3MOPA

The ternary death domain complex of myd88, irak4, and irak2
Total Genus 30
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
30
sequence length
105
structure length
105
Chain Sequence
MLPLAALNMRVRRRLSLFLNVRTQVAADWTALAEEMDFEYLEIRQLETQADPTGRLLDAWQGRPGASVGRLLELLTKLGRDDVLLELGPSIEEDCQKYIAAALEH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling.
pubmed doi rcsb
molecule tags Signaling protein, immune system
source organism Homo sapiens
molecule keywords Myeloid differentiation primary response protein MyD88
total genus 30
structure length 105
sequence length 105
chains with identical sequence B, C, D, E, F
ec nomenclature
pdb deposition date 2010-04-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00531 Death Death domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.533.10 Mainly Alpha Orthogonal Bundle Death Domain, Fas Death Domain, Fas 3mopA00
1CY5A 4ZBWA 1WH4A 4RHWE 2DBFA 4N1KA 2HM2Q 2LWDA 1DDFA 1Z6TA 3T6PA 2N00A 4NQKA 4M9ZA 4A2WA 2N1FA 1N3KA 2LWEA 1WMGA 2DBGA 4N1JA 4M9SA 3MOPG 4O7QA 2YU0A 2L9MA 2NZ7A 2M5VA 2NAQA 3EZQA 4O9FA 2YQFA 4O6XA 2B1WA 4O9LA 2KN6A 2OF5A 1E3YA 2MS7A 2N97A 2VGQA 4A2QA 4QOBA 3J63A 2MS8A 3MOPA 3LQQA 2KM6A 3MOPK 1YGOA 3EZQB 2LS7A 2N7ZA 1C15A 3CRDA 2N80A 2MN4A 2P1HA 3J6JA 4JUPA 2MB9A 4N1LA 3YGSC 3KATA 2BBRA 2NSNA 1UCPA 2L6AA 4F44A 4M9XA 4LWDA 1A1WA 2MPCA 1WXPA 1FADA 1E41A 1D2ZA 4F42A 1NGRA 2A9IA 4UZ0A 3QF2A 2YVIA 1D2ZB 2DBDA 4JQWA 4E9MA 4DWNA 4I16A 1ICHA 2G7RA 4IZ7B 2GF5A 4D8OA 3CL3A 4IZ5E 2O71A 1A1ZA 2N83A 1CWWA 4EWIA 2D96A 2DBHA 2DO9A 2IB1A 2OF5H 3LQRA 4RHWA 1PN5A 2YGSA 1DGNA 4P4HI 2A5YB 2F1SA 4IZAB 4P4HA 4FH0A 3YGSP 2BBZA
chains in the Genus database with same CATH superfamily
1CY5A 4ZBWA 1WH4A 4RHWE 2DBFA 4N1KA 2HM2Q 2LWDA 1DDFA 1Z6TA 3T6PA 2N00A 4NQKA 4M9ZA 4A2WA 2N1FA 1N3KA 2LWEA 1WMGA 2DBGA 4N1JA 4M9SA 3MOPG 4O7QA 2YU0A 2L9MA 2NZ7A 2M5VA 2NAQA 3EZQA 4O9FA 2YQFA 4O6XA 2B1WA 4O9LA 2KN6A 2OF5A 1E3YA 2MS7A 2N97A 2VGQA 4A2QA 4QOBA 3J63A 2MS8A 3MOPA 3LQQA 2KM6A 3MOPK 1YGOA 3EZQB 2LS7A 2N7ZA 1C15A 3CRDA 2N80A 2MN4A 2P1HA 3J6JA 4JUPA 2MB9A 4N1LA 3YGSC 3KATA 2NSNA 2BBRA 1UCPA 2L6AA 4F44A 4M9XA 4LWDA 1A1WA 2MPCA 1WXPA 1FADA 1E41A 1D2ZA 4F42A 1NGRA 2A9IA 4UZ0A 3QF2A 2YVIA 1D2ZB 2DBDA 4JQWA 4E9MA 4DWNA 4I16A 1ICHA 2G7RA 4IZ7B 2GF5A 4D8OA 3CL3A 4IZ5E 2O71A 1A1ZA 2N83A 1CWWA 4EWIA 2D96A 2DBHA 2DO9A 2IB1A 2OF5H 3LQRA 4RHWA 1PN5A 2YGSA 1DGNA 4P4HI 2A5YB 2XV9A 2F1SA 4IZAB 4P4HA 4FH0A 3YGSP 2BBZA 2MJMA
chains in the Genus database with same CATH topology
1CY5A 4ZBWA 1WH4A 4RHWE 2DBFA 4N1KA 2HM2Q 2LWDA 1DDFA 1Z6TA 3T6PA 2N00A 4NQKA 4M9ZA 4A2WA 2N1FA 1N3KA 2LWEA 1WMGA 2DBGA 4N1JA 4M9SA 3MOPG 4O7QA 2YU0A 2L9MA 2NZ7A 2M5VA 2NAQA 3EZQA 4O9FA 2YQFA 4O6XA 2B1WA 4O9LA 2KN6A 2OF5A 1E3YA 2MS7A 2N97A 2VGQA 4A2QA 4QOBA 3J63A 2MS8A 3MOPA 3LQQA 2KM6A 3MOPK 1YGOA 3EZQB 2LS7A 2N7ZA 1C15A 3CRDA 2N80A 2MN4A 2P1HA 3J6JA 4JUPA 2MB9A 4N1LA 3YGSC 3KATA 2NSNA 2BBRA 1UCPA 2L6AA 4F44A 4M9XA 4LWDA 1A1WA 2MPCA 1WXPA 1FADA 1E41A 1D2ZA 4F42A 1NGRA 2A9IA 4UZ0A 3QF2A 2YVIA 1D2ZB 2DBDA 4JQWA 4E9MA 4DWNA 4I16A 1ICHA 2G7RA 4IZ7B 2GF5A 4D8OA 3CL3A 4IZ5E 2O71A 1A1ZA 2N83A 1CWWA 4EWIA 2D96A 2DBHA 2DO9A 2IB1A 2OF5H 3LQRA 4RHWA 1PN5A 2YGSA 1DGNA 4P4HI 2A5YB 2XV9A 2F1SA 4IZAB 4P4HA 4FH0A 3YGSP 2BBZA 2MJMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1CY5 A;  4ZBW A;  1WH4 A;  4RHW E;  2DBF A;  4N1K A;  2HM2 Q;  2LWD A;  1DDF A;  1Z6T A;  3T6P A;  2N00 A;  4NQK A;  4M9Z A;  4A2W A;  2N1F A;  1N3K A;  2LWE A;  1WMG A;  2DBG A;  4N1J A;  4M9S A;  3MOP G;  4O7Q A;  2YU0 A;  2L9M A;  2NZ7 A;  2M5V A;  2NAQ A;  3EZQ A;  4O9F A;  2YQF A;  4O6X A;  2B1W A;  4O9L A;  2KN6 A;  2OF5 A;  1E3Y A;  2MS7 A;  2N97 A;  2VGQ A;  4A2Q A;  4QOB A;  3J63 A;  2MS8 A;  3MOP A;  3LQQ A;  2KM6 A;  3MOP K;  1YGO A;  3EZQ B;  2LS7 A;  2N7Z A;  1C15 A;  3CRD A;  2N80 A;  2MN4 A;  2P1H A;  3J6J A;  4JUP A;  2MB9 A;  4N1L A;  3YGS C;  3KAT A;  2BBR A;  2NSN A;  1UCP A;  2L6A A;  4F44 A;  4M9X A;  4LWD A;  1A1W A;  2MPC A;  1WXP A;  1FAD A;  1E41 A;  1D2Z A;  4F42 A;  1NGR A;  2A9I A;  4UZ0 A;  3QF2 A;  2YVI A;  1D2Z B;  2DBD A;  4JQW A;  4E9M A;  4DWN A;  4I16 A;  1ICH A;  2G7R A;  4IZ7 B;  2GF5 A;  4D8O A;  3CL3 A;  4IZ5 E;  2O71 A;  1A1Z A;  2N83 A;  1CWW A;  4EWI A;  2D96 A;  2DBH A;  2DO9 A;  2IB1 A;  2OF5 H;  3LQR A;  4RHW A;  1PN5 A;  2YGS A;  1DGN A;  4P4H I;  2A5Y B;  2F1S A;  4IZA B;  4P4H A;  4FH0 A;  3YGS P;  2BBZ A; 
#chains in the Genus database with same CATH topology
 1CY5 A;  4ZBW A;  1WH4 A;  4RHW E;  2DBF A;  4N1K A;  2HM2 Q;  2LWD A;  1DDF A;  1Z6T A;  3T6P A;  2N00 A;  4NQK A;  4M9Z A;  4A2W A;  2N1F A;  1N3K A;  2LWE A;  1WMG A;  2DBG A;  4N1J A;  4M9S A;  3MOP G;  4O7Q A;  2YU0 A;  2L9M A;  2NZ7 A;  2M5V A;  2NAQ A;  3EZQ A;  4O9F A;  2YQF A;  4O6X A;  2B1W A;  4O9L A;  2KN6 A;  2OF5 A;  1E3Y A;  2MS7 A;  2N97 A;  2VGQ A;  4A2Q A;  4QOB A;  3J63 A;  2MS8 A;  3MOP A;  3LQQ A;  2KM6 A;  3MOP K;  1YGO A;  3EZQ B;  2LS7 A;  2N7Z A;  1C15 A;  3CRD A;  2N80 A;  2MN4 A;  2P1H A;  3J6J A;  4JUP A;  2MB9 A;  4N1L A;  3YGS C;  3KAT A;  2NSN A;  2BBR A;  1UCP A;  2L6A A;  4F44 A;  4M9X A;  4LWD A;  1A1W A;  2MPC A;  1WXP A;  1FAD A;  1E41 A;  1D2Z A;  4F42 A;  1NGR A;  2A9I A;  4UZ0 A;  3QF2 A;  2YVI A;  1D2Z B;  2DBD A;  4JQW A;  4E9M A;  4DWN A;  4I16 A;  1ICH A;  2G7R A;  4IZ7 B;  2GF5 A;  4D8O A;  3CL3 A;  4IZ5 E;  2O71 A;  1A1Z A;  2N83 A;  1CWW A;  4EWI A;  2D96 A;  2DBH A;  2DO9 A;  2IB1 A;  2OF5 H;  3LQR A;  4RHW A;  1PN5 A;  2YGS A;  1DGN A;  4P4H I;  2A5Y B;  2XV9 A;  2F1S A;  4IZA B;  4P4H A;  4FH0 A;  3YGS P;  2BBZ A;  2MJM A; 
#chains in the Genus database with same CATH homology
 1CY5 A;  4ZBW A;  1WH4 A;  4RHW E;  2DBF A;  4N1K A;  2HM2 Q;  2LWD A;  1DDF A;  1Z6T A;  3T6P A;  2N00 A;  4NQK A;  4M9Z A;  4A2W A;  2N1F A;  1N3K A;  2LWE A;  1WMG A;  2DBG A;  4N1J A;  4M9S A;  3MOP G;  4O7Q A;  2YU0 A;  2L9M A;  2NZ7 A;  2M5V A;  2NAQ A;  3EZQ A;  4O9F A;  2YQF A;  4O6X A;  2B1W A;  4O9L A;  2KN6 A;  2OF5 A;  1E3Y A;  2MS7 A;  2N97 A;  2VGQ A;  4A2Q A;  4QOB A;  3J63 A;  2MS8 A;  3MOP A;  3LQQ A;  2KM6 A;  3MOP K;  1YGO A;  3EZQ B;  2LS7 A;  2N7Z A;  1C15 A;  3CRD A;  2N80 A;  2MN4 A;  2P1H A;  3J6J A;  4JUP A;  2MB9 A;  4N1L A;  3YGS C;  3KAT A;  2NSN A;  2BBR A;  1UCP A;  2L6A A;  4F44 A;  4M9X A;  4LWD A;  1A1W A;  2MPC A;  1WXP A;  1FAD A;  1E41 A;  1D2Z A;  4F42 A;  1NGR A;  2A9I A;  4UZ0 A;  3QF2 A;  2YVI A;  1D2Z B;  2DBD A;  4JQW A;  4E9M A;  4DWN A;  4I16 A;  1ICH A;  2G7R A;  4IZ7 B;  2GF5 A;  4D8O A;  3CL3 A;  4IZ5 E;  2O71 A;  1A1Z A;  2N83 A;  1CWW A;  4EWI A;  2D96 A;  2DBH A;  2DO9 A;  2IB1 A;  2OF5 H;  3LQR A;  4RHW A;  1PN5 A;  2YGS A;  1DGN A;  4P4H I;  2A5Y B;  2XV9 A;  2F1S A;  4IZA B;  4P4H A;  4FH0 A;  3YGS P;  2BBZ A;  2MJM A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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