3U88C

Crystal structure of human menin in complex with mll1 and ledgf
Total Genus 31
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
31
sequence length
82
structure length
82
Chain Sequence
MDSRLQRIHAEIKNSLKIDNLDVNRCIEALDELASLQVTMQQAQKHTEMITTLKKIRRFKVSQVIMEKSTMLYNKFKNMFLV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Menin
publication title The same pocket in menin binds both MLL and JUND but has opposite effects on transcription.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transcription
total genus 31
structure length 82
sequence length 82
chains with identical sequence D
ec nomenclature
pdb deposition date 2011-10-16
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.930.10 Mainly Alpha Up-down Bundle Transcription Elongation Factor S-II; Chain A Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 3u88C00
3HPHE 2XPLA 3OAKA 3O8ZA 2XPPA 1Z9EA 2XPNA 3U88C 1WJTA 2B4JC 1EO0A 3NFQA 2XPOA 3HPGG 2N3AB 3F9KC
chains in the Genus database with same CATH superfamily
5HKWA 3U88C 4RR2B 4X3RA 4P4JA 5F13A 1Z8LA 3F9KC 4P4DA 3S9LA 4NGQA 2XPOA 3BUMB 3S9MA 3D7GA 4BPXB 3SJGA 5HKZA 4W9YA 3BUNB 2JBJA 3SJXA 3OAKA 2C6GA 3BHXA 3RBUA 3D7DA 4NGNA 2Y1MA 5AXIA 4P45A 4OC1A 2XEIA 4P4IA 3BI0A 5J3XA 4MCRA 1Z9EA 3FF3A 4P4FA 3VRRA 1WJTA 3BI1A 2XPNA 3OB1B 4BTFA 2XPLA 3FEEA 4MCPA 4OC2A 2Y1NA 5D29A 1YVHA 3O8ZA 4P4BA 1B47A 4OC4A 1EO0A 2PVWA 3IWWA 4BPUB 4NGRA 4A4BA 4NGPA 3SJEA 2XPPA 4BPWB 2XEJA 1FBVA 2PVVA 3ZNIA 3BUWB 3BXMA 4MCSA 5BY0A 3VRNA 3HMJG 3BUXB 3OP0A 5ELYA 3OB2B 4NGTA 3D7HA 3FEDA 3VROA 3KASA 4NGSA 3SJFA 4MCQA 2OOTA 2CIJA 2JBKA 3BUOB 4OC3A 3S9NA 4LQGA 3HPGG 2VKZG 4OC0A 3FECA 4JYWA 4GPLB 4P4EA 3HPHE 2C6PA 4NGMA 1CX8A 2CBLA 2B4JC 3VGOA 4P44A 4OC5A 3VRQA 2C6CA 3VRPA 2N3AB 4A4CA 3PFVA 3PLFB 2DLAA 3D7FA 3NFQA 5F09A 1DE4C 2XEGA 4OMEA 4JZ0A 3PT1A 2OR4A 2UV8G 5HKYA 2XEFA
chains in the Genus database with same CATH topology
3HPHE 2XPLA 3OAKA 3O8ZA 2XPPA 1Z9EA 2XPNA 3U88C 1WJTA 2B4JC 1EO0A 3NFQA 2XPOA 3HPGG 2N3AB 3F9KC
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3HPH E;  2XPL A;  3OAK A;  3O8Z A;  2XPP A;  1Z9E A;  2XPN A;  3U88 C;  1WJT A;  2B4J C;  1EO0 A;  3NFQ A;  2XPO A;  3HPG G;  2N3A B;  3F9K C; 
#chains in the Genus database with same CATH topology
 5HKW A;  3U88 C;  4RR2 B;  4X3R A;  4P4J A;  5F13 A;  1Z8L A;  3F9K C;  4P4D A;  3S9L A;  4NGQ A;  2XPO A;  3BUM B;  3S9M A;  3D7G A;  4BPX B;  3SJG A;  5HKZ A;  4W9Y A;  3BUN B;  2JBJ A;  3SJX A;  3OAK A;  2C6G A;  3BHX A;  3RBU A;  3D7D A;  4NGN A;  2Y1M A;  5AXI A;  4P45 A;  4OC1 A;  2XEI A;  4P4I A;  3BI0 A;  5J3X A;  4MCR A;  1Z9E A;  3FF3 A;  4P4F A;  3VRR A;  1WJT A;  3BI1 A;  2XPN A;  3OB1 B;  4BTF A;  2XPL A;  3FEE A;  4MCP A;  4OC2 A;  2Y1N A;  5D29 A;  1YVH A;  3O8Z A;  4P4B A;  1B47 A;  4OC4 A;  1EO0 A;  2PVW A;  3IWW A;  4BPU B;  4NGR A;  4A4B A;  4NGP A;  3SJE A;  2XPP A;  4BPW B;  2XEJ A;  1FBV A;  2PVV A;  3ZNI A;  3BUW B;  3BXM A;  4MCS A;  5BY0 A;  3VRN A;  3HMJ G;  3BUX B;  3OP0 A;  5ELY A;  3OB2 B;  4NGT A;  3D7H A;  3FED A;  3VRO A;  3KAS A;  4NGS A;  3SJF A;  4MCQ A;  2OOT A;  2CIJ A;  2JBK A;  3BUO B;  4OC3 A;  3S9N A;  4LQG A;  3HPG G;  2VKZ G;  4OC0 A;  3FEC A;  4JYW A;  4GPL B;  4P4E A;  3HPH E;  2C6P A;  4NGM A;  1CX8 A;  2CBL A;  2B4J C;  3VGO A;  4P44 A;  4OC5 A;  3VRQ A;  2C6C A;  3VRP A;  2N3A B;  4A4C A;  3PFV A;  3PLF B;  2DLA A;  3D7F A;  3NFQ A;  5F09 A;  1DE4 C;  2XEG A;  4OME A;  4JZ0 A;  3PT1 A;  2OR4 A;  2UV8 G;  5HKY A;  2XEF A; 
#chains in the Genus database with same CATH homology
 3HPH E;  2XPL A;  3OAK A;  3O8Z A;  2XPP A;  1Z9E A;  2XPN A;  3U88 C;  1WJT A;  2B4J C;  1EO0 A;  3NFQ A;  2XPO A;  3HPG G;  2N3A B;  3F9K C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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