2CX8A

Crystal structure of methyltransferase with ligand(sah)
Total Genus 70
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
70
Knots found
sequence length
225
structure length
225
Chain Sequence
HRAFSPGLTGVLPLRETRHLVEVLRARVGDRFTVFDGEREALAEVVDLGPPLRYRVLEERRPEREVGVEVVLYVALLKGDKLAEVVRAATELGATRIQPLVTRHSVPKEMGEGKLRRLRAVALEAAKQSGRVVVPEVLPPIPLKAVPQVAQGLVAHVGATARVREVLDPEKPLALAVGPEGGFAEEEVALLEARGFTPVSLGRRILRAETAALALLALCTAGEGR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Transferase
molecule keywords methyl transferase
publication title Crystal structure of methyltransferase with ligand(SAH)
rcsb
source organism Thermus thermophilus
total genus 70
structure length 225
sequence length 225
chains with identical sequence B
other databases KnotProt 2.0: K +31
ec nomenclature
pdb deposition date 2005-06-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF04452 Methyltrans_RNA RNA methyltransferase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.240.20 Mainly Beta Beta Barrel Ribosomal Protein L25; Chain P Hypothetical PUA domain-like; domain 1 2cx8A01
3.40.1280.10 Alpha Beta 3-Layer(aba) Sandwich Alpha/beta knot Alpha/beta knot 2cx8A02
3BBEA 3N4JA 4XBOA 4YQ4A 4YQKA 5GMBA 5FAIA 4YQ2A 1UAMA 4YQGA 4YQ3A 1MXIA 2EGVA 3NK7A 1GZ0A 4YQDA 2QMMA 4YQPA 1J85A 3KY7A 1NS5A 1TO0A 4YQ9A 2QWVA 4YPWA 3BBHA 4PZKA 4KDZA 3IEFA 4E8BA 1UALA 4JAKA 1X7PA 1VHYA 3ONPA 3E5YA 4YQOA 2Z0YA 4YQ0A 3OIJA 3DCMX 4MCCA 2V3KA 4YQLA 4CNGA 1X7OA 4H3YA 2EGWA 4YQ5A 4YQCA 4YQRA 1NXZA 5GM8A 1OY5A 4YQSA 4H3ZA 4YQ1A 4KGNA 4IG6A 4L69A 4YQQA 4J3CA 5CO4A 4CNFA 4YQ7A 4YQNA 4YQJA 4JALA 4CNDA 1P9PA 4MCDA 4YVIA 3QUVA 4YQTA 1VHKA 2O3AA 4YPYA 3O7BA 5D9FA 4FAKA 3KW2A 3GYQA 4YVGA 1V2XA 4X3MA 4CNEA 3ILKA 4YVJA 4YQIA 2CX8A 1K3RA 4YQAA 3NK6A 4X3LA 3L8UA 4YVKA 3N4KA 3KTYA 4YPZA 3IC6A 1Z85A 4YQ6A 4YPXA 2V3JA 2YY8A 4YVHA 4YQ8A 4RG1A 5GMCA 1V6ZA 1VH0A 4YQBA 3OIIA 1UAKA 3AI9X 1O6DA 3AIAA 1ZJRA 3BBDA 1UAJA 3OINA 2I6DA 4MCBA 1IPAA 3AXZA 3KNUA 2HA8A 2NWAA
chains in the Genus database with same CATH superfamily
3W2WB 3BBEA 3N4JA 4XBOA 4YQ4A 4YQKA 5GMBA 2ZJRS 5FAIA 2PI8A 4YQ2A 4JXZA 1UAMA 2PNWA 4UY88 2RE8A 4YQGA 4YQ3A 1MXIA 2EGVA 3NK7A 1GZ0A 4YQDA 2QMMA 2AE0X 4YQPA 1J85A 3KY7A 5BNZA 1NS5A 1TO0A 1QRTA 4YQ9A 2QWVA 4YPWA 2RD2A 3BBHA 4WCES 2HA8A 4IO9S 4PZKA 5HL7S 4KDZA 3IEFA 4WFNS 4H4KA 4E8BA 1EUQA 1UALA 4JAKA 1X7PA 1VHYA 1FEUA 3ONPA 5DM6S 3E5YA 4YQOA 2Z0YA 3X1LB 4YQ0A 4WFBS 3OIJA 3DCMX 3CF5S 2PJJA 4WFAS 4MCCA 2V3KA 2PICA 4YQLA 4CNGA 1EXDA 1QTQA 1X7OA 4H3YA 3AIIA 2EGWA 4YQ5A 5GAHW 4YQCA 3CZBA 4YQRA 1NXZA 1EUYA 5GM8A 2GAEA 1O0CA 1OY5A 4H3ZA 4YQSA 4YQ1A 4KGNA 4U67S 4IG6A 3DLLS 4L69A 4YQQA 4J3CA 5CO4A 1ZJWA 4CNFA 4JXXA 4YQ7A 4YQNA 3J7ZV 4JWJA 4YQJA 4JALA 1O0BA 4CNDA 3W2VB 1P9PA 4MCDA 4YVIA 3QUVA 4YQTA 1UDXA 1VHKA 2O3AA 4YPYA 3O7BA 4V194 2ZJQS 5D9FA 4FAKA 3KW2A 3GYQA 4JWHA 4YVGA 1V2XA 4X3MA 4JWFA 5DM7S 3ILKA 4CNEA 4YVJA 4H3SA 4YQIA 5JVGS 4IOCS 2CX8A 2HZ7A 1K3RA 4YQAA 3NK6A 4X3LA 5JVHS 3L8UA 4YVKA 1D6KA 1QRSA 3N4KA 3KTYA 4YPZA 1Z85A 3IC6A 4IOAS 4JWGA 4WF9S 4YQ6A 4YPXA 2V3JA 2G6GA 2YY8A 4JYZA 2G5DA 4FMWA 1B75A 4YVHA 4YQ8A 1GTSA 4RG1A 5GMCA 1V6ZA 1VH0A 1NYLA 5GAGW 3PIOS 4YQBA 3OIIA 5IZNA 1UAKA 1O6DA 3AI9X 3AIAA 5GAEW 1QRUA 1ZJRA 3PIPS 3BBDA 1UAJA 3OINA 2I6DA 4MCBA 1IPAA 3AXZA 2ZJPS 5GADW 1DFUP 3KNUA 4P2BA 1GTRA 2NWAA
chains in the Genus database with same CATH topology
3BBEA 3N4JA 4XBOA 4YQ4A 4YQKA 5GMBA 5FAIA 4YQ2A 1UAMA 4YQGA 4YQ3A 1MXIA 2EGVA 3NK7A 1GZ0A 4YQDA 2QMMA 4YQPA 1J85A 3KY7A 1NS5A 1TO0A 4YQ9A 2QWVA 4YPWA 3BBHA 4PZKA 4KDZA 3IEFA 4E8BA 1UALA 4JAKA 1X7PA 1VHYA 3ONPA 3E5YA 4YQOA 2Z0YA 4YQ0A 3OIJA 3DCMX 4MCCA 2V3KA 4YQLA 4CNGA 1X7OA 4H3YA 2EGWA 4YQ5A 4YQCA 4YQRA 1NXZA 5GM8A 1OY5A 4YQSA 4H3ZA 4YQ1A 4KGNA 4IG6A 4L69A 4YQQA 4J3CA 5CO4A 4CNFA 4YQ7A 4YQNA 4JWJA 4YQJA 4JALA 4CNDA 1P9PA 4MCDA 4YVIA 3QUVA 4YQTA 1VHKA 2O3AA 4YPYA 3O7BA 5D9FA 4FAKA 3KW2A 3GYQA 4JWHA 4YVGA 1V2XA 4X3MA 4JWFA 4CNEA 3ILKA 4YVJA 4YQIA 2CX8A 1K3RA 4YQAA 3NK6A 4X3LA 3L8UA 4YVKA 3N4KA 3KTYA 4YPZA 3IC6A 1Z85A 4JWGA 4YQ6A 4YPXA 2V3JA 2YY8A 4FMWA 4YVHA 4YQ8A 4RG1A 5GMCA 1V6ZA 1VH0A 4YQBA 3OIIA 1UAKA 3AI9X 1O6DA 3AIAA 1ZJRA 3BBDA 1UAJA 3OINA 2I6DA 4MCBA 1IPAA 3AXZA 3KNUA 2HA8A 2NWAA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3BBE A;  3N4J A;  4XBO A;  4YQ4 A;  4YQK A;  5GMB A;  5FAI A;  4YQ2 A;  1UAM A;  4YQG A;  4YQ3 A;  1MXI A;  2EGV A;  3NK7 A;  1GZ0 A;  4YQD A;  2QMM A;  4YQP A;  1J85 A;  3KY7 A;  1NS5 A;  1TO0 A;  4YQ9 A;  2QWV A;  4YPW A;  3BBH A;  4PZK A;  4KDZ A;  3IEF A;  4E8B A;  1UAL A;  4JAK A;  1X7P A;  1VHY A;  3ONP A;  3E5Y A;  4YQO A;  2Z0Y A;  4YQ0 A;  3OIJ A;  3DCM X;  4MCC A;  2V3K A;  4YQL A;  4CNG A;  1X7O A;  4H3Y A;  2EGW A;  4YQ5 A;  4YQC A;  4YQR A;  1NXZ A;  5GM8 A;  1OY5 A;  4YQS A;  4H3Z A;  4YQ1 A;  4KGN A;  4IG6 A;  4L69 A;  4YQQ A;  4J3C A;  5CO4 A;  4CNF A;  4YQ7 A;  4YQN A;  4YQJ A;  4JAL A;  4CND A;  1P9P A;  4MCD A;  4YVI A;  3QUV A;  4YQT A;  1VHK A;  2O3A A;  4YPY A;  3O7B A;  5D9F A;  4FAK A;  3KW2 A;  3GYQ A;  4YVG A;  1V2X A;  4X3M A;  4CNE A;  3ILK A;  4YVJ A;  4YQI A;  2CX8 A;  1K3R A;  4YQA A;  3NK6 A;  4X3L A;  3L8U A;  4YVK A;  3N4K A;  3KTY A;  4YPZ A;  3IC6 A;  1Z85 A;  4YQ6 A;  4YPX A;  2V3J A;  2YY8 A;  4YVH A;  4YQ8 A;  4RG1 A;  5GMC A;  1V6Z A;  1VH0 A;  4YQB A;  3OII A;  1UAK A;  3AI9 X;  1O6D A;  3AIA A;  1ZJR A;  3BBD A;  1UAJ A;  3OIN A;  2I6D A;  4MCB A;  1IPA A;  3AXZ A;  3KNU A;  2HA8 A;  2NWA A; 
#chains in the Genus database with same CATH topology
 3W2W B;  3BBE A;  3N4J A;  4XBO A;  4YQ4 A;  4YQK A;  5GMB A;  2ZJR S;  5FAI A;  2PI8 A;  4YQ2 A;  4JXZ A;  1UAM A;  2PNW A;  4UY8 8;  2RE8 A;  4YQG A;  4YQ3 A;  1MXI A;  2EGV A;  3NK7 A;  1GZ0 A;  4YQD A;  2QMM A;  2AE0 X;  4YQP A;  1J85 A;  3KY7 A;  5BNZ A;  1NS5 A;  1TO0 A;  1QRT A;  4YQ9 A;  2QWV A;  4YPW A;  2RD2 A;  3BBH A;  4WCE S;  2HA8 A;  4IO9 S;  4PZK A;  5HL7 S;  4KDZ A;  3IEF A;  4WFN S;  4H4K A;  4E8B A;  1EUQ A;  1UAL A;  4JAK A;  1X7P A;  1VHY A;  1FEU A;  3ONP A;  5DM6 S;  3E5Y A;  4YQO A;  2Z0Y A;  3X1L B;  4YQ0 A;  4WFB S;  3OIJ A;  3DCM X;  3CF5 S;  2PJJ A;  4WFA S;  4MCC A;  2V3K A;  2PIC A;  4YQL A;  4CNG A;  1EXD A;  1QTQ A;  1X7O A;  4H3Y A;  3AII A;  2EGW A;  4YQ5 A;  5GAH W;  4YQC A;  3CZB A;  4YQR A;  1NXZ A;  1EUY A;  5GM8 A;  2GAE A;  1O0C A;  1OY5 A;  4H3Z A;  4YQS A;  4YQ1 A;  4KGN A;  4U67 S;  4IG6 A;  3DLL S;  4L69 A;  4YQQ A;  4J3C A;  5CO4 A;  1ZJW A;  4CNF A;  4JXX A;  4YQ7 A;  4YQN A;  3J7Z V;  4JWJ A;  4YQJ A;  4JAL A;  1O0B A;  4CND A;  3W2V B;  1P9P A;  4MCD A;  4YVI A;  3QUV A;  4YQT A;  1UDX A;  1VHK A;  2O3A A;  4YPY A;  3O7B A;  4V19 4;  2ZJQ S;  5D9F A;  4FAK A;  3KW2 A;  3GYQ A;  4JWH A;  4YVG A;  1V2X A;  4X3M A;  4JWF A;  5DM7 S;  3ILK A;  4CNE A;  4YVJ A;  4H3S A;  4YQI A;  5JVG S;  4IOC S;  2CX8 A;  2HZ7 A;  1K3R A;  4YQA A;  3NK6 A;  4X3L A;  5JVH S;  3L8U A;  4YVK A;  1D6K A;  1QRS A;  3N4K A;  3KTY A;  4YPZ A;  1Z85 A;  3IC6 A;  4IOA S;  4JWG A;  4WF9 S;  4YQ6 A;  4YPX A;  2V3J A;  2G6G A;  2YY8 A;  4JYZ A;  2G5D A;  4FMW A;  1B75 A;  4YVH A;  4YQ8 A;  1GTS A;  4RG1 A;  5GMC A;  1V6Z A;  1VH0 A;  1NYL A;  5GAG W;  3PIO S;  4YQB A;  3OII A;  5IZN A;  1UAK A;  1O6D A;  3AI9 X;  3AIA A;  5GAE W;  1QRU A;  1ZJR A;  3PIP S;  3BBD A;  1UAJ A;  3OIN A;  2I6D A;  4MCB A;  1IPA A;  3AXZ A;  2ZJP S;  5GAD W;  1DFU P;  3KNU A;  4P2B A;  1GTR A;  2NWA A; 
#chains in the Genus database with same CATH homology
 3BBE A;  3N4J A;  4XBO A;  4YQ4 A;  4YQK A;  5GMB A;  5FAI A;  4YQ2 A;  1UAM A;  4YQG A;  4YQ3 A;  1MXI A;  2EGV A;  3NK7 A;  1GZ0 A;  4YQD A;  2QMM A;  4YQP A;  1J85 A;  3KY7 A;  1NS5 A;  1TO0 A;  4YQ9 A;  2QWV A;  4YPW A;  3BBH A;  4PZK A;  4KDZ A;  3IEF A;  4E8B A;  1UAL A;  4JAK A;  1X7P A;  1VHY A;  3ONP A;  3E5Y A;  4YQO A;  2Z0Y A;  4YQ0 A;  3OIJ A;  3DCM X;  4MCC A;  2V3K A;  4YQL A;  4CNG A;  1X7O A;  4H3Y A;  2EGW A;  4YQ5 A;  4YQC A;  4YQR A;  1NXZ A;  5GM8 A;  1OY5 A;  4YQS A;  4H3Z A;  4YQ1 A;  4KGN A;  4IG6 A;  4L69 A;  4YQQ A;  4J3C A;  5CO4 A;  4CNF A;  4YQ7 A;  4YQN A;  4JWJ A;  4YQJ A;  4JAL A;  4CND A;  1P9P A;  4MCD A;  4YVI A;  3QUV A;  4YQT A;  1VHK A;  2O3A A;  4YPY A;  3O7B A;  5D9F A;  4FAK A;  3KW2 A;  3GYQ A;  4JWH A;  4YVG A;  1V2X A;  4X3M A;  4JWF A;  4CNE A;  3ILK A;  4YVJ A;  4YQI A;  2CX8 A;  1K3R A;  4YQA A;  3NK6 A;  4X3L A;  3L8U A;  4YVK A;  3N4K A;  3KTY A;  4YPZ A;  3IC6 A;  1Z85 A;  4JWG A;  4YQ6 A;  4YPX A;  2V3J A;  2YY8 A;  4FMW A;  4YVH A;  4YQ8 A;  4RG1 A;  5GMC A;  1V6Z A;  1VH0 A;  4YQB A;  3OII A;  1UAK A;  3AI9 X;  1O6D A;  3AIA A;  1ZJR A;  3BBD A;  1UAJ A;  3OIN A;  2I6D A;  4MCB A;  1IPA A;  3AXZ A;  3KNU A;  2HA8 A;  2NWA A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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