4BPXB

Crystal structure of human primase in complex with the primase- binding motif of dna polymerase alpha
Total Genus 50
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
50
sequence length
217
structure length
181
Chain Sequence
ISLIEFENLAIDRVKLLKSVENLSKLESELRKLRRDHISHFILRLAYCQSEELRRWFIQQEMDLLRFRFSILPKDKIQDFLKDSQLQFEAISDEEKTLREQEIVASSPSLLGFESIYKIPFADALDLFRGRKVYLEDGFAYVPLKDIVAIILNEFRAKLSKALALTARSLDERLQPLLNHL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structures of Human Primase Reveal Design of Nucleotide Elongation Site and Mode of Pol Alpha Tethering
pubmed doi rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords DNA PRIMASE SMALL SUBUNIT
total genus 50
structure length 181
sequence length 217
chains with identical sequence D
ec nomenclature ec 2.7.7.-:
pdb deposition date 2013-05-28
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.930.80 Mainly Alpha Up-down Bundle Transcription Elongation Factor S-II; Chain A Transcription Elongation Factor S-II; Chain A 4bpxB00
4RR2B 4BPWB 4BPUB 4BPXB
chains in the Genus database with same CATH superfamily
1FBVA 4P4EA 2PVWA 4NGNA 3PFVA 4W9YA 5HKWA 3BI1A 4NGTA 3SJFA 3SJXA 4MCQA 2XEIA 3RBUA 3D7DA 3VRRA 3KASA 1DE4C 3SJEA 3U88C 3D7FA 3BXMA 3BUXB 4X3RA 2JBKA 5HKYA 3VGOA 3S9NA 3PLFB 2VKZG 4A4CA 2XEGA 3OAKA 3BUNB 4GPLB 4OC4A 3ZNIA 2C6GA 3FECA 5HKZA 3S9LA 2XPLA 3BUMB 5J3XA 4LQGA 1Z8LA 3IWWA 2C6CA 2XPPA 5D29A 2Y1MA 3D7GA 1YVHA 4OC1A 2XEJA 4RR2B 3FEDA 3OB1B 1B47A 4P44A 4OC0A 4JZ0A 4MCSA 3S9MA 4NGPA 3OB2B 2C6PA 2DLAA 3VRPA 4NGQA 3BUWB 2CIJA 4JYWA 4A4BA 3BUOB 4P4JA 2B4JC 3SJGA 2OOTA 4OC5A 4P4BA 3BI0A 4OC3A 3OP0A 1CX8A 4NGRA 3HPHE 5F13A 3F9KC 3FF3A 2JBJA 3VROA 1WJTA 2OR4A 4MCPA 3HMJG 3NFQA 3O8ZA 1EO0A 5AXIA 3BHXA 4OMEA 2XPOA 2Y1NA 4MCRA 2XEFA 5BY0A 2N3AB 4P4IA 3HPGG 4OC2A 2UV8G 2PVVA 2XPNA 1Z9EA 4P4DA 4P45A 2CBLA 4BTFA 3D7HA 5F09A 4NGMA 4BPWB 3PT1A 3VRNA 4NGSA 5ELYA 3FEEA 4BPUB 4P4FA 3VRQA 4BPXB
chains in the Genus database with same CATH topology
2UV8G 4BPWB 4BPUB 3PT1A 3HMJG 4RR2B 5BY0A 2VKZG 2DLAA 5F13A 4BPXB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4RR2 B;  4BPW B;  4BPU B;  4BPX B; 
#chains in the Genus database with same CATH topology
 1FBV A;  4P4E A;  2PVW A;  4NGN A;  3PFV A;  4W9Y A;  5HKW A;  3BI1 A;  4NGT A;  3SJF A;  3SJX A;  4MCQ A;  2XEI A;  3RBU A;  3D7D A;  3VRR A;  3KAS A;  1DE4 C;  3SJE A;  3U88 C;  3D7F A;  3BXM A;  3BUX B;  4X3R A;  2JBK A;  5HKY A;  3VGO A;  3S9N A;  3PLF B;  2VKZ G;  4A4C A;  2XEG A;  3OAK A;  3BUN B;  4GPL B;  4OC4 A;  3ZNI A;  2C6G A;  3FEC A;  5HKZ A;  3S9L A;  2XPL A;  3BUM B;  5J3X A;  4LQG A;  1Z8L A;  3IWW A;  2C6C A;  2XPP A;  5D29 A;  2Y1M A;  3D7G A;  1YVH A;  4OC1 A;  2XEJ A;  4RR2 B;  3FED A;  3OB1 B;  1B47 A;  4P44 A;  4OC0 A;  4JZ0 A;  4MCS A;  3S9M A;  4NGP A;  3OB2 B;  2C6P A;  2DLA A;  3VRP A;  4NGQ A;  3BUW B;  2CIJ A;  4JYW A;  4A4B A;  3BUO B;  4P4J A;  2B4J C;  3SJG A;  2OOT A;  4OC5 A;  4P4B A;  3BI0 A;  4OC3 A;  3OP0 A;  1CX8 A;  4NGR A;  3HPH E;  5F13 A;  3F9K C;  3FF3 A;  2JBJ A;  3VRO A;  1WJT A;  2OR4 A;  4MCP A;  3HMJ G;  3NFQ A;  3O8Z A;  1EO0 A;  5AXI A;  3BHX A;  4OME A;  2XPO A;  2Y1N A;  4MCR A;  2XEF A;  5BY0 A;  2N3A B;  4P4I A;  3HPG G;  4OC2 A;  2UV8 G;  2PVV A;  2XPN A;  1Z9E A;  4P4D A;  4P45 A;  2CBL A;  4BTF A;  3D7H A;  5F09 A;  4NGM A;  4BPW B;  3PT1 A;  3VRN A;  4NGS A;  5ELY A;  3FEE A;  4BPU B;  4P4F A;  3VRQ A;  4BPX B; 
#chains in the Genus database with same CATH homology
 2UV8 G;  4BPW B;  4BPU B;  3PT1 A;  3HMJ G;  4RR2 B;  5BY0 A;  2VKZ G;  2DLA A;  5F13 A;  4BPX B; 
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similar chains in the Genus database (?% sequence similarity)
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#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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