3NWYA

Structure and allosteric regulation of the uridine monophosphate kinase from mycobacterium tuberculosis
Total Genus 73
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
73
sequence length
235
structure length
227
Chain Sequence
LSGYSRVLLKLGGEMFGGGQVGLDPDVVAQVARQIADVVRGGVQIAVVIGGGNFAQLQQLGMERTRSDYMGMLGTVMNSLALQDFLEKEGIVTRVQTAITMGQVAEPYLPLRAVRHLEKGRVVIFGAGMGLPYFSTDTTAAQRALEIGADVVLMAKAVDGVFAEPEAELLTAVSHREVLDRGLRVADATAFSLCMDNGMPILVFNLLTDGNIARAVRGEKIGTLVTT
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title Structural and functional characterization of the Mycobacterium tuberculosis uridine monophosphate kinase: insights into the allosteric regulation.
pubmed doi rcsb
molecule tags Transferase
source organism Mycobacterium tuberculosis
molecule keywords Uridylate kinase
total genus 73
structure length 227
sequence length 235
chains with identical sequence B, C, D, E, F
ec nomenclature ec 2.7.4.22: UMP kinase.
pdb deposition date 2010-07-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00696 AA_kinase Amino acid kinase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.1160.10 Alpha Beta 3-Layer(aba) Sandwich Carbamate kinase Acetylglutamate kinase-like 3nwyA00
2A1FA 4I49A 4KZTA 2WE4A 2HMFA 3S6HA 3ZZGA 3L76A 2J4KA 4NDRB 2BTYA 2J4LA 3S6KA 2BNDA 4A7XA 1B7BA 2RD5A 3ZZIA 1YBDA 3QVHA 3QVFA 3LL9A 4F6TA 4NDOB 2W21A 2V5HA 3QURA 3KZFA 2CDQA 2OGXB 2AP9A 4NDPB 3L86A 2E9YA 3EK5A 2BMUA 3EK6A 3AAWA 3K4OA 3QUNA 4AB7A 2JI5A 2BUFA 3AB4A 3U6UA 4NDQA 3K56A 3WWNA 3QUOA 2J5TA 2J5VA 4OLCA 3C1MA 3TVIA 2IJ9A 4NDRA 3D41A 3AB2A 2JJ4A 4A7WA 3C1NA 3K4YA 3T7BA 3D2MA 3ZZFA 2V4YA 4Q1TA 2JJXA 2BNEA 2BNFA 4NDOA 2R8VA 2OGXA 1Z9DA 2X2WA 3K52A 4NDPA 3C20A 2AKOA 4F6TB 1E19A 4AXSA 1OH9A 2BRXA 3LL5A 3WWMA 1GSJA 1OHBA 1GS5A 3D2PA 2WXBA 2VA1A 3S6GA 4JZ8A 1OHAA 4USJA 2J0WA 2J0XA 4JZ7A 2BRIA 2J4JA 2R98A 4JZ9A 3ZZHA 3NWYA 2WE5A 3B8GA 3D40A 3LKKA 4NDQB
chains in the Genus database with same CATH superfamily
2A1FA 4I49A 4KZTA 2WE4A 2HMFA 3S6HA 3ZZGA 3L76A 2J4KA 4NDRB 2BTYA 2J4LA 3S6KA 2BNDA 4A7XA 1B7BA 2RD5A 3ZZIA 1YBDA 3QVHA 3QVFA 3LL9A 4F6TA 4NDOB 2W21A 2V5HA 3QURA 3KZFA 2CDQA 2OGXB 2AP9A 4NDPB 3L86A 2E9YA 3EK5A 2BMUA 3EK6A 3AAWA 3K4OA 3QUNA 4AB7A 2JI5A 2BUFA 3AB4A 3U6UA 4NDQA 3K56A 3WWNA 3QUOA 2J5TA 2J5VA 4OLCA 3C1MA 3TVIA 2IJ9A 4NDRA 3D41A 3AB2A 2JJ4A 4A7WA 3C1NA 3K4YA 3T7BA 3D2MA 3ZZFA 2V4YA 4Q1TA 2JJXA 2BNEA 2BNFA 4NDOA 2R8VA 2OGXA 1Z9DA 2X2WA 3K52A 4NDPA 3C20A 2AKOA 4F6TB 1E19A 4AXSA 1OH9A 2BRXA 3LL5A 3WWMA 1GSJA 1OHBA 1GS5A 3D2PA 2WXBA 2VA1A 3S6GA 4JZ8A 1OHAA 4USJA 2J0WA 2J0XA 4JZ7A 2BRIA 2J4JA 2R98A 4JZ9A 3ZZHA 3NWYA 2WE5A 3B8GA 3D40A 3LKKA 4NDQB
chains in the Genus database with same CATH topology
2A1FA 4I49A 4KZTA 2WE4A 2HMFA 3S6HA 3ZZGA 3L76A 2J4KA 4NDRB 2BTYA 2J4LA 3S6KA 2BNDA 4A7XA 1B7BA 2RD5A 3ZZIA 1YBDA 3QVHA 3QVFA 3LL9A 4F6TA 4NDOB 2W21A 2V5HA 3QURA 3KZFA 2CDQA 2OGXB 2AP9A 4NDPB 3L86A 2E9YA 3EK5A 2BMUA 3EK6A 3AAWA 3K4OA 3QUNA 4AB7A 2JI5A 2BUFA 3AB4A 3U6UA 4NDQA 3K56A 3WWNA 3QUOA 2J5TA 2J5VA 4OLCA 3C1MA 3TVIA 2IJ9A 4NDRA 3D41A 3AB2A 2JJ4A 4A7WA 3C1NA 3K4YA 3T7BA 3D2MA 3ZZFA 2V4YA 4Q1TA 2JJXA 2BNEA 2BNFA 4NDOA 2R8VA 2OGXA 1Z9DA 2X2WA 3K52A 4NDPA 3C20A 2AKOA 4F6TB 1E19A 4AXSA 1OH9A 2BRXA 3LL5A 3WWMA 1GSJA 1OHBA 1GS5A 3D2PA 2WXBA 2VA1A 3S6GA 4JZ8A 1OHAA 4USJA 2J0WA 2J0XA 4JZ7A 2BRIA 2J4JA 2R98A 4JZ9A 3ZZHA 3NWYA 2WE5A 3B8GA 3D40A 3LKKA 4NDQB
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 2A1F A;  4I49 A;  4KZT A;  2WE4 A;  2HMF A;  3S6H A;  3ZZG A;  3L76 A;  2J4K A;  4NDR B;  2BTY A;  2J4L A;  3S6K A;  2BND A;  4A7X A;  1B7B A;  2RD5 A;  3ZZI A;  1YBD A;  3QVH A;  3QVF A;  3LL9 A;  4F6T A;  4NDO B;  2W21 A;  2V5H A;  3QUR A;  3KZF A;  2CDQ A;  2OGX B;  2AP9 A;  4NDP B;  3L86 A;  2E9Y A;  3EK5 A;  2BMU A;  3EK6 A;  3AAW A;  3K4O A;  3QUN A;  4AB7 A;  2JI5 A;  2BUF A;  3AB4 A;  3U6U A;  4NDQ A;  3K56 A;  3WWN A;  3QUO A;  2J5T A;  2J5V A;  4OLC A;  3C1M A;  3TVI A;  2IJ9 A;  4NDR A;  3D41 A;  3AB2 A;  2JJ4 A;  4A7W A;  3C1N A;  3K4Y A;  3T7B A;  3D2M A;  3ZZF A;  2V4Y A;  4Q1T A;  2JJX A;  2BNE A;  2BNF A;  4NDO A;  2R8V A;  2OGX A;  1Z9D A;  2X2W A;  3K52 A;  4NDP A;  3C20 A;  2AKO A;  4F6T B;  1E19 A;  4AXS A;  1OH9 A;  2BRX A;  3LL5 A;  3WWM A;  1GSJ A;  1OHB A;  1GS5 A;  3D2P A;  2WXB A;  2VA1 A;  3S6G A;  4JZ8 A;  1OHA A;  4USJ A;  2J0W A;  2J0X A;  4JZ7 A;  2BRI A;  2J4J A;  2R98 A;  4JZ9 A;  3ZZH A;  3NWY A;  2WE5 A;  3B8G A;  3D40 A;  3LKK A;  4NDQ B; 
#chains in the Genus database with same CATH topology
 2A1F A;  4I49 A;  4KZT A;  2WE4 A;  2HMF A;  3S6H A;  3ZZG A;  3L76 A;  2J4K A;  4NDR B;  2BTY A;  2J4L A;  3S6K A;  2BND A;  4A7X A;  1B7B A;  2RD5 A;  3ZZI A;  1YBD A;  3QVH A;  3QVF A;  3LL9 A;  4F6T A;  4NDO B;  2W21 A;  2V5H A;  3QUR A;  3KZF A;  2CDQ A;  2OGX B;  2AP9 A;  4NDP B;  3L86 A;  2E9Y A;  3EK5 A;  2BMU A;  3EK6 A;  3AAW A;  3K4O A;  3QUN A;  4AB7 A;  2JI5 A;  2BUF A;  3AB4 A;  3U6U A;  4NDQ A;  3K56 A;  3WWN A;  3QUO A;  2J5T A;  2J5V A;  4OLC A;  3C1M A;  3TVI A;  2IJ9 A;  4NDR A;  3D41 A;  3AB2 A;  2JJ4 A;  4A7W A;  3C1N A;  3K4Y A;  3T7B A;  3D2M A;  3ZZF A;  2V4Y A;  4Q1T A;  2JJX A;  2BNE A;  2BNF A;  4NDO A;  2R8V A;  2OGX A;  1Z9D A;  2X2W A;  3K52 A;  4NDP A;  3C20 A;  2AKO A;  4F6T B;  1E19 A;  4AXS A;  1OH9 A;  2BRX A;  3LL5 A;  3WWM A;  1GSJ A;  1OHB A;  1GS5 A;  3D2P A;  2WXB A;  2VA1 A;  3S6G A;  4JZ8 A;  1OHA A;  4USJ A;  2J0W A;  2J0X A;  4JZ7 A;  2BRI A;  2J4J A;  2R98 A;  4JZ9 A;  3ZZH A;  3NWY A;  2WE5 A;  3B8G A;  3D40 A;  3LKK A;  4NDQ B; 
#chains in the Genus database with same CATH homology
 2A1F A;  4I49 A;  4KZT A;  2WE4 A;  2HMF A;  3S6H A;  3ZZG A;  3L76 A;  2J4K A;  4NDR B;  2BTY A;  2J4L A;  3S6K A;  2BND A;  4A7X A;  1B7B A;  2RD5 A;  3ZZI A;  1YBD A;  3QVH A;  3QVF A;  3LL9 A;  4F6T A;  4NDO B;  2W21 A;  2V5H A;  3QUR A;  3KZF A;  2CDQ A;  2OGX B;  2AP9 A;  4NDP B;  3L86 A;  2E9Y A;  3EK5 A;  2BMU A;  3EK6 A;  3AAW A;  3K4O A;  3QUN A;  4AB7 A;  2JI5 A;  2BUF A;  3AB4 A;  3U6U A;  4NDQ A;  3K56 A;  3WWN A;  3QUO A;  2J5T A;  2J5V A;  4OLC A;  3C1M A;  3TVI A;  2IJ9 A;  4NDR A;  3D41 A;  3AB2 A;  2JJ4 A;  4A7W A;  3C1N A;  3K4Y A;  3T7B A;  3D2M A;  3ZZF A;  2V4Y A;  4Q1T A;  2JJX A;  2BNE A;  2BNF A;  4NDO A;  2R8V A;  2OGX A;  1Z9D A;  2X2W A;  3K52 A;  4NDP A;  3C20 A;  2AKO A;  4F6T B;  1E19 A;  4AXS A;  1OH9 A;  2BRX A;  3LL5 A;  3WWM A;  1GSJ A;  1OHB A;  1GS5 A;  3D2P A;  2WXB A;  2VA1 A;  3S6G A;  4JZ8 A;  1OHA A;  4USJ A;  2J0W A;  2J0X A;  4JZ7 A;  2BRI A;  2J4J A;  2R98 A;  4JZ9 A;  3ZZH A;  3NWY A;  2WE5 A;  3B8G A;  3D40 A;  3LKK A;  4NDQ B;
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...
How to cite