3NWYA

Structure and allosteric regulation of the uridine monophosphate kinase from mycobacterium tuberculosis
Total Genus 73
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
73
sequence length
235
structure length
227
Chain Sequence
LSGYSRVLLKLGGEMFGGGQVGLDPDVVAQVARQIADVVRGGVQIAVVIGGGNFAQLQQLGMERTRSDYMGMLGTVMNSLALQDFLEKEGIVTRVQTAITMGQVAEPYLPLRAVRHLEKGRVVIFGAGMGLPYFSTDTTAAQRALEIGADVVLMAKAVDGVFAEPEAELLTAVSHREVLDRGLRVADATAFSLCMDNGMPILVFNLLTDGNIARAVRGEKIGTLVTT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Structural and functional characterization of the Mycobacterium tuberculosis uridine monophosphate kinase: insights into the allosteric regulation.
pubmed doi rcsb
molecule tags Transferase
source organism Mycobacterium tuberculosis
molecule keywords Uridylate kinase
total genus 73
structure length 227
sequence length 235
chains with identical sequence B, C, D, E, F
ec nomenclature ec 2.7.4.22: UMP kinase.
pdb deposition date 2010-07-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00696 AA_kinase Amino acid kinase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.1160.10 Alpha Beta 3-Layer(aba) Sandwich Carbamate kinase Acetylglutamate kinase-like 3nwyA00
3QURA 2BRXA 2R98A 3EK5A 3L86A 3C1MA 3QUNA 2J0WA 3K56A 2RD5A 4A7XA 2BNEA 2JI5A 3C1NA 2J5VA 3D40A 2WE4A 4F6TA 4NDPA 3ZZIA 2OGXB 3ZZGA 2JJ4A 4JZ7A 3QUOA 3T7BA 2IJ9A 3LL9A 1B7BA 3S6KA 4USJA 4Q1TA 3LL5A 2BTYA 4NDQB 2AP9A 3D2MA 2J0XA 3D2PA 3TVIA 2J5TA 2R8VA 3WWMA 2V5HA 4JZ9A 4OLCA 3AB4A 2AKOA 2E9YA 3K4YA 3K4OA 2JJXA 1GS5A 1E19A 4NDQA 3L76A 2W21A 3S6GA 2CDQA 3WWNA 4NDRB 1OHAA 1OHBA 1GSJA 3EK6A 3ZZFA 4AB7A 3QVFA 2V4YA 4I49A 1Z9DA 2WE5A 3C20A 2J4KA 2OGXA 4KZTA 4AXSA 3K52A 2J4JA 4A7WA 3KZFA 2BNDA 3D41A 2WXBA 1OH9A 4NDOB 3QVHA 2HMFA 4JZ8A 3U6UA 2VA1A 3AAWA 2A1FA 3B8GA 3AB2A 2BRIA 2BNFA 3S6HA 2J4LA 3ZZHA 3NWYA 2X2WA 4NDOA 2BUFA 4F6TB 4NDRA 3LKKA 1YBDA 2BMUA 4NDPB
chains in the Genus database with same CATH superfamily
3QURA 2BRXA 2R98A 3EK5A 3L86A 3C1MA 3QUNA 2J0WA 3K56A 2RD5A 4A7XA 2BNEA 2JI5A 3C1NA 2J5VA 3D40A 2WE4A 4F6TA 4NDPA 3ZZIA 2OGXB 3ZZGA 2JJ4A 4JZ7A 3QUOA 3T7BA 2IJ9A 3LL9A 1B7BA 3S6KA 4USJA 4Q1TA 3LL5A 2BTYA 4NDQB 2AP9A 3D2MA 2J0XA 3D2PA 3TVIA 2J5TA 2R8VA 3WWMA 2V5HA 4JZ9A 4OLCA 3AB4A 2AKOA 2E9YA 3K4YA 3K4OA 2JJXA 1GS5A 1E19A 4NDQA 3L76A 2W21A 3S6GA 2CDQA 3WWNA 4NDRB 1OHAA 1OHBA 1GSJA 3EK6A 3ZZFA 4AB7A 3QVFA 2V4YA 4I49A 1Z9DA 2WE5A 3C20A 2J4KA 2OGXA 4KZTA 4AXSA 3K52A 2J4JA 4A7WA 3KZFA 2BNDA 3D41A 2WXBA 1OH9A 4NDOB 3QVHA 2HMFA 4JZ8A 3U6UA 2VA1A 3AAWA 2A1FA 3B8GA 3AB2A 2BRIA 2BNFA 3S6HA 2J4LA 3ZZHA 3NWYA 2X2WA 4NDOA 2BUFA 4F6TB 4NDRA 3LKKA 1YBDA 2BMUA 4NDPB
chains in the Genus database with same CATH topology
3QURA 2BRXA 2R98A 3EK5A 3L86A 3C1MA 3QUNA 2J0WA 3K56A 2RD5A 4A7XA 2BNEA 2JI5A 3C1NA 2J5VA 3D40A 2WE4A 4F6TA 4NDPA 3ZZIA 2OGXB 3ZZGA 2JJ4A 4JZ7A 3QUOA 3T7BA 2IJ9A 3LL9A 1B7BA 3S6KA 4USJA 4Q1TA 3LL5A 2BTYA 4NDQB 2AP9A 3D2MA 2J0XA 3D2PA 3TVIA 2J5TA 2R8VA 3WWMA 2V5HA 4JZ9A 4OLCA 3AB4A 2AKOA 2E9YA 3K4YA 3K4OA 2JJXA 1GS5A 1E19A 4NDQA 3L76A 2W21A 3S6GA 2CDQA 3WWNA 4NDRB 1OHAA 1OHBA 1GSJA 3EK6A 3ZZFA 4AB7A 3QVFA 2V4YA 4I49A 1Z9DA 2WE5A 3C20A 2J4KA 2OGXA 4KZTA 4AXSA 3K52A 2J4JA 4A7WA 3KZFA 2BNDA 3D41A 2WXBA 1OH9A 4NDOB 3QVHA 2HMFA 4JZ8A 3U6UA 2VA1A 3AAWA 2A1FA 3B8GA 3AB2A 2BRIA 2BNFA 3S6HA 2J4LA 3ZZHA 3NWYA 2X2WA 4NDOA 2BUFA 4F6TB 4NDRA 3LKKA 1YBDA 2BMUA 4NDPB
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 3QUR A;  2BRX A;  2R98 A;  3EK5 A;  3L86 A;  3C1M A;  3QUN A;  2J0W A;  3K56 A;  2RD5 A;  4A7X A;  2BNE A;  2JI5 A;  3C1N A;  2J5V A;  3D40 A;  2WE4 A;  4F6T A;  4NDP A;  3ZZI A;  2OGX B;  3ZZG A;  2JJ4 A;  4JZ7 A;  3QUO A;  3T7B A;  2IJ9 A;  3LL9 A;  1B7B A;  3S6K A;  4USJ A;  4Q1T A;  3LL5 A;  2BTY A;  4NDQ B;  2AP9 A;  3D2M A;  2J0X A;  3D2P A;  3TVI A;  2J5T A;  2R8V A;  3WWM A;  2V5H A;  4JZ9 A;  4OLC A;  3AB4 A;  2AKO A;  2E9Y A;  3K4Y A;  3K4O A;  2JJX A;  1GS5 A;  1E19 A;  4NDQ A;  3L76 A;  2W21 A;  3S6G A;  2CDQ A;  3WWN A;  4NDR B;  1OHA A;  1OHB A;  1GSJ A;  3EK6 A;  3ZZF A;  4AB7 A;  3QVF A;  2V4Y A;  4I49 A;  1Z9D A;  2WE5 A;  3C20 A;  2J4K A;  2OGX A;  4KZT A;  4AXS A;  3K52 A;  2J4J A;  4A7W A;  3KZF A;  2BND A;  3D41 A;  2WXB A;  1OH9 A;  4NDO B;  3QVH A;  2HMF A;  4JZ8 A;  3U6U A;  2VA1 A;  3AAW A;  2A1F A;  3B8G A;  3AB2 A;  2BRI A;  2BNF A;  3S6H A;  2J4L A;  3ZZH A;  3NWY A;  2X2W A;  4NDO A;  2BUF A;  4F6T B;  4NDR A;  3LKK A;  1YBD A;  2BMU A;  4NDP B; 
#chains in the Genus database with same CATH topology
 3QUR A;  2BRX A;  2R98 A;  3EK5 A;  3L86 A;  3C1M A;  3QUN A;  2J0W A;  3K56 A;  2RD5 A;  4A7X A;  2BNE A;  2JI5 A;  3C1N A;  2J5V A;  3D40 A;  2WE4 A;  4F6T A;  4NDP A;  3ZZI A;  2OGX B;  3ZZG A;  2JJ4 A;  4JZ7 A;  3QUO A;  3T7B A;  2IJ9 A;  3LL9 A;  1B7B A;  3S6K A;  4USJ A;  4Q1T A;  3LL5 A;  2BTY A;  4NDQ B;  2AP9 A;  3D2M A;  2J0X A;  3D2P A;  3TVI A;  2J5T A;  2R8V A;  3WWM A;  2V5H A;  4JZ9 A;  4OLC A;  3AB4 A;  2AKO A;  2E9Y A;  3K4Y A;  3K4O A;  2JJX A;  1GS5 A;  1E19 A;  4NDQ A;  3L76 A;  2W21 A;  3S6G A;  2CDQ A;  3WWN A;  4NDR B;  1OHA A;  1OHB A;  1GSJ A;  3EK6 A;  3ZZF A;  4AB7 A;  3QVF A;  2V4Y A;  4I49 A;  1Z9D A;  2WE5 A;  3C20 A;  2J4K A;  2OGX A;  4KZT A;  4AXS A;  3K52 A;  2J4J A;  4A7W A;  3KZF A;  2BND A;  3D41 A;  2WXB A;  1OH9 A;  4NDO B;  3QVH A;  2HMF A;  4JZ8 A;  3U6U A;  2VA1 A;  3AAW A;  2A1F A;  3B8G A;  3AB2 A;  2BRI A;  2BNF A;  3S6H A;  2J4L A;  3ZZH A;  3NWY A;  2X2W A;  4NDO A;  2BUF A;  4F6T B;  4NDR A;  3LKK A;  1YBD A;  2BMU A;  4NDP B; 
#chains in the Genus database with same CATH homology
 3QUR A;  2BRX A;  2R98 A;  3EK5 A;  3L86 A;  3C1M A;  3QUN A;  2J0W A;  3K56 A;  2RD5 A;  4A7X A;  2BNE A;  2JI5 A;  3C1N A;  2J5V A;  3D40 A;  2WE4 A;  4F6T A;  4NDP A;  3ZZI A;  2OGX B;  3ZZG A;  2JJ4 A;  4JZ7 A;  3QUO A;  3T7B A;  2IJ9 A;  3LL9 A;  1B7B A;  3S6K A;  4USJ A;  4Q1T A;  3LL5 A;  2BTY A;  4NDQ B;  2AP9 A;  3D2M A;  2J0X A;  3D2P A;  3TVI A;  2J5T A;  2R8V A;  3WWM A;  2V5H A;  4JZ9 A;  4OLC A;  3AB4 A;  2AKO A;  2E9Y A;  3K4Y A;  3K4O A;  2JJX A;  1GS5 A;  1E19 A;  4NDQ A;  3L76 A;  2W21 A;  3S6G A;  2CDQ A;  3WWN A;  4NDR B;  1OHA A;  1OHB A;  1GSJ A;  3EK6 A;  3ZZF A;  4AB7 A;  3QVF A;  2V4Y A;  4I49 A;  1Z9D A;  2WE5 A;  3C20 A;  2J4K A;  2OGX A;  4KZT A;  4AXS A;  3K52 A;  2J4J A;  4A7W A;  3KZF A;  2BND A;  3D41 A;  2WXB A;  1OH9 A;  4NDO B;  3QVH A;  2HMF A;  4JZ8 A;  3U6U A;  2VA1 A;  3AAW A;  2A1F A;  3B8G A;  3AB2 A;  2BRI A;  2BNF A;  3S6H A;  2J4L A;  3ZZH A;  3NWY A;  2X2W A;  4NDO A;  2BUF A;  4F6T B;  4NDR A;  3LKK A;  1YBD A;  2BMU A;  4NDP B;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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