3NWYA

Structure and allosteric regulation of the uridine monophosphate kinase from mycobacterium tuberculosis
Total Genus 73
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
73
sequence length
235
structure length
227
Chain Sequence
LSGYSRVLLKLGGEMFGGGQVGLDPDVVAQVARQIADVVRGGVQIAVVIGGGNFAQLQQLGMERTRSDYMGMLGTVMNSLALQDFLEKEGIVTRVQTAITMGQVAEPYLPLRAVRHLEKGRVVIFGAGMGLPYFSTDTTAAQRALEIGADVVLMAKAVDGVFAEPEAELLTAVSHREVLDRGLRVADATAFSLCMDNGMPILVFNLLTDGNIARAVRGEKIGTLVTT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Structural and functional characterization of the Mycobacterium tuberculosis uridine monophosphate kinase: insights into the allosteric regulation.
pubmed doi rcsb
molecule keywords Uridylate kinase
molecule tags Transferase
source organism Mycobacterium tuberculosis
total genus 73
structure length 227
sequence length 235
chains with identical sequence B, C, D, E, F
ec nomenclature ec 2.7.4.22: UMP kinase.
pdb deposition date 2010-07-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00696 AA_kinase Amino acid kinase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.1160.10 Alpha Beta 3-Layer(aba) Sandwich Carbamate kinase Acetylglutamate kinase-like 3nwyA00
4I49A 2HMFA 2BNDA 2AP9A 4JZ8A 2VA1A 4NDQB 3WWNA 2J5VA 2R98A 4NDRB 3K4YA 1OHBA 2J0XA 2AKOA 3TVIA 2WE4A 1GSJA 3LL5A 2JJ4A 3QURA 2BNEA 3QVFA 2BMUA 3ZZHA 3QVHA 4JZ7A 3S6KA 4USJA 2X2WA 2RD5A 2J4LA 2W21A 2J5TA 3D41A 2A1FA 3L86A 1OH9A 2IJ9A 3QUOA 3S6GA 3T7BA 4NDPA 2WE5A 2OGXA 3LKKA 3K52A 3C1MA 2V4YA 3QUNA 2R8VA 4A7XA 2BRIA 3ZZGA 4NDRA 2BUFA 3L76A 3LL9A 3D2MA 3D40A 4NDQA 3ZZFA 1YBDA 3S6HA 3ZZIA 2E9YA 3WWMA 3C20A 4A7WA 3KZFA 2BTYA 4F6TB 3AAWA 4NDOB 2BRXA 3K4OA 4Q1TA 3NWYA 4JZ9A 2WXBA 2V5HA 4OLCA 3EK6A 3AB4A 3D2PA 1Z9DA 2CDQA 2J4JA 3EK5A 4AXSA 1GS5A 1OHAA 2J0WA 2JI5A 3B8GA 3C1NA 4F6TA 4NDPB 1E19A 4NDOA 3U6UA 2OGXB 2JJXA 3AB2A 4AB7A 4KZTA 2J4KA 1B7BA 3K56A 2BNFA
chains in the Genus database with same CATH superfamily
4I49A 2HMFA 2BNDA 2AP9A 4JZ8A 2VA1A 4NDQB 3WWNA 2J5VA 2R98A 4NDRB 3K4YA 1OHBA 2J0XA 2AKOA 3TVIA 2WE4A 1GSJA 3LL5A 2JJ4A 3QURA 2BNEA 3QVFA 2BMUA 3ZZHA 3QVHA 4JZ7A 3S6KA 4USJA 2X2WA 2RD5A 2J4LA 2W21A 2J5TA 3D41A 2A1FA 3L86A 1OH9A 2IJ9A 3QUOA 3S6GA 3T7BA 4NDPA 2WE5A 2OGXA 3LKKA 3K52A 3C1MA 2V4YA 3QUNA 2R8VA 4A7XA 2BRIA 3ZZGA 4NDRA 2BUFA 3L76A 3LL9A 3D2MA 3D40A 4NDQA 3ZZFA 1YBDA 3S6HA 3ZZIA 2E9YA 3WWMA 3C20A 4A7WA 3KZFA 2BTYA 4F6TB 3AAWA 4NDOB 2BRXA 3K4OA 4Q1TA 3NWYA 4JZ9A 2WXBA 2V5HA 4OLCA 3EK6A 3AB4A 3D2PA 1Z9DA 2CDQA 2J4JA 3EK5A 4AXSA 1GS5A 1OHAA 2J0WA 2JI5A 3B8GA 3C1NA 4F6TA 4NDPB 1E19A 4NDOA 3U6UA 2OGXB 2JJXA 3AB2A 4AB7A 4KZTA 2J4KA 1B7BA 3K56A 2BNFA
chains in the Genus database with same CATH topology
4I49A 2HMFA 2BNDA 2AP9A 4JZ8A 2VA1A 4NDQB 3WWNA 2J5VA 2R98A 4NDRB 3K4YA 1OHBA 2J0XA 2AKOA 3TVIA 2WE4A 1GSJA 3LL5A 2JJ4A 3QURA 2BNEA 3QVFA 2BMUA 3ZZHA 3QVHA 4JZ7A 3S6KA 4USJA 2X2WA 2RD5A 2J4LA 2W21A 2J5TA 3D41A 2A1FA 3L86A 1OH9A 2IJ9A 3QUOA 3S6GA 3T7BA 4NDPA 2WE5A 2OGXA 3LKKA 3K52A 3C1MA 2V4YA 3QUNA 2R8VA 4A7XA 2BRIA 3ZZGA 4NDRA 2BUFA 3L76A 3LL9A 3D2MA 3D40A 4NDQA 3ZZFA 1YBDA 3S6HA 3ZZIA 2E9YA 3WWMA 3C20A 4A7WA 3KZFA 2BTYA 4F6TB 3AAWA 4NDOB 2BRXA 3K4OA 4Q1TA 3NWYA 4JZ9A 2WXBA 2V5HA 4OLCA 3EK6A 3AB4A 3D2PA 1Z9DA 2CDQA 2J4JA 3EK5A 4AXSA 1GS5A 1OHAA 2J0WA 2JI5A 3B8GA 3C1NA 4F6TA 4NDPB 1E19A 4NDOA 3U6UA 2OGXB 2JJXA 3AB2A 4AB7A 4KZTA 2J4KA 1B7BA 3K56A 2BNFA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 4I49 A;  2HMF A;  2BND A;  2AP9 A;  4JZ8 A;  2VA1 A;  4NDQ B;  3WWN A;  2J5V A;  2R98 A;  4NDR B;  3K4Y A;  1OHB A;  2J0X A;  2AKO A;  3TVI A;  2WE4 A;  1GSJ A;  3LL5 A;  2JJ4 A;  3QUR A;  2BNE A;  3QVF A;  2BMU A;  3ZZH A;  3QVH A;  4JZ7 A;  3S6K A;  4USJ A;  2X2W A;  2RD5 A;  2J4L A;  2W21 A;  2J5T A;  3D41 A;  2A1F A;  3L86 A;  1OH9 A;  2IJ9 A;  3QUO A;  3S6G A;  3T7B A;  4NDP A;  2WE5 A;  2OGX A;  3LKK A;  3K52 A;  3C1M A;  2V4Y A;  3QUN A;  2R8V A;  4A7X A;  2BRI A;  3ZZG A;  4NDR A;  2BUF A;  3L76 A;  3LL9 A;  3D2M A;  3D40 A;  4NDQ A;  3ZZF A;  1YBD A;  3S6H A;  3ZZI A;  2E9Y A;  3WWM A;  3C20 A;  4A7W A;  3KZF A;  2BTY A;  4F6T B;  3AAW A;  4NDO B;  2BRX A;  3K4O A;  4Q1T A;  3NWY A;  4JZ9 A;  2WXB A;  2V5H A;  4OLC A;  3EK6 A;  3AB4 A;  3D2P A;  1Z9D A;  2CDQ A;  2J4J A;  3EK5 A;  4AXS A;  1GS5 A;  1OHA A;  2J0W A;  2JI5 A;  3B8G A;  3C1N A;  4F6T A;  4NDP B;  1E19 A;  4NDO A;  3U6U A;  2OGX B;  2JJX A;  3AB2 A;  4AB7 A;  4KZT A;  2J4K A;  1B7B A;  3K56 A;  2BNF A; 
#chains in the Genus database with same CATH topology
 4I49 A;  2HMF A;  2BND A;  2AP9 A;  4JZ8 A;  2VA1 A;  4NDQ B;  3WWN A;  2J5V A;  2R98 A;  4NDR B;  3K4Y A;  1OHB A;  2J0X A;  2AKO A;  3TVI A;  2WE4 A;  1GSJ A;  3LL5 A;  2JJ4 A;  3QUR A;  2BNE A;  3QVF A;  2BMU A;  3ZZH A;  3QVH A;  4JZ7 A;  3S6K A;  4USJ A;  2X2W A;  2RD5 A;  2J4L A;  2W21 A;  2J5T A;  3D41 A;  2A1F A;  3L86 A;  1OH9 A;  2IJ9 A;  3QUO A;  3S6G A;  3T7B A;  4NDP A;  2WE5 A;  2OGX A;  3LKK A;  3K52 A;  3C1M A;  2V4Y A;  3QUN A;  2R8V A;  4A7X A;  2BRI A;  3ZZG A;  4NDR A;  2BUF A;  3L76 A;  3LL9 A;  3D2M A;  3D40 A;  4NDQ A;  3ZZF A;  1YBD A;  3S6H A;  3ZZI A;  2E9Y A;  3WWM A;  3C20 A;  4A7W A;  3KZF A;  2BTY A;  4F6T B;  3AAW A;  4NDO B;  2BRX A;  3K4O A;  4Q1T A;  3NWY A;  4JZ9 A;  2WXB A;  2V5H A;  4OLC A;  3EK6 A;  3AB4 A;  3D2P A;  1Z9D A;  2CDQ A;  2J4J A;  3EK5 A;  4AXS A;  1GS5 A;  1OHA A;  2J0W A;  2JI5 A;  3B8G A;  3C1N A;  4F6T A;  4NDP B;  1E19 A;  4NDO A;  3U6U A;  2OGX B;  2JJX A;  3AB2 A;  4AB7 A;  4KZT A;  2J4K A;  1B7B A;  3K56 A;  2BNF A; 
#chains in the Genus database with same CATH homology
 4I49 A;  2HMF A;  2BND A;  2AP9 A;  4JZ8 A;  2VA1 A;  4NDQ B;  3WWN A;  2J5V A;  2R98 A;  4NDR B;  3K4Y A;  1OHB A;  2J0X A;  2AKO A;  3TVI A;  2WE4 A;  1GSJ A;  3LL5 A;  2JJ4 A;  3QUR A;  2BNE A;  3QVF A;  2BMU A;  3ZZH A;  3QVH A;  4JZ7 A;  3S6K A;  4USJ A;  2X2W A;  2RD5 A;  2J4L A;  2W21 A;  2J5T A;  3D41 A;  2A1F A;  3L86 A;  1OH9 A;  2IJ9 A;  3QUO A;  3S6G A;  3T7B A;  4NDP A;  2WE5 A;  2OGX A;  3LKK A;  3K52 A;  3C1M A;  2V4Y A;  3QUN A;  2R8V A;  4A7X A;  2BRI A;  3ZZG A;  4NDR A;  2BUF A;  3L76 A;  3LL9 A;  3D2M A;  3D40 A;  4NDQ A;  3ZZF A;  1YBD A;  3S6H A;  3ZZI A;  2E9Y A;  3WWM A;  3C20 A;  4A7W A;  3KZF A;  2BTY A;  4F6T B;  3AAW A;  4NDO B;  2BRX A;  3K4O A;  4Q1T A;  3NWY A;  4JZ9 A;  2WXB A;  2V5H A;  4OLC A;  3EK6 A;  3AB4 A;  3D2P A;  1Z9D A;  2CDQ A;  2J4J A;  3EK5 A;  4AXS A;  1GS5 A;  1OHA A;  2J0W A;  2JI5 A;  3B8G A;  3C1N A;  4F6T A;  4NDP B;  1E19 A;  4NDO A;  3U6U A;  2OGX B;  2JJX A;  3AB2 A;  4AB7 A;  4KZT A;  2J4K A;  1B7B A;  3K56 A;  2BNF A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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