3U88C

Crystal structure of human menin in complex with mll1 and ledgf
Total Genus 31
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
31
sequence length
82
structure length
82
Chain Sequence
b'MDSRLQRIHAEIKNSLKIDNLDVNRCIEALDELASLQVTMQQAQKHTEMITTLKKIRRFKVSQVIMEKSTMLYNKFKNMFLV'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Menin
publication title The same pocket in menin binds both MLL and JUND but has opposite effects on transcription.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transcription
total genus 31
structure length 82
sequence length 82
chains with identical sequence D
ec nomenclature
pdb deposition date 2011-10-16
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.930.10 Mainly Alpha Up-down Bundle Transcription Elongation Factor S-II; Chain A Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 3u88C00
2XPNA 2XPPA 3NFQA 1Z9EA 3HPGG 1WJTA 1EO0A 3F9KC 3HPHE 3O8ZA 2XPOA 3OAKA 2XPLA 2B4JC 2N3AB 3U88C
chains in the Genus database with same CATH superfamily
4P4JA 1YVHA 3BHXA 2XEIA 3PLFB 3PT1A 4NGNA 3U88C 2PVWA 3BI0A 3D7FA 3PFVA 4NGSA 5J3XA 4OC3A 3SJGA 3VGOA 1Z8LA 5AXIA 2XEJA 4MCPA 2N3AB 4NGRA 4OC2A 4MCRA 3HMJG 4BPUB 4P45A 2DLAA 5BY0A 3SJEA 4P4EA 1DE4C 4RR2B 4NGQA 4JZ0A 4OC4A 4OC5A 4P4FA 3OB2B 3BUXB 3D7DA 2JBKA 1EO0A 2XEFA 3OP0A 2XPOA 2B4JC 3NFQA 4BPXB 3HPHE 4GPLB 3S9NA 3BUNB 3S9MA 4P4IA 1Z9EA 4P4DA 4NGMA 5HKZA 3OB1B 3BUWB 3BXMA 2PVVA 4JYWA 3FEDA 4NGPA 4P4BA 5D29A 3VRRA 1CX8A 3VRNA 2CBLA 4NGTA 2OOTA 3RBUA 3VRQA 3BUMB 3BUOB 3IWWA 3O8ZA 3D7HA 3SJFA 1FBVA 5HKWA 2XPNA 3HPGG 2Y1NA 4X3RA 4BTFA 2UV8G 2XEGA 3FEEA 4A4CA 5ELYA 2Y1MA 3ZNIA 2VKZG 4MCSA 2XPPA 5HKYA 3VRPA 4W9YA 4LQGA 5F09A 4A4BA 2XPLA 4BPWB 4OMEA 2C6CA 4MCQA 4OC0A 2C6GA 3OAKA 4P44A 1B47A 3F9KC 3S9LA 3SJXA 3BI1A 3D7GA 3FECA 2C6PA 1WJTA 3FF3A 3VROA 2CIJA 4OC1A 2JBJA 2OR4A 3KASA 5F13A
chains in the Genus database with same CATH topology
2XPNA 2XPPA 3NFQA 1Z9EA 3HPGG 1WJTA 1EO0A 3F9KC 3HPHE 3O8ZA 2XPOA 3OAKA 2XPLA 2B4JC 2N3AB 3U88C
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2XPN A;  2XPP A;  3NFQ A;  1Z9E A;  3HPG G;  1WJT A;  1EO0 A;  3F9K C;  3HPH E;  3O8Z A;  2XPO A;  3OAK A;  2XPL A;  2B4J C;  2N3A B;  3U88 C; 
#chains in the Genus database with same CATH topology
 4P4J A;  1YVH A;  3BHX A;  2XEI A;  3PLF B;  3PT1 A;  4NGN A;  3U88 C;  2PVW A;  3BI0 A;  3D7F A;  3PFV A;  4NGS A;  5J3X A;  4OC3 A;  3SJG A;  3VGO A;  1Z8L A;  5AXI A;  2XEJ A;  4MCP A;  2N3A B;  4NGR A;  4OC2 A;  4MCR A;  3HMJ G;  4BPU B;  4P45 A;  2DLA A;  5BY0 A;  3SJE A;  4P4E A;  1DE4 C;  4RR2 B;  4NGQ A;  4JZ0 A;  4OC4 A;  4OC5 A;  4P4F A;  3OB2 B;  3BUX B;  3D7D A;  2JBK A;  1EO0 A;  2XEF A;  3OP0 A;  2XPO A;  2B4J C;  3NFQ A;  4BPX B;  3HPH E;  4GPL B;  3S9N A;  3BUN B;  3S9M A;  4P4I A;  1Z9E A;  4P4D A;  4NGM A;  5HKZ A;  3OB1 B;  3BUW B;  3BXM A;  2PVV A;  4JYW A;  3FED A;  4NGP A;  4P4B A;  5D29 A;  3VRR A;  1CX8 A;  3VRN A;  2CBL A;  4NGT A;  2OOT A;  3RBU A;  3VRQ A;  3BUM B;  3BUO B;  3IWW A;  3O8Z A;  3D7H A;  3SJF A;  1FBV A;  5HKW A;  2XPN A;  3HPG G;  2Y1N A;  4X3R A;  4BTF A;  2UV8 G;  2XEG A;  3FEE A;  4A4C A;  5ELY A;  2Y1M A;  3ZNI A;  2VKZ G;  4MCS A;  2XPP A;  5HKY A;  3VRP A;  4W9Y A;  4LQG A;  5F09 A;  4A4B A;  2XPL A;  4BPW B;  4OME A;  2C6C A;  4MCQ A;  4OC0 A;  2C6G A;  3OAK A;  4P44 A;  1B47 A;  3F9K C;  3S9L A;  3SJX A;  3BI1 A;  3D7G A;  3FEC A;  2C6P A;  1WJT A;  3FF3 A;  3VRO A;  2CIJ A;  4OC1 A;  2JBJ A;  2OR4 A;  3KAS A;  5F13 A; 
#chains in the Genus database with same CATH homology
 2XPN A;  2XPP A;  3NFQ A;  1Z9E A;  3HPG G;  1WJT A;  1EO0 A;  3F9K C;  3HPH E;  3O8Z A;  2XPO A;  3OAK A;  2XPL A;  2B4J C;  2N3A B;  3U88 C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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