3U88C

Crystal structure of human menin in complex with mll1 and ledgf
Total Genus 31
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
31
sequence length
82
structure length
82
Chain Sequence
MDSRLQRIHAEIKNSLKIDNLDVNRCIEALDELASLQVTMQQAQKHTEMITTLKKIRRFKVSQVIMEKSTMLYNKFKNMFLV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title The same pocket in menin binds both MLL and JUND but has opposite effects on transcription.
pubmed doi rcsb
molecule tags Transcription
source organism Homo sapiens
molecule keywords Menin
total genus 31
structure length 82
sequence length 82
chains with identical sequence D
ec nomenclature
pdb deposition date 2011-10-16
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.930.10 Mainly Alpha Up-down Bundle Transcription Elongation Factor S-II; Chain A Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 3u88C00
2XPNA 2XPOA 3F9KC 2B4JC 2XPPA 3HPGG 1EO0A 3O8ZA 1Z9EA 3NFQA 3OAKA 2N3AB 3U88C 1WJTA 3HPHE 2XPLA
chains in the Genus database with same CATH superfamily
3BUOB 3KASA 4MCPA 3PLFB 3VRQA 2C6GA 4MCQA 5J3XA 3BI1A 1Z8LA 2JBKA 4NGPA 4P4BA 3OAKA 4OC0A 4JZ0A 4NGSA 4W9YA 2XEJA 3D7DA 4MCRA 3FEEA 3F9KC 5D29A 3VRNA 3FECA 2PVWA 3U88C 5F09A 3D7HA 3VRPA 2XPNA 3BUXB 5HKYA 3FF3A 4MCSA 4LQGA 3BHXA 3PFVA 3S9NA 1YVHA 4P4EA 4P4DA 1CX8A 4NGNA 4BPXB 4NGTA 3D7GA 1FBVA 4NGQA 3ZNIA 4NGRA 2N3AB 4OC5A 4P4JA 4OC2A 5ELYA 3SJGA 3SJXA 3SJFA 1DE4C 4OMEA 2Y1NA 4NGMA 2B4JC 2C6CA 3HPGG 3S9LA 5HKZA 3BUNB 5HKWA 2CBLA 4OC1A 1B47A 2Y1MA 2XPPA 4A4CA 2UV8G 4P4FA 4OC3A 3BUMB 4OC4A 4BTFA 3D7FA 4BPWB 4P45A 2DLAA 2JBJA 3HMJG 3OB1B 2XEGA 3SJEA 4BPUB 4RR2B 3S9MA 3BUWB 3RBUA 4A4BA 3NFQA 3HPHE 2XPLA 4P44A 4GPLB 2XPOA 3OB2B 4X3RA 3O8ZA 3VGOA 1Z9EA 1WJTA 5F13A 1EO0A 3VRRA 3VROA 2PVVA 3FEDA 4JYWA 5AXIA 3BI0A 2CIJA 3PT1A 2C6PA 3IWWA 4P4IA 3OP0A 3BXMA 2OR4A 5BY0A 2VKZG 2XEFA 2XEIA 2OOTA
chains in the Genus database with same CATH topology
2XPNA 2XPOA 3F9KC 2B4JC 2XPPA 3HPGG 1EO0A 3O8ZA 1Z9EA 3NFQA 3OAKA 2N3AB 3U88C 1WJTA 3HPHE 2XPLA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2XPN A;  2XPO A;  3F9K C;  2B4J C;  2XPP A;  3HPG G;  1EO0 A;  3O8Z A;  1Z9E A;  3NFQ A;  3OAK A;  2N3A B;  3U88 C;  1WJT A;  3HPH E;  2XPL A; 
#chains in the Genus database with same CATH topology
 3BUO B;  3KAS A;  4MCP A;  3PLF B;  3VRQ A;  2C6G A;  4MCQ A;  5J3X A;  3BI1 A;  1Z8L A;  2JBK A;  4NGP A;  4P4B A;  3OAK A;  4OC0 A;  4JZ0 A;  4NGS A;  4W9Y A;  2XEJ A;  3D7D A;  4MCR A;  3FEE A;  3F9K C;  5D29 A;  3VRN A;  3FEC A;  2PVW A;  3U88 C;  5F09 A;  3D7H A;  3VRP A;  2XPN A;  3BUX B;  5HKY A;  3FF3 A;  4MCS A;  4LQG A;  3BHX A;  3PFV A;  3S9N A;  1YVH A;  4P4E A;  4P4D A;  1CX8 A;  4NGN A;  4BPX B;  4NGT A;  3D7G A;  1FBV A;  4NGQ A;  3ZNI A;  4NGR A;  2N3A B;  4OC5 A;  4P4J A;  4OC2 A;  5ELY A;  3SJG A;  3SJX A;  3SJF A;  1DE4 C;  4OME A;  2Y1N A;  4NGM A;  2B4J C;  2C6C A;  3HPG G;  3S9L A;  5HKZ A;  3BUN B;  5HKW A;  2CBL A;  4OC1 A;  1B47 A;  2Y1M A;  2XPP A;  4A4C A;  2UV8 G;  4P4F A;  4OC3 A;  3BUM B;  4OC4 A;  4BTF A;  3D7F A;  4BPW B;  4P45 A;  2DLA A;  2JBJ A;  3HMJ G;  3OB1 B;  2XEG A;  3SJE A;  4BPU B;  4RR2 B;  3S9M A;  3BUW B;  3RBU A;  4A4B A;  3NFQ A;  3HPH E;  2XPL A;  4P44 A;  4GPL B;  2XPO A;  3OB2 B;  4X3R A;  3O8Z A;  3VGO A;  1Z9E A;  1WJT A;  5F13 A;  1EO0 A;  3VRR A;  3VRO A;  2PVV A;  3FED A;  4JYW A;  5AXI A;  3BI0 A;  2CIJ A;  3PT1 A;  2C6P A;  3IWW A;  4P4I A;  3OP0 A;  3BXM A;  2OR4 A;  5BY0 A;  2VKZ G;  2XEF A;  2XEI A;  2OOT A; 
#chains in the Genus database with same CATH homology
 2XPN A;  2XPO A;  3F9K C;  2B4J C;  2XPP A;  3HPG G;  1EO0 A;  3O8Z A;  1Z9E A;  3NFQ A;  3OAK A;  2N3A B;  3U88 C;  1WJT A;  3HPH E;  2XPL A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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