3U88C

Crystal structure of human menin in complex with mll1 and ledgf
Total Genus 31
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
31
sequence length
82
structure length
82
Chain Sequence
MDSRLQRIHAEIKNSLKIDNLDVNRCIEALDELASLQVTMQQAQKHTEMITTLKKIRRFKVSQVIMEKSTMLYNKFKNMFLV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title The same pocket in menin binds both MLL and JUND but has opposite effects on transcription.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transcription
molecule keywords Menin
total genus 31
structure length 82
sequence length 82
chains with identical sequence D
ec nomenclature
pdb deposition date 2011-10-16
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.930.10 Mainly Alpha Up-down Bundle Transcription Elongation Factor S-II; Chain A Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 3u88C00
2B4JC 2XPOA 2N3AB 3F9KC 2XPLA 2XPNA 3OAKA 3U88C 3HPGG 2XPPA 3HPHE 1EO0A 1WJTA 1Z9EA 3NFQA 3O8ZA
chains in the Genus database with same CATH superfamily
2PVVA 2VKZG 4OC3A 3FEDA 3HPGG 3BUWB 4OMEA 5HKWA 4X3RA 3SJFA 3OB2B 4JYWA 3SJEA 3BHXA 4NGQA 3KASA 2XPLA 3VRRA 2XEGA 3BUMB 2Y1MA 3PT1A 5AXIA 4P44A 3D7GA 5J3XA 4LQGA 4MCRA 2XEFA 1DE4C 3PFVA 2XPPA 4NGMA 3VRQA 2XEIA 3D7DA 4NGPA 3PLFB 2JBJA 5BY0A 3FF3A 4BTFA 5HKZA 3O8ZA 4RR2B 4BPXB 3FEEA 4BPWB 3VRNA 5HKYA 2B4JC 3BUOB 3OAKA 4P4EA 4W9YA 3BXMA 2OOTA 1Z8LA 2UV8G 4P4BA 3BI0A 5D29A 3VGOA 1FBVA 3U88C 3D7FA 1YVHA 3BUNB 4OC0A 3D7HA 3BI1A 3OB1B 2PVWA 4OC1A 4P4DA 3F9KC 2XPNA 2C6GA 4NGRA 3HMJG 2C6CA 3HPHE 3S9NA 4P4FA 4OC5A 4BPUB 2N3AB 1B47A 1EO0A 3VRPA 2OR4A 2XEJA 4A4CA 3S9MA 2CIJA 4P45A 1Z9EA 4NGSA 3FECA 5F09A 4P4IA 3OP0A 4NGTA 4MCSA 4MCPA 4OC4A 2CBLA 3SJGA 3S9LA 4OC2A 4P4JA 3VROA 2Y1NA 4MCQA 4GPLB 3ZNIA 3SJXA 2C6PA 3BUXB 3RBUA 1WJTA 2JBKA 5ELYA 2XPOA 3IWWA 4A4BA 1CX8A 2DLAA 4JZ0A 4NGNA 3NFQA 5F13A
chains in the Genus database with same CATH topology
2B4JC 2XPOA 2N3AB 3F9KC 2XPLA 2XPNA 3OAKA 3U88C 3HPGG 2XPPA 3HPHE 1EO0A 1WJTA 1Z9EA 3NFQA 3O8ZA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2B4J C;  2XPO A;  2N3A B;  3F9K C;  2XPL A;  2XPN A;  3OAK A;  3U88 C;  3HPG G;  2XPP A;  3HPH E;  1EO0 A;  1WJT A;  1Z9E A;  3NFQ A;  3O8Z A; 
#chains in the Genus database with same CATH topology
 2PVV A;  2VKZ G;  4OC3 A;  3FED A;  3HPG G;  3BUW B;  4OME A;  5HKW A;  4X3R A;  3SJF A;  3OB2 B;  4JYW A;  3SJE A;  3BHX A;  4NGQ A;  3KAS A;  2XPL A;  3VRR A;  2XEG A;  3BUM B;  2Y1M A;  3PT1 A;  5AXI A;  4P44 A;  3D7G A;  5J3X A;  4LQG A;  4MCR A;  2XEF A;  1DE4 C;  3PFV A;  2XPP A;  4NGM A;  3VRQ A;  2XEI A;  3D7D A;  4NGP A;  3PLF B;  2JBJ A;  5BY0 A;  3FF3 A;  4BTF A;  5HKZ A;  3O8Z A;  4RR2 B;  4BPX B;  3FEE A;  4BPW B;  3VRN A;  5HKY A;  2B4J C;  3BUO B;  3OAK A;  4P4E A;  4W9Y A;  3BXM A;  2OOT A;  1Z8L A;  2UV8 G;  4P4B A;  3BI0 A;  5D29 A;  3VGO A;  1FBV A;  3U88 C;  3D7F A;  1YVH A;  3BUN B;  4OC0 A;  3D7H A;  3BI1 A;  3OB1 B;  2PVW A;  4OC1 A;  4P4D A;  3F9K C;  2XPN A;  2C6G A;  4NGR A;  3HMJ G;  2C6C A;  3HPH E;  3S9N A;  4P4F A;  4OC5 A;  4BPU B;  2N3A B;  1B47 A;  1EO0 A;  3VRP A;  2OR4 A;  2XEJ A;  4A4C A;  3S9M A;  2CIJ A;  4P45 A;  1Z9E A;  4NGS A;  3FEC A;  5F09 A;  4P4I A;  3OP0 A;  4NGT A;  4MCS A;  4MCP A;  4OC4 A;  2CBL A;  3SJG A;  3S9L A;  4OC2 A;  4P4J A;  3VRO A;  2Y1N A;  4MCQ A;  4GPL B;  3ZNI A;  3SJX A;  2C6P A;  3BUX B;  3RBU A;  1WJT A;  2JBK A;  5ELY A;  2XPO A;  3IWW A;  4A4B A;  1CX8 A;  2DLA A;  4JZ0 A;  4NGN A;  3NFQ A;  5F13 A; 
#chains in the Genus database with same CATH homology
 2B4J C;  2XPO A;  2N3A B;  3F9K C;  2XPL A;  2XPN A;  3OAK A;  3U88 C;  3HPG G;  2XPP A;  3HPH E;  1EO0 A;  1WJT A;  1Z9E A;  3NFQ A;  3O8Z A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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