3NWYA

Structure and allosteric regulation of the uridine monophosphate kinase from mycobacterium tuberculosis
Total Genus 73
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
73
sequence length
235
structure length
227
Chain Sequence
LSGYSRVLLKLGGEMFGGGQVGLDPDVVAQVARQIADVVRGGVQIAVVIGGGNFAQLQQLGMERTRSDYMGMLGTVMNSLALQDFLEKEGIVTRVQTAITMGQVAEPYLPLRAVRHLEKGRVVIFGAGMGLPYFSTDTTAAQRALEIGADVVLMAKAVDGVFAEPEAELLTAVSHREVLDRGLRVADATAFSLCMDNGMPILVFNLLTDGNIARAVRGEKIGTLVTT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Structural and functional characterization of the Mycobacterium tuberculosis uridine monophosphate kinase: insights into the allosteric regulation.
pubmed doi rcsb
molecule keywords Uridylate kinase
molecule tags Transferase
source organism Mycobacterium tuberculosis
total genus 73
structure length 227
sequence length 235
chains with identical sequence B, C, D, E, F
ec nomenclature ec 2.7.4.22: UMP kinase.
pdb deposition date 2010-07-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00696 AA_kinase Amino acid kinase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.1160.10 Alpha Beta 3-Layer(aba) Sandwich Carbamate kinase Acetylglutamate kinase-like 3nwyA00
2VA1A 3L86A 4F6TB 3QUNA 3U6UA 2RD5A 2AP9A 3C1MA 4USJA 2J4LA 4JZ7A 1GS5A 2X2WA 4NDOB 1E19A 4NDPA 3D2MA 3WWMA 4KZTA 2V5HA 4JZ8A 3LKKA 4JZ9A 2R8VA 4NDQB 2J4JA 2JJXA 3TVIA 3D2PA 3ZZFA 4A7WA 4NDRA 3AAWA 2CDQA 1Z9DA 3K52A 2BTYA 3LL5A 3S6HA 2J0WA 3D41A 2J0XA 3QURA 2OGXA 2WXBA 3K4YA 2JI5A 3K56A 2J5TA 2BUFA 2WE5A 3AB2A 2BRIA 4A7XA 3B8GA 4F6TA 3EK5A 3QVHA 1OH9A 2J5VA 2R98A 2IJ9A 4NDOA 1OHAA 3ZZHA 3S6KA 3ZZIA 2BNEA 3K4OA 2J4KA 3D40A 4AXSA 1B7BA 2W21A 3QUOA 4NDPB 4NDQA 4Q1TA 2V4YA 2WE4A 3ZZGA 3AB4A 2AKOA 1YBDA 4I49A 3NWYA 1GSJA 2BRXA 4NDRB 2E9YA 2HMFA 4OLCA 3L76A 1OHBA 4AB7A 2JJ4A 2BNFA 2OGXB 2A1FA 2BNDA 3C20A 3C1NA 3WWNA 3KZFA 3EK6A 3LL9A 2BMUA 3QVFA 3S6GA 3T7BA
chains in the Genus database with same CATH superfamily
2VA1A 3L86A 4F6TB 3QUNA 3U6UA 2RD5A 2AP9A 3C1MA 4USJA 2J4LA 4JZ7A 1GS5A 2X2WA 4NDOB 1E19A 4NDPA 3D2MA 3WWMA 4KZTA 2V5HA 4JZ8A 3LKKA 4JZ9A 2R8VA 4NDQB 2J4JA 2JJXA 3TVIA 3D2PA 3ZZFA 4A7WA 4NDRA 3AAWA 2CDQA 1Z9DA 3K52A 2BTYA 3LL5A 3S6HA 2J0WA 3D41A 2J0XA 3QURA 2OGXA 2WXBA 3K4YA 2JI5A 3K56A 2J5TA 2BUFA 2WE5A 3AB2A 2BRIA 4A7XA 3B8GA 4F6TA 3EK5A 3QVHA 1OH9A 2J5VA 2R98A 2IJ9A 4NDOA 1OHAA 3ZZHA 3S6KA 3ZZIA 2BNEA 3K4OA 2J4KA 3D40A 4AXSA 1B7BA 2W21A 3QUOA 4NDPB 4NDQA 4Q1TA 2V4YA 2WE4A 3ZZGA 3AB4A 2AKOA 1YBDA 4I49A 3NWYA 1GSJA 2BRXA 4NDRB 2E9YA 2HMFA 4OLCA 3L76A 1OHBA 4AB7A 2JJ4A 2BNFA 2OGXB 2A1FA 2BNDA 3C20A 3C1NA 3WWNA 3KZFA 3EK6A 3LL9A 2BMUA 3QVFA 3S6GA 3T7BA
chains in the Genus database with same CATH topology
2VA1A 3L86A 4F6TB 3QUNA 3U6UA 2RD5A 2AP9A 3C1MA 4USJA 2J4LA 4JZ7A 1GS5A 2X2WA 4NDOB 1E19A 4NDPA 3D2MA 3WWMA 4KZTA 2V5HA 4JZ8A 3LKKA 4JZ9A 2R8VA 4NDQB 2J4JA 2JJXA 3TVIA 3D2PA 3ZZFA 4A7WA 4NDRA 3AAWA 2CDQA 1Z9DA 3K52A 2BTYA 3LL5A 3S6HA 2J0WA 3D41A 2J0XA 3QURA 2OGXA 2WXBA 3K4YA 2JI5A 3K56A 2J5TA 2BUFA 2WE5A 3AB2A 2BRIA 4A7XA 3B8GA 4F6TA 3EK5A 3QVHA 1OH9A 2J5VA 2R98A 2IJ9A 4NDOA 1OHAA 3ZZHA 3S6KA 3ZZIA 2BNEA 3K4OA 2J4KA 3D40A 4AXSA 1B7BA 2W21A 3QUOA 4NDPB 4NDQA 4Q1TA 2V4YA 2WE4A 3ZZGA 3AB4A 2AKOA 1YBDA 4I49A 3NWYA 1GSJA 2BRXA 4NDRB 2E9YA 2HMFA 4OLCA 3L76A 1OHBA 4AB7A 2JJ4A 2BNFA 2OGXB 2A1FA 2BNDA 3C20A 3C1NA 3WWNA 3KZFA 3EK6A 3LL9A 2BMUA 3QVFA 3S6GA 3T7BA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 2VA1 A;  3L86 A;  4F6T B;  3QUN A;  3U6U A;  2RD5 A;  2AP9 A;  3C1M A;  4USJ A;  2J4L A;  4JZ7 A;  1GS5 A;  2X2W A;  4NDO B;  1E19 A;  4NDP A;  3D2M A;  3WWM A;  4KZT A;  2V5H A;  4JZ8 A;  3LKK A;  4JZ9 A;  2R8V A;  4NDQ B;  2J4J A;  2JJX A;  3TVI A;  3D2P A;  3ZZF A;  4A7W A;  4NDR A;  3AAW A;  2CDQ A;  1Z9D A;  3K52 A;  2BTY A;  3LL5 A;  3S6H A;  2J0W A;  3D41 A;  2J0X A;  3QUR A;  2OGX A;  2WXB A;  3K4Y A;  2JI5 A;  3K56 A;  2J5T A;  2BUF A;  2WE5 A;  3AB2 A;  2BRI A;  4A7X A;  3B8G A;  4F6T A;  3EK5 A;  3QVH A;  1OH9 A;  2J5V A;  2R98 A;  2IJ9 A;  4NDO A;  1OHA A;  3ZZH A;  3S6K A;  3ZZI A;  2BNE A;  3K4O A;  2J4K A;  3D40 A;  4AXS A;  1B7B A;  2W21 A;  3QUO A;  4NDP B;  4NDQ A;  4Q1T A;  2V4Y A;  2WE4 A;  3ZZG A;  3AB4 A;  2AKO A;  1YBD A;  4I49 A;  3NWY A;  1GSJ A;  2BRX A;  4NDR B;  2E9Y A;  2HMF A;  4OLC A;  3L76 A;  1OHB A;  4AB7 A;  2JJ4 A;  2BNF A;  2OGX B;  2A1F A;  2BND A;  3C20 A;  3C1N A;  3WWN A;  3KZF A;  3EK6 A;  3LL9 A;  2BMU A;  3QVF A;  3S6G A;  3T7B A; 
#chains in the Genus database with same CATH topology
 2VA1 A;  3L86 A;  4F6T B;  3QUN A;  3U6U A;  2RD5 A;  2AP9 A;  3C1M A;  4USJ A;  2J4L A;  4JZ7 A;  1GS5 A;  2X2W A;  4NDO B;  1E19 A;  4NDP A;  3D2M A;  3WWM A;  4KZT A;  2V5H A;  4JZ8 A;  3LKK A;  4JZ9 A;  2R8V A;  4NDQ B;  2J4J A;  2JJX A;  3TVI A;  3D2P A;  3ZZF A;  4A7W A;  4NDR A;  3AAW A;  2CDQ A;  1Z9D A;  3K52 A;  2BTY A;  3LL5 A;  3S6H A;  2J0W A;  3D41 A;  2J0X A;  3QUR A;  2OGX A;  2WXB A;  3K4Y A;  2JI5 A;  3K56 A;  2J5T A;  2BUF A;  2WE5 A;  3AB2 A;  2BRI A;  4A7X A;  3B8G A;  4F6T A;  3EK5 A;  3QVH A;  1OH9 A;  2J5V A;  2R98 A;  2IJ9 A;  4NDO A;  1OHA A;  3ZZH A;  3S6K A;  3ZZI A;  2BNE A;  3K4O A;  2J4K A;  3D40 A;  4AXS A;  1B7B A;  2W21 A;  3QUO A;  4NDP B;  4NDQ A;  4Q1T A;  2V4Y A;  2WE4 A;  3ZZG A;  3AB4 A;  2AKO A;  1YBD A;  4I49 A;  3NWY A;  1GSJ A;  2BRX A;  4NDR B;  2E9Y A;  2HMF A;  4OLC A;  3L76 A;  1OHB A;  4AB7 A;  2JJ4 A;  2BNF A;  2OGX B;  2A1F A;  2BND A;  3C20 A;  3C1N A;  3WWN A;  3KZF A;  3EK6 A;  3LL9 A;  2BMU A;  3QVF A;  3S6G A;  3T7B A; 
#chains in the Genus database with same CATH homology
 2VA1 A;  3L86 A;  4F6T B;  3QUN A;  3U6U A;  2RD5 A;  2AP9 A;  3C1M A;  4USJ A;  2J4L A;  4JZ7 A;  1GS5 A;  2X2W A;  4NDO B;  1E19 A;  4NDP A;  3D2M A;  3WWM A;  4KZT A;  2V5H A;  4JZ8 A;  3LKK A;  4JZ9 A;  2R8V A;  4NDQ B;  2J4J A;  2JJX A;  3TVI A;  3D2P A;  3ZZF A;  4A7W A;  4NDR A;  3AAW A;  2CDQ A;  1Z9D A;  3K52 A;  2BTY A;  3LL5 A;  3S6H A;  2J0W A;  3D41 A;  2J0X A;  3QUR A;  2OGX A;  2WXB A;  3K4Y A;  2JI5 A;  3K56 A;  2J5T A;  2BUF A;  2WE5 A;  3AB2 A;  2BRI A;  4A7X A;  3B8G A;  4F6T A;  3EK5 A;  3QVH A;  1OH9 A;  2J5V A;  2R98 A;  2IJ9 A;  4NDO A;  1OHA A;  3ZZH A;  3S6K A;  3ZZI A;  2BNE A;  3K4O A;  2J4K A;  3D40 A;  4AXS A;  1B7B A;  2W21 A;  3QUO A;  4NDP B;  4NDQ A;  4Q1T A;  2V4Y A;  2WE4 A;  3ZZG A;  3AB4 A;  2AKO A;  1YBD A;  4I49 A;  3NWY A;  1GSJ A;  2BRX A;  4NDR B;  2E9Y A;  2HMF A;  4OLC A;  3L76 A;  1OHB A;  4AB7 A;  2JJ4 A;  2BNF A;  2OGX B;  2A1F A;  2BND A;  3C20 A;  3C1N A;  3WWN A;  3KZF A;  3EK6 A;  3LL9 A;  2BMU A;  3QVF A;  3S6G A;  3T7B A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
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