3LREA

Crystal structure analysis of human kinesin-8 motor domain
Total Genus 94
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
94
sequence length
342
structure length
289
Chain Sequence
MKVVVRVRPENTKEKAAGFHKVVHVVDKHILVFDNKDLKFVFDAVFDETSTQSEVFEHTTKPILRSFLNGYNCTVLAYGATGAGKTHTMLGSADEPGVMYLTMLHLYKCMDEIKEEKICSTAVSYLEVYNEQIRDLLVNSGPLAVREDTQKGVVVHGLTLHQPKSSEEILHLLDNGNKNRTQHATSSRSHAVFQIYLRQQDKTASINQNVRIAKMSLIDLAGSERNRSLLALGNVINALAIPYRNSKLTRLLKDSLGGNCQTIMIAAVSPSSVFYDDTYNTLKYANRAK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Insight into the molecular mechanism of the multitasking kinesin-8 motor.
pubmed doi rcsb
molecule tags Motor protein
source organism Homo sapiens
molecule keywords Kinesin-like protein KIF18A
total genus 94
structure length 289
sequence length 342
chains with identical sequence B
ec nomenclature
pdb deposition date 2010-02-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 3lreA00
1KK7A 4A5YA 2X2RA 2ZFKA 4ZCAA 4LNUK 3CJOA 3GBJA 4H1GA 5LT2A 2ZFIA 4A51A 2MYSA 4GKRA 2G1QA 4BBGA 2GRYA 3ZCWA 1MMAA 1RY6A 4E7SA 2FL2A 2X51A 2VVGA 1Q0BA 1N6MA 2NCDA 5GSZA 3HQDA 4UBFA 1VFVA 4PFOA 2Y65A 1BG2A 3DC4A 3WPNA 1VOMA 4BXNA 1I6IA 1BR2A 1D0YA 1II6A 4ANJA 1VFWA 1VFZA 3X2TA 3ZFCA 2FMEA 2XAEA 4AS7A 2Q2YA 3KARA 3B6UA 3K5EA 1D0ZA 3K3BA 3PXNA 1F9TA 4PJMA 1D1AA 2UYMA 1T5CA 2VB6A 4PJLA 4PK4A 1D0XA 2VASA 2FKYA 4FRZA 4Y05A 4A14A 2Y5WA 3H4SA 3B6VA 1FMVA 1V8JA 4PJJA 3L1CA 3NWNA 4DBQA 2X7EA 1MMDA 1SDMA 3WRDA 1MNEA 3KENA 3CNZA 1G8XA 2X7DA 2X7CA 4HNAK 4DBRA 4A50A 5LT4A 2Q2ZA 1D1CA 1D1BA 2GM1A 1MMGA 3U06A 1BR1A 1F9VA 2XT3A 1GOJA 4A1ZA 4E7ZA 3DCBA 4PJNA 4A28A 1F9UA 1I5SA 1F9WA 5LT1A 4AP0A 2FL6A 4BN2A 5HLEA 2ZFMA 1X88A 2KINA 1FMWA 2V26A 1BR4A 1CZ7A 2PG2A 1V8KA 2HEHA 3T0QA 3L9HA 1LKXA 3LREA 4ZHIA 2WOGA 4PFPA 1LVKA 2ZFLA 1MMNA 2UYIA 2IEHA 1YRSA 4ETPA 3ZFDA 5LT3A 2OWMA 1MKJA 4B7BA 3COBA 5LT0A 3KINA 3BFNA 2ZFJA 1VFXA
chains in the Genus database with same CATH superfamily
1KK7A 4A5YA 2X2RA 2ZFKA 4ZCAA 4LNUK 3CJOA 3GBJA 4H1GA 5LT2A 2ZFIA 4A51A 2MYSA 4GKRA 2G1QA 4BBGA 2GRYA 3ZCWA 1MMAA 1RY6A 4E7SA 2FL2A 2X51A 2VVGA 1Q0BA 1N6MA 2NCDA 5GSZA 3HQDA 4UBFA 1VFVA 2O0AA 4PFOA 2Y65A 1BG2A 3DC4A 3WPNA 1VOMA 4BXNA 1I6IA 1BR2A 1D0YA 1II6A 4ANJA 1VFWA 1VFZA 3X2TA 3ZFCA 2FMEA 2XAEA 4AS7A 2Q2YA 3KARA 3B6UA 3K5EA 1D0ZA 3K3BA 3PXNA 4ETPB 1F9TA 4PJMA 1D1AA 2UYMA 1T5CA 2VB6A 4PJLA 4PK4A 1D0XA 2VASA 2FKYA 4FRZA 4Y05A 4A14A 2Y5WA 3H4SA 3B6VA 1FMVA 1V8JA 4PJJA 3L1CA 3NWNA 4DBQA 2X7EA 1MMDA 1SDMA 3WRDA 1MNEA 3KENA 3CNZA 1G8XA 2X7DA 2X7CA 4HNAK 4DBRA 4A50A 5LT4A 2Q2ZA 1D1CA 1D1BA 2GM1A 1MMGA 3U06A 1BR1A 1F9VA 2XT3A 1GOJA 4A1ZA 4E7ZA 3DCBA 4PJNA 4GKQA 1F9UA 1I5SA 4A28A 1F9WA 5LT1A 4AP0A 2FL6A 4BN2A 5HLEA 2ZFMA 1X88A 2KINA 1FMWA 2V26A 1BR4A 1CZ7A 2PG2A 1V8KA 2HEHA 3T0QA 3L9HA 1LKXA 3LREA 4ZHIA 2WOGA 4GKPA 4PFPA 1LVKA 2ZFLA 1MMNA 2UYIA 2IEHA 1YRSA 4ETPA 3ZFDA 5LT3A 2OWMA 1MKJA 4B7BA 3COBA 5LT0A 3KINA 3BFNA 2ZFJA 1VFXA
chains in the Genus database with same CATH topology
1KK7A 4A5YA 2X2RA 2ZFKA 4ZCAA 4LNUK 3CJOA 3GBJA 4H1GA 5LT2A 2ZFIA 4A51A 2MYSA 4GKRA 2G1QA 4BBGA 2GRYA 3ZCWA 1MMAA 1RY6A 4E7SA 2FL2A 2X51A 2VVGA 1Q0BA 1N6MA 2NCDA 5GSZA 3HQDA 4UBFA 1VFVA 4PFOA 2Y65A 1BG2A 3DC4A 3WPNA 1VOMA 4BXNA 1I6IA 1BR2A 1D0YA 1II6A 4ANJA 1VFWA 1VFZA 3X2TA 3ZFCA 2FMEA 2XAEA 4AS7A 2Q2YA 3KARA 3B6UA 3K5EA 1D0ZA 3K3BA 3PXNA 1F9TA 4PJMA 1D1AA 2UYMA 1T5CA 2VB6A 4PJLA 4PK4A 1D0XA 2VASA 2FKYA 4FRZA 4Y05A 4A14A 2Y5WA 3H4SA 3B6VA 1FMVA 1V8JA 4PJJA 3L1CA 3NWNA 4DBQA 2X7EA 1MMDA 1SDMA 3WRDA 1MNEA 3KENA 3CNZA 1G8XA 2X7DA 2X7CA 4HNAK 4DBRA 4A50A 5LT4A 2Q2ZA 1D1CA 1D1BA 2GM1A 1MMGA 3U06A 1BR1A 1F9VA 2XT3A 1GOJA 4A1ZA 4E7ZA 3DCBA 4PJNA 4A28A 1F9UA 1I5SA 1F9WA 5LT1A 4AP0A 2FL6A 4BN2A 5HLEA 2ZFMA 1X88A 2KINA 1FMWA 2V26A 1BR4A 1CZ7A 2PG2A 1V8KA 2HEHA 3T0QA 3L9HA 1LKXA 3LREA 4ZHIA 2WOGA 4PFPA 1LVKA 2ZFLA 1MMNA 2UYIA 2IEHA 1YRSA 4ETPA 3ZFDA 5LT3A 2OWMA 1MKJA 4B7BA 3COBA 5LT0A 3KINA 3BFNA 2ZFJA 1VFXA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1KK7 A;  4A5Y A;  2X2R A;  2ZFK A;  4ZCA A;  4LNU K;  3CJO A;  3GBJ A;  4H1G A;  5LT2 A;  2ZFI A;  4A51 A;  2MYS A;  4GKR A;  2G1Q A;  4BBG A;  2GRY A;  3ZCW A;  1MMA A;  1RY6 A;  4E7S A;  2FL2 A;  2X51 A;  2VVG A;  1Q0B A;  1N6M A;  2NCD A;  5GSZ A;  3HQD A;  4UBF A;  1VFV A;  4PFO A;  2Y65 A;  1BG2 A;  3DC4 A;  3WPN A;  1VOM A;  4BXN A;  1I6I A;  1BR2 A;  1D0Y A;  1II6 A;  4ANJ A;  1VFW A;  1VFZ A;  3X2T A;  3ZFC A;  2FME A;  2XAE A;  4AS7 A;  2Q2Y A;  3KAR A;  3B6U A;  3K5E A;  1D0Z A;  3K3B A;  3PXN A;  1F9T A;  4PJM A;  1D1A A;  2UYM A;  1T5C A;  2VB6 A;  4PJL A;  4PK4 A;  1D0X A;  2VAS A;  2FKY A;  4FRZ A;  4Y05 A;  4A14 A;  2Y5W A;  3H4S A;  3B6V A;  1FMV A;  1V8J A;  4PJJ A;  3L1C A;  3NWN A;  4DBQ A;  2X7E A;  1MMD A;  1SDM A;  3WRD A;  1MNE A;  3KEN A;  3CNZ A;  1G8X A;  2X7D A;  2X7C A;  4HNA K;  4DBR A;  4A50 A;  5LT4 A;  2Q2Z A;  1D1C A;  1D1B A;  2GM1 A;  1MMG A;  3U06 A;  1BR1 A;  1F9V A;  2XT3 A;  1GOJ A;  4A1Z A;  4E7Z A;  3DCB A;  4PJN A;  4A28 A;  1F9U A;  1I5S A;  1F9W A;  5LT1 A;  4AP0 A;  2FL6 A;  4BN2 A;  5HLE A;  2ZFM A;  1X88 A;  2KIN A;  1FMW A;  2V26 A;  1BR4 A;  1CZ7 A;  2PG2 A;  1V8K A;  2HEH A;  3T0Q A;  3L9H A;  1LKX A;  3LRE A;  4ZHI A;  2WOG A;  4PFP A;  1LVK A;  2ZFL A;  1MMN A;  2UYI A;  2IEH A;  1YRS A;  4ETP A;  3ZFD A;  5LT3 A;  2OWM A;  1MKJ A;  4B7B A;  3COB A;  5LT0 A;  3KIN A;  3BFN A;  2ZFJ A;  1VFX A; 
#chains in the Genus database with same CATH topology
 1KK7 A;  4A5Y A;  2X2R A;  2ZFK A;  4ZCA A;  4LNU K;  3CJO A;  3GBJ A;  4H1G A;  5LT2 A;  2ZFI A;  4A51 A;  2MYS A;  4GKR A;  2G1Q A;  4BBG A;  2GRY A;  3ZCW A;  1MMA A;  1RY6 A;  4E7S A;  2FL2 A;  2X51 A;  2VVG A;  1Q0B A;  1N6M A;  2NCD A;  5GSZ A;  3HQD A;  4UBF A;  1VFV A;  2O0A A;  4PFO A;  2Y65 A;  1BG2 A;  3DC4 A;  3WPN A;  1VOM A;  4BXN A;  1I6I A;  1BR2 A;  1D0Y A;  1II6 A;  4ANJ A;  1VFW A;  1VFZ A;  3X2T A;  3ZFC A;  2FME A;  2XAE A;  4AS7 A;  2Q2Y A;  3KAR A;  3B6U A;  3K5E A;  1D0Z A;  3K3B A;  3PXN A;  4ETP B;  1F9T A;  4PJM A;  1D1A A;  2UYM A;  1T5C A;  2VB6 A;  4PJL A;  4PK4 A;  1D0X A;  2VAS A;  2FKY A;  4FRZ A;  4Y05 A;  4A14 A;  2Y5W A;  3H4S A;  3B6V A;  1FMV A;  1V8J A;  4PJJ A;  3L1C A;  3NWN A;  4DBQ A;  2X7E A;  1MMD A;  1SDM A;  3WRD A;  1MNE A;  3KEN A;  3CNZ A;  1G8X A;  2X7D A;  2X7C A;  4HNA K;  4DBR A;  4A50 A;  5LT4 A;  2Q2Z A;  1D1C A;  1D1B A;  2GM1 A;  1MMG A;  3U06 A;  1BR1 A;  1F9V A;  2XT3 A;  1GOJ A;  4A1Z A;  4E7Z A;  3DCB A;  4PJN A;  4GKQ A;  1F9U A;  1I5S A;  4A28 A;  1F9W A;  5LT1 A;  4AP0 A;  2FL6 A;  4BN2 A;  5HLE A;  2ZFM A;  1X88 A;  2KIN A;  1FMW A;  2V26 A;  1BR4 A;  1CZ7 A;  2PG2 A;  1V8K A;  2HEH A;  3T0Q A;  3L9H A;  1LKX A;  3LRE A;  4ZHI A;  2WOG A;  4GKP A;  4PFP A;  1LVK A;  2ZFL A;  1MMN A;  2UYI A;  2IEH A;  1YRS A;  4ETP A;  3ZFD A;  5LT3 A;  2OWM A;  1MKJ A;  4B7B A;  3COB A;  5LT0 A;  3KIN A;  3BFN A;  2ZFJ A;  1VFX A; 
#chains in the Genus database with same CATH homology
 1KK7 A;  4A5Y A;  2X2R A;  2ZFK A;  4ZCA A;  4LNU K;  3CJO A;  3GBJ A;  4H1G A;  5LT2 A;  2ZFI A;  4A51 A;  2MYS A;  4GKR A;  2G1Q A;  4BBG A;  2GRY A;  3ZCW A;  1MMA A;  1RY6 A;  4E7S A;  2FL2 A;  2X51 A;  2VVG A;  1Q0B A;  1N6M A;  2NCD A;  5GSZ A;  3HQD A;  4UBF A;  1VFV A;  4PFO A;  2Y65 A;  1BG2 A;  3DC4 A;  3WPN A;  1VOM A;  4BXN A;  1I6I A;  1BR2 A;  1D0Y A;  1II6 A;  4ANJ A;  1VFW A;  1VFZ A;  3X2T A;  3ZFC A;  2FME A;  2XAE A;  4AS7 A;  2Q2Y A;  3KAR A;  3B6U A;  3K5E A;  1D0Z A;  3K3B A;  3PXN A;  1F9T A;  4PJM A;  1D1A A;  2UYM A;  1T5C A;  2VB6 A;  4PJL A;  4PK4 A;  1D0X A;  2VAS A;  2FKY A;  4FRZ A;  4Y05 A;  4A14 A;  2Y5W A;  3H4S A;  3B6V A;  1FMV A;  1V8J A;  4PJJ A;  3L1C A;  3NWN A;  4DBQ A;  2X7E A;  1MMD A;  1SDM A;  3WRD A;  1MNE A;  3KEN A;  3CNZ A;  1G8X A;  2X7D A;  2X7C A;  4HNA K;  4DBR A;  4A50 A;  5LT4 A;  2Q2Z A;  1D1C A;  1D1B A;  2GM1 A;  1MMG A;  3U06 A;  1BR1 A;  1F9V A;  2XT3 A;  1GOJ A;  4A1Z A;  4E7Z A;  3DCB A;  4PJN A;  4A28 A;  1F9U A;  1I5S A;  1F9W A;  5LT1 A;  4AP0 A;  2FL6 A;  4BN2 A;  5HLE A;  2ZFM A;  1X88 A;  2KIN A;  1FMW A;  2V26 A;  1BR4 A;  1CZ7 A;  2PG2 A;  1V8K A;  2HEH A;  3T0Q A;  3L9H A;  1LKX A;  3LRE A;  4ZHI A;  2WOG A;  4PFP A;  1LVK A;  2ZFL A;  1MMN A;  2UYI A;  2IEH A;  1YRS A;  4ETP A;  3ZFD A;  5LT3 A;  2OWM A;  1MKJ A;  4B7B A;  3COB A;  5LT0 A;  3KIN A;  3BFN A;  2ZFJ A;  1VFX A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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