3U88C

Crystal structure of human menin in complex with mll1 and ledgf
Total Genus 31
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
31
sequence length
82
structure length
82
Chain Sequence
MDSRLQRIHAEIKNSLKIDNLDVNRCIEALDELASLQVTMQQAQKHTEMITTLKKIRRFKVSQVIMEKSTMLYNKFKNMFLV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transcription
molecule keywords Menin
publication title The same pocket in menin binds both MLL and JUND but has opposite effects on transcription.
pubmed doi rcsb
source organism Homo sapiens
total genus 31
structure length 82
sequence length 82
chains with identical sequence D
ec nomenclature
pdb deposition date 2011-10-16
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.930.10 Mainly Alpha Up-down Bundle Transcription Elongation Factor S-II; Chain A Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 3u88C00
3HPHE 1EO0A 1Z9EA 2B4JC 3HPGG 3NFQA 2XPNA 3OAKA 2XPLA 3F9KC 3O8ZA 2XPOA 3U88C 2XPPA 2N3AB 1WJTA
chains in the Genus database with same CATH superfamily
3SJXA 2CIJA 3OP0A 3FECA 4BTFA 2DLAA 4A4BA 5F13A 1Z9EA 4W9YA 3BI1A 4NGPA 5BY0A 2Y1NA 2XEGA 4LQGA 3U88C 3KASA 2B4JC 4JYWA 2OR4A 4A4CA 4OC5A 4JZ0A 3PLFB 3HPHE 5D29A 3BI0A 4NGSA 3PFVA 3VRQA 3BUMB 2JBKA 4P4EA 5F09A 4BPXB 5HKYA 3BUNB 2PVVA 4RR2B 3D7HA 5HKZA 3VRPA 2VKZG 3VGOA 2XEIA 3S9NA 3HPGG 3D7FA 3SJEA 5HKWA 3OAKA 4MCRA 4OC2A 2C6GA 3FF3A 3S9LA 2UV8G 4OC1A 3HMJG 4P4IA 4MCQA 1FBVA 2PVWA 4OC0A 1DE4C 2Y1MA 3D7GA 3NFQA 4BPWB 3FEEA 3SJGA 5AXIA 2C6CA 4P4DA 3BUXB 4P4BA 2XPPA 3O8ZA 3BUOB 2XEJA 4NGMA 1CX8A 2XPNA 3FEDA 3D7DA 3F9KC 3ZNIA 1Z8LA 3IWWA 4GPLB 4OMEA 3OB2B 4X3RA 2N3AB 4MCPA 5J3XA 4P45A 4OC4A 4NGNA 2JBJA 2XPOA 1B47A 2XEFA 1WJTA 3BXMA 4P44A 4P4JA 4NGQA 2XPLA 4MCSA 3VRNA 2OOTA 3VRRA 1YVHA 3RBUA 5ELYA 2CBLA 4NGTA 2C6PA 3BHXA 4BPUB 4P4FA 4OC3A 4NGRA 3S9MA 3VROA 3OB1B 3BUWB 1EO0A 3SJFA 3PT1A
chains in the Genus database with same CATH topology
3HPHE 1EO0A 1Z9EA 2B4JC 3HPGG 3NFQA 2XPNA 3OAKA 2XPLA 3F9KC 3O8ZA 2XPOA 3U88C 2XPPA 2N3AB 1WJTA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3HPH E;  1EO0 A;  1Z9E A;  2B4J C;  3HPG G;  3NFQ A;  2XPN A;  3OAK A;  2XPL A;  3F9K C;  3O8Z A;  2XPO A;  3U88 C;  2XPP A;  2N3A B;  1WJT A; 
#chains in the Genus database with same CATH topology
 3SJX A;  2CIJ A;  3OP0 A;  3FEC A;  4BTF A;  2DLA A;  4A4B A;  5F13 A;  1Z9E A;  4W9Y A;  3BI1 A;  4NGP A;  5BY0 A;  2Y1N A;  2XEG A;  4LQG A;  3U88 C;  3KAS A;  2B4J C;  4JYW A;  2OR4 A;  4A4C A;  4OC5 A;  4JZ0 A;  3PLF B;  3HPH E;  5D29 A;  3BI0 A;  4NGS A;  3PFV A;  3VRQ A;  3BUM B;  2JBK A;  4P4E A;  5F09 A;  4BPX B;  5HKY A;  3BUN B;  2PVV A;  4RR2 B;  3D7H A;  5HKZ A;  3VRP A;  2VKZ G;  3VGO A;  2XEI A;  3S9N A;  3HPG G;  3D7F A;  3SJE A;  5HKW A;  3OAK A;  4MCR A;  4OC2 A;  2C6G A;  3FF3 A;  3S9L A;  2UV8 G;  4OC1 A;  3HMJ G;  4P4I A;  4MCQ A;  1FBV A;  2PVW A;  4OC0 A;  1DE4 C;  2Y1M A;  3D7G A;  3NFQ A;  4BPW B;  3FEE A;  3SJG A;  5AXI A;  2C6C A;  4P4D A;  3BUX B;  4P4B A;  2XPP A;  3O8Z A;  3BUO B;  2XEJ A;  4NGM A;  1CX8 A;  2XPN A;  3FED A;  3D7D A;  3F9K C;  3ZNI A;  1Z8L A;  3IWW A;  4GPL B;  4OME A;  3OB2 B;  4X3R A;  2N3A B;  4MCP A;  5J3X A;  4P45 A;  4OC4 A;  4NGN A;  2JBJ A;  2XPO A;  1B47 A;  2XEF A;  1WJT A;  3BXM A;  4P44 A;  4P4J A;  4NGQ A;  2XPL A;  4MCS A;  3VRN A;  2OOT A;  3VRR A;  1YVH A;  3RBU A;  5ELY A;  2CBL A;  4NGT A;  2C6P A;  3BHX A;  4BPU B;  4P4F A;  4OC3 A;  4NGR A;  3S9M A;  3VRO A;  3OB1 B;  3BUW B;  1EO0 A;  3SJF A;  3PT1 A; 
#chains in the Genus database with same CATH homology
 3HPH E;  1EO0 A;  1Z9E A;  2B4J C;  3HPG G;  3NFQ A;  2XPN A;  3OAK A;  2XPL A;  3F9K C;  3O8Z A;  2XPO A;  3U88 C;  2XPP A;  2N3A B;  1WJT A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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