2CX8A

Crystal structure of methyltransferase with ligand(sah)
Total Genus 70
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
70
Knots found
sequence length
225
structure length
225
Chain Sequence
HRAFSPGLTGVLPLRETRHLVEVLRARVGDRFTVFDGEREALAEVVDLGPPLRYRVLEERRPEREVGVEVVLYVALLKGDKLAEVVRAATELGATRIQPLVTRHSVPKEMGEGKLRRLRAVALEAAKQSGRVVVPEVLPPIPLKAVPQVAQGLVAHVGATARVREVLDPEKPLALAVGPEGGFAEEEVALLEARGFTPVSLGRRILRAETAALALLALCTAGEGR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords methyl transferase
publication title Crystal structure of methyltransferase with ligand(SAH)
rcsb
source organism Thermus thermophilus
molecule tags Transferase
total genus 70
structure length 225
sequence length 225
chains with identical sequence B
other databases KnotProt 2.0: K +31
ec nomenclature
pdb deposition date 2005-06-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF04452 Methyltrans_RNA RNA methyltransferase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.240.20 Mainly Beta Beta Barrel Ribosomal Protein L25; Chain P Hypothetical PUA domain-like; domain 1 2cx8A01
3.40.1280.10 Alpha Beta 3-Layer(aba) Sandwich Alpha/beta knot Alpha/beta knot 2cx8A02
3AI9X 5GMBA 4MCDA 1UALA 4YQIA 4CNGA 1K3RA 3N4KA 4YVJA 4PZKA 4YQ6A 3OINA 4JALA 4YVHA 2QWVA 4YQ2A 1P9PA 4YQSA 4X3MA 4KDZA 1V6ZA 4YQ8A 4YQ5A 1VH0A 4YVGA 3NK7A 2CX8A 4YQQA 2V3KA 2Z0YA 4YQLA 3KNUA 4H3YA 3O7BA 4CNEA 4YQ0A 4MCCA 4E8BA 4YPWA 4YQ4A 4L69A 2QMMA 1MXIA 3DCMX 3KY7A 4YQNA 2EGWA 4YQGA 4YQKA 3AXZA 3IEFA 1OY5A 1UAJA 4YVIA 1IPAA 3KTYA 1NS5A 2I6DA 4YQJA 4YQDA 4CNFA 3E5YA 3AIAA 4MCBA 4YQBA 4J3CA 1X7OA 5GMCA 4X3LA 1X7PA 4YQPA 3L8UA 2YY8A 5FAIA 4YPYA 1O6DA 3QUVA 4YQAA 1GZ0A 1Z85A 4YQ3A 3ONPA 4RG1A 3N4JA 3BBEA 4YQRA 1VHYA 1J85A 4CNDA 4YQOA 4YQ1A 4YVKA 3BBHA 1NXZA 3BBDA 2EGVA 4H3ZA 4JAKA 2NWAA 3OIIA 4KGNA 2V3JA 5D9FA 2O3AA 1UAMA 4YPZA 1UAKA 5GM8A 4XBOA 5CO4A 4YPXA 3IC6A 2HA8A 3KW2A 4YQCA 4YQTA 4IG6A 1TO0A 4FAKA 1ZJRA 1VHKA 3ILKA 1V2XA 3NK6A 3OIJA 3GYQA 4YQ9A 4YQ7A
chains in the Genus database with same CATH superfamily
3AI9X 5GMBA 4H3SA 4MCDA 5HL7S 1EXDA 1UALA 3W2WB 4YQIA 4CNGA 1FEUA 1K3RA 3N4KA 1GTRA 4PZKA 1D6KA 4YQ6A 4YVJA 4WCES 3OINA 2GAEA 4JALA 5GADW 4YVHA 1QRSA 2QWVA 4YQ2A 1P9PA 3W2VB 1O0CA 3J7ZV 3PIOS 4YQSA 2ZJQS 2RE8A 5GAEW 2RD2A 4X3MA 4KDZA 1V6ZA 4YQ8A 4YQ5A 4IO9S 1VH0A 4WFBS 4YVGA 3NK7A 2CX8A 4YQQA 2V3KA 2Z0YA 5GAHW 4YQLA 5JVHS 3X1LB 3KNUA 4H3YA 1O0BA 4JWGA 3AIIA 4H4KA 3O7BA 1NYLA 4CNEA 4YQNA 4YQ0A 4MCCA 4E8BA 4YPWA 4YQ4A 4L69A 1EUYA 2QMMA 1MXIA 4V194 5BNZA 3DCMX 2EGWA 3CZBA 3KY7A 4YQKA 3AXZA 4JXXA 3IEFA 4YQGA 1OY5A 1UAJA 4YVIA 1IPAA 1ZJWA 1NS5A 2I6DA 3KTYA 4YQJA 4YQDA 3CF5S 4CNFA 2HZ7A 3E5YA 4IOAS 3AIAA 4MCBA 2G6GA 4JYZA 4YQBA 3DLLS 2AE0X 4J3CA 2PJJA 1X7OA 1UDXA 2G5DA 5GMCA 4FMWA 4X3LA 1X7PA 4YQPA 3L8UA 2YY8A 5FAIA 4JWFA 1B75A 4YPYA 1O6DA 3QUVA 4YQAA 1GZ0A 5JVGS 1Z85A 4U67S 4YQ3A 3ONPA 4RG1A 4IOCS 1QRTA 4WFAS 3BBEA 3N4JA 4YQRA 1VHYA 1J85A 4CNDA 5DM7S 2PNWA 4YQOA 4YQ1A 4YVKA 3BBHA 1NXZA 4WF9S 3BBDA 5DM6S 2EGVA 4UY88 2PICA 4H3ZA 1QRUA 4JWHA 4WFNS 4JAKA 2ZJRS 2NWAA 3OIIA 4KGNA 2V3JA 2PI8A 5D9FA 2O3AA 1UAMA 4YPZA 1UAKA 5GM8A 4XBOA 5CO4A 4YPXA 3IC6A 4P2BA 5IZNA 2HA8A 3KW2A 4YQCA 4YQTA 4JXZA 4IG6A 2ZJPS 1QTQA 1TO0A 4FAKA 1ZJRA 1VHKA 3ILKA 1GTSA 1V2XA 3PIPS 1DFUP 5GAGW 4JWJA 3NK6A 1EUQA 3OIJA 3GYQA 4YQ9A 4YQ7A
chains in the Genus database with same CATH topology
3AI9X 5GMBA 4MCDA 1UALA 4YQIA 4CNGA 1K3RA 3N4KA 4YVJA 4PZKA 4YQ6A 3OINA 4JALA 4YVHA 2QWVA 4YQ2A 1P9PA 4YQSA 4X3MA 4KDZA 1V6ZA 4YQ8A 4YQ5A 1VH0A 4YVGA 3NK7A 2CX8A 4YQQA 2V3KA 2Z0YA 4YQLA 3KNUA 4H3YA 4JWGA 3O7BA 4CNEA 4YQ0A 4MCCA 4E8BA 4YPWA 4YQ4A 4L69A 2QMMA 1MXIA 3DCMX 3KY7A 4YQNA 2EGWA 4YQGA 4YQKA 3AXZA 3IEFA 1OY5A 1UAJA 4YVIA 1IPAA 3KTYA 1NS5A 2I6DA 4YQJA 4YQDA 4CNFA 3E5YA 3AIAA 4MCBA 4YQBA 4J3CA 1X7OA 5GMCA 4FMWA 4X3LA 1X7PA 4YQPA 3L8UA 2YY8A 5FAIA 4JWFA 4YPYA 1O6DA 3QUVA 4YQAA 1GZ0A 1Z85A 4YQ3A 3ONPA 4RG1A 3N4JA 3BBEA 4YQRA 1VHYA 1J85A 4CNDA 4YQOA 4YQ1A 4YVKA 3BBHA 1NXZA 3BBDA 2EGVA 4H3ZA 4JWHA 4JAKA 2NWAA 3OIIA 4KGNA 2V3JA 5D9FA 2O3AA 1UAMA 4YPZA 1UAKA 5GM8A 4XBOA 5CO4A 4YPXA 3IC6A 2HA8A 3KW2A 4YQCA 4YQTA 4IG6A 1TO0A 4FAKA 1ZJRA 1VHKA 3ILKA 1V2XA 4JWJA 3NK6A 3OIJA 3GYQA 4YQ9A 4YQ7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3AI9 X;  5GMB A;  4MCD A;  1UAL A;  4YQI A;  4CNG A;  1K3R A;  3N4K A;  4YVJ A;  4PZK A;  4YQ6 A;  3OIN A;  4JAL A;  4YVH A;  2QWV A;  4YQ2 A;  1P9P A;  4YQS A;  4X3M A;  4KDZ A;  1V6Z A;  4YQ8 A;  4YQ5 A;  1VH0 A;  4YVG A;  3NK7 A;  2CX8 A;  4YQQ A;  2V3K A;  2Z0Y A;  4YQL A;  3KNU A;  4H3Y A;  3O7B A;  4CNE A;  4YQ0 A;  4MCC A;  4E8B A;  4YPW A;  4YQ4 A;  4L69 A;  2QMM A;  1MXI A;  3DCM X;  3KY7 A;  4YQN A;  2EGW A;  4YQG A;  4YQK A;  3AXZ A;  3IEF A;  1OY5 A;  1UAJ A;  4YVI A;  1IPA A;  3KTY A;  1NS5 A;  2I6D A;  4YQJ A;  4YQD A;  4CNF A;  3E5Y A;  3AIA A;  4MCB A;  4YQB A;  4J3C A;  1X7O A;  5GMC A;  4X3L A;  1X7P A;  4YQP A;  3L8U A;  2YY8 A;  5FAI A;  4YPY A;  1O6D A;  3QUV A;  4YQA A;  1GZ0 A;  1Z85 A;  4YQ3 A;  3ONP A;  4RG1 A;  3N4J A;  3BBE A;  4YQR A;  1VHY A;  1J85 A;  4CND A;  4YQO A;  4YQ1 A;  4YVK A;  3BBH A;  1NXZ A;  3BBD A;  2EGV A;  4H3Z A;  4JAK A;  2NWA A;  3OII A;  4KGN A;  2V3J A;  5D9F A;  2O3A A;  1UAM A;  4YPZ A;  1UAK A;  5GM8 A;  4XBO A;  5CO4 A;  4YPX A;  3IC6 A;  2HA8 A;  3KW2 A;  4YQC A;  4YQT A;  4IG6 A;  1TO0 A;  4FAK A;  1ZJR A;  1VHK A;  3ILK A;  1V2X A;  3NK6 A;  3OIJ A;  3GYQ A;  4YQ9 A;  4YQ7 A; 
#chains in the Genus database with same CATH topology
 3AI9 X;  5GMB A;  4H3S A;  4MCD A;  5HL7 S;  1EXD A;  1UAL A;  3W2W B;  4YQI A;  4CNG A;  1FEU A;  1K3R A;  3N4K A;  1GTR A;  4PZK A;  1D6K A;  4YQ6 A;  4YVJ A;  4WCE S;  3OIN A;  2GAE A;  4JAL A;  5GAD W;  4YVH A;  1QRS A;  2QWV A;  4YQ2 A;  1P9P A;  3W2V B;  1O0C A;  3J7Z V;  3PIO S;  4YQS A;  2ZJQ S;  2RE8 A;  5GAE W;  2RD2 A;  4X3M A;  4KDZ A;  1V6Z A;  4YQ8 A;  4YQ5 A;  4IO9 S;  1VH0 A;  4WFB S;  4YVG A;  3NK7 A;  2CX8 A;  4YQQ A;  2V3K A;  2Z0Y A;  5GAH W;  4YQL A;  5JVH S;  3X1L B;  3KNU A;  4H3Y A;  1O0B A;  4JWG A;  3AII A;  4H4K A;  3O7B A;  1NYL A;  4CNE A;  4YQN A;  4YQ0 A;  4MCC A;  4E8B A;  4YPW A;  4YQ4 A;  4L69 A;  1EUY A;  2QMM A;  1MXI A;  4V19 4;  5BNZ A;  3DCM X;  2EGW A;  3CZB A;  3KY7 A;  4YQK A;  3AXZ A;  4JXX A;  3IEF A;  4YQG A;  1OY5 A;  1UAJ A;  4YVI A;  1IPA A;  1ZJW A;  1NS5 A;  2I6D A;  3KTY A;  4YQJ A;  4YQD A;  3CF5 S;  4CNF A;  2HZ7 A;  3E5Y A;  4IOA S;  3AIA A;  4MCB A;  2G6G A;  4JYZ A;  4YQB A;  3DLL S;  2AE0 X;  4J3C A;  2PJJ A;  1X7O A;  1UDX A;  2G5D A;  5GMC A;  4FMW A;  4X3L A;  1X7P A;  4YQP A;  3L8U A;  2YY8 A;  5FAI A;  4JWF A;  1B75 A;  4YPY A;  1O6D A;  3QUV A;  4YQA A;  1GZ0 A;  5JVG S;  1Z85 A;  4U67 S;  4YQ3 A;  3ONP A;  4RG1 A;  4IOC S;  1QRT A;  4WFA S;  3BBE A;  3N4J A;  4YQR A;  1VHY A;  1J85 A;  4CND A;  5DM7 S;  2PNW A;  4YQO A;  4YQ1 A;  4YVK A;  3BBH A;  1NXZ A;  4WF9 S;  3BBD A;  5DM6 S;  2EGV A;  4UY8 8;  2PIC A;  4H3Z A;  1QRU A;  4JWH A;  4WFN S;  4JAK A;  2ZJR S;  2NWA A;  3OII A;  4KGN A;  2V3J A;  2PI8 A;  5D9F A;  2O3A A;  1UAM A;  4YPZ A;  1UAK A;  5GM8 A;  4XBO A;  5CO4 A;  4YPX A;  3IC6 A;  4P2B A;  5IZN A;  2HA8 A;  3KW2 A;  4YQC A;  4YQT A;  4JXZ A;  4IG6 A;  2ZJP S;  1QTQ A;  1TO0 A;  4FAK A;  1ZJR A;  1VHK A;  3ILK A;  1GTS A;  1V2X A;  3PIP S;  1DFU P;  5GAG W;  4JWJ A;  3NK6 A;  1EUQ A;  3OIJ A;  3GYQ A;  4YQ9 A;  4YQ7 A; 
#chains in the Genus database with same CATH homology
 3AI9 X;  5GMB A;  4MCD A;  1UAL A;  4YQI A;  4CNG A;  1K3R A;  3N4K A;  4YVJ A;  4PZK A;  4YQ6 A;  3OIN A;  4JAL A;  4YVH A;  2QWV A;  4YQ2 A;  1P9P A;  4YQS A;  4X3M A;  4KDZ A;  1V6Z A;  4YQ8 A;  4YQ5 A;  1VH0 A;  4YVG A;  3NK7 A;  2CX8 A;  4YQQ A;  2V3K A;  2Z0Y A;  4YQL A;  3KNU A;  4H3Y A;  4JWG A;  3O7B A;  4CNE A;  4YQ0 A;  4MCC A;  4E8B A;  4YPW A;  4YQ4 A;  4L69 A;  2QMM A;  1MXI A;  3DCM X;  3KY7 A;  4YQN A;  2EGW A;  4YQG A;  4YQK A;  3AXZ A;  3IEF A;  1OY5 A;  1UAJ A;  4YVI A;  1IPA A;  3KTY A;  1NS5 A;  2I6D A;  4YQJ A;  4YQD A;  4CNF A;  3E5Y A;  3AIA A;  4MCB A;  4YQB A;  4J3C A;  1X7O A;  5GMC A;  4FMW A;  4X3L A;  1X7P A;  4YQP A;  3L8U A;  2YY8 A;  5FAI A;  4JWF A;  4YPY A;  1O6D A;  3QUV A;  4YQA A;  1GZ0 A;  1Z85 A;  4YQ3 A;  3ONP A;  4RG1 A;  3N4J A;  3BBE A;  4YQR A;  1VHY A;  1J85 A;  4CND A;  4YQO A;  4YQ1 A;  4YVK A;  3BBH A;  1NXZ A;  3BBD A;  2EGV A;  4H3Z A;  4JWH A;  4JAK A;  2NWA A;  3OII A;  4KGN A;  2V3J A;  5D9F A;  2O3A A;  1UAM A;  4YPZ A;  1UAK A;  5GM8 A;  4XBO A;  5CO4 A;  4YPX A;  3IC6 A;  2HA8 A;  3KW2 A;  4YQC A;  4YQT A;  4IG6 A;  1TO0 A;  4FAK A;  1ZJR A;  1VHK A;  3ILK A;  1V2X A;  4JWJ A;  3NK6 A;  3OIJ A;  3GYQ A;  4YQ9 A;  4YQ7 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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