2CX8A

Crystal structure of methyltransferase with ligand(sah)
Total Genus 70
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
70
Knots found
sequence length
225
structure length
225
Chain Sequence
HRAFSPGLTGVLPLRETRHLVEVLRARVGDRFTVFDGEREALAEVVDLGPPLRYRVLEERRPEREVGVEVVLYVALLKGDKLAEVVRAATELGATRIQPLVTRHSVPKEMGEGKLRRLRAVALEAAKQSGRVVVPEVLPPIPLKAVPQVAQGLVAHVGATARVREVLDPEKPLALAVGPEGGFAEEEVALLEARGFTPVSLGRRILRAETAALALLALCTAGEGR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords methyl transferase
publication title Crystal structure of methyltransferase with ligand(SAH)
rcsb
source organism Thermus thermophilus
molecule tags Transferase
total genus 70
structure length 225
sequence length 225
chains with identical sequence B
other databases KnotProt 2.0: K +31
ec nomenclature
pdb deposition date 2005-06-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF04452 Methyltrans_RNA RNA methyltransferase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.240.20 Mainly Beta Beta Barrel Ribosomal Protein L25; Chain P Hypothetical PUA domain-like; domain 1 2cx8A01
3.40.1280.10 Alpha Beta 3-Layer(aba) Sandwich Alpha/beta knot Alpha/beta knot 2cx8A02
1IPAA 4MCBA 1VHYA 4PZKA 5GM8A 4YQ0A 1UAJA 5FAIA 4YPYA 1UAKA 4YQGA 4CNFA 1OY5A 1NS5A 4X3MA 2Z0YA 3KTYA 3OIJA 2HA8A 2EGVA 3N4KA 2O3AA 1V6ZA 4YQDA 2YY8A 3GYQA 4YVGA 2V3KA 4CNGA 3KY7A 4YPXA 4YQRA 4YVJA 4YQOA 3N4JA 4YQNA 4YQBA 4YQKA 3OINA 4YQ2A 3KNUA 4YQQA 4JAKA 4YQAA 4YVHA 4MCDA 1VH0A 4YVIA 3ILKA 4YQPA 4YVKA 4H3ZA 3OIIA 4YQCA 4J3CA 3AXZA 4KGNA 2QMMA 3O7BA 4YQTA 2EGWA 3AIAA 1K3RA 2I6DA 1X7PA 1X7OA 4YPWA 4CNDA 4YQ8A 5D9FA 2NWAA 1TO0A 1UAMA 4E8BA 5CO4A 4CNEA 1V2XA 4YQ1A 4YQ6A 4RG1A 1NXZA 2QWVA 4X3LA 4YQSA 3KW2A 3L8UA 4YQLA 3IEFA 3ONPA 5GMBA 2V3JA 4YQJA 4YQ9A 1P9PA 3AI9X 4YQ3A 1UALA 3E5YA 1Z85A 4IG6A 4YQIA 1GZ0A 1VHKA 4MCCA 4XBOA 4YPZA 3NK7A 3QUVA 4KDZA 1ZJRA 1J85A 3BBEA 4YQ4A 4L69A 5GMCA 4JALA 1O6DA 4FAKA 3NK6A 4H3YA 2CX8A 1MXIA 3DCMX 3IC6A 4YQ5A 4YQ7A 3BBHA 3BBDA
chains in the Genus database with same CATH superfamily
1EXDA 1IPAA 1VHYA 4MCBA 4PZKA 5GM8A 5DM7S 1UAJA 4YQ0A 5FAIA 3X1LB 1B75A 4YPYA 1UAKA 2G5DA 2PI8A 5GAEW 4YQGA 4CNFA 2ZJQS 1OY5A 1NS5A 4UY88 4X3MA 1UDXA 1O0BA 1ZJWA 2Z0YA 5HL7S 3KTYA 3OIJA 2HA8A 4JWGA 2EGVA 5BNZA 3N4KA 2O3AA 4WFBS 1V6ZA 4YQDA 2YY8A 3GYQA 4YVGA 2V3KA 4CNGA 3CZBA 4P2BA 1FEUA 4JXZA 3KY7A 4YPXA 2AE0X 4YQRA 4YVJA 4YQOA 5JVHS 3N4JA 4YQNA 2PNWA 5GADW 4YQBA 4YQKA 3OINA 4YQ2A 3KNUA 4YQQA 4JAKA 1QRUA 1D6KA 4YQAA 4YVHA 2PICA 4MCDA 3AIIA 1VH0A 4YVIA 3ILKA 4H3SA 4YQPA 4YVKA 2ZJRS 3OIIA 4H3ZA 4YQCA 4J3CA 3PIOS 2QMMA 2PJJA 5JVGS 3AXZA 3O7BA 4KGNA 4YQTA 4IOAS 2EGWA 3AIAA 1K3RA 2I6DA 1X7PA 1X7OA 4YPWA 3CF5S 4CNDA 4YQ8A 2G6GA 1NYLA 5D9FA 2NWAA 1O0CA 4WFAS 1TO0A 1UAMA 4E8BA 3J7ZV 5CO4A 4CNEA 1V2XA 4JWJA 4YQ1A 1GTSA 4YQ6A 4FMWA 4RG1A 4WCES 1NXZA 2QWVA 2GAEA 4X3LA 4YQSA 3KW2A 1EUYA 1GTRA 3L8UA 1QRTA 4YQLA 3IEFA 3ONPA 5GMBA 4JYZA 2V3JA 4YQJA 4YQ9A 5IZNA 1P9PA 3AI9X 4YQ3A 1UALA 3E5YA 1Z85A 4IG6A 4YQIA 5DM6S 4V194 1QTQA 3W2VB 1VHKA 4IOCS 1GZ0A 4MCCA 4WFNS 5GAHW 3DLLS 2HZ7A 4H4KA 4XBOA 4YPZA 4JXXA 3NK7A 3QUVA 4KDZA 1QRSA 1ZJRA 4JWFA 1J85A 5GAGW 3BBEA 4YQ4A 4WF9S 4L69A 5GMCA 4JALA 4U67S 1O6DA 4FAKA 1EUQA 2RE8A 3PIPS 4IO9S 3NK6A 4H3YA 2RD2A 2CX8A 1MXIA 3DCMX 3W2WB 1DFUP 3IC6A 4YQ5A 4JWHA 4YQ7A 3BBHA 3BBDA 2ZJPS
chains in the Genus database with same CATH topology
1IPAA 4MCBA 1VHYA 4PZKA 5GM8A 4YQ0A 1UAJA 5FAIA 4YPYA 1UAKA 4YQGA 4CNFA 1OY5A 1NS5A 4X3MA 2Z0YA 3KTYA 3OIJA 2HA8A 4JWGA 2EGVA 3N4KA 2O3AA 1V6ZA 4YQDA 2YY8A 3GYQA 4YVGA 2V3KA 4CNGA 3KY7A 4YPXA 4YQRA 4YVJA 4YQOA 3N4JA 4YQNA 4YQBA 4YQKA 3OINA 4YQ2A 3KNUA 4YQQA 4JAKA 4YQAA 4YVHA 4MCDA 1VH0A 4YVIA 3ILKA 4YQPA 4YVKA 4H3ZA 3OIIA 4YQCA 4J3CA 3AXZA 4KGNA 2QMMA 3O7BA 4YQTA 2EGWA 3AIAA 1K3RA 2I6DA 1X7PA 1X7OA 4YPWA 4CNDA 4YQ8A 5D9FA 2NWAA 1TO0A 1UAMA 4E8BA 5CO4A 4CNEA 1V2XA 4JWJA 4YQ1A 4YQ6A 4FMWA 4RG1A 1NXZA 2QWVA 4X3LA 4YQSA 3KW2A 3L8UA 4YQLA 3IEFA 3ONPA 5GMBA 2V3JA 4YQJA 4YQ9A 1P9PA 3AI9X 4YQ3A 1UALA 3E5YA 1Z85A 4IG6A 4YQIA 1GZ0A 1VHKA 4MCCA 4XBOA 4YPZA 3NK7A 3QUVA 4KDZA 1ZJRA 4JWFA 1J85A 3BBEA 4YQ4A 4L69A 5GMCA 4JALA 1O6DA 4FAKA 3NK6A 4H3YA 2CX8A 1MXIA 3DCMX 3IC6A 4YQ5A 4JWHA 4YQ7A 3BBHA 3BBDA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1IPA A;  4MCB A;  1VHY A;  4PZK A;  5GM8 A;  4YQ0 A;  1UAJ A;  5FAI A;  4YPY A;  1UAK A;  4YQG A;  4CNF A;  1OY5 A;  1NS5 A;  4X3M A;  2Z0Y A;  3KTY A;  3OIJ A;  2HA8 A;  2EGV A;  3N4K A;  2O3A A;  1V6Z A;  4YQD A;  2YY8 A;  3GYQ A;  4YVG A;  2V3K A;  4CNG A;  3KY7 A;  4YPX A;  4YQR A;  4YVJ A;  4YQO A;  3N4J A;  4YQN A;  4YQB A;  4YQK A;  3OIN A;  4YQ2 A;  3KNU A;  4YQQ A;  4JAK A;  4YQA A;  4YVH A;  4MCD A;  1VH0 A;  4YVI A;  3ILK A;  4YQP A;  4YVK A;  4H3Z A;  3OII A;  4YQC A;  4J3C A;  3AXZ A;  4KGN A;  2QMM A;  3O7B A;  4YQT A;  2EGW A;  3AIA A;  1K3R A;  2I6D A;  1X7P A;  1X7O A;  4YPW A;  4CND A;  4YQ8 A;  5D9F A;  2NWA A;  1TO0 A;  1UAM A;  4E8B A;  5CO4 A;  4CNE A;  1V2X A;  4YQ1 A;  4YQ6 A;  4RG1 A;  1NXZ A;  2QWV A;  4X3L A;  4YQS A;  3KW2 A;  3L8U A;  4YQL A;  3IEF A;  3ONP A;  5GMB A;  2V3J A;  4YQJ A;  4YQ9 A;  1P9P A;  3AI9 X;  4YQ3 A;  1UAL A;  3E5Y A;  1Z85 A;  4IG6 A;  4YQI A;  1GZ0 A;  1VHK A;  4MCC A;  4XBO A;  4YPZ A;  3NK7 A;  3QUV A;  4KDZ A;  1ZJR A;  1J85 A;  3BBE A;  4YQ4 A;  4L69 A;  5GMC A;  4JAL A;  1O6D A;  4FAK A;  3NK6 A;  4H3Y A;  2CX8 A;  1MXI A;  3DCM X;  3IC6 A;  4YQ5 A;  4YQ7 A;  3BBH A;  3BBD A; 
#chains in the Genus database with same CATH topology
 1EXD A;  1IPA A;  1VHY A;  4MCB A;  4PZK A;  5GM8 A;  5DM7 S;  1UAJ A;  4YQ0 A;  5FAI A;  3X1L B;  1B75 A;  4YPY A;  1UAK A;  2G5D A;  2PI8 A;  5GAE W;  4YQG A;  4CNF A;  2ZJQ S;  1OY5 A;  1NS5 A;  4UY8 8;  4X3M A;  1UDX A;  1O0B A;  1ZJW A;  2Z0Y A;  5HL7 S;  3KTY A;  3OIJ A;  2HA8 A;  4JWG A;  2EGV A;  5BNZ A;  3N4K A;  2O3A A;  4WFB S;  1V6Z A;  4YQD A;  2YY8 A;  3GYQ A;  4YVG A;  2V3K A;  4CNG A;  3CZB A;  4P2B A;  1FEU A;  4JXZ A;  3KY7 A;  4YPX A;  2AE0 X;  4YQR A;  4YVJ A;  4YQO A;  5JVH S;  3N4J A;  4YQN A;  2PNW A;  5GAD W;  4YQB A;  4YQK A;  3OIN A;  4YQ2 A;  3KNU A;  4YQQ A;  4JAK A;  1QRU A;  1D6K A;  4YQA A;  4YVH A;  2PIC A;  4MCD A;  3AII A;  1VH0 A;  4YVI A;  3ILK A;  4H3S A;  4YQP A;  4YVK A;  2ZJR S;  3OII A;  4H3Z A;  4YQC A;  4J3C A;  3PIO S;  2QMM A;  2PJJ A;  5JVG S;  3AXZ A;  3O7B A;  4KGN A;  4YQT A;  4IOA S;  2EGW A;  3AIA A;  1K3R A;  2I6D A;  1X7P A;  1X7O A;  4YPW A;  3CF5 S;  4CND A;  4YQ8 A;  2G6G A;  1NYL A;  5D9F A;  2NWA A;  1O0C A;  4WFA S;  1TO0 A;  1UAM A;  4E8B A;  3J7Z V;  5CO4 A;  4CNE A;  1V2X A;  4JWJ A;  4YQ1 A;  1GTS A;  4YQ6 A;  4FMW A;  4RG1 A;  4WCE S;  1NXZ A;  2QWV A;  2GAE A;  4X3L A;  4YQS A;  3KW2 A;  1EUY A;  1GTR A;  3L8U A;  1QRT A;  4YQL A;  3IEF A;  3ONP A;  5GMB A;  4JYZ A;  2V3J A;  4YQJ A;  4YQ9 A;  5IZN A;  1P9P A;  3AI9 X;  4YQ3 A;  1UAL A;  3E5Y A;  1Z85 A;  4IG6 A;  4YQI A;  5DM6 S;  4V19 4;  1QTQ A;  3W2V B;  1VHK A;  4IOC S;  1GZ0 A;  4MCC A;  4WFN S;  5GAH W;  3DLL S;  2HZ7 A;  4H4K A;  4XBO A;  4YPZ A;  4JXX A;  3NK7 A;  3QUV A;  4KDZ A;  1QRS A;  1ZJR A;  4JWF A;  1J85 A;  5GAG W;  3BBE A;  4YQ4 A;  4WF9 S;  4L69 A;  5GMC A;  4JAL A;  4U67 S;  1O6D A;  4FAK A;  1EUQ A;  2RE8 A;  3PIP S;  4IO9 S;  3NK6 A;  4H3Y A;  2RD2 A;  2CX8 A;  1MXI A;  3DCM X;  3W2W B;  1DFU P;  3IC6 A;  4YQ5 A;  4JWH A;  4YQ7 A;  3BBH A;  3BBD A;  2ZJP S; 
#chains in the Genus database with same CATH homology
 1IPA A;  4MCB A;  1VHY A;  4PZK A;  5GM8 A;  4YQ0 A;  1UAJ A;  5FAI A;  4YPY A;  1UAK A;  4YQG A;  4CNF A;  1OY5 A;  1NS5 A;  4X3M A;  2Z0Y A;  3KTY A;  3OIJ A;  2HA8 A;  4JWG A;  2EGV A;  3N4K A;  2O3A A;  1V6Z A;  4YQD A;  2YY8 A;  3GYQ A;  4YVG A;  2V3K A;  4CNG A;  3KY7 A;  4YPX A;  4YQR A;  4YVJ A;  4YQO A;  3N4J A;  4YQN A;  4YQB A;  4YQK A;  3OIN A;  4YQ2 A;  3KNU A;  4YQQ A;  4JAK A;  4YQA A;  4YVH A;  4MCD A;  1VH0 A;  4YVI A;  3ILK A;  4YQP A;  4YVK A;  4H3Z A;  3OII A;  4YQC A;  4J3C A;  3AXZ A;  4KGN A;  2QMM A;  3O7B A;  4YQT A;  2EGW A;  3AIA A;  1K3R A;  2I6D A;  1X7P A;  1X7O A;  4YPW A;  4CND A;  4YQ8 A;  5D9F A;  2NWA A;  1TO0 A;  1UAM A;  4E8B A;  5CO4 A;  4CNE A;  1V2X A;  4JWJ A;  4YQ1 A;  4YQ6 A;  4FMW A;  4RG1 A;  1NXZ A;  2QWV A;  4X3L A;  4YQS A;  3KW2 A;  3L8U A;  4YQL A;  3IEF A;  3ONP A;  5GMB A;  2V3J A;  4YQJ A;  4YQ9 A;  1P9P A;  3AI9 X;  4YQ3 A;  1UAL A;  3E5Y A;  1Z85 A;  4IG6 A;  4YQI A;  1GZ0 A;  1VHK A;  4MCC A;  4XBO A;  4YPZ A;  3NK7 A;  3QUV A;  4KDZ A;  1ZJR A;  4JWF A;  1J85 A;  3BBE A;  4YQ4 A;  4L69 A;  5GMC A;  4JAL A;  1O6D A;  4FAK A;  3NK6 A;  4H3Y A;  2CX8 A;  1MXI A;  3DCM X;  3IC6 A;  4YQ5 A;  4JWH A;  4YQ7 A;  3BBH A;  3BBD A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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