4BPUB

Crystal structure of human primase in heterodimeric form, comprising pris and truncated pril lacking the c-terminal fe-s domain.
Total Genus 70
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
70
sequence length
244
structure length
216
Chain Sequence
KLRLAGYLQPPSENISLIEFENLAIDRVKLLKSVENLGVSYVKGTEQYQSKLESELRKLKFPRRRDHISHFILRLAYCQSEELRRWFIQQEMDLLRFRFSILPKDKIQDFLKDSQLQFEAISDEEKTLREQEIVASSPSLLGFESIYKIPFADALDLFRGRKVYLEDGFAYVPLKDIVAIILNEFRAKLSKALALTARSLPAVQSDERLQPLLNHL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structures of Human Primase Reveal Design of Nucleotide Elongation Site and Mode of Pol Alpha Tethering
pubmed doi rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords DNA PRIMASE SMALL SUBUNIT
total genus 70
structure length 216
sequence length 244
chains with identical sequence D
ec nomenclature ec 2.7.7.-:
pdb deposition date 2013-05-28
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.930.80 Mainly Alpha Up-down Bundle Transcription Elongation Factor S-II; Chain A Transcription Elongation Factor S-II; Chain A 4bpuB00
4BPUB 4BPWB 4RR2B 4BPXB
chains in the Genus database with same CATH superfamily
3BI0A 2C6PA 3KASA 3BUNB 2UV8G 3VRRA 2C6CA 3SJXA 5F09A 2XPPA 4OC5A 4MCRA 4P4BA 4X3RA 1WJTA 3O8ZA 3PFVA 4NGMA 2XEJA 2C6GA 4OC0A 4NGSA 4BTFA 3BI1A 2Y1MA 3D7DA 3SJGA 3HPGG 2PVVA 3BUXB 4OC2A 4P4EA 5ELYA 1DE4C 4P4DA 3BUMB 4P44A 3BHXA 4OC1A 2XPOA 2XPLA 4LQGA 3S9MA 3OP0A 3BUOB 1FBVA 2B4JC 3HPHE 3VROA 3FEEA 3SJEA 3VRPA 5HKWA 5BY0A 2XEGA 2DLAA 3F9KC 5F13A 4GPLB 3D7HA 3ZNIA 3OAKA 4P4FA 5HKYA 3OB1B 3IWWA 3FEDA 3NFQA 1YVHA 4P45A 4MCPA 4A4BA 3BXMA 3RBUA 2XEIA 3BUWB 1Z8LA 4P4JA 4P4IA 3S9LA 4JYWA 4MCSA 2OR4A 2Y1NA 2N3AB 3S9NA 1EO0A 4OC3A 4NGNA 2CIJA 3HMJG 3VGOA 2VKZG 4W9YA 2JBJA 1Z9EA 3SJFA 3U88C 5AXIA 4BPWB 2XPNA 4NGTA 2XEFA 3D7GA 4RR2B 5D29A 2CBLA 4JZ0A 3D7FA 3OB2B 4MCQA 3VRNA 4BPUB 4NGPA 3PT1A 4NGQA 1B47A 4BPXB 2JBKA 3PLFB 5J3XA 2OOTA 5HKZA 3VRQA 4A4CA 3FECA 4NGRA 2PVWA 4OMEA 1CX8A 3FF3A 4OC4A
chains in the Genus database with same CATH topology
2DLAA 2VKZG 5F13A 4BPWB 4BPUB 3PT1A 2UV8G 4RR2B 5BY0A 3HMJG 4BPXB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4BPU B;  4BPW B;  4RR2 B;  4BPX B; 
#chains in the Genus database with same CATH topology
 3BI0 A;  2C6P A;  3KAS A;  3BUN B;  2UV8 G;  3VRR A;  2C6C A;  3SJX A;  5F09 A;  2XPP A;  4OC5 A;  4MCR A;  4P4B A;  4X3R A;  1WJT A;  3O8Z A;  3PFV A;  4NGM A;  2XEJ A;  2C6G A;  4OC0 A;  4NGS A;  4BTF A;  3BI1 A;  2Y1M A;  3D7D A;  3SJG A;  3HPG G;  2PVV A;  3BUX B;  4OC2 A;  4P4E A;  5ELY A;  1DE4 C;  4P4D A;  3BUM B;  4P44 A;  3BHX A;  4OC1 A;  2XPO A;  2XPL A;  4LQG A;  3S9M A;  3OP0 A;  3BUO B;  1FBV A;  2B4J C;  3HPH E;  3VRO A;  3FEE A;  3SJE A;  3VRP A;  5HKW A;  5BY0 A;  2XEG A;  2DLA A;  3F9K C;  5F13 A;  4GPL B;  3D7H A;  3ZNI A;  3OAK A;  4P4F A;  5HKY A;  3OB1 B;  3IWW A;  3FED A;  3NFQ A;  1YVH A;  4P45 A;  4MCP A;  4A4B A;  3BXM A;  3RBU A;  2XEI A;  3BUW B;  1Z8L A;  4P4J A;  4P4I A;  3S9L A;  4JYW A;  4MCS A;  2OR4 A;  2Y1N A;  2N3A B;  3S9N A;  1EO0 A;  4OC3 A;  4NGN A;  2CIJ A;  3HMJ G;  3VGO A;  2VKZ G;  4W9Y A;  2JBJ A;  1Z9E A;  3SJF A;  3U88 C;  5AXI A;  4BPW B;  2XPN A;  4NGT A;  2XEF A;  3D7G A;  4RR2 B;  5D29 A;  2CBL A;  4JZ0 A;  3D7F A;  3OB2 B;  4MCQ A;  3VRN A;  4BPU B;  4NGP A;  3PT1 A;  4NGQ A;  1B47 A;  4BPX B;  2JBK A;  3PLF B;  5J3X A;  2OOT A;  5HKZ A;  3VRQ A;  4A4C A;  3FEC A;  4NGR A;  2PVW A;  4OME A;  1CX8 A;  3FF3 A;  4OC4 A; 
#chains in the Genus database with same CATH homology
 2DLA A;  2VKZ G;  5F13 A;  4BPW B;  4BPU B;  3PT1 A;  2UV8 G;  4RR2 B;  5BY0 A;  3HMJ G;  4BPX B; 
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similar chains in the Genus database (?% sequence similarity)
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#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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