1S4DA

Crystal structure analysis of the s-adenosyl-l-methionine dependent uroporphyrinogen-iii c-methyltransferase sumt
Total Genus 68
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
68
sequence length
265
structure length
256
Chain Sequence
FAGLPALEKGSVWLVGAGPGDPGLLTLHAANALRQADVIVHDALVNEDCLKLARPGAVLEFAGKRGPSPKQRDISLRLVELARAGNRVLRLKGGDPFVFGRGGEEALTLVEHQVPFRIVPGITAGIGGLAYAGIPVTHREVNHAVTFLTGHDRINWQGIASGSPVIVMYMAMKHIGAITANLIAGGRSPDEPVAFVCNAATPQQAVLETTLARAEADVAAAGLEPPAIVVVGEVVRLRAALDWIGALDGRKLAADP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure/Function Studies on a S-Adenosyl-l-methionine-dependent Uroporphyrinogen III C Methyltransferase (SUMT), a Key Regulatory Enzyme of Tetrapyrrole Biosynthesis
pubmed doi rcsb
molecule tags Transferase
source organism Pseudomonas denitrificans
molecule keywords Uroporphyrin-III C-methyltransferase
total genus 68
structure length 256
sequence length 265
chains with identical sequence B, D, E, F, G, H, I, J, K, L, M
ec nomenclature ec 2.1.1.107: Uroporphyrinogen-III C-methyltransferase.
pdb deposition date 2004-01-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00590 TP_methylase Tetrapyrrole (Corrin/Porphyrin) Methylases
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.950.10 Alpha Beta 2-Layer Sandwich Methyltransferase, Cobalt-precorrin-4 Transmethylase; Domain 2 Methyltransferase, Cobalt-precorrin-4 Transmethylase; Domain 2 1s4dA02
3.40.1010.10 Alpha Beta 3-Layer(aba) Sandwich Cobalt-precorrin-4 Transmethylase; domain 1 Cobalt-precorrin-4 Transmethylase; Domain 1 1s4dA01
1WYZA 2E8HA 2EMUA 2EL1A 2DV3A 5HW4A 2ED3A 2OWUA 1PJTA 1VA0A 2PCGA 2E15A 2E0NA 1CBFA 2EL0A 1V9AA 1VCEA 2E7RA 2EH5A 3FFYA 2YBOA 2E8SA 2EN5A 1VE2A 2BB3A 2E0KA 2E08A 2HR8A 1PJSA 2EHLA 2E4NA 2OWKA 2PB4A 2PCHA 2DXXA 2DSGA 2ENIA 2P6KA 2E8QA 2NPNA 2PB5A 3NDCA 2EGLA 2PCIA 2DSHA 2PB6A 2EJKA 2YBQA 2E17A 2HUQA 4E16A 3NEIA 2ED5A 2DV5A 2HUVA 2PCAA 3ND1A 2EL2A 3HH1A 2PCMA 2DXWA 2EGSA 2EH2A 2E4RA 2EGBA 2P6DA 2DEKA 2HUXA 2P6LA 1PJQA 2DV7A 2EK7A 2EJZA 1WNGA 2P5FA 2OWGA 2QBUA 2EHCA 2ZVBA 2EJJA 1S4DA 2CBFA 1WDEA 2ELDA 2HUTA 2OWFA 2OWVA 2P2XA 2EK3A 2E8RA 2ELEA 2EK2A 2ZVCA 2DXVA 2DSIA 2EMRA 1VHVA 2Z6RA 3FQ6A 2E16A 2EH4A 2P9DA 3NUTA 2P5CA 2E07A 2EKAA 3I4TA 3KWPA 2PCKA 2EL3A 2DV4A 2EEQA 2P6IA 2EK4A
chains in the Genus database with same CATH superfamily
3ZGNA 1WYZA 2E8HA 2EMUA 4H4EA 2EL1A 3T0FA 2DV3A 5HW4A 3UV3A 2ED3A 3UWMA 2OWUA 1PJTA 1VA0A 2PCGA 2E15A 3URKA 2E0NA 1CBFA 2EL0A 1V9AA 1VCEA 2E7RA 2EH5A 3FFYA 2YBOA 2E8SA 2EN5A 3UTDA 1VE2A 2BB3A 2E0KA 2E08A 3KEFA 2HR8A 1PJSA 2EHLA 2E4NA 2OWKA 2PB4A 2PCHA 3UV7A 2DXXA 2DSGA 2ENIA 2P6KA 2E8QA 2NPNA 3SZOA 3UTCA 2PB5A 3NDCA 2EGLA 4MV5A 2PCIA 2DSHA 2KYYA 2PB6A 2EJKA 2YBQA 3KELA 2E17A 2HUQA 4E16A 3NEIA 3DNFA 2ED5A 2DV5A 2HUVA 2PCAA 3ND1A 3UV6A 3KE9A 2EL2A 3HH1A 4N7BA 2PCMA 2DXWA 2EGSA 2EH2A 2E4RA 2EGBA 2P6DA 2DEKA 3LMMA 4H4CA 4H4DA 2HUXA 2P6LA 1PJQA 3KEMA 2DV7A 2EK7A 2EJZA 1WNGA 2P5FA 3T0GA 2OWGA 2QBUA 2EHCA 2ZVBA 2EJJA 1S4DA 2CBFA 1WDEA 2ELDA 2HUTA 2OWFA 4MUYA 3KE8A 2OWVA 2P2XA 2EK3A 2E8RA 3SZLA 2ELEA 2EK2A 3SZUA 2ZVCA 2DXVA 2DSIA 4MV0A 2EMRA 1VHVA 4MUXA 2Z6RA 3FQ6A 2E16A 2EH4A 2P9DA 3NUTA 3ZGLA 3F7TA 2P5CA 3TIXB 4EB3A 2E07A 2EKAA 3I4TA 3KWPA 2PCKA 2EL3A 2DV4A 2EEQA 2P6IA 2EK4A
chains in the Genus database with same CATH topology
3ZGNA 1WYZA 2E8HA 2EMUA 4H4EA 2EL1A 3T0FA 2DV3A 5HW4A 3UV3A 2ED3A 3UWMA 2OWUA 1PJTA 1VA0A 2PCGA 2E15A 3URKA 2E0NA 1CBFA 2EL0A 1V9AA 1VCEA 2E7RA 2EH5A 3FFYA 2YBOA 2E8SA 2EN5A 3UTDA 1VE2A 2BB3A 2E0KA 2E08A 3KEFA 2HR8A 1PJSA 2EHLA 2E4NA 2OWKA 2PB4A 2PCHA 3UV7A 2DXXA 2DSGA 2ENIA 2P6KA 2E8QA 2NPNA 3SZOA 3UTCA 2PB5A 3NDCA 2EGLA 4MV5A 2PCIA 2DSHA 2KYYA 2PB6A 2EJKA 2YBQA 3KELA 2E17A 2HUQA 4E16A 3NEIA 3DNFA 2ED5A 2DV5A 2HUVA 2PCAA 3ND1A 3UV6A 3KE9A 2EL2A 3HH1A 4N7BA 2PCMA 2DXWA 2EGSA 2EH2A 2E4RA 2EGBA 2P6DA 2DEKA 3LMMA 4H4CA 4H4DA 2HUXA 2P6LA 1PJQA 3KEMA 2DV7A 2EK7A 2EJZA 1WNGA 2P5FA 3T0GA 2OWGA 2QBUA 2EHCA 2ZVBA 2EJJA 1S4DA 2CBFA 1WDEA 2ELDA 2HUTA 2OWFA 4MUYA 3KE8A 2OWVA 2P2XA 2EK3A 2E8RA 3SZLA 2ELEA 2EK2A 3SZUA 2ZVCA 2DXVA 2DSIA 4MV0A 2EMRA 1VHVA 4MUXA 2Z6RA 3FQ6A 2E16A 2EH4A 2P9DA 3NUTA 3ZGLA 3F7TA 2P5CA 3TIXB 4EB3A 2E07A 2EKAA 3I4TA 3KWPA 2PCKA 2EL3A 2DV4A 2EEQA 2P6IA 2EK4A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1WYZ A;  2E8H A;  2EMU A;  2EL1 A;  2DV3 A;  5HW4 A;  2ED3 A;  2OWU A;  1PJT A;  1VA0 A;  2PCG A;  2E15 A;  2E0N A;  1CBF A;  2EL0 A;  1V9A A;  1VCE A;  2E7R A;  2EH5 A;  3FFY A;  2YBO A;  2E8S A;  2EN5 A;  1VE2 A;  2BB3 A;  2E0K A;  2E08 A;  2HR8 A;  1PJS A;  2EHL A;  2E4N A;  2OWK A;  2PB4 A;  2PCH A;  2DXX A;  2DSG A;  2ENI A;  2P6K A;  2E8Q A;  2NPN A;  2PB5 A;  3NDC A;  2EGL A;  2PCI A;  2DSH A;  2PB6 A;  2EJK A;  2YBQ A;  2E17 A;  2HUQ A;  4E16 A;  3NEI A;  2ED5 A;  2DV5 A;  2HUV A;  2PCA A;  3ND1 A;  2EL2 A;  3HH1 A;  2PCM A;  2DXW A;  2EGS A;  2EH2 A;  2E4R A;  2EGB A;  2P6D A;  2DEK A;  2HUX A;  2P6L A;  1PJQ A;  2DV7 A;  2EK7 A;  2EJZ A;  1WNG A;  2P5F A;  2OWG A;  2QBU A;  2EHC A;  2ZVB A;  2EJJ A;  1S4D A;  2CBF A;  1WDE A;  2ELD A;  2HUT A;  2OWF A;  2OWV A;  2P2X A;  2EK3 A;  2E8R A;  2ELE A;  2EK2 A;  2ZVC A;  2DXV A;  2DSI A;  2EMR A;  1VHV A;  2Z6R A;  3FQ6 A;  2E16 A;  2EH4 A;  2P9D A;  3NUT A;  2P5C A;  2E07 A;  2EKA A;  3I4T A;  3KWP A;  2PCK A;  2EL3 A;  2DV4 A;  2EEQ A;  2P6I A;  2EK4 A; 
#chains in the Genus database with same CATH topology
 3ZGN A;  1WYZ A;  2E8H A;  2EMU A;  4H4E A;  2EL1 A;  3T0F A;  2DV3 A;  5HW4 A;  3UV3 A;  2ED3 A;  3UWM A;  2OWU A;  1PJT A;  1VA0 A;  2PCG A;  2E15 A;  3URK A;  2E0N A;  1CBF A;  2EL0 A;  1V9A A;  1VCE A;  2E7R A;  2EH5 A;  3FFY A;  2YBO A;  2E8S A;  2EN5 A;  3UTD A;  1VE2 A;  2BB3 A;  2E0K A;  2E08 A;  3KEF A;  2HR8 A;  1PJS A;  2EHL A;  2E4N A;  2OWK A;  2PB4 A;  2PCH A;  3UV7 A;  2DXX A;  2DSG A;  2ENI A;  2P6K A;  2E8Q A;  2NPN A;  3SZO A;  3UTC A;  2PB5 A;  3NDC A;  2EGL A;  4MV5 A;  2PCI A;  2DSH A;  2KYY A;  2PB6 A;  2EJK A;  2YBQ A;  3KEL A;  2E17 A;  2HUQ A;  4E16 A;  3NEI A;  3DNF A;  2ED5 A;  2DV5 A;  2HUV A;  2PCA A;  3ND1 A;  3UV6 A;  3KE9 A;  2EL2 A;  3HH1 A;  4N7B A;  2PCM A;  2DXW A;  2EGS A;  2EH2 A;  2E4R A;  2EGB A;  2P6D A;  2DEK A;  3LMM A;  4H4C A;  4H4D A;  2HUX A;  2P6L A;  1PJQ A;  3KEM A;  2DV7 A;  2EK7 A;  2EJZ A;  1WNG A;  2P5F A;  3T0G A;  2OWG A;  2QBU A;  2EHC A;  2ZVB A;  2EJJ A;  1S4D A;  2CBF A;  1WDE A;  2ELD A;  2HUT A;  2OWF A;  4MUY A;  3KE8 A;  2OWV A;  2P2X A;  2EK3 A;  2E8R A;  3SZL A;  2ELE A;  2EK2 A;  3SZU A;  2ZVC A;  2DXV A;  2DSI A;  4MV0 A;  2EMR A;  1VHV A;  4MUX A;  2Z6R A;  3FQ6 A;  2E16 A;  2EH4 A;  2P9D A;  3NUT A;  3ZGL A;  3F7T A;  2P5C A;  3TIX B;  4EB3 A;  2E07 A;  2EKA A;  3I4T A;  3KWP A;  2PCK A;  2EL3 A;  2DV4 A;  2EEQ A;  2P6I A;  2EK4 A; 
#chains in the Genus database with same CATH homology
 3ZGN A;  1WYZ A;  2E8H A;  2EMU A;  4H4E A;  2EL1 A;  3T0F A;  2DV3 A;  5HW4 A;  3UV3 A;  2ED3 A;  3UWM A;  2OWU A;  1PJT A;  1VA0 A;  2PCG A;  2E15 A;  3URK A;  2E0N A;  1CBF A;  2EL0 A;  1V9A A;  1VCE A;  2E7R A;  2EH5 A;  3FFY A;  2YBO A;  2E8S A;  2EN5 A;  3UTD A;  1VE2 A;  2BB3 A;  2E0K A;  2E08 A;  3KEF A;  2HR8 A;  1PJS A;  2EHL A;  2E4N A;  2OWK A;  2PB4 A;  2PCH A;  3UV7 A;  2DXX A;  2DSG A;  2ENI A;  2P6K A;  2E8Q A;  2NPN A;  3SZO A;  3UTC A;  2PB5 A;  3NDC A;  2EGL A;  4MV5 A;  2PCI A;  2DSH A;  2KYY A;  2PB6 A;  2EJK A;  2YBQ A;  3KEL A;  2E17 A;  2HUQ A;  4E16 A;  3NEI A;  3DNF A;  2ED5 A;  2DV5 A;  2HUV A;  2PCA A;  3ND1 A;  3UV6 A;  3KE9 A;  2EL2 A;  3HH1 A;  4N7B A;  2PCM A;  2DXW A;  2EGS A;  2EH2 A;  2E4R A;  2EGB A;  2P6D A;  2DEK A;  3LMM A;  4H4C A;  4H4D A;  2HUX A;  2P6L A;  1PJQ A;  3KEM A;  2DV7 A;  2EK7 A;  2EJZ A;  1WNG A;  2P5F A;  3T0G A;  2OWG A;  2QBU A;  2EHC A;  2ZVB A;  2EJJ A;  1S4D A;  2CBF A;  1WDE A;  2ELD A;  2HUT A;  2OWF A;  4MUY A;  3KE8 A;  2OWV A;  2P2X A;  2EK3 A;  2E8R A;  3SZL A;  2ELE A;  2EK2 A;  3SZU A;  2ZVC A;  2DXV A;  2DSI A;  4MV0 A;  2EMR A;  1VHV A;  4MUX A;  2Z6R A;  3FQ6 A;  2E16 A;  2EH4 A;  2P9D A;  3NUT A;  3ZGL A;  3F7T A;  2P5C A;  3TIX B;  4EB3 A;  2E07 A;  2EKA A;  3I4T A;  3KWP A;  2PCK A;  2EL3 A;  2DV4 A;  2EEQ A;  2P6I A;  2EK4 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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