4OLCA

Carbamate kinase from giardia lamblia thiocarbamoylated by disulfiram on cys242
Total Genus 100
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
100
sequence length
315
structure length
308
Chain Sequence
SAGKTVVIALGGNAMLQAKEKGDYDTQRKNVEIAASEIYKIHKAGYKVVLTSGNGPQVGAIKLQNQAAAGVSPEMPLHVCGAMSQGFIGYMMSQAMDNVFCANNEPANCVTCVTQTLVDPKDQAFTNPTKPVGRFYTEQEAKDLMAANPGKILREDAGRGWRVVVPSPRPLEIVEYGVIKTLIDNNVLVICTNGGGIPCKRENKVISGVDAVIDKDLATSLLAKTLNSDYLMILTDVLNACIRKLEEIKLSEILALEKDGHFAAGSMGPKVRAAIEFTQATGKMSIITSLSTAVDALNGKCGTRIIKD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Carbamate kinase
publication title Structural Basis for Inactivation of Giardia lamblia Carbamate Kinase by Disulfiram.
pubmed doi rcsb
source organism Giardia lamblia
molecule tags Transferase
total genus 100
structure length 308
sequence length 315
chains with identical sequence B, C, D
ec nomenclature ec 2.7.2.2: Carbamate kinase.
pdb deposition date 2014-01-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00696 AA_kinase Amino acid kinase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.1160.10 Alpha Beta 3-Layer(aba) Sandwich Carbamate kinase Acetylglutamate kinase-like 4olcA00
2HMFA 3T7BA 4NDOA 2R8VA 4NDRA 3QURA 4NDQA 2W21A 2J4KA 4NDOB 4F6TA 3U6UA 2J5VA 2OGXA 2CDQA 3AAWA 2R98A 3K56A 3S6GA 4A7XA 4JZ8A 2J0XA 4NDPA 2OGXB 3D40A 2J4JA 3C1MA 3ZZGA 1OH9A 2BTYA 3WWNA 4Q1TA 2VA1A 4JZ7A 3S6KA 4I49A 4USJA 2JJ4A 3EK5A 4A7WA 3C20A 3QVFA 3WWMA 3K4YA 2IJ9A 1OHBA 2BNFA 4KZTA 4OLCA 2JI5A 4AB7A 3TVIA 2JJXA 3ZZHA 3L76A 1GS5A 1OHAA 3S6HA 2J4LA 2X2WA 3ZZIA 2BRXA 3D41A 3AB2A 2A1FA 2WXBA 4JZ9A 1Z9DA 3QVHA 2RD5A 3EK6A 3ZZFA 3D2PA 3K52A 2AKOA 2BRIA 2J0WA 2V4YA 1B7BA 3QUNA 2J5TA 1GSJA 2BMUA 2V5HA 4NDRB 2E9YA 3B8GA 3LKKA 3LL9A 4NDQB 2AP9A 4F6TB 3KZFA 2BNEA 1YBDA 3D2MA 4AXSA 2BUFA 2BNDA 2WE5A 3AB4A 3QUOA 3NWYA 4NDPB 2WE4A 3L86A 1E19A 3LL5A 3C1NA 3K4OA
chains in the Genus database with same CATH superfamily
2HMFA 3T7BA 4NDOA 2R8VA 4NDRA 3QURA 4NDQA 2W21A 2J4KA 4NDOB 4F6TA 3U6UA 2J5VA 2OGXA 2CDQA 3AAWA 2R98A 3K56A 3S6GA 4A7XA 4JZ8A 2J0XA 4NDPA 2OGXB 3D40A 2J4JA 3C1MA 3ZZGA 1OH9A 2BTYA 3WWNA 4Q1TA 2VA1A 4JZ7A 3S6KA 4I49A 4USJA 2JJ4A 3EK5A 4A7WA 3C20A 3QVFA 3WWMA 3K4YA 2IJ9A 1OHBA 2BNFA 4KZTA 4OLCA 2JI5A 4AB7A 3TVIA 2JJXA 3ZZHA 3L76A 1GS5A 1OHAA 3S6HA 2J4LA 2X2WA 3ZZIA 2BRXA 3D41A 3AB2A 2A1FA 2WXBA 4JZ9A 1Z9DA 3QVHA 2RD5A 3EK6A 3ZZFA 3D2PA 3K52A 2AKOA 2BRIA 2J0WA 2V4YA 1B7BA 3QUNA 2J5TA 1GSJA 2BMUA 2V5HA 4NDRB 2E9YA 3B8GA 3LKKA 3LL9A 4NDQB 2AP9A 4F6TB 3KZFA 2BNEA 1YBDA 3D2MA 4AXSA 2BUFA 2BNDA 2WE5A 3AB4A 3QUOA 3NWYA 4NDPB 2WE4A 3L86A 1E19A 3LL5A 3C1NA 3K4OA
chains in the Genus database with same CATH topology
2HMFA 3T7BA 4NDOA 2R8VA 4NDRA 3QURA 4NDQA 2W21A 2J4KA 4NDOB 4F6TA 3U6UA 2J5VA 2OGXA 2CDQA 3AAWA 2R98A 3K56A 3S6GA 4A7XA 4JZ8A 2J0XA 4NDPA 2OGXB 3D40A 2J4JA 3C1MA 3ZZGA 1OH9A 2BTYA 3WWNA 4Q1TA 2VA1A 4JZ7A 3S6KA 4I49A 4USJA 2JJ4A 3EK5A 4A7WA 3C20A 3QVFA 3WWMA 3K4YA 2IJ9A 1OHBA 2BNFA 4KZTA 4OLCA 2JI5A 4AB7A 3TVIA 2JJXA 3ZZHA 3L76A 1GS5A 1OHAA 3S6HA 2J4LA 2X2WA 3ZZIA 2BRXA 3D41A 3AB2A 2A1FA 2WXBA 4JZ9A 1Z9DA 3QVHA 2RD5A 3EK6A 3ZZFA 3D2PA 3K52A 2AKOA 2BRIA 2J0WA 2V4YA 1B7BA 3QUNA 2J5TA 1GSJA 2BMUA 2V5HA 4NDRB 2E9YA 3B8GA 3LKKA 3LL9A 4NDQB 2AP9A 4F6TB 3KZFA 2BNEA 1YBDA 3D2MA 4AXSA 2BUFA 2BNDA 2WE5A 3AB4A 3QUOA 3NWYA 4NDPB 2WE4A 3L86A 1E19A 3LL5A 3C1NA 3K4OA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2HMF A;  3T7B A;  4NDO A;  2R8V A;  4NDR A;  3QUR A;  4NDQ A;  2W21 A;  2J4K A;  4NDO B;  4F6T A;  3U6U A;  2J5V A;  2OGX A;  2CDQ A;  3AAW A;  2R98 A;  3K56 A;  3S6G A;  4A7X A;  4JZ8 A;  2J0X A;  4NDP A;  2OGX B;  3D40 A;  2J4J A;  3C1M A;  3ZZG A;  1OH9 A;  2BTY A;  3WWN A;  4Q1T A;  2VA1 A;  4JZ7 A;  3S6K A;  4I49 A;  4USJ A;  2JJ4 A;  3EK5 A;  4A7W A;  3C20 A;  3QVF A;  3WWM A;  3K4Y A;  2IJ9 A;  1OHB A;  2BNF A;  4KZT A;  4OLC A;  2JI5 A;  4AB7 A;  3TVI A;  2JJX A;  3ZZH A;  3L76 A;  1GS5 A;  1OHA A;  3S6H A;  2J4L A;  2X2W A;  3ZZI A;  2BRX A;  3D41 A;  3AB2 A;  2A1F A;  2WXB A;  4JZ9 A;  1Z9D A;  3QVH A;  2RD5 A;  3EK6 A;  3ZZF A;  3D2P A;  3K52 A;  2AKO A;  2BRI A;  2J0W A;  2V4Y A;  1B7B A;  3QUN A;  2J5T A;  1GSJ A;  2BMU A;  2V5H A;  4NDR B;  2E9Y A;  3B8G A;  3LKK A;  3LL9 A;  4NDQ B;  2AP9 A;  4F6T B;  3KZF A;  2BNE A;  1YBD A;  3D2M A;  4AXS A;  2BUF A;  2BND A;  2WE5 A;  3AB4 A;  3QUO A;  3NWY A;  4NDP B;  2WE4 A;  3L86 A;  1E19 A;  3LL5 A;  3C1N A;  3K4O A; 
#chains in the Genus database with same CATH topology
 2HMF A;  3T7B A;  4NDO A;  2R8V A;  4NDR A;  3QUR A;  4NDQ A;  2W21 A;  2J4K A;  4NDO B;  4F6T A;  3U6U A;  2J5V A;  2OGX A;  2CDQ A;  3AAW A;  2R98 A;  3K56 A;  3S6G A;  4A7X A;  4JZ8 A;  2J0X A;  4NDP A;  2OGX B;  3D40 A;  2J4J A;  3C1M A;  3ZZG A;  1OH9 A;  2BTY A;  3WWN A;  4Q1T A;  2VA1 A;  4JZ7 A;  3S6K A;  4I49 A;  4USJ A;  2JJ4 A;  3EK5 A;  4A7W A;  3C20 A;  3QVF A;  3WWM A;  3K4Y A;  2IJ9 A;  1OHB A;  2BNF A;  4KZT A;  4OLC A;  2JI5 A;  4AB7 A;  3TVI A;  2JJX A;  3ZZH A;  3L76 A;  1GS5 A;  1OHA A;  3S6H A;  2J4L A;  2X2W A;  3ZZI A;  2BRX A;  3D41 A;  3AB2 A;  2A1F A;  2WXB A;  4JZ9 A;  1Z9D A;  3QVH A;  2RD5 A;  3EK6 A;  3ZZF A;  3D2P A;  3K52 A;  2AKO A;  2BRI A;  2J0W A;  2V4Y A;  1B7B A;  3QUN A;  2J5T A;  1GSJ A;  2BMU A;  2V5H A;  4NDR B;  2E9Y A;  3B8G A;  3LKK A;  3LL9 A;  4NDQ B;  2AP9 A;  4F6T B;  3KZF A;  2BNE A;  1YBD A;  3D2M A;  4AXS A;  2BUF A;  2BND A;  2WE5 A;  3AB4 A;  3QUO A;  3NWY A;  4NDP B;  2WE4 A;  3L86 A;  1E19 A;  3LL5 A;  3C1N A;  3K4O A; 
#chains in the Genus database with same CATH homology
 2HMF A;  3T7B A;  4NDO A;  2R8V A;  4NDR A;  3QUR A;  4NDQ A;  2W21 A;  2J4K A;  4NDO B;  4F6T A;  3U6U A;  2J5V A;  2OGX A;  2CDQ A;  3AAW A;  2R98 A;  3K56 A;  3S6G A;  4A7X A;  4JZ8 A;  2J0X A;  4NDP A;  2OGX B;  3D40 A;  2J4J A;  3C1M A;  3ZZG A;  1OH9 A;  2BTY A;  3WWN A;  4Q1T A;  2VA1 A;  4JZ7 A;  3S6K A;  4I49 A;  4USJ A;  2JJ4 A;  3EK5 A;  4A7W A;  3C20 A;  3QVF A;  3WWM A;  3K4Y A;  2IJ9 A;  1OHB A;  2BNF A;  4KZT A;  4OLC A;  2JI5 A;  4AB7 A;  3TVI A;  2JJX A;  3ZZH A;  3L76 A;  1GS5 A;  1OHA A;  3S6H A;  2J4L A;  2X2W A;  3ZZI A;  2BRX A;  3D41 A;  3AB2 A;  2A1F A;  2WXB A;  4JZ9 A;  1Z9D A;  3QVH A;  2RD5 A;  3EK6 A;  3ZZF A;  3D2P A;  3K52 A;  2AKO A;  2BRI A;  2J0W A;  2V4Y A;  1B7B A;  3QUN A;  2J5T A;  1GSJ A;  2BMU A;  2V5H A;  4NDR B;  2E9Y A;  3B8G A;  3LKK A;  3LL9 A;  4NDQ B;  2AP9 A;  4F6T B;  3KZF A;  2BNE A;  1YBD A;  3D2M A;  4AXS A;  2BUF A;  2BND A;  2WE5 A;  3AB4 A;  3QUO A;  3NWY A;  4NDP B;  2WE4 A;  3L86 A;  1E19 A;  3LL5 A;  3C1N A;  3K4O A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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