4YQRA

Crystal structure of trmd, a m1g37 trna methyltransferase with sam-competitive compounds
Total Genus 74
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
74
Knots found
sequence length
248
structure length
240
Chain Sequence
SHMWIGVISLFPEMFKAITEFGVTGRAVKHNLLKVECWNPRDFTFDKHKTVDDRPYGGGPGMLMMVQPLRDAIHTAKAAAGEGAKVIYLSPQGRKLDQGGVTELAQNQKLILVCGRYEGIDERLIQTEIDEEWSIGDYVLTGGELPAMTLIDAVARFIPGVLGSFADGLLDCPHYTRPEVLEGLTVPPVLMSGHHEEIRKWRLKQSLQRTWLRRPELLEGLALTDEQRKLLKEAQAEHNS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of TrmD, a M1G37 tRNA Methyltransferase with SAM-competitive compounds
rcsb
molecule keywords tRNA (guanine-N(1)-)-methyltransferase
molecule tags Transferase/transferase inhibitor
source organism Haemophilus influenzae (strain atcc 51907 / dsm 11121 / kw20 / rd)
total genus 74
structure length 240
sequence length 248
other databases KnotProt 2.0: K +31
ec nomenclature ec 2.1.1.228: tRNA (guanine(37)-N(1))-methyltransferase.
pdb deposition date 2015-03-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01746 tRNA_m1G_MT tRNA (Guanine-1)-methyltransferase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.1270.20 Mainly Alpha Orthogonal Bundle Trp Operon Repressor; Chain A tRNA(m1g37)methyltransferase, domain 2 4yqrA02
3.40.1280.10 Alpha Beta 3-Layer(aba) Sandwich Alpha/beta knot Alpha/beta knot 4yqrA01
3BBEA 1Z85A 3KY7A 1X7OA 3OIIA 1UAMA 4RG1A 3KTYA 3N4KA 4XBOA 4H3YA 5FAIA 4YQRA 1VH0A 2O3AA 3KW2A 2QMMA 3NK7A 1NXZA 4H3ZA 5CO4A 3QUVA 1V6ZA 4PZKA 1VHKA 3IEFA 4YQAA 4MCDA 3KNUA 4YQ7A 4YQCA 4YPZA 3E5YA 4X3LA 1MXIA 3AIAA 4CNFA 3DCMX 2I6DA 4YQ3A 1P9PA 4YQJA 2CX8A 3O7BA 1VHYA 4YQPA 2EGWA 4YQ6A 3BBDA 1K3RA 4MCCA 4YVGA 4J3CA 2EGVA 4YPWA 4X3MA 4CNEA 3AI9X 4YQ9A 4KDZA 4YVJA 4YQ4A 1TO0A 4YVKA 4YQOA 4YQ5A 4YQQA 4YVIA 3ONPA 4YQ0A 4JALA 2Z0YA 4YQDA 3IC6A 2YY8A 4YPXA 5GMCA 1ZJRA 1O6DA 3L8UA 1X7PA 3BBHA 5GM8A 4YPYA 4CNDA 4YQSA 1UALA 4CNGA 3NK6A 4MCBA 4YQ1A 2V3KA 2HA8A 3OIJA 4YQTA 4KGNA 4IG6A 3OINA 3ILKA 4YQLA 4YVHA 3AXZA 2QWVA 4YQBA 5D9FA 4YQ2A 4L69A 3N4JA 1J85A 1UAKA 4YQ8A 4YQGA 4FAKA 2V3JA 1NS5A 4JAKA 4YQIA 3GYQA 1IPAA 1GZ0A 4YQNA 4E8BA 4YQKA 5GMBA 1UAJA 1V2XA 1OY5A
chains in the Genus database with same CATH superfamily
3BBEA 1Z85A 3KY7A 1MI7R 1X7OA 3OIIA 1UAMA 4RG1A 1WRTR 3KTYA 3N4KA 4XBOA 4H3YA 2OZ9R 5FAIA 4YQRA 1VH0A 2O3AA 3KW2A 2QMMA 3NK7A 1NXZA 4JWGA 4H3ZA 3WRPA 5CO4A 3QUVA 1V6ZA 4PZKA 1VHKA 3IEFA 4YQAA 4MCDA 3KNUA 1TROA 4YQ7A 4YQCA 4YPZA 3E5YA 4X3LA 3KORA 1MXIA 3AIAA 4CNFA 3DCMX 2I6DA 4YQ3A 4FMWA 1P9PA 4YQJA 2CX8A 3O7BA 1VHYA 1CO0A 4YQPA 2EGWA 4YQ6A 3BBDA 1K3RA 4MCCA 4YVGA 1TRRA 4J3CA 2EGVA 4YPWA 4X3MA 4JWFA 4CNEA 3SSXN 3AI9X 4YQ9A 3G1CA 4KDZA 4YVJA 4YQ4A 1TO0A 4JWJA 4YVKA 4YQOA 4YQ5A 4YQQA 1RCSA 4YVIA 3ONPA 4YQ0A 4JALA 2Z0YA 4YQDA 3IC6A 2YY8A 4YPXA 5GMCA 1ZJRA 1O6DA 3L8UA 1X7PA 3BBHA 5GM8A 4YPYA 3SSWN 4CNDA 4JWHA 4YQSA 1WRPR 1UALA 4CNGA 3NK6A 4MCBA 4YQ1A 2V3KA 1JHGA 2HA8A 4YQTA 3OIJA 3FRWA 4KGNA 4IG6A 3OINA 3ILKA 4YQLA 4YVHA 3AXZA 2QWVA 4YQBA 2XDIA 1ZT9A 5D9FA 4YQ2A 4L69A 3N4JA 1J85A 1UAKA 4YQ8A 4YQGA 4FAKA 2V3JA 1NS5A 4JAKA 4YQIA 3GYQA 1IPAA 1GZ0A 1WRSR 4YQNA 4E8BA 4YQKA 5GMBA 1UAJA 1V2XA 1OY5A
chains in the Genus database with same CATH topology
3BBEA 1Z85A 3KY7A 1X7OA 3OIIA 1UAMA 4RG1A 3KTYA 3N4KA 4XBOA 4H3YA 5FAIA 4YQRA 1VH0A 2O3AA 3KW2A 2QMMA 3NK7A 1NXZA 4JWGA 4H3ZA 5CO4A 3QUVA 1V6ZA 4PZKA 1VHKA 3IEFA 4YQAA 4MCDA 3KNUA 4YQ7A 4YQCA 4YPZA 3E5YA 4X3LA 1MXIA 3AIAA 4CNFA 3DCMX 2I6DA 4YQ3A 4FMWA 1P9PA 4YQJA 2CX8A 3O7BA 1VHYA 4YQPA 2EGWA 4YQ6A 3BBDA 1K3RA 4MCCA 4YVGA 4J3CA 2EGVA 4YPWA 4X3MA 4JWFA 4CNEA 3AI9X 4YQ9A 4KDZA 4YVJA 4YQ4A 1TO0A 4JWJA 4YVKA 4YQOA 4YQ5A 4YQQA 4YVIA 3ONPA 4YQ0A 4JALA 2Z0YA 4YQDA 3IC6A 2YY8A 4YPXA 5GMCA 1ZJRA 1O6DA 3L8UA 1X7PA 3BBHA 5GM8A 4YPYA 4CNDA 4JWHA 4YQSA 1UALA 4CNGA 3NK6A 4MCBA 4YQ1A 2V3KA 2HA8A 3OIJA 4YQTA 4KGNA 4IG6A 3OINA 3ILKA 4YQLA 4YVHA 3AXZA 2QWVA 4YQBA 5D9FA 4YQ2A 4L69A 3N4JA 1J85A 1UAKA 4YQ8A 4YQGA 4FAKA 2V3JA 1NS5A 4JAKA 4YQIA 3GYQA 1IPAA 1GZ0A 4YQNA 4E8BA 4YQKA 5GMBA 1UAJA 1V2XA 1OY5A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3BBE A;  1Z85 A;  3KY7 A;  1X7O A;  3OII A;  1UAM A;  4RG1 A;  3KTY A;  3N4K A;  4XBO A;  4H3Y A;  5FAI A;  4YQR A;  1VH0 A;  2O3A A;  3KW2 A;  2QMM A;  3NK7 A;  1NXZ A;  4H3Z A;  5CO4 A;  3QUV A;  1V6Z A;  4PZK A;  1VHK A;  3IEF A;  4YQA A;  4MCD A;  3KNU A;  4YQ7 A;  4YQC A;  4YPZ A;  3E5Y A;  4X3L A;  1MXI A;  3AIA A;  4CNF A;  3DCM X;  2I6D A;  4YQ3 A;  1P9P A;  4YQJ A;  2CX8 A;  3O7B A;  1VHY A;  4YQP A;  2EGW A;  4YQ6 A;  3BBD A;  1K3R A;  4MCC A;  4YVG A;  4J3C A;  2EGV A;  4YPW A;  4X3M A;  4CNE A;  3AI9 X;  4YQ9 A;  4KDZ A;  4YVJ A;  4YQ4 A;  1TO0 A;  4YVK A;  4YQO A;  4YQ5 A;  4YQQ A;  4YVI A;  3ONP A;  4YQ0 A;  4JAL A;  2Z0Y A;  4YQD A;  3IC6 A;  2YY8 A;  4YPX A;  5GMC A;  1ZJR A;  1O6D A;  3L8U A;  1X7P A;  3BBH A;  5GM8 A;  4YPY A;  4CND A;  4YQS A;  1UAL A;  4CNG A;  3NK6 A;  4MCB A;  4YQ1 A;  2V3K A;  2HA8 A;  3OIJ A;  4YQT A;  4KGN A;  4IG6 A;  3OIN A;  3ILK A;  4YQL A;  4YVH A;  3AXZ A;  2QWV A;  4YQB A;  5D9F A;  4YQ2 A;  4L69 A;  3N4J A;  1J85 A;  1UAK A;  4YQ8 A;  4YQG A;  4FAK A;  2V3J A;  1NS5 A;  4JAK A;  4YQI A;  3GYQ A;  1IPA A;  1GZ0 A;  4YQN A;  4E8B A;  4YQK A;  5GMB A;  1UAJ A;  1V2X A;  1OY5 A; 
#chains in the Genus database with same CATH topology
 3BBE A;  1Z85 A;  3KY7 A;  1MI7 R;  1X7O A;  3OII A;  1UAM A;  4RG1 A;  1WRT R;  3KTY A;  3N4K A;  4XBO A;  4H3Y A;  2OZ9 R;  5FAI A;  4YQR A;  1VH0 A;  2O3A A;  3KW2 A;  2QMM A;  3NK7 A;  1NXZ A;  4JWG A;  4H3Z A;  3WRP A;  5CO4 A;  3QUV A;  1V6Z A;  4PZK A;  1VHK A;  3IEF A;  4YQA A;  4MCD A;  3KNU A;  1TRO A;  4YQ7 A;  4YQC A;  4YPZ A;  3E5Y A;  4X3L A;  3KOR A;  1MXI A;  3AIA A;  4CNF A;  3DCM X;  2I6D A;  4YQ3 A;  4FMW A;  1P9P A;  4YQJ A;  2CX8 A;  3O7B A;  1VHY A;  1CO0 A;  4YQP A;  2EGW A;  4YQ6 A;  3BBD A;  1K3R A;  4MCC A;  4YVG A;  1TRR A;  4J3C A;  2EGV A;  4YPW A;  4X3M A;  4JWF A;  4CNE A;  3SSX N;  3AI9 X;  4YQ9 A;  3G1C A;  4KDZ A;  4YVJ A;  4YQ4 A;  1TO0 A;  4JWJ A;  4YVK A;  4YQO A;  4YQ5 A;  4YQQ A;  1RCS A;  4YVI A;  3ONP A;  4YQ0 A;  4JAL A;  2Z0Y A;  4YQD A;  3IC6 A;  2YY8 A;  4YPX A;  5GMC A;  1ZJR A;  1O6D A;  3L8U A;  1X7P A;  3BBH A;  5GM8 A;  4YPY A;  3SSW N;  4CND A;  4JWH A;  4YQS A;  1WRP R;  1UAL A;  4CNG A;  3NK6 A;  4MCB A;  4YQ1 A;  2V3K A;  1JHG A;  2HA8 A;  4YQT A;  3OIJ A;  3FRW A;  4KGN A;  4IG6 A;  3OIN A;  3ILK A;  4YQL A;  4YVH A;  3AXZ A;  2QWV A;  4YQB A;  2XDI A;  1ZT9 A;  5D9F A;  4YQ2 A;  4L69 A;  3N4J A;  1J85 A;  1UAK A;  4YQ8 A;  4YQG A;  4FAK A;  2V3J A;  1NS5 A;  4JAK A;  4YQI A;  3GYQ A;  1IPA A;  1GZ0 A;  1WRS R;  4YQN A;  4E8B A;  4YQK A;  5GMB A;  1UAJ A;  1V2X A;  1OY5 A; 
#chains in the Genus database with same CATH homology
 3BBE A;  1Z85 A;  3KY7 A;  1X7O A;  3OII A;  1UAM A;  4RG1 A;  3KTY A;  3N4K A;  4XBO A;  4H3Y A;  5FAI A;  4YQR A;  1VH0 A;  2O3A A;  3KW2 A;  2QMM A;  3NK7 A;  1NXZ A;  4JWG A;  4H3Z A;  5CO4 A;  3QUV A;  1V6Z A;  4PZK A;  1VHK A;  3IEF A;  4YQA A;  4MCD A;  3KNU A;  4YQ7 A;  4YQC A;  4YPZ A;  3E5Y A;  4X3L A;  1MXI A;  3AIA A;  4CNF A;  3DCM X;  2I6D A;  4YQ3 A;  4FMW A;  1P9P A;  4YQJ A;  2CX8 A;  3O7B A;  1VHY A;  4YQP A;  2EGW A;  4YQ6 A;  3BBD A;  1K3R A;  4MCC A;  4YVG A;  4J3C A;  2EGV A;  4YPW A;  4X3M A;  4JWF A;  4CNE A;  3AI9 X;  4YQ9 A;  4KDZ A;  4YVJ A;  4YQ4 A;  1TO0 A;  4JWJ A;  4YVK A;  4YQO A;  4YQ5 A;  4YQQ A;  4YVI A;  3ONP A;  4YQ0 A;  4JAL A;  2Z0Y A;  4YQD A;  3IC6 A;  2YY8 A;  4YPX A;  5GMC A;  1ZJR A;  1O6D A;  3L8U A;  1X7P A;  3BBH A;  5GM8 A;  4YPY A;  4CND A;  4JWH A;  4YQS A;  1UAL A;  4CNG A;  3NK6 A;  4MCB A;  4YQ1 A;  2V3K A;  2HA8 A;  3OIJ A;  4YQT A;  4KGN A;  4IG6 A;  3OIN A;  3ILK A;  4YQL A;  4YVH A;  3AXZ A;  2QWV A;  4YQB A;  5D9F A;  4YQ2 A;  4L69 A;  3N4J A;  1J85 A;  1UAK A;  4YQ8 A;  4YQG A;  4FAK A;  2V3J A;  1NS5 A;  4JAK A;  4YQI A;  3GYQ A;  1IPA A;  1GZ0 A;  4YQN A;  4E8B A;  4YQK A;  5GMB A;  1UAJ A;  1V2X A;  1OY5 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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