2CX8A

Crystal structure of methyltransferase with ligand(sah)
Total Genus 70
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
70
Knots found
sequence length
225
structure length
225
Chain Sequence
b'HRAFSPGLTGVLPLRETRHLVEVLRARVGDRFTVFDGEREALAEVVDLGPPLRYRVLEERRPEREVGVEVVLYVALLKGDKLAEVVRAATELGATRIQPLVTRHSVPKEMGEGKLRRLRAVALEAAKQSGRVVVPEVLPPIPLKAVPQVAQGLVAHVGATARVREVLDPEKPLALAVGPEGGFAEEEVALLEARGFTPVSLGRRILRAETAALALLALCTAGEGR'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords methyl transferase
publication title Crystal structure of methyltransferase with ligand(SAH)
rcsb
source organism Thermus thermophilus
molecule tags Transferase
total genus 70
structure length 225
sequence length 225
chains with identical sequence B
other databases KnotProt 2.0: K +31
ec nomenclature
pdb deposition date 2005-06-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF04452 Methyltrans_RNA RNA methyltransferase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.240.20 Mainly Beta Beta Barrel Ribosomal Protein L25; Chain P Hypothetical PUA domain-like; domain 1 2cx8A01
3.40.1280.10 Alpha Beta 3-Layer(aba) Sandwich Alpha/beta knot Alpha/beta knot 2cx8A02
4FAKA 1K3RA 4YQGA 4YQIA 2QMMA 1IPAA 3OIIA 4YQ1A 3L8UA 4MCDA 3NK6A 4YQBA 4H3YA 4X3MA 1ZJRA 2HA8A 4YQ2A 4YPXA 1VHKA 1OY5A 1V6ZA 4JAKA 3AXZA 2EGWA 2V3KA 4YQQA 5FAIA 3KY7A 2I6DA 4YQDA 4CNDA 5D9FA 3BBEA 1VH0A 1UAJA 4YVHA 2O3AA 1O6DA 1Z85A 2NWAA 4E8BA 1V2XA 4YQ6A 4XBOA 2CX8A 4X3LA 2YY8A 1NXZA 1UALA 2V3JA 4YQKA 4YQ8A 3OINA 1TO0A 1UAKA 3BBDA 4KGNA 3AIAA 3KNUA 2QWVA 4YQJA 3IEFA 4YVKA 4RG1A 5GM8A 4YPZA 4YQNA 4J3CA 1VHYA 4YQ4A 1P9PA 3O7BA 4YVGA 4YQ7A 4YQ9A 2EGVA 3DCMX 4YPYA 4MCCA 5CO4A 1J85A 4MCBA 3AI9X 3BBHA 4CNGA 2Z0YA 4YQ5A 3KW2A 4KDZA 4YVIA 4YVJA 1X7PA 4CNFA 3IC6A 4YQ3A 1UAMA 3NK7A 4YQCA 4CNEA 3ONPA 4YPWA 1GZ0A 4YQAA 5GMCA 3KTYA 3QUVA 4YQPA 4YQRA 3GYQA 3OIJA 1NS5A 3E5YA 4H3ZA 4PZKA 4YQ0A 4JALA 3ILKA 1MXIA 4YQOA 4YQTA 4L69A 4YQLA 3N4JA 5GMBA 1X7OA 3N4KA 4YQSA 4IG6A
chains in the Genus database with same CATH superfamily
4FAKA 1K3RA 4YQGA 4IOCS 4YQIA 2QMMA 1IPAA 3X1LB 3OIIA 4YQ1A 3L8UA 3J7ZV 1DFUP 4MCDA 3NK6A 2ZJRS 5JVHS 4H3YA 4YQBA 4X3MA 2G5DA 1ZJRA 4V194 2HA8A 4WFNS 4YQ2A 4YPXA 1VHKA 1QRTA 1OY5A 1V6ZA 4WFAS 4IOAS 4JAKA 3AXZA 2EGWA 2PICA 2V3KA 1NYLA 5IZNA 2PJJA 2I6DA 3KY7A 4YQDA 4YQQA 5FAIA 4CNDA 4UY88 1ZJWA 4JWGA 5BNZA 5D9FA 3BBEA 1VH0A 1UAJA 4YVHA 2O3AA 1O6DA 1Z85A 2NWAA 4E8BA 1V2XA 4WF9S 4YQ6A 3W2WB 2AE0X 4XBOA 2CX8A 4H3SA 1QTQA 1FEUA 4X3LA 2YY8A 1NXZA 1QRUA 4FMWA 4WFBS 1UALA 2V3JA 4YQKA 3DLLS 4YQ8A 3OINA 2RD2A 1TO0A 2RE8A 1UAKA 4JYZA 4H4KA 1GTRA 3BBDA 4KGNA 5DM6S 3AIAA 3KNUA 3CF5S 2ZJPS 1O0BA 2QWVA 4YQJA 4JWHA 3IEFA 4YVKA 4RG1A 3CZBA 4YPZA 5GM8A 4J3CA 4YQNA 1VHYA 4YQ4A 5GAGW 1EXDA 1P9PA 3O7BA 4YVGA 1D6KA 3PIPS 4YQ7A 4YQ9A 2HZ7A 2EGVA 3DCMX 4YPYA 4MCCA 5DM7S 5CO4A 1J85A 4MCBA 3AI9X 3BBHA 4CNGA 2PI8A 2Z0YA 4YQ5A 4U67S 1UDXA 3KW2A 3W2VB 4KDZA 4YVJA 4YVIA 4JWJA 1X7PA 4CNFA 3IC6A 4YQ3A 2G6GA 1UAMA 3NK7A 4YQCA 4CNEA 4JXXA 1QRSA 3ONPA 4YPWA 1EUQA 1GZ0A 4IO9S 3PIOS 4YQAA 5JVGS 5GMCA 3KTYA 3QUVA 4YQPA 4WCES 4YQRA 3GYQA 2PNWA 3OIJA 5GAEW 4JXZA 3AIIA 1NS5A 3E5YA 4H3ZA 1GTSA 1EUYA 4PZKA 2ZJQS 1B75A 4YQ0A 4JALA 3ILKA 5GAHW 1MXIA 4YQOA 4YQTA 4L69A 2GAEA 4YQLA 1O0CA 5HL7S 3N4JA 5GMBA 5GADW 4P2BA 1X7OA 3N4KA 4JWFA 4YQSA 4IG6A
chains in the Genus database with same CATH topology
4FAKA 1K3RA 4YQGA 4YQIA 2QMMA 1IPAA 3OIIA 4YQ1A 3L8UA 4MCDA 3NK6A 4YQBA 4H3YA 4X3MA 1ZJRA 2HA8A 4YQ2A 4YPXA 1VHKA 1OY5A 1V6ZA 4JAKA 3AXZA 2EGWA 2V3KA 4YQQA 5FAIA 3KY7A 2I6DA 4YQDA 4CNDA 4JWGA 5D9FA 3BBEA 1VH0A 1UAJA 4YVHA 2O3AA 1O6DA 1Z85A 2NWAA 4E8BA 1V2XA 4YQ6A 4XBOA 2CX8A 4X3LA 2YY8A 1NXZA 4FMWA 1UALA 2V3JA 4YQKA 4YQ8A 3OINA 1TO0A 1UAKA 3BBDA 4KGNA 3AIAA 3KNUA 2QWVA 4YQJA 4JWHA 3IEFA 4YVKA 4RG1A 5GM8A 4YPZA 4YQNA 4J3CA 1VHYA 4YQ4A 1P9PA 3O7BA 4YVGA 4YQ7A 4YQ9A 2EGVA 3DCMX 4YPYA 4MCCA 5CO4A 1J85A 4MCBA 3AI9X 3BBHA 4CNGA 2Z0YA 4YQ5A 3KW2A 4KDZA 4YVIA 4YVJA 4JWJA 1X7PA 4CNFA 3IC6A 4YQ3A 1UAMA 3NK7A 4YQCA 4CNEA 3ONPA 4YPWA 1GZ0A 4YQAA 5GMCA 3KTYA 3QUVA 4YQPA 4YQRA 3GYQA 3OIJA 1NS5A 3E5YA 4H3ZA 4PZKA 4YQ0A 4JALA 3ILKA 1MXIA 4YQOA 4YQTA 4L69A 4YQLA 3N4JA 5GMBA 1X7OA 3N4KA 4JWFA 4YQSA 4IG6A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4FAK A;  1K3R A;  4YQG A;  4YQI A;  2QMM A;  1IPA A;  3OII A;  4YQ1 A;  3L8U A;  4MCD A;  3NK6 A;  4YQB A;  4H3Y A;  4X3M A;  1ZJR A;  2HA8 A;  4YQ2 A;  4YPX A;  1VHK A;  1OY5 A;  1V6Z A;  4JAK A;  3AXZ A;  2EGW A;  2V3K A;  4YQQ A;  5FAI A;  3KY7 A;  2I6D A;  4YQD A;  4CND A;  5D9F A;  3BBE A;  1VH0 A;  1UAJ A;  4YVH A;  2O3A A;  1O6D A;  1Z85 A;  2NWA A;  4E8B A;  1V2X A;  4YQ6 A;  4XBO A;  2CX8 A;  4X3L A;  2YY8 A;  1NXZ A;  1UAL A;  2V3J A;  4YQK A;  4YQ8 A;  3OIN A;  1TO0 A;  1UAK A;  3BBD A;  4KGN A;  3AIA A;  3KNU A;  2QWV A;  4YQJ A;  3IEF A;  4YVK A;  4RG1 A;  5GM8 A;  4YPZ A;  4YQN A;  4J3C A;  1VHY A;  4YQ4 A;  1P9P A;  3O7B A;  4YVG A;  4YQ7 A;  4YQ9 A;  2EGV A;  3DCM X;  4YPY A;  4MCC A;  5CO4 A;  1J85 A;  4MCB A;  3AI9 X;  3BBH A;  4CNG A;  2Z0Y A;  4YQ5 A;  3KW2 A;  4KDZ A;  4YVI A;  4YVJ A;  1X7P A;  4CNF A;  3IC6 A;  4YQ3 A;  1UAM A;  3NK7 A;  4YQC A;  4CNE A;  3ONP A;  4YPW A;  1GZ0 A;  4YQA A;  5GMC A;  3KTY A;  3QUV A;  4YQP A;  4YQR A;  3GYQ A;  3OIJ A;  1NS5 A;  3E5Y A;  4H3Z A;  4PZK A;  4YQ0 A;  4JAL A;  3ILK A;  1MXI A;  4YQO A;  4YQT A;  4L69 A;  4YQL A;  3N4J A;  5GMB A;  1X7O A;  3N4K A;  4YQS A;  4IG6 A; 
#chains in the Genus database with same CATH topology
 4FAK A;  1K3R A;  4YQG A;  4IOC S;  4YQI A;  2QMM A;  1IPA A;  3X1L B;  3OII A;  4YQ1 A;  3L8U A;  3J7Z V;  1DFU P;  4MCD A;  3NK6 A;  2ZJR S;  5JVH S;  4H3Y A;  4YQB A;  4X3M A;  2G5D A;  1ZJR A;  4V19 4;  2HA8 A;  4WFN S;  4YQ2 A;  4YPX A;  1VHK A;  1QRT A;  1OY5 A;  1V6Z A;  4WFA S;  4IOA S;  4JAK A;  3AXZ A;  2EGW A;  2PIC A;  2V3K A;  1NYL A;  5IZN A;  2PJJ A;  2I6D A;  3KY7 A;  4YQD A;  4YQQ A;  5FAI A;  4CND A;  4UY8 8;  1ZJW A;  4JWG A;  5BNZ A;  5D9F A;  3BBE A;  1VH0 A;  1UAJ A;  4YVH A;  2O3A A;  1O6D A;  1Z85 A;  2NWA A;  4E8B A;  1V2X A;  4WF9 S;  4YQ6 A;  3W2W B;  2AE0 X;  4XBO A;  2CX8 A;  4H3S A;  1QTQ A;  1FEU A;  4X3L A;  2YY8 A;  1NXZ A;  1QRU A;  4FMW A;  4WFB S;  1UAL A;  2V3J A;  4YQK A;  3DLL S;  4YQ8 A;  3OIN A;  2RD2 A;  1TO0 A;  2RE8 A;  1UAK A;  4JYZ A;  4H4K A;  1GTR A;  3BBD A;  4KGN A;  5DM6 S;  3AIA A;  3KNU A;  3CF5 S;  2ZJP S;  1O0B A;  2QWV A;  4YQJ A;  4JWH A;  3IEF A;  4YVK A;  4RG1 A;  3CZB A;  4YPZ A;  5GM8 A;  4J3C A;  4YQN A;  1VHY A;  4YQ4 A;  5GAG W;  1EXD A;  1P9P A;  3O7B A;  4YVG A;  1D6K A;  3PIP S;  4YQ7 A;  4YQ9 A;  2HZ7 A;  2EGV A;  3DCM X;  4YPY A;  4MCC A;  5DM7 S;  5CO4 A;  1J85 A;  4MCB A;  3AI9 X;  3BBH A;  4CNG A;  2PI8 A;  2Z0Y A;  4YQ5 A;  4U67 S;  1UDX A;  3KW2 A;  3W2V B;  4KDZ A;  4YVJ A;  4YVI A;  4JWJ A;  1X7P A;  4CNF A;  3IC6 A;  4YQ3 A;  2G6G A;  1UAM A;  3NK7 A;  4YQC A;  4CNE A;  4JXX A;  1QRS A;  3ONP A;  4YPW A;  1EUQ A;  1GZ0 A;  4IO9 S;  3PIO S;  4YQA A;  5JVG S;  5GMC A;  3KTY A;  3QUV A;  4YQP A;  4WCE S;  4YQR A;  3GYQ A;  2PNW A;  3OIJ A;  5GAE W;  4JXZ A;  3AII A;  1NS5 A;  3E5Y A;  4H3Z A;  1GTS A;  1EUY A;  4PZK A;  2ZJQ S;  1B75 A;  4YQ0 A;  4JAL A;  3ILK A;  5GAH W;  1MXI A;  4YQO A;  4YQT A;  4L69 A;  2GAE A;  4YQL A;  1O0C A;  5HL7 S;  3N4J A;  5GMB A;  5GAD W;  4P2B A;  1X7O A;  3N4K A;  4JWF A;  4YQS A;  4IG6 A; 
#chains in the Genus database with same CATH homology
 4FAK A;  1K3R A;  4YQG A;  4YQI A;  2QMM A;  1IPA A;  3OII A;  4YQ1 A;  3L8U A;  4MCD A;  3NK6 A;  4YQB A;  4H3Y A;  4X3M A;  1ZJR A;  2HA8 A;  4YQ2 A;  4YPX A;  1VHK A;  1OY5 A;  1V6Z A;  4JAK A;  3AXZ A;  2EGW A;  2V3K A;  4YQQ A;  5FAI A;  3KY7 A;  2I6D A;  4YQD A;  4CND A;  4JWG A;  5D9F A;  3BBE A;  1VH0 A;  1UAJ A;  4YVH A;  2O3A A;  1O6D A;  1Z85 A;  2NWA A;  4E8B A;  1V2X A;  4YQ6 A;  4XBO A;  2CX8 A;  4X3L A;  2YY8 A;  1NXZ A;  4FMW A;  1UAL A;  2V3J A;  4YQK A;  4YQ8 A;  3OIN A;  1TO0 A;  1UAK A;  3BBD A;  4KGN A;  3AIA A;  3KNU A;  2QWV A;  4YQJ A;  4JWH A;  3IEF A;  4YVK A;  4RG1 A;  5GM8 A;  4YPZ A;  4YQN A;  4J3C A;  1VHY A;  4YQ4 A;  1P9P A;  3O7B A;  4YVG A;  4YQ7 A;  4YQ9 A;  2EGV A;  3DCM X;  4YPY A;  4MCC A;  5CO4 A;  1J85 A;  4MCB A;  3AI9 X;  3BBH A;  4CNG A;  2Z0Y A;  4YQ5 A;  3KW2 A;  4KDZ A;  4YVI A;  4YVJ A;  4JWJ A;  1X7P A;  4CNF A;  3IC6 A;  4YQ3 A;  1UAM A;  3NK7 A;  4YQC A;  4CNE A;  3ONP A;  4YPW A;  1GZ0 A;  4YQA A;  5GMC A;  3KTY A;  3QUV A;  4YQP A;  4YQR A;  3GYQ A;  3OIJ A;  1NS5 A;  3E5Y A;  4H3Z A;  4PZK A;  4YQ0 A;  4JAL A;  3ILK A;  1MXI A;  4YQO A;  4YQT A;  4L69 A;  4YQL A;  3N4J A;  5GMB A;  1X7O A;  3N4K A;  4JWF A;  4YQS A;  4IG6 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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