3LREA

Crystal structure analysis of human kinesin-8 motor domain
Total Genus 94
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
94
sequence length
342
structure length
289
Chain Sequence
MKVVVRVRPENTKEKAAGFHKVVHVVDKHILVFDNKDLKFVFDAVFDETSTQSEVFEHTTKPILRSFLNGYNCTVLAYGATGAGKTHTMLGSADEPGVMYLTMLHLYKCMDEIKEEKICSTAVSYLEVYNEQIRDLLVNSGPLAVREDTQKGVVVHGLTLHQPKSSEEILHLLDNGNKNRTQHATSSRSHAVFQIYLRQQDKTASINQNVRIAKMSLIDLAGSERNRSLLALGNVINALAIPYRNSKLTRLLKDSLGGNCQTIMIAAVSPSSVFYDDTYNTLKYANRAK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title Insight into the molecular mechanism of the multitasking kinesin-8 motor.
pubmed doi rcsb
molecule tags Motor protein
source organism Homo sapiens
molecule keywords Kinesin-like protein KIF18A
total genus 94
structure length 289
sequence length 342
chains with identical sequence B
ec nomenclature
pdb deposition date 2010-02-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 3lreA00
4A50A 3L1CA 4PJNA 3COBA 2Y5WA 4ZHIA 1RY6A 2VVGA 1VFVA 2WOGA 2NCDA 2Q2ZA 2IEHA 4ANJA 2FL6A 1V8KA 1VOMA 4PK4A 4PJJA 3BFNA 3CNZA 4E7SA 2ZFJA 4PFPA 2G1QA 4A14A 4ZCAA 2ZFLA 3KARA 3WPNA 1BR2A 1V8JA 4PFOA 3K5EA 4DBQA 4LNUK 4A28A 1F9TA 4B7BA 1LKXA 4PJLA 1F9WA 1GOJA 2V26A 1BG2A 4PJMA 4AS7A 1MKJA 5HLEA 1BR4A 3H4SA 2OWMA 2KINA 3B6VA 2X7CA 2X7EA 1D1CA 4GKRA 1MMNA 3DC4A 1N6MA 2PG2A 4BN2A 2ZFIA 3KENA 1I6IA 2UYMA 5LT4A 1FMWA 3X2TA 3K3BA 1T5CA 5LT3A 1FMVA 2FL2A 2HEHA 4BBGA 1Q0BA 5GSZA 1KK7A 2MYSA 2VASA 4FRZA 3NWNA 1CZ7A 1I5SA 3ZFDA 1VFWA 4ETPA 5LT1A 2GRYA 1G8XA 3PXNA 4A5YA 1VFZA 3LREA 2ZFMA 2Q2YA 1MMAA 4DBRA 3HQDA 3ZCWA 3DCBA 4BXNA 1MMDA 1F9VA 1D1AA 4H1GA 3T0QA 3L9HA 3B6UA 1BR1A 1MMGA 2GM1A 2XAEA 4Y05A 4A51A 1D0XA 3KINA 4AP0A 4UBFA 1II6A 1YRSA 3ZFCA 3CJOA 2UYIA 1X88A 3WRDA 2VB6A 2XT3A 4A1ZA 2X2RA 5LT2A 2Y65A 5LT0A 2X7DA 1F9UA 2FKYA 2X51A 4HNAK 3U06A 2ZFKA 1LVKA 4E7ZA 1D0ZA 1D1BA 1SDMA 2FMEA 1MNEA 1VFXA 1D0YA 3GBJA
chains in the Genus database with same CATH superfamily
4A50A 3L1CA 4PJNA 3COBA 2Y5WA 4ZHIA 1RY6A 2VVGA 1VFVA 2WOGA 2NCDA 2Q2ZA 2IEHA 4ANJA 2FL6A 1V8KA 1VOMA 4PK4A 4PJJA 3BFNA 3CNZA 4E7SA 2ZFJA 4PFPA 2G1QA 4A14A 4ZCAA 2ZFLA 3KARA 3WPNA 1BR2A 1V8JA 4PFOA 3K5EA 4DBQA 4LNUK 4A28A 4GKPA 1F9TA 4B7BA 1LKXA 4PJLA 1F9WA 4ETPB 1GOJA 2V26A 1BG2A 4PJMA 4AS7A 1MKJA 5HLEA 1BR4A 3H4SA 2OWMA 2KINA 3B6VA 2X7CA 2X7EA 1D1CA 4GKRA 1MMNA 3DC4A 1N6MA 2PG2A 4BN2A 2ZFIA 3KENA 1I6IA 2UYMA 5LT4A 1FMWA 3X2TA 3K3BA 1T5CA 5LT3A 1FMVA 2FL2A 2HEHA 4BBGA 1Q0BA 5GSZA 1KK7A 2MYSA 2VASA 4FRZA 3NWNA 1CZ7A 1I5SA 3ZFDA 1VFWA 4ETPA 5LT1A 2GRYA 1G8XA 3PXNA 4A5YA 4GKQA 1VFZA 3LREA 2ZFMA 2Q2YA 1MMAA 4DBRA 3HQDA 3ZCWA 3DCBA 4BXNA 1MMDA 1F9VA 1D1AA 4H1GA 3T0QA 3L9HA 3B6UA 1BR1A 1MMGA 2GM1A 2XAEA 4Y05A 4A51A 2O0AA 1D0XA 3KINA 4AP0A 4UBFA 1II6A 1YRSA 3ZFCA 3CJOA 2UYIA 1X88A 3WRDA 2VB6A 2XT3A 4A1ZA 2X2RA 5LT2A 2Y65A 5LT0A 2X7DA 1F9UA 2FKYA 2X51A 4HNAK 3U06A 2ZFKA 1LVKA 4E7ZA 1D0ZA 1D1BA 1SDMA 2FMEA 1MNEA 1VFXA 1D0YA 3GBJA
chains in the Genus database with same CATH topology
4A50A 3L1CA 4PJNA 3COBA 2Y5WA 4ZHIA 1RY6A 2VVGA 1VFVA 2WOGA 2NCDA 2Q2ZA 2IEHA 4ANJA 2FL6A 1V8KA 1VOMA 4PK4A 4PJJA 3BFNA 3CNZA 4E7SA 2ZFJA 4PFPA 2G1QA 4A14A 4ZCAA 2ZFLA 3KARA 3WPNA 1BR2A 1V8JA 4PFOA 3K5EA 4DBQA 4LNUK 4A28A 1F9TA 4B7BA 1LKXA 4PJLA 1F9WA 1GOJA 2V26A 1BG2A 4PJMA 4AS7A 1MKJA 5HLEA 1BR4A 3H4SA 2OWMA 2KINA 3B6VA 2X7CA 2X7EA 1D1CA 4GKRA 1MMNA 3DC4A 1N6MA 2PG2A 4BN2A 2ZFIA 3KENA 1I6IA 2UYMA 5LT4A 1FMWA 3X2TA 3K3BA 1T5CA 5LT3A 1FMVA 2FL2A 2HEHA 4BBGA 1Q0BA 5GSZA 1KK7A 2MYSA 2VASA 4FRZA 3NWNA 1CZ7A 1I5SA 3ZFDA 1VFWA 4ETPA 5LT1A 2GRYA 1G8XA 3PXNA 4A5YA 1VFZA 3LREA 2ZFMA 2Q2YA 1MMAA 4DBRA 3HQDA 3ZCWA 3DCBA 4BXNA 1MMDA 1F9VA 1D1AA 4H1GA 3T0QA 3L9HA 3B6UA 1BR1A 1MMGA 2GM1A 2XAEA 4Y05A 4A51A 1D0XA 3KINA 4AP0A 4UBFA 1II6A 1YRSA 3ZFCA 3CJOA 2UYIA 1X88A 3WRDA 2VB6A 2XT3A 4A1ZA 2X2RA 5LT2A 2Y65A 5LT0A 2X7DA 1F9UA 2FKYA 2X51A 4HNAK 3U06A 2ZFKA 1LVKA 4E7ZA 1D0ZA 1D1BA 1SDMA 2FMEA 1MNEA 1VFXA 1D0YA 3GBJA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4A50 A;  3L1C A;  4PJN A;  3COB A;  2Y5W A;  4ZHI A;  1RY6 A;  2VVG A;  1VFV A;  2WOG A;  2NCD A;  2Q2Z A;  2IEH A;  4ANJ A;  2FL6 A;  1V8K A;  1VOM A;  4PK4 A;  4PJJ A;  3BFN A;  3CNZ A;  4E7S A;  2ZFJ A;  4PFP A;  2G1Q A;  4A14 A;  4ZCA A;  2ZFL A;  3KAR A;  3WPN A;  1BR2 A;  1V8J A;  4PFO A;  3K5E A;  4DBQ A;  4LNU K;  4A28 A;  1F9T A;  4B7B A;  1LKX A;  4PJL A;  1F9W A;  1GOJ A;  2V26 A;  1BG2 A;  4PJM A;  4AS7 A;  1MKJ A;  5HLE A;  1BR4 A;  3H4S A;  2OWM A;  2KIN A;  3B6V A;  2X7C A;  2X7E A;  1D1C A;  4GKR A;  1MMN A;  3DC4 A;  1N6M A;  2PG2 A;  4BN2 A;  2ZFI A;  3KEN A;  1I6I A;  2UYM A;  5LT4 A;  1FMW A;  3X2T A;  3K3B A;  1T5C A;  5LT3 A;  1FMV A;  2FL2 A;  2HEH A;  4BBG A;  1Q0B A;  5GSZ A;  1KK7 A;  2MYS A;  2VAS A;  4FRZ A;  3NWN A;  1CZ7 A;  1I5S A;  3ZFD A;  1VFW A;  4ETP A;  5LT1 A;  2GRY A;  1G8X A;  3PXN A;  4A5Y A;  1VFZ A;  3LRE A;  2ZFM A;  2Q2Y A;  1MMA A;  4DBR A;  3HQD A;  3ZCW A;  3DCB A;  4BXN A;  1MMD A;  1F9V A;  1D1A A;  4H1G A;  3T0Q A;  3L9H A;  3B6U A;  1BR1 A;  1MMG A;  2GM1 A;  2XAE A;  4Y05 A;  4A51 A;  1D0X A;  3KIN A;  4AP0 A;  4UBF A;  1II6 A;  1YRS A;  3ZFC A;  3CJO A;  2UYI A;  1X88 A;  3WRD A;  2VB6 A;  2XT3 A;  4A1Z A;  2X2R A;  5LT2 A;  2Y65 A;  5LT0 A;  2X7D A;  1F9U A;  2FKY A;  2X51 A;  4HNA K;  3U06 A;  2ZFK A;  1LVK A;  4E7Z A;  1D0Z A;  1D1B A;  1SDM A;  2FME A;  1MNE A;  1VFX A;  1D0Y A;  3GBJ A; 
#chains in the Genus database with same CATH topology
 4A50 A;  3L1C A;  4PJN A;  3COB A;  2Y5W A;  4ZHI A;  1RY6 A;  2VVG A;  1VFV A;  2WOG A;  2NCD A;  2Q2Z A;  2IEH A;  4ANJ A;  2FL6 A;  1V8K A;  1VOM A;  4PK4 A;  4PJJ A;  3BFN A;  3CNZ A;  4E7S A;  2ZFJ A;  4PFP A;  2G1Q A;  4A14 A;  4ZCA A;  2ZFL A;  3KAR A;  3WPN A;  1BR2 A;  1V8J A;  4PFO A;  3K5E A;  4DBQ A;  4LNU K;  4A28 A;  4GKP A;  1F9T A;  4B7B A;  1LKX A;  4PJL A;  1F9W A;  4ETP B;  1GOJ A;  2V26 A;  1BG2 A;  4PJM A;  4AS7 A;  1MKJ A;  5HLE A;  1BR4 A;  3H4S A;  2OWM A;  2KIN A;  3B6V A;  2X7C A;  2X7E A;  1D1C A;  4GKR A;  1MMN A;  3DC4 A;  1N6M A;  2PG2 A;  4BN2 A;  2ZFI A;  3KEN A;  1I6I A;  2UYM A;  5LT4 A;  1FMW A;  3X2T A;  3K3B A;  1T5C A;  5LT3 A;  1FMV A;  2FL2 A;  2HEH A;  4BBG A;  1Q0B A;  5GSZ A;  1KK7 A;  2MYS A;  2VAS A;  4FRZ A;  3NWN A;  1CZ7 A;  1I5S A;  3ZFD A;  1VFW A;  4ETP A;  5LT1 A;  2GRY A;  1G8X A;  3PXN A;  4A5Y A;  4GKQ A;  1VFZ A;  3LRE A;  2ZFM A;  2Q2Y A;  1MMA A;  4DBR A;  3HQD A;  3ZCW A;  3DCB A;  4BXN A;  1MMD A;  1F9V A;  1D1A A;  4H1G A;  3T0Q A;  3L9H A;  3B6U A;  1BR1 A;  1MMG A;  2GM1 A;  2XAE A;  4Y05 A;  4A51 A;  2O0A A;  1D0X A;  3KIN A;  4AP0 A;  4UBF A;  1II6 A;  1YRS A;  3ZFC A;  3CJO A;  2UYI A;  1X88 A;  3WRD A;  2VB6 A;  2XT3 A;  4A1Z A;  2X2R A;  5LT2 A;  2Y65 A;  5LT0 A;  2X7D A;  1F9U A;  2FKY A;  2X51 A;  4HNA K;  3U06 A;  2ZFK A;  1LVK A;  4E7Z A;  1D0Z A;  1D1B A;  1SDM A;  2FME A;  1MNE A;  1VFX A;  1D0Y A;  3GBJ A; 
#chains in the Genus database with same CATH homology
 4A50 A;  3L1C A;  4PJN A;  3COB A;  2Y5W A;  4ZHI A;  1RY6 A;  2VVG A;  1VFV A;  2WOG A;  2NCD A;  2Q2Z A;  2IEH A;  4ANJ A;  2FL6 A;  1V8K A;  1VOM A;  4PK4 A;  4PJJ A;  3BFN A;  3CNZ A;  4E7S A;  2ZFJ A;  4PFP A;  2G1Q A;  4A14 A;  4ZCA A;  2ZFL A;  3KAR A;  3WPN A;  1BR2 A;  1V8J A;  4PFO A;  3K5E A;  4DBQ A;  4LNU K;  4A28 A;  1F9T A;  4B7B A;  1LKX A;  4PJL A;  1F9W A;  1GOJ A;  2V26 A;  1BG2 A;  4PJM A;  4AS7 A;  1MKJ A;  5HLE A;  1BR4 A;  3H4S A;  2OWM A;  2KIN A;  3B6V A;  2X7C A;  2X7E A;  1D1C A;  4GKR A;  1MMN A;  3DC4 A;  1N6M A;  2PG2 A;  4BN2 A;  2ZFI A;  3KEN A;  1I6I A;  2UYM A;  5LT4 A;  1FMW A;  3X2T A;  3K3B A;  1T5C A;  5LT3 A;  1FMV A;  2FL2 A;  2HEH A;  4BBG A;  1Q0B A;  5GSZ A;  1KK7 A;  2MYS A;  2VAS A;  4FRZ A;  3NWN A;  1CZ7 A;  1I5S A;  3ZFD A;  1VFW A;  4ETP A;  5LT1 A;  2GRY A;  1G8X A;  3PXN A;  4A5Y A;  1VFZ A;  3LRE A;  2ZFM A;  2Q2Y A;  1MMA A;  4DBR A;  3HQD A;  3ZCW A;  3DCB A;  4BXN A;  1MMD A;  1F9V A;  1D1A A;  4H1G A;  3T0Q A;  3L9H A;  3B6U A;  1BR1 A;  1MMG A;  2GM1 A;  2XAE A;  4Y05 A;  4A51 A;  1D0X A;  3KIN A;  4AP0 A;  4UBF A;  1II6 A;  1YRS A;  3ZFC A;  3CJO A;  2UYI A;  1X88 A;  3WRD A;  2VB6 A;  2XT3 A;  4A1Z A;  2X2R A;  5LT2 A;  2Y65 A;  5LT0 A;  2X7D A;  1F9U A;  2FKY A;  2X51 A;  4HNA K;  3U06 A;  2ZFK A;  1LVK A;  4E7Z A;  1D0Z A;  1D1B A;  1SDM A;  2FME A;  1MNE A;  1VFX A;  1D0Y A;  3GBJ A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...