2CX8A

Crystal structure of methyltransferase with ligand(sah)
Total Genus 70
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
70
Knots found
sequence length
225
structure length
225
Chain Sequence
HRAFSPGLTGVLPLRETRHLVEVLRARVGDRFTVFDGEREALAEVVDLGPPLRYRVLEERRPEREVGVEVVLYVALLKGDKLAEVVRAATELGATRIQPLVTRHSVPKEMGEGKLRRLRAVALEAAKQSGRVVVPEVLPPIPLKAVPQVAQGLVAHVGATARVREVLDPEKPLALAVGPEGGFAEEEVALLEARGFTPVSLGRRILRAETAALALLALCTAGEGR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of methyltransferase with ligand(SAH)
rcsb
source organism Thermus thermophilus
molecule tags Transferase
molecule keywords methyl transferase
total genus 70
structure length 225
sequence length 225
chains with identical sequence B
other databases KnotProt 2.0: K +31
ec nomenclature
pdb deposition date 2005-06-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF04452 Methyltrans_RNA RNA methyltransferase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.240.20 Mainly Beta Beta Barrel Ribosomal Protein L25; Chain P Hypothetical PUA domain-like; domain 1 2cx8A01
3.40.1280.10 Alpha Beta 3-Layer(aba) Sandwich Alpha/beta knot Alpha/beta knot 2cx8A02
3KY7A 5D9FA 4YQLA 4YQDA 4YQTA 2I6DA 3NK7A 2QWVA 4YQKA 4E8BA 3GYQA 4YVKA 3OIJA 1P9PA 4YQ8A 3E5YA 3BBHA 3OIIA 4YQGA 3ONPA 1NS5A 4YPXA 4YQQA 3O7BA 4CNFA 3KW2A 1V6ZA 1V2XA 1UAJA 1OY5A 4YQ4A 1VH0A 4YQ5A 4RG1A 3BBEA 2QMMA 4YQOA 4JAKA 3BBDA 3OINA 4KDZA 3AXZA 4YQ0A 2EGWA 4YQ2A 4YQ3A 2YY8A 4YQ6A 1MXIA 5CO4A 2HA8A 1VHYA 2CX8A 4X3MA 4L69A 1GZ0A 4XBOA 1NXZA 4YQNA 2EGVA 3N4KA 4YQPA 4CNGA 1IPAA 4MCDA 4MCCA 4CNDA 3L8UA 1O6DA 1K3RA 4KGNA 5GM8A 4YQ7A 4FAKA 1X7PA 3IEFA 3QUVA 3AI9X 4YQCA 4H3ZA 3N4JA 4CNEA 2Z0YA 1Z85A 3ILKA 3KNUA 4X3LA 3KTYA 1UALA 4YQSA 4YVHA 4YPYA 4YPWA 4MCBA 4YQAA 3AIAA 4YVGA 4YQ1A 4YQ9A 4YQBA 2V3KA 5FAIA 4YPZA 1VHKA 1X7OA 2O3AA 1J85A 1ZJRA 4YQRA 4J3CA 3IC6A 4IG6A 1TO0A 5GMBA 4YVJA 1UAMA 4JALA 2NWAA 4H3YA 4YQJA 3DCMX 1UAKA 5GMCA 4YQIA 3NK6A 4YVIA 2V3JA 4PZKA
chains in the Genus database with same CATH superfamily
3KY7A 1QRUA 5D9FA 5IZNA 4U67S 4YQLA 4YQDA 4YQTA 4IOAS 4IO9S 5BNZA 2I6DA 3DLLS 3NK7A 2RE8A 2QWVA 3PIOS 4YQKA 4E8BA 3GYQA 1O0BA 2PICA 4YVKA 3OIJA 1D6KA 4H4KA 1P9PA 4WFNS 4YQ8A 4UY88 3E5YA 3BBHA 3OIIA 4YQGA 3ONPA 3AIIA 4V194 1NS5A 4YPXA 4YQQA 3O7BA 4CNFA 3KW2A 1V6ZA 1V2XA 3CF5S 1UAJA 1GTSA 1GTRA 1OY5A 1O0CA 2G6GA 3W2VB 4YQ4A 1NYLA 5GADW 4JYZA 1VH0A 4YQ5A 4RG1A 3BBEA 3CZBA 1B75A 2QMMA 4WFBS 4H3SA 4YQOA 2GAEA 1UDXA 3W2WB 4JAKA 4WCES 3BBDA 4KDZA 3AXZA 3OINA 4YQ0A 2EGWA 1DFUP 4YQ2A 4YQ3A 2YY8A 4YQ6A 1MXIA 5CO4A 2HA8A 1FEUA 1VHYA 4JWJA 2CX8A 4X3MA 4L69A 1GZ0A 4XBOA 1NXZA 2ZJRS 4YQNA 2EGVA 2PI8A 5DM6S 3N4KA 4YQPA 4FMWA 4CNGA 1IPAA 4MCDA 4MCCA 5HL7S 4JWFA 2PNWA 2G5DA 4CNDA 4WF9S 5GAHW 5GAGW 5JVHS 4JXXA 5GAEW 3L8UA 1O6DA 4JXZA 1K3RA 4KGNA 2ZJPS 3J7ZV 5GM8A 4YQ7A 4FAKA 1X7PA 3IEFA 3QUVA 3AI9X 4YQCA 4H3ZA 3N4JA 4CNEA 2Z0YA 1Z85A 3ILKA 3KNUA 4X3LA 3KTYA 4P2BA 1EUQA 1UALA 4IOCS 4YQSA 2AE0X 5DM7S 4YVHA 2HZ7A 4YPYA 4YPWA 4MCBA 4YQAA 3AIAA 2RD2A 4YVGA 4YQ1A 4YQ9A 2ZJQS 4YQBA 2V3KA 2PJJA 1EUYA 5FAIA 4YPZA 4JWGA 1VHKA 1ZJWA 1X7OA 1J85A 1ZJRA 2O3AA 4YQRA 4J3CA 3IC6A 1QRSA 4IG6A 1TO0A 5GMBA 3X1LB 1EXDA 4YVJA 4WFAS 1UAMA 4JALA 1QTQA 2NWAA 4H3YA 4YQJA 3DCMX 5JVGS 4JWHA 1UAKA 5GMCA 4YQIA 3NK6A 4YVIA 1QRTA 3PIPS 2V3JA 4PZKA
chains in the Genus database with same CATH topology
3KY7A 5D9FA 4YQLA 4YQDA 4YQTA 2I6DA 3NK7A 2QWVA 4YQKA 4E8BA 3GYQA 4YVKA 3OIJA 1P9PA 4YQ8A 3E5YA 3BBHA 3OIIA 4YQGA 3ONPA 1NS5A 4YPXA 4YQQA 3O7BA 4CNFA 3KW2A 1V6ZA 1V2XA 1UAJA 1OY5A 4YQ4A 1VH0A 4YQ5A 4RG1A 3BBEA 2QMMA 4YQOA 4JAKA 3BBDA 3OINA 4KDZA 3AXZA 4YQ0A 2EGWA 4YQ2A 4YQ3A 2YY8A 4YQ6A 1MXIA 5CO4A 2HA8A 1VHYA 4JWJA 2CX8A 4X3MA 4L69A 1GZ0A 4XBOA 1NXZA 4YQNA 2EGVA 3N4KA 4YQPA 4FMWA 4CNGA 1IPAA 4MCDA 4MCCA 4JWFA 4CNDA 3L8UA 1O6DA 1K3RA 4KGNA 5GM8A 4YQ7A 4FAKA 1X7PA 3IEFA 3QUVA 3AI9X 4YQCA 4H3ZA 3N4JA 4CNEA 2Z0YA 1Z85A 3ILKA 3KNUA 4X3LA 3KTYA 1UALA 4YQSA 4YVHA 4YPYA 4YPWA 4MCBA 4YQAA 3AIAA 4YVGA 4YQ1A 4YQ9A 4YQBA 2V3KA 5FAIA 4YPZA 4JWGA 1VHKA 1X7OA 2O3AA 1J85A 1ZJRA 4YQRA 4J3CA 3IC6A 4IG6A 1TO0A 5GMBA 4YVJA 1UAMA 4JALA 2NWAA 4H3YA 4YQJA 3DCMX 4JWHA 1UAKA 5GMCA 4YQIA 3NK6A 4YVIA 2V3JA 4PZKA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3KY7 A;  5D9F A;  4YQL A;  4YQD A;  4YQT A;  2I6D A;  3NK7 A;  2QWV A;  4YQK A;  4E8B A;  3GYQ A;  4YVK A;  3OIJ A;  1P9P A;  4YQ8 A;  3E5Y A;  3BBH A;  3OII A;  4YQG A;  3ONP A;  1NS5 A;  4YPX A;  4YQQ A;  3O7B A;  4CNF A;  3KW2 A;  1V6Z A;  1V2X A;  1UAJ A;  1OY5 A;  4YQ4 A;  1VH0 A;  4YQ5 A;  4RG1 A;  3BBE A;  2QMM A;  4YQO A;  4JAK A;  3BBD A;  3OIN A;  4KDZ A;  3AXZ A;  4YQ0 A;  2EGW A;  4YQ2 A;  4YQ3 A;  2YY8 A;  4YQ6 A;  1MXI A;  5CO4 A;  2HA8 A;  1VHY A;  2CX8 A;  4X3M A;  4L69 A;  1GZ0 A;  4XBO A;  1NXZ A;  4YQN A;  2EGV A;  3N4K A;  4YQP A;  4CNG A;  1IPA A;  4MCD A;  4MCC A;  4CND A;  3L8U A;  1O6D A;  1K3R A;  4KGN A;  5GM8 A;  4YQ7 A;  4FAK A;  1X7P A;  3IEF A;  3QUV A;  3AI9 X;  4YQC A;  4H3Z A;  3N4J A;  4CNE A;  2Z0Y A;  1Z85 A;  3ILK A;  3KNU A;  4X3L A;  3KTY A;  1UAL A;  4YQS A;  4YVH A;  4YPY A;  4YPW A;  4MCB A;  4YQA A;  3AIA A;  4YVG A;  4YQ1 A;  4YQ9 A;  4YQB A;  2V3K A;  5FAI A;  4YPZ A;  1VHK A;  1X7O A;  2O3A A;  1J85 A;  1ZJR A;  4YQR A;  4J3C A;  3IC6 A;  4IG6 A;  1TO0 A;  5GMB A;  4YVJ A;  1UAM A;  4JAL A;  2NWA A;  4H3Y A;  4YQJ A;  3DCM X;  1UAK A;  5GMC A;  4YQI A;  3NK6 A;  4YVI A;  2V3J A;  4PZK A; 
#chains in the Genus database with same CATH topology
 3KY7 A;  1QRU A;  5D9F A;  5IZN A;  4U67 S;  4YQL A;  4YQD A;  4YQT A;  4IOA S;  4IO9 S;  5BNZ A;  2I6D A;  3DLL S;  3NK7 A;  2RE8 A;  2QWV A;  3PIO S;  4YQK A;  4E8B A;  3GYQ A;  1O0B A;  2PIC A;  4YVK A;  3OIJ A;  1D6K A;  4H4K A;  1P9P A;  4WFN S;  4YQ8 A;  4UY8 8;  3E5Y A;  3BBH A;  3OII A;  4YQG A;  3ONP A;  3AII A;  4V19 4;  1NS5 A;  4YPX A;  4YQQ A;  3O7B A;  4CNF A;  3KW2 A;  1V6Z A;  1V2X A;  3CF5 S;  1UAJ A;  1GTS A;  1GTR A;  1OY5 A;  1O0C A;  2G6G A;  3W2V B;  4YQ4 A;  1NYL A;  5GAD W;  4JYZ A;  1VH0 A;  4YQ5 A;  4RG1 A;  3BBE A;  3CZB A;  1B75 A;  2QMM A;  4WFB S;  4H3S A;  4YQO A;  2GAE A;  1UDX A;  3W2W B;  4JAK A;  4WCE S;  3BBD A;  4KDZ A;  3AXZ A;  3OIN A;  4YQ0 A;  2EGW A;  1DFU P;  4YQ2 A;  4YQ3 A;  2YY8 A;  4YQ6 A;  1MXI A;  5CO4 A;  2HA8 A;  1FEU A;  1VHY A;  4JWJ A;  2CX8 A;  4X3M A;  4L69 A;  1GZ0 A;  4XBO A;  1NXZ A;  2ZJR S;  4YQN A;  2EGV A;  2PI8 A;  5DM6 S;  3N4K A;  4YQP A;  4FMW A;  4CNG A;  1IPA A;  4MCD A;  4MCC A;  5HL7 S;  4JWF A;  2PNW A;  2G5D A;  4CND A;  4WF9 S;  5GAH W;  5GAG W;  5JVH S;  4JXX A;  5GAE W;  3L8U A;  1O6D A;  4JXZ A;  1K3R A;  4KGN A;  2ZJP S;  3J7Z V;  5GM8 A;  4YQ7 A;  4FAK A;  1X7P A;  3IEF A;  3QUV A;  3AI9 X;  4YQC A;  4H3Z A;  3N4J A;  4CNE A;  2Z0Y A;  1Z85 A;  3ILK A;  3KNU A;  4X3L A;  3KTY A;  4P2B A;  1EUQ A;  1UAL A;  4IOC S;  4YQS A;  2AE0 X;  5DM7 S;  4YVH A;  2HZ7 A;  4YPY A;  4YPW A;  4MCB A;  4YQA A;  3AIA A;  2RD2 A;  4YVG A;  4YQ1 A;  4YQ9 A;  2ZJQ S;  4YQB A;  2V3K A;  2PJJ A;  1EUY A;  5FAI A;  4YPZ A;  4JWG A;  1VHK A;  1ZJW A;  1X7O A;  1J85 A;  1ZJR A;  2O3A A;  4YQR A;  4J3C A;  3IC6 A;  1QRS A;  4IG6 A;  1TO0 A;  5GMB A;  3X1L B;  1EXD A;  4YVJ A;  4WFA S;  1UAM A;  4JAL A;  1QTQ A;  2NWA A;  4H3Y A;  4YQJ A;  3DCM X;  5JVG S;  4JWH A;  1UAK A;  5GMC A;  4YQI A;  3NK6 A;  4YVI A;  1QRT A;  3PIP S;  2V3J A;  4PZK A; 
#chains in the Genus database with same CATH homology
 3KY7 A;  5D9F A;  4YQL A;  4YQD A;  4YQT A;  2I6D A;  3NK7 A;  2QWV A;  4YQK A;  4E8B A;  3GYQ A;  4YVK A;  3OIJ A;  1P9P A;  4YQ8 A;  3E5Y A;  3BBH A;  3OII A;  4YQG A;  3ONP A;  1NS5 A;  4YPX A;  4YQQ A;  3O7B A;  4CNF A;  3KW2 A;  1V6Z A;  1V2X A;  1UAJ A;  1OY5 A;  4YQ4 A;  1VH0 A;  4YQ5 A;  4RG1 A;  3BBE A;  2QMM A;  4YQO A;  4JAK A;  3BBD A;  3OIN A;  4KDZ A;  3AXZ A;  4YQ0 A;  2EGW A;  4YQ2 A;  4YQ3 A;  2YY8 A;  4YQ6 A;  1MXI A;  5CO4 A;  2HA8 A;  1VHY A;  4JWJ A;  2CX8 A;  4X3M A;  4L69 A;  1GZ0 A;  4XBO A;  1NXZ A;  4YQN A;  2EGV A;  3N4K A;  4YQP A;  4FMW A;  4CNG A;  1IPA A;  4MCD A;  4MCC A;  4JWF A;  4CND A;  3L8U A;  1O6D A;  1K3R A;  4KGN A;  5GM8 A;  4YQ7 A;  4FAK A;  1X7P A;  3IEF A;  3QUV A;  3AI9 X;  4YQC A;  4H3Z A;  3N4J A;  4CNE A;  2Z0Y A;  1Z85 A;  3ILK A;  3KNU A;  4X3L A;  3KTY A;  1UAL A;  4YQS A;  4YVH A;  4YPY A;  4YPW A;  4MCB A;  4YQA A;  3AIA A;  4YVG A;  4YQ1 A;  4YQ9 A;  4YQB A;  2V3K A;  5FAI A;  4YPZ A;  4JWG A;  1VHK A;  1X7O A;  2O3A A;  1J85 A;  1ZJR A;  4YQR A;  4J3C A;  3IC6 A;  4IG6 A;  1TO0 A;  5GMB A;  4YVJ A;  1UAM A;  4JAL A;  2NWA A;  4H3Y A;  4YQJ A;  3DCM X;  4JWH A;  1UAK A;  5GMC A;  4YQI A;  3NK6 A;  4YVI A;  2V3J A;  4PZK A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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