4BPUB

Crystal structure of human primase in heterodimeric form, comprising pris and truncated pril lacking the c-terminal fe-s domain.
Total Genus 70
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
70
sequence length
244
structure length
216
Chain Sequence
KLRLAGYLQPPSENISLIEFENLAIDRVKLLKSVENLGVSYVKGTEQYQSKLESELRKLKFPRRRDHISHFILRLAYCQSEELRRWFIQQEMDLLRFRFSILPKDKIQDFLKDSQLQFEAISDEEKTLREQEIVASSPSLLGFESIYKIPFADALDLFRGRKVYLEDGFAYVPLKDIVAIILNEFRAKLSKALALTARSLPAVQSDERLQPLLNHL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Transferase
molecule keywords DNA PRIMASE SMALL SUBUNIT
publication title Structures of Human Primase Reveal Design of Nucleotide Elongation Site and Mode of Pol Alpha Tethering
pubmed doi rcsb
source organism Homo sapiens
total genus 70
structure length 216
sequence length 244
chains with identical sequence D
ec nomenclature ec 2.7.7.-:
pdb deposition date 2013-05-28
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.930.80 Mainly Alpha Up-down Bundle Transcription Elongation Factor S-II; Chain A Transcription Elongation Factor S-II; Chain A 4bpuB00
4BPUB 4BPWB 4BPXB 4RR2B
chains in the Genus database with same CATH superfamily
1WJTA 2OR4A 1DE4C 1FBVA 4BPXB 3SJFA 4OC3A 2Y1NA 3HPGG 2Y1MA 5HKWA 3VRPA 2N3AB 4OC2A 5ELYA 5HKYA 5AXIA 3D7GA 3FEEA 4P4EA 3BUMB 4NGNA 3BXMA 3SJXA 3S9LA 3BUXB 2XPLA 3PLFB 2XPOA 4BTFA 2C6PA 2VKZG 4OC0A 5D29A 4NGTA 3PFVA 2PVVA 2JBJA 2OOTA 3VRRA 1CX8A 4W9YA 4RR2B 2XPPA 4MCSA 4MCPA 3BHXA 2C6CA 3OB1B 4OMEA 2XPNA 4NGPA 2JBKA 2XEFA 3D7DA 3HPHE 4JYWA 4P44A 3RBUA 4BPWB 4P4IA 3D7HA 3VRNA 1Z9EA 1YVHA 1B47A 3OB2B 3OP0A 4P4DA 5HKZA 3S9NA 4MCRA 3D7FA 2XEJA 3IWWA 3BUWB 3VGOA 2UV8G 4NGSA 3PT1A 4OC4A 4X3RA 3SJEA 2B4JC 1Z8LA 5F09A 3U88C 3O8ZA 4NGQA 4P4BA 3FEDA 4NGRA 4NGMA 4OC5A 5J3XA 1EO0A 3OAKA 3SJGA 4P4FA 5F13A 2CBLA 4MCQA 4BPUB 3BUOB 2XEGA 2CIJA 2DLAA 4LQGA 4JZ0A 5BY0A 2C6GA 2XEIA 3VROA 4P4JA 4P45A 3KASA 3VRQA 3S9MA 3FF3A 3BI0A 3BI1A 3F9KC 2PVWA 4OC1A 3BUNB 4GPLB 3ZNIA 3HMJG 3FECA 4A4BA 3NFQA 4A4CA
chains in the Genus database with same CATH topology
5F13A 2UV8G 4RR2B 5BY0A 3HMJG 2VKZG 4BPUB 3PT1A 4BPXB 4BPWB 2DLAA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4BPU B;  4BPW B;  4BPX B;  4RR2 B; 
#chains in the Genus database with same CATH topology
 1WJT A;  2OR4 A;  1DE4 C;  1FBV A;  4BPX B;  3SJF A;  4OC3 A;  2Y1N A;  3HPG G;  2Y1M A;  5HKW A;  3VRP A;  2N3A B;  4OC2 A;  5ELY A;  5HKY A;  5AXI A;  3D7G A;  3FEE A;  4P4E A;  3BUM B;  4NGN A;  3BXM A;  3SJX A;  3S9L A;  3BUX B;  2XPL A;  3PLF B;  2XPO A;  4BTF A;  2C6P A;  2VKZ G;  4OC0 A;  5D29 A;  4NGT A;  3PFV A;  2PVV A;  2JBJ A;  2OOT A;  3VRR A;  1CX8 A;  4W9Y A;  4RR2 B;  2XPP A;  4MCS A;  4MCP A;  3BHX A;  2C6C A;  3OB1 B;  4OME A;  2XPN A;  4NGP A;  2JBK A;  2XEF A;  3D7D A;  3HPH E;  4JYW A;  4P44 A;  3RBU A;  4BPW B;  4P4I A;  3D7H A;  3VRN A;  1Z9E A;  1YVH A;  1B47 A;  3OB2 B;  3OP0 A;  4P4D A;  5HKZ A;  3S9N A;  4MCR A;  3D7F A;  2XEJ A;  3IWW A;  3BUW B;  3VGO A;  2UV8 G;  4NGS A;  3PT1 A;  4OC4 A;  4X3R A;  3SJE A;  2B4J C;  1Z8L A;  5F09 A;  3U88 C;  3O8Z A;  4NGQ A;  4P4B A;  3FED A;  4NGR A;  4NGM A;  4OC5 A;  5J3X A;  1EO0 A;  3OAK A;  3SJG A;  4P4F A;  5F13 A;  2CBL A;  4MCQ A;  4BPU B;  3BUO B;  2XEG A;  2CIJ A;  2DLA A;  4LQG A;  4JZ0 A;  5BY0 A;  2C6G A;  2XEI A;  3VRO A;  4P4J A;  4P45 A;  3KAS A;  3VRQ A;  3S9M A;  3FF3 A;  3BI0 A;  3BI1 A;  3F9K C;  2PVW A;  4OC1 A;  3BUN B;  4GPL B;  3ZNI A;  3HMJ G;  3FEC A;  4A4B A;  3NFQ A;  4A4C A; 
#chains in the Genus database with same CATH homology
 5F13 A;  2UV8 G;  4RR2 B;  5BY0 A;  3HMJ G;  2VKZ G;  4BPU B;  3PT1 A;  4BPX B;  4BPW B;  2DLA A; 
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similar chains in the Genus database (?% sequence similarity)
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#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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