4FMWA

Crystal structure of methyltransferase domain of human rna (guanine-9-) methyltransferase domain containing protein 2
Total Genus 58
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
58
Knots found
sequence length
182
structure length
178
Chain Sequence
RDVVHSTLRLIIDCSFDHLMVLKDIKKLHKQIQRCYAENRRALHPVQFYLTSHGGQLKKNMDENDKGWVNWKDIHIKPEHYSELIKKEDLIYLTSDSPNILKELDESKAYVIGGLVDHNHHKGLTYKQASDYGINHAQLPLGNFVRKVLAVNHVFEIILEYLETRDWQEAFFTILPQR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Transferase
source organism Homo sapiens
publication title Crystal structure of methyltransferase domain of human RNA (guanine-9-) methyltransferase domain containing protein 2
rcsb
molecule keywords RNA (guanine-9-)-methyltransferase domain-containing protein
total genus 58
structure length 178
sequence length 182
chains with identical sequence B
other databases KnotProt 2.0: K +31
ec nomenclature ec 2.1.1.221: tRNA (guanine(9)-N(1))-methyltransferase.
pdb deposition date 2012-06-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01746 tRNA_m1G_MT tRNA (Guanine-1)-methyltransferase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.1280.30 Alpha Beta 3-Layer(aba) Sandwich Alpha/beta knot Alpha/beta knot 4fmwA00
4JWHA 4JWFA 4JWGA 4JWJA 4FMWA
chains in the Genus database with same CATH superfamily
3KW2A 3KY7A 5GMCA 3KNUA 4JWFA 4JWGA 4J3CA 4FMWA 3OIJA 1V6ZA 4YQKA 4RG1A 5D9FA 1NXZA 4IG6A 2QWVA 4YQBA 4CNGA 4YVKA 3BBHA 4YQNA 4YVIA 1OY5A 4FAKA 2V3KA 2YY8A 1NS5A 4CNEA 1MXIA 4YPXA 4KDZA 4CNFA 2QMMA 5GMBA 4YVGA 4H3YA 4E8BA 1UAMA 3ILKA 2O3AA 3L8UA 1UALA 4MCDA 3O7BA 4L69A 4YQ5A 5CO4A 1X7PA 4JAKA 3IC6A 3QUVA 4YQTA 3OINA 4JALA 4YQ3A 4YQ4A 4YPZA 4XBOA 4YQPA 4YQ0A 3AIAA 3N4KA 3NK7A 2Z0YA 1O6DA 5GM8A 1ZJRA 1GZ0A 1Z85A 2I6DA 4YQOA 4YQ8A 4YQCA 2EGVA 4YQIA 4YQ1A 4YVJA 3DCMX 4YQRA 3AI9X 1VH0A 3BBEA 3ONPA 4PZKA 1VHKA 4H3ZA 4YQLA 4YPWA 2V3JA 4KGNA 4YQJA 4X3MA 1VHYA 4YVHA 4YQGA 1K3RA 4YQ7A 1UAJA 4X3LA 3N4JA 1P9PA 1V2XA 2HA8A 4YQSA 4MCBA 4JWJA 3BBDA 2EGWA 1IPAA 3OIIA 4YPYA 3NK6A 4YQQA 1X7OA 1UAKA 3AXZA 4CNDA 4YQ9A 3IEFA 4YQ6A 4YQAA 4JWHA 1J85A 4MCCA 4YQDA 1TO0A 3E5YA 2CX8A 4YQ2A 3GYQA 3KTYA 5FAIA
chains in the Genus database with same CATH topology
3KW2A 3KY7A 5GMCA 3KNUA 4JWFA 4JWGA 4J3CA 4FMWA 3OIJA 1V6ZA 4YQKA 4RG1A 5D9FA 1NXZA 4IG6A 2QWVA 4YQBA 4CNGA 4YVKA 3BBHA 4YQNA 4YVIA 1OY5A 4FAKA 2V3KA 2YY8A 1NS5A 4CNEA 1MXIA 4YPXA 4KDZA 4CNFA 2QMMA 5GMBA 4YVGA 4H3YA 4E8BA 1UAMA 3ILKA 2O3AA 3L8UA 1UALA 4MCDA 3O7BA 4L69A 4YQ5A 5CO4A 1X7PA 4JAKA 3IC6A 3QUVA 4YQTA 3OINA 4JALA 4YQ3A 4YQ4A 4YPZA 4XBOA 4YQPA 4YQ0A 3AIAA 3N4KA 3NK7A 2Z0YA 1O6DA 5GM8A 1ZJRA 1GZ0A 1Z85A 2I6DA 4YQOA 4YQ8A 4YQCA 2EGVA 4YQIA 4YQ1A 4YVJA 3DCMX 4YQRA 3AI9X 1VH0A 3BBEA 3ONPA 4PZKA 1VHKA 4H3ZA 4YQLA 4YPWA 2V3JA 4KGNA 4YQJA 4X3MA 1VHYA 4YVHA 4YQGA 1K3RA 4YQ7A 1UAJA 4X3LA 3N4JA 1P9PA 1V2XA 2HA8A 4YQSA 4MCBA 4JWJA 3BBDA 2EGWA 1IPAA 3OIIA 4YPYA 3NK6A 4YQQA 1X7OA 1UAKA 3AXZA 4CNDA 4YQ9A 3IEFA 4YQ6A 4YQAA 4JWHA 1J85A 4MCCA 4YQDA 1TO0A 3E5YA 2CX8A 4YQ2A 3GYQA 3KTYA 5FAIA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4JWH A;  4JWF A;  4JWG A;  4JWJ A;  4FMW A; 
#chains in the Genus database with same CATH topology
 3KW2 A;  3KY7 A;  5GMC A;  3KNU A;  4JWF A;  4JWG A;  4J3C A;  4FMW A;  3OIJ A;  1V6Z A;  4YQK A;  4RG1 A;  5D9F A;  1NXZ A;  4IG6 A;  2QWV A;  4YQB A;  4CNG A;  4YVK A;  3BBH A;  4YQN A;  4YVI A;  1OY5 A;  4FAK A;  2V3K A;  2YY8 A;  1NS5 A;  4CNE A;  1MXI A;  4YPX A;  4KDZ A;  4CNF A;  2QMM A;  5GMB A;  4YVG A;  4H3Y A;  4E8B A;  1UAM A;  3ILK A;  2O3A A;  3L8U A;  1UAL A;  4MCD A;  3O7B A;  4L69 A;  4YQ5 A;  5CO4 A;  1X7P A;  4JAK A;  3IC6 A;  3QUV A;  4YQT A;  3OIN A;  4JAL A;  4YQ3 A;  4YQ4 A;  4YPZ A;  4XBO A;  4YQP A;  4YQ0 A;  3AIA A;  3N4K A;  3NK7 A;  2Z0Y A;  1O6D A;  5GM8 A;  1ZJR A;  1GZ0 A;  1Z85 A;  2I6D A;  4YQO A;  4YQ8 A;  4YQC A;  2EGV A;  4YQI A;  4YQ1 A;  4YVJ A;  3DCM X;  4YQR A;  3AI9 X;  1VH0 A;  3BBE A;  3ONP A;  4PZK A;  1VHK A;  4H3Z A;  4YQL A;  4YPW A;  2V3J A;  4KGN A;  4YQJ A;  4X3M A;  1VHY A;  4YVH A;  4YQG A;  1K3R A;  4YQ7 A;  1UAJ A;  4X3L A;  3N4J A;  1P9P A;  1V2X A;  2HA8 A;  4YQS A;  4MCB A;  4JWJ A;  3BBD A;  2EGW A;  1IPA A;  3OII A;  4YPY A;  3NK6 A;  4YQQ A;  1X7O A;  1UAK A;  3AXZ A;  4CND A;  4YQ9 A;  3IEF A;  4YQ6 A;  4YQA A;  4JWH A;  1J85 A;  4MCC A;  4YQD A;  1TO0 A;  3E5Y A;  2CX8 A;  4YQ2 A;  3GYQ A;  3KTY A;  5FAI A; 
#chains in the Genus database with same CATH homology
 3KW2 A;  3KY7 A;  5GMC A;  3KNU A;  4JWF A;  4JWG A;  4J3C A;  4FMW A;  3OIJ A;  1V6Z A;  4YQK A;  4RG1 A;  5D9F A;  1NXZ A;  4IG6 A;  2QWV A;  4YQB A;  4CNG A;  4YVK A;  3BBH A;  4YQN A;  4YVI A;  1OY5 A;  4FAK A;  2V3K A;  2YY8 A;  1NS5 A;  4CNE A;  1MXI A;  4YPX A;  4KDZ A;  4CNF A;  2QMM A;  5GMB A;  4YVG A;  4H3Y A;  4E8B A;  1UAM A;  3ILK A;  2O3A A;  3L8U A;  1UAL A;  4MCD A;  3O7B A;  4L69 A;  4YQ5 A;  5CO4 A;  1X7P A;  4JAK A;  3IC6 A;  3QUV A;  4YQT A;  3OIN A;  4JAL A;  4YQ3 A;  4YQ4 A;  4YPZ A;  4XBO A;  4YQP A;  4YQ0 A;  3AIA A;  3N4K A;  3NK7 A;  2Z0Y A;  1O6D A;  5GM8 A;  1ZJR A;  1GZ0 A;  1Z85 A;  2I6D A;  4YQO A;  4YQ8 A;  4YQC A;  2EGV A;  4YQI A;  4YQ1 A;  4YVJ A;  3DCM X;  4YQR A;  3AI9 X;  1VH0 A;  3BBE A;  3ONP A;  4PZK A;  1VHK A;  4H3Z A;  4YQL A;  4YPW A;  2V3J A;  4KGN A;  4YQJ A;  4X3M A;  1VHY A;  4YVH A;  4YQG A;  1K3R A;  4YQ7 A;  1UAJ A;  4X3L A;  3N4J A;  1P9P A;  1V2X A;  2HA8 A;  4YQS A;  4MCB A;  4JWJ A;  3BBD A;  2EGW A;  1IPA A;  3OII A;  4YPY A;  3NK6 A;  4YQQ A;  1X7O A;  1UAK A;  3AXZ A;  4CND A;  4YQ9 A;  3IEF A;  4YQ6 A;  4YQA A;  4JWH A;  1J85 A;  4MCC A;  4YQD A;  1TO0 A;  3E5Y A;  2CX8 A;  4YQ2 A;  3GYQ A;  3KTY A;  5FAI A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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