2KN6A

Structure of full-length human asc (apoptosis-associated speck-like protein containing a card)
Total Genus 54
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
54
sequence length
195
structure length
195
Chain Sequence
MGRARDAILDALENLTAEELKKFKLKLLSVPLREGYGRIPRGALLSMDALDLTDKLVSFYLETYGAELTANVLRDMGLQEMAGQLQAATHQGSGAAPAGIQAPPQSAAKPGLHFIDQHRAALIARVTNVEWLLDALYGKVLTDEQYQAVRAEPTNPSKMRKLFSFTPAWNWTCKDLLLQALRESQSYLVEDLERS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure and interdomain dynamics of apoptosis-associated speck-like protein containing a CARD (ASC)
pubmed doi rcsb
source organism Homo sapiens
molecule tags Apoptosis
molecule keywords Apoptosis-associated speck-like protein containing a CARD
total genus 54
structure length 195
sequence length 195
ec nomenclature
pdb deposition date 2009-08-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00619 CARD Caspase recruitment domain
A PF02758 PYRIN PAAD/DAPIN/Pyrin domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.533.10 Mainly Alpha Orthogonal Bundle Death Domain, Fas Death Domain, Fas 2kn6A01
1.10.533.10 Mainly Alpha Orthogonal Bundle Death Domain, Fas Death Domain, Fas 2kn6A02
4M9SA 2HM2Q 4LWDA 2LWEA 3CL3A 4O6XA 4QOBA 1Z6TA 1D2ZA 1NGRA 2OF5A 2A5YB 1WH4A 2P1HA 3EZQA 2KM6A 4O9FA 3LQRA 1CY5A 4ZBWA 1PN5A 3KATA 2NAQA 1C15A 4JQWA 2B1WA 2N00A 2YQFA 4UZ0A 2DBDA 1WMGA 1A1WA 2MS8A 2N7ZA 2KN6A 4P4HA 2DBGA 1DGNA 2N83A 2DBFA 4A2QA 4N1JA 4A2WA 4RHWA 2LWDA 2MS7A 2BBRA 2YU0A 4IZ5E 3YGSP 4RHWE 2D96A 2YVIA 1N3KA 1D2ZB 2L9MA 4FH0A 2A9IA 4M9ZA 1E3YA 1DDFA 2MN4A 2N97A 4F42A 4O9LA 4DWNA 2NZ7A 3MOPG 3MOPA 1FADA 1UCPA 4N1KA 3LQQA 1A1ZA 2LS7A 2OF5H 3J63A 4N1LA 4P4HI 1ICHA 3J6JA 1E41A 2VGQA 2DO9A 2M5VA 4IZAB 3YGSC 2DBHA 2N1FA 2O71A 4D8OA 2MB9A 4EWIA 2IB1A 4IZ7B 2N80A 2GF5A 3MOPK 2NSNA 2MPCA 4JUPA 1CWWA 4E9MA 4I16A 2YGSA 4M9XA 2L6AA 3EZQB 1YGOA 2BBZA 4F44A 3T6PA 4O7QA 4NQKA 3CRDA 2G7RA 2F1SA 3QF2A 1WXPA
chains in the Genus database with same CATH superfamily
4M9SA 2HM2Q 4LWDA 2LWEA 3CL3A 4O6XA 4QOBA 1Z6TA 1D2ZA 1NGRA 2OF5A 2A5YB 1WH4A 2P1HA 3EZQA 2KM6A 4O9FA 3LQRA 1CY5A 4ZBWA 1PN5A 3KATA 2NAQA 1C15A 4JQWA 2B1WA 2MJMA 2N00A 2YQFA 4UZ0A 2DBDA 1WMGA 1A1WA 2MS8A 2N7ZA 2KN6A 4P4HA 2DBGA 1DGNA 2N83A 2DBFA 4A2QA 4N1JA 4A2WA 4RHWA 2LWDA 2MS7A 2BBRA 2YU0A 4IZ5E 3YGSP 4RHWE 2D96A 2YVIA 1N3KA 1D2ZB 2L9MA 4FH0A 2A9IA 4M9ZA 1E3YA 1DDFA 2MN4A 2N97A 4F42A 4O9LA 2XV9A 4DWNA 2NZ7A 3MOPG 3MOPA 1FADA 1UCPA 4N1KA 3LQQA 1A1ZA 2LS7A 2OF5H 3J63A 4N1LA 4P4HI 1ICHA 3J6JA 1E41A 2VGQA 2DO9A 2M5VA 4IZAB 3YGSC 2DBHA 2N1FA 2O71A 4D8OA 2MB9A 4EWIA 2IB1A 4IZ7B 2N80A 2GF5A 3MOPK 2NSNA 2MPCA 4JUPA 1CWWA 4E9MA 4I16A 2YGSA 4M9XA 2L6AA 3EZQB 1YGOA 2BBZA 4F44A 3T6PA 4O7QA 4NQKA 3CRDA 2G7RA 2F1SA 3QF2A 1WXPA
chains in the Genus database with same CATH topology
4M9SA 2HM2Q 4LWDA 2LWEA 3CL3A 4O6XA 4QOBA 1Z6TA 1D2ZA 1NGRA 2OF5A 2A5YB 1WH4A 2P1HA 3EZQA 2KM6A 4O9FA 3LQRA 1CY5A 4ZBWA 1PN5A 3KATA 2NAQA 1C15A 4JQWA 2B1WA 2MJMA 2N00A 2YQFA 4UZ0A 2DBDA 1WMGA 1A1WA 2MS8A 2N7ZA 2KN6A 4P4HA 2DBGA 1DGNA 2N83A 2DBFA 4A2QA 4N1JA 4A2WA 4RHWA 2LWDA 2MS7A 2BBRA 2YU0A 4IZ5E 3YGSP 4RHWE 2D96A 2YVIA 1N3KA 1D2ZB 2L9MA 4FH0A 2A9IA 4M9ZA 1E3YA 1DDFA 2MN4A 2N97A 4F42A 4O9LA 2XV9A 4DWNA 2NZ7A 3MOPG 3MOPA 1FADA 1UCPA 4N1KA 3LQQA 1A1ZA 2LS7A 2OF5H 3J63A 4N1LA 4P4HI 1ICHA 3J6JA 1E41A 2VGQA 2DO9A 2M5VA 4IZAB 3YGSC 2DBHA 2N1FA 2O71A 4D8OA 2MB9A 4EWIA 2IB1A 4IZ7B 2N80A 2GF5A 3MOPK 2NSNA 2MPCA 4JUPA 1CWWA 4E9MA 4I16A 2YGSA 4M9XA 2L6AA 3EZQB 1YGOA 2BBZA 4F44A 3T6PA 4O7QA 4NQKA 3CRDA 2G7RA 2F1SA 3QF2A 1WXPA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4M9S A;  2HM2 Q;  4LWD A;  2LWE A;  3CL3 A;  4O6X A;  4QOB A;  1Z6T A;  1D2Z A;  1NGR A;  2OF5 A;  2A5Y B;  1WH4 A;  2P1H A;  3EZQ A;  2KM6 A;  4O9F A;  3LQR A;  1CY5 A;  4ZBW A;  1PN5 A;  3KAT A;  2NAQ A;  1C15 A;  4JQW A;  2B1W A;  2N00 A;  2YQF A;  4UZ0 A;  2DBD A;  1WMG A;  1A1W A;  2MS8 A;  2N7Z A;  2KN6 A;  4P4H A;  2DBG A;  1DGN A;  2N83 A;  2DBF A;  4A2Q A;  4N1J A;  4A2W A;  4RHW A;  2LWD A;  2MS7 A;  2BBR A;  2YU0 A;  4IZ5 E;  3YGS P;  4RHW E;  2D96 A;  2YVI A;  1N3K A;  1D2Z B;  2L9M A;  4FH0 A;  2A9I A;  4M9Z A;  1E3Y A;  1DDF A;  2MN4 A;  2N97 A;  4F42 A;  4O9L A;  4DWN A;  2NZ7 A;  3MOP G;  3MOP A;  1FAD A;  1UCP A;  4N1K A;  3LQQ A;  1A1Z A;  2LS7 A;  2OF5 H;  3J63 A;  4N1L A;  4P4H I;  1ICH A;  3J6J A;  1E41 A;  2VGQ A;  2DO9 A;  2M5V A;  4IZA B;  3YGS C;  2DBH A;  2N1F A;  2O71 A;  4D8O A;  2MB9 A;  4EWI A;  2IB1 A;  4IZ7 B;  2N80 A;  2GF5 A;  3MOP K;  2NSN A;  2MPC A;  4JUP A;  1CWW A;  4E9M A;  4I16 A;  2YGS A;  4M9X A;  2L6A A;  3EZQ B;  1YGO A;  2BBZ A;  4F44 A;  3T6P A;  4O7Q A;  4NQK A;  3CRD A;  2G7R A;  2F1S A;  3QF2 A;  1WXP A; 
#chains in the Genus database with same CATH topology
 4M9S A;  2HM2 Q;  4LWD A;  2LWE A;  3CL3 A;  4O6X A;  4QOB A;  1Z6T A;  1D2Z A;  1NGR A;  2OF5 A;  2A5Y B;  1WH4 A;  2P1H A;  3EZQ A;  2KM6 A;  4O9F A;  3LQR A;  1CY5 A;  4ZBW A;  1PN5 A;  3KAT A;  2NAQ A;  1C15 A;  4JQW A;  2B1W A;  2MJM A;  2N00 A;  2YQF A;  4UZ0 A;  2DBD A;  1WMG A;  1A1W A;  2MS8 A;  2N7Z A;  2KN6 A;  4P4H A;  2DBG A;  1DGN A;  2N83 A;  2DBF A;  4A2Q A;  4N1J A;  4A2W A;  4RHW A;  2LWD A;  2MS7 A;  2BBR A;  2YU0 A;  4IZ5 E;  3YGS P;  4RHW E;  2D96 A;  2YVI A;  1N3K A;  1D2Z B;  2L9M A;  4FH0 A;  2A9I A;  4M9Z A;  1E3Y A;  1DDF A;  2MN4 A;  2N97 A;  4F42 A;  4O9L A;  2XV9 A;  4DWN A;  2NZ7 A;  3MOP G;  3MOP A;  1FAD A;  1UCP A;  4N1K A;  3LQQ A;  1A1Z A;  2LS7 A;  2OF5 H;  3J63 A;  4N1L A;  4P4H I;  1ICH A;  3J6J A;  1E41 A;  2VGQ A;  2DO9 A;  2M5V A;  4IZA B;  3YGS C;  2DBH A;  2N1F A;  2O71 A;  4D8O A;  2MB9 A;  4EWI A;  2IB1 A;  4IZ7 B;  2N80 A;  2GF5 A;  3MOP K;  2NSN A;  2MPC A;  4JUP A;  1CWW A;  4E9M A;  4I16 A;  2YGS A;  4M9X A;  2L6A A;  3EZQ B;  1YGO A;  2BBZ A;  4F44 A;  3T6P A;  4O7Q A;  4NQK A;  3CRD A;  2G7R A;  2F1S A;  3QF2 A;  1WXP A; 
#chains in the Genus database with same CATH homology
 4M9S A;  2HM2 Q;  4LWD A;  2LWE A;  3CL3 A;  4O6X A;  4QOB A;  1Z6T A;  1D2Z A;  1NGR A;  2OF5 A;  2A5Y B;  1WH4 A;  2P1H A;  3EZQ A;  2KM6 A;  4O9F A;  3LQR A;  1CY5 A;  4ZBW A;  1PN5 A;  3KAT A;  2NAQ A;  1C15 A;  4JQW A;  2B1W A;  2MJM A;  2N00 A;  2YQF A;  4UZ0 A;  2DBD A;  1WMG A;  1A1W A;  2MS8 A;  2N7Z A;  2KN6 A;  4P4H A;  2DBG A;  1DGN A;  2N83 A;  2DBF A;  4A2Q A;  4N1J A;  4A2W A;  4RHW A;  2LWD A;  2MS7 A;  2BBR A;  2YU0 A;  4IZ5 E;  3YGS P;  4RHW E;  2D96 A;  2YVI A;  1N3K A;  1D2Z B;  2L9M A;  4FH0 A;  2A9I A;  4M9Z A;  1E3Y A;  1DDF A;  2MN4 A;  2N97 A;  4F42 A;  4O9L A;  2XV9 A;  4DWN A;  2NZ7 A;  3MOP G;  3MOP A;  1FAD A;  1UCP A;  4N1K A;  3LQQ A;  1A1Z A;  2LS7 A;  2OF5 H;  3J63 A;  4N1L A;  4P4H I;  1ICH A;  3J6J A;  1E41 A;  2VGQ A;  2DO9 A;  2M5V A;  4IZA B;  3YGS C;  2DBH A;  2N1F A;  2O71 A;  4D8O A;  2MB9 A;  4EWI A;  2IB1 A;  4IZ7 B;  2N80 A;  2GF5 A;  3MOP K;  2NSN A;  2MPC A;  4JUP A;  1CWW A;  4E9M A;  4I16 A;  2YGS A;  4M9X A;  2L6A A;  3EZQ B;  1YGO A;  2BBZ A;  4F44 A;  3T6P A;  4O7Q A;  4NQK A;  3CRD A;  2G7R A;  2F1S A;  3QF2 A;  1WXP A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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