4A1Z | Genus

Total Genus 101

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	101
sequence length	348
structure length	327
Chain Sequence	KNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERYTWEEVPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSEEAGNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPE

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Motor protein
source organism	Homo sapiens
publication title	The Mitotic Kinesin Eg5 Overcomes Inhibition to the Phase I/II Clinical Candidate Sb743921 by an Allosteric Resistance Mechanism. pubmed doi rcsb
molecule keywords	KINESIN-LIKE PROTEIN KIF11
total genus	101
structure length	327
sequence length	348
chains with identical sequence	B
ec nomenclature
pdb deposition date	2011-09-20

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00225	Kinesin	Kinesin motor domain

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
3.40.850.10	Alpha Beta	3-Layer(aba) Sandwich	Kinesin	Kinesin motor domain	4a1zA00

3HQDA 1VOMA 1D1AA 2Q2ZA 1Q0BA 3U06A 1CZ7A 2GM1A 3L1CA 4PJLA 4A5YA 1MMNA 1D1CA 3X2TA 3COBA 2OWMA 1I5SA 1N6MA 2FMEA 4GKRA 2UYMA 3L9HA 2VASA 4A51A 2X7CA 3ZFDA 2VVGA 5GSZA 2IEHA 3GBJA 1MMGA 3DC4A 3CNZA 1LKXA 4DBQA 5LT2A 4A1ZA 4AP0A 3H4SA 1BR4A 1X88A 1GOJA 3KINA 1D0ZA 1LVKA 2PG2A 2X7DA 2KINA 1MMDA 2X7EA 4BBGA 2X51A 1VFXA 3K5EA 4PFPA 1F9TA 2V26A 2HEHA 2UYIA 1II6A 4B7BA 1F9UA 2WOGA 4PJJA 2ZFKA 1VFZA 2FKYA 2ZFMA 3ZCWA 4ANJA 1G8XA 1FMVA 4HNAK 4DBRA 1I6IA 2X2RA 2ZFIA 4LNUK 3LREA 1KK7A 4PK4A 1VFVA 2Q2YA 1BG2A 1FMWA 1MNEA 2FL2A 3KARA 1V8KA 1YRSA 4E7ZA 3KENA 3WRDA 1F9VA 3ZFCA 2Y65A 3DCBA 4A28A 2G1QA 1BR1A 2Y5WA 2XAEA 4ETPA 4BN2A 4E7SA 3PXNA 5HLEA 5LT0A 1VFWA 3T0QA 5LT4A 2NCDA 3WPNA 3NWNA 4H1GA 4UBFA 1D0XA 3BFNA 5LT3A 1F9WA 1D0YA 1T5CA 1MMAA 4Y05A 4BXNA 4AS7A 2GRYA 4PJMA 1V8JA 1D1BA 4ZCAA 5LT1A 2VB6A 1MKJA 2MYSA 4A50A 4FRZA 2XT3A 4PJNA 3B6VA 2ZFLA 4ZHIA 2ZFJA 3CJOA 1RY6A 3K3BA 1SDMA 4PFOA 1BR2A 3B6UA 2FL6A 4A14A
chains in the Genus database with same CATH superfamily

3HQDA 1VOMA 1D1AA 2Q2ZA 1Q0BA 3U06A 1CZ7A 2GM1A 3L1CA 4PJLA 4A5YA 1MMNA 1D1CA 3X2TA 3COBA 2OWMA 1I5SA 4GKQA 1N6MA 2FMEA 4GKRA 2UYMA 3L9HA 2VASA 4A51A 4GKPA 2X7CA 3ZFDA 2VVGA 5GSZA 2IEHA 3GBJA 1MMGA 3DC4A 3CNZA 1LKXA 4DBQA 5LT2A 4A1ZA 4AP0A 3H4SA 1BR4A 1X88A 1GOJA 3KINA 1D0ZA 1LVKA 2PG2A 2X7DA 2KINA 1MMDA 2X7EA 4BBGA 2X51A 1VFXA 3K5EA 4PFPA 1F9TA 2V26A 2HEHA 2UYIA 1II6A 4B7BA 1F9UA 2WOGA 4PJJA 2ZFKA 1VFZA 2FKYA 2ZFMA 3ZCWA 4ANJA 1G8XA 1FMVA 4HNAK 4DBRA 1I6IA 2X2RA 2ZFIA 4LNUK 3LREA 1KK7A 4PK4A 1VFVA 2Q2YA 1BG2A 1FMWA 1MNEA 2FL2A 3KARA 1V8KA 1YRSA 4E7ZA 3KENA 3WRDA 1F9VA 3ZFCA 2Y65A 3DCBA 4A28A 2G1QA 1BR1A 2Y5WA 2XAEA 4ETPA 4BN2A 4E7SA 3PXNA 5HLEA 5LT0A 1VFWA 3T0QA 5LT4A 2NCDA 3WPNA 3NWNA 4H1GA 4UBFA 1D0XA 3BFNA 5LT3A 1F9WA 1D0YA 1T5CA 1MMAA 4Y05A 4ETPB 4BXNA 4AS7A 2GRYA 4PJMA 1V8JA 1D1BA 4ZCAA 2O0AA 5LT1A 2VB6A 1MKJA 2MYSA 4A50A 4FRZA 2XT3A 4PJNA 3B6VA 2ZFLA 4ZHIA 2ZFJA 3CJOA 1RY6A 3K3BA 1SDMA 4PFOA 1BR2A 3B6UA 2FL6A 4A14A
chains in the Genus database with same CATH topology

#chains in the Genus database with same CATH superfamily
 3HQD A;  1VOM A;  1D1A A;  2Q2Z A;  1Q0B A;  3U06 A;  1CZ7 A;  2GM1 A;  3L1C A;  4PJL A;  4A5Y A;  1MMN A;  1D1C A;  3X2T A;  3COB A;  2OWM A;  1I5S A;  1N6M A;  2FME A;  4GKR A;  2UYM A;  3L9H A;  2VAS A;  4A51 A;  2X7C A;  3ZFD A;  2VVG A;  5GSZ A;  2IEH A;  3GBJ A;  1MMG A;  3DC4 A;  3CNZ A;  1LKX A;  4DBQ A;  5LT2 A;  4A1Z A;  4AP0 A;  3H4S A;  1BR4 A;  1X88 A;  1GOJ A;  3KIN A;  1D0Z A;  1LVK A;  2PG2 A;  2X7D A;  2KIN A;  1MMD A;  2X7E A;  4BBG A;  2X51 A;  1VFX A;  3K5E A;  4PFP A;  1F9T A;  2V26 A;  2HEH A;  2UYI A;  1II6 A;  4B7B A;  1F9U A;  2WOG A;  4PJJ A;  2ZFK A;  1VFZ A;  2FKY A;  2ZFM A;  3ZCW A;  4ANJ A;  1G8X A;  1FMV A;  4HNA K;  4DBR A;  1I6I A;  2X2R A;  2ZFI A;  4LNU K;  3LRE A;  1KK7 A;  4PK4 A;  1VFV A;  2Q2Y A;  1BG2 A;  1FMW A;  1MNE A;  2FL2 A;  3KAR A;  1V8K A;  1YRS A;  4E7Z A;  3KEN A;  3WRD A;  1F9V A;  3ZFC A;  2Y65 A;  3DCB A;  4A28 A;  2G1Q A;  1BR1 A;  2Y5W A;  2XAE A;  4ETP A;  4BN2 A;  4E7S A;  3PXN A;  5HLE A;  5LT0 A;  1VFW A;  3T0Q A;  5LT4 A;  2NCD A;  3WPN A;  3NWN A;  4H1G A;  4UBF A;  1D0X A;  3BFN A;  5LT3 A;  1F9W A;  1D0Y A;  1T5C A;  1MMA A;  4Y05 A;  4BXN A;  4AS7 A;  2GRY A;  4PJM A;  1V8J A;  1D1B A;  4ZCA A;  5LT1 A;  2VB6 A;  1MKJ A;  2MYS A;  4A50 A;  4FRZ A;  2XT3 A;  4PJN A;  3B6V A;  2ZFL A;  4ZHI A;  2ZFJ A;  3CJO A;  1RY6 A;  3K3B A;  1SDM A;  4PFO A;  1BR2 A;  3B6U A;  2FL6 A;  4A14 A; 
#chains in the Genus database with same CATH topology
 3HQD A;  1VOM A;  1D1A A;  2Q2Z A;  1Q0B A;  3U06 A;  1CZ7 A;  2GM1 A;  3L1C A;  4PJL A;  4A5Y A;  1MMN A;  1D1C A;  3X2T A;  3COB A;  2OWM A;  1I5S A;  4GKQ A;  1N6M A;  2FME A;  4GKR A;  2UYM A;  3L9H A;  2VAS A;  4A51 A;  4GKP A;  2X7C A;  3ZFD A;  2VVG A;  5GSZ A;  2IEH A;  3GBJ A;  1MMG A;  3DC4 A;  3CNZ A;  1LKX A;  4DBQ A;  5LT2 A;  4A1Z A;  4AP0 A;  3H4S A;  1BR4 A;  1X88 A;  1GOJ A;  3KIN A;  1D0Z A;  1LVK A;  2PG2 A;  2X7D A;  2KIN A;  1MMD A;  2X7E A;  4BBG A;  2X51 A;  1VFX A;  3K5E A;  4PFP A;  1F9T A;  2V26 A;  2HEH A;  2UYI A;  1II6 A;  4B7B A;  1F9U A;  2WOG A;  4PJJ A;  2ZFK A;  1VFZ A;  2FKY A;  2ZFM A;  3ZCW A;  4ANJ A;  1G8X A;  1FMV A;  4HNA K;  4DBR A;  1I6I A;  2X2R A;  2ZFI A;  4LNU K;  3LRE A;  1KK7 A;  4PK4 A;  1VFV A;  2Q2Y A;  1BG2 A;  1FMW A;  1MNE A;  2FL2 A;  3KAR A;  1V8K A;  1YRS A;  4E7Z A;  3KEN A;  3WRD A;  1F9V A;  3ZFC A;  2Y65 A;  3DCB A;  4A28 A;  2G1Q A;  1BR1 A;  2Y5W A;  2XAE A;  4ETP A;  4BN2 A;  4E7S A;  3PXN A;  5HLE A;  5LT0 A;  1VFW A;  3T0Q A;  5LT4 A;  2NCD A;  3WPN A;  3NWN A;  4H1G A;  4UBF A;  1D0X A;  3BFN A;  5LT3 A;  1F9W A;  1D0Y A;  1T5C A;  1MMA A;  4Y05 A;  4ETP B;  4BXN A;  4AS7 A;  2GRY A;  4PJM A;  1V8J A;  1D1B A;  4ZCA A;  2O0A A;  5LT1 A;  2VB6 A;  1MKJ A;  2MYS A;  4A50 A;  4FRZ A;  2XT3 A;  4PJN A;  3B6V A;  2ZFL A;  4ZHI A;  2ZFJ A;  3CJO A;  1RY6 A;  3K3B A;  1SDM A;  4PFO A;  1BR2 A;  3B6U A;  2FL6 A;  4A14 A; 
#chains in the Genus database with same CATH homology
 3HQD A;  1VOM A;  1D1A A;  2Q2Z A;  1Q0B A;  3U06 A;  1CZ7 A;  2GM1 A;  3L1C A;  4PJL A;  4A5Y A;  1MMN A;  1D1C A;  3X2T A;  3COB A;  2OWM A;  1I5S A;  1N6M A;  2FME A;  4GKR A;  2UYM A;  3L9H A;  2VAS A;  4A51 A;  2X7C A;  3ZFD A;  2VVG A;  5GSZ A;  2IEH A;  3GBJ A;  1MMG A;  3DC4 A;  3CNZ A;  1LKX A;  4DBQ A;  5LT2 A;  4A1Z A;  4AP0 A;  3H4S A;  1BR4 A;  1X88 A;  1GOJ A;  3KIN A;  1D0Z A;  1LVK A;  2PG2 A;  2X7D A;  2KIN A;  1MMD A;  2X7E A;  4BBG A;  2X51 A;  1VFX A;  3K5E A;  4PFP A;  1F9T A;  2V26 A;  2HEH A;  2UYI A;  1II6 A;  4B7B A;  1F9U A;  2WOG A;  4PJJ A;  2ZFK A;  1VFZ A;  2FKY A;  2ZFM A;  3ZCW A;  4ANJ A;  1G8X A;  1FMV A;  4HNA K;  4DBR A;  1I6I A;  2X2R A;  2ZFI A;  4LNU K;  3LRE A;  1KK7 A;  4PK4 A;  1VFV A;  2Q2Y A;  1BG2 A;  1FMW A;  1MNE A;  2FL2 A;  3KAR A;  1V8K A;  1YRS A;  4E7Z A;  3KEN A;  3WRD A;  1F9V A;  3ZFC A;  2Y65 A;  3DCB A;  4A28 A;  2G1Q A;  1BR1 A;  2Y5W A;  2XAE A;  4ETP A;  4BN2 A;  4E7S A;  3PXN A;  5HLE A;  5LT0 A;  1VFW A;  3T0Q A;  5LT4 A;  2NCD A;  3WPN A;  3NWN A;  4H1G A;  4UBF A;  1D0X A;  3BFN A;  5LT3 A;  1F9W A;  1D0Y A;  1T5C A;  1MMA A;  4Y05 A;  4BXN A;  4AS7 A;  2GRY A;  4PJM A;  1V8J A;  1D1B A;  4ZCA A;  5LT1 A;  2VB6 A;  1MKJ A;  2MYS A;  4A50 A;  4FRZ A;  2XT3 A;  4PJN A;  3B6V A;  2ZFL A;  4ZHI A;  2ZFJ A;  3CJO A;  1RY6 A;  3K3B A;  1SDM A;  4PFO A;  1BR2 A;  3B6U A;  2FL6 A;  4A14 A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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4A1ZA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations