;  2ZFM A;  2OWM A;  1F9T A;  4BN2 A;  1MKJ A;  1V8J A;  3U06 A;  1MMN A;  5HLE A;  3ZCW A;  3B6U A;  2FL6 A;  5GSZ A;  4H1G A;  3GBJ A;  1FMW A;  3ZFC A;  2WOG A;  2X51 A;  2Y5W A;  3DC4 A;  4PK4 A;  3T0Q A;  1GOJ A;  4AS7 A;  1LVK A;  4A5Y A;  2Q2Z A;  1BR2 A;  1II6 A;  2VB6 A;  2Y65 A;  3B6V A;  4E7S A;  2ZFL A;  2MYS A;  2HEH A;  1D1A A;  4ZCA A;  2KIN A;  2FL2 A;  2FKY A;  3L9H A;  1LKX A;  3X2T A;  2IEH A;  3COB A;  2VVG A;  1X88 A;  5LT2 A;  1VFX A;  4A51 A;  4ETP A;  4A1Z A;  1MMG A;  3WPN A;  1D0Z A;  1VFZ A;  1D1C A;  4A50 A;  1RY6 A;  1SDM A;  1F9U A;  1MMA A;  4A14 A;  2UYI A;  2XT3 A;  2FME A;  3KAR A;  3CNZ A;  2XAE A;  2X7C A;  5LT1 A;  2GRY A;  5LT0 A;  2UYM A;  5LT3 A;  2ZFK A;  1BR1 A;  3H4S A;  4AP0 A;  3PXN A;  1V8K A;  4PJL A;  4A28 A;  4BBG A;  2ZFJ A;  1MMD A;  4UBF A;  4PJM A;  2GM1 A;  4LNU K;  3K5E A;  1FMV A;  4Y05 A;  3KEN A;  3CJO A;  1CZ7 A;  2X7E A;  1BR4 A;  3LRE A;  5LT4 A;  4BXN A;  2X7D A;  1BG2 A;  3WRD A;  4GKR A;  4PJN A;  3ZFD A;  4PFO A; 
#chains in the Genus database with same CATH topology
 2ZFI A;  3NWN A;  1Q0B A;  1I5S A;  3K3B A;  2O0A A;  1VOM A;  1VFW A;  2VAS A;  2Q2Y A;  2NCD A;  1F9V A;  2X2R A;  4PJJ A;  4E7Z A;  1KK7 A;  1F9W A;  4DBQ A;  1I6I A;  4B7B A;  1T5C A;  1N6M A;  4PFP A;  2PG2 A;  1YRS A;  3L1C A;  4ANJ A;  1D0X A;  3BFN A;  1G8X A;  2G1Q A;  3HQD A;  4DBR A;  4FRZ A;  4HNA K;  1MNE A;  3KIN A;  4ZHI A;  2V26 A;  1D0Y A;  4GKQ A;  1VFV A;  1D1B A;  3DCB A;  2ZFM A;  2OWM A;  1F9T A;  4BN2 A;  1MKJ A;  1V8J A;  3U06 A;  1MMN A;  5HLE A;  3ZCW A;  3B6U A;  2FL6 A;  5GSZ A;  4H1G A;  3GBJ A;  1FMW A;  3ZFC A;  2WOG A;  2X51 A;  2Y5W A;  3DC4 A;  4PK4 A;  3T0Q A;  1GOJ A;  4AS7 A;  1LVK A;  4A5Y A;  2Q2Z A;  1BR2 A;  1II6 A;  2VB6 A;  2Y65 A;  3B6V A;  4E7S A;  2ZFL A;  2MYS A;  4ETP B;  2HEH A;  1D1A A;  4ZCA A;  2KIN A;  2FL2 A;  2FKY A;  3L9H A;  1LKX A;  3X2T A;  2IEH A;  3COB A;  2VVG A;  1X88 A;  5LT2 A;  1VFX A;  4A51 A;  4ETP A;  4A1Z A;  1MMG A;  3WPN A;  1D0Z A;  1VFZ A;  1D1C A;  4GKP A;  4A50 A;  1RY6 A;  1SDM A;  1F9U A;  1MMA A;  4A14 A;  2UYI A;  2XT3 A;  2FME A;  3KAR A;  3CNZ A;  2XAE A;  2X7C A;  5LT1 A;  2GRY A;  5LT0 A;  2UYM A;  5LT3 A;  2ZFK A;  1BR1 A;  3H4S A;  4AP0 A;  3PXN A;  1V8K A;  4PJL A;  4A28 A;  4BBG A;  2ZFJ A;  1MMD A;  4UBF A;  4PJM A;  2GM1 A;  4LNU K;  3K5E A;  1FMV A;  4Y05 A;  3KEN A;  3CJO A;  1CZ7 A;  2X7E A;  1BR4 A;  3LRE A;  5LT4 A;  4BXN A;  2X7D A;  1BG2 A;  3WRD A;  4GKR A;  4PJN A;  3ZFD A;  4PFO A; 
#chains in the Genus database with same CATH homology
 2ZFI A;  3NWN A;  1Q0B A;  1I5S A;  3K3B A;  1VOM A;  1VFW A;  2VAS A;  2Q2Y A;  2NCD A;  1F9V A;  2X2R A;  4PJJ A;  4E7Z A;  1KK7 A;  1F9W A;  4DBQ A;  1I6I A;  4B7B A;  1T5C A;  1N6M A;  4PFP A;  2PG2 A;  1YRS A;  3L1C A;  4ANJ A;  1D0X A;  3BFN A;  1G8X A;  2G1Q A;  3HQD A;  4DBR A;  4FRZ A;  4HNA K;  1MNE A;  3KIN A;  4ZHI A;  2V26 A;  1D0Y A;  1VFV A;  1D1B A;  3DCB A;  2ZFM A;  2OWM A;  1F9T A;  4BN2 A;  1MKJ A;  1V8J A;  3U06 A;  1MMN A;  5HLE A;  3ZCW A;  3B6U A;  2FL6 A;  5GSZ A;  4H1G A;  3GBJ A;  1FMW A;  3ZFC A;  2WOG A;  2X51 A;  2Y5W A;  3DC4 A;  4PK4 A;  3T0Q A;  1GOJ A;  4AS7 A;  1LVK A;  4A5Y A;  2Q2Z A;  1BR2 A;  1II6 A;  2VB6 A;  2Y65 A;  3B6V A;  4E7S A;  2ZFL A;  2MYS A;  2HEH A;  1D1A A;  4ZCA A;  2KIN A;  2FL2 A;  2FKY A;  3L9H A;  1LKX A;  3X2T A;  2IEH A;  3COB A;  2VVG A;  1X88 A;  5LT2 A;  1VFX A;  4A51 A;  4ETP A;  4A1Z A;  1MMG A;  3WPN A;  1D0Z A;  1VFZ A;  1D1C A;  4A50 A;  1RY6 A;  1SDM A;  1F9U A;  1MMA A;  4A14 A;  2UYI A;  2XT3 A;  2FME A;  3KAR A;  3CNZ A;  2XAE A;  2X7C A;  5LT1 A;  2GRY A;  5LT0 A;  2UYM A;  5LT3 A;  2ZFK A;  1BR1 A;  3H4S A;  4AP0 A;  3PXN A;  1V8K A;  4PJL A;  4A28 A;  4BBG A;  2ZFJ A;  1MMD A;  4UBF A;  4PJM A;  2GM1 A;  4LNU K;  3K5E A;  1FMV A;  4Y05 A;  3KEN A;  3CJO A;  1CZ7 A;  2X7E A;  1BR4 A;  3LRE A;  5LT4 A;  4BXN A;  2X7D A;  1BG2 A;  3WRD A;  4GKR A;  4PJN A;  3ZFD A;  4PFO A; 
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similar chains in the Genus database (?% sequence similarity)
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