3YGSP

Apaf-1 card in complex with prodomain of procaspase-9
Total Genus 38
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
38
sequence length
97
structure length
97
Chain Sequence
SMDEADRRLLRRCRLRLVEELQVDQLWDVLLSRELFRPHMIEDIQRAGSGSRRDQARQLIIDLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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molecule tags Apoptosis
molecule keywords APOPTOTIC PROTEASE ACTIVATING FACTOR 1
publication title Structural basis of procaspase-9 recruitment by the apoptotic protease-activating factor 1.
pubmed doi rcsb
source organism Homo sapiens
total genus 38
structure length 97
sequence length 97
ec nomenclature ec 3.4.22.62: Caspase-9.
pdb deposition date 1999-05-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
P PF00619 CARD Caspase recruitment domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.533.10 Mainly Alpha Orthogonal Bundle Death Domain, Fas Death Domain, Fas 3ygsP00
4IZAB 1WMGA 2A9IA 4DWNA 3MOPK 2A5YB 1E3YA 4M9SA 2MS8A 4P4HI 4A2QA 2F1SA 3YGSP 1NGRA 2B1WA 2BBRA 2YGSA 2YU0A 3QF2A 1YGOA 2DBHA 4IZ5E 4N1JA 4UZ0A 3LQRA 4F44A 1DDFA 1C15A 4A2WA 2L9MA 2P1HA 4N1LA 1DGNA 2LWDA 1D2ZB 2MN4A 3CRDA 4QOBA 2OF5A 1FADA 1N3KA 2N97A 3CL3A 3J63A 2L6AA 2N80A 2D96A 4P4HA 3J6JA 2YVIA 2NZ7A 2M5VA 2G7RA 4F42A 2MB9A 2N83A 1PN5A 1CWWA 2KN6A 4N1KA 4JQWA 4O9LA 1UCPA 2N1FA 4JUPA 4O9FA 2KM6A 2YQFA 2IB1A 1A1ZA 3YGSC 4NQKA 1WXPA 2NAQA 4M9ZA 3EZQA 1WH4A 2DBFA 2DBGA 2DBDA 4ZBWA 2N00A 3MOPG 1Z6TA 1D2ZA 2GF5A 2NSNA 2DO9A 4RHWE 1CY5A 1A1WA 2MS7A 2VGQA 4RHWA 2LS7A 2OF5H 3LQQA 4IZ7B 4LWDA 3T6PA 4E9MA 4O7QA 2BBZA 4EWIA 4FH0A 2LWEA 1E41A 3KATA 2HM2Q 2N7ZA 4D8OA 2O71A 4I16A 3EZQB 4O6XA 4M9XA 1ICHA 2MPCA 3MOPA
chains in the Genus database with same CATH superfamily
4IZAB 1WMGA 2A9IA 4DWNA 3MOPK 2A5YB 1E3YA 4M9SA 2MS8A 4P4HI 4A2QA 2F1SA 3YGSP 1NGRA 2B1WA 2BBRA 2YGSA 2YU0A 3QF2A 1YGOA 2DBHA 4IZ5E 4N1JA 4UZ0A 3LQRA 4F44A 1DDFA 1C15A 2XV9A 4A2WA 2L9MA 2P1HA 4N1LA 1DGNA 2LWDA 1D2ZB 2MN4A 3CRDA 4QOBA 2OF5A 1FADA 1N3KA 2N97A 3CL3A 3J63A 2L6AA 2N80A 2D96A 4P4HA 3J6JA 2YVIA 2NZ7A 2M5VA 2G7RA 4F42A 2MB9A 2N83A 1PN5A 1CWWA 2KN6A 4N1KA 4JQWA 4O9LA 1UCPA 2N1FA 4JUPA 4O9FA 2KM6A 2YQFA 2IB1A 1A1ZA 3YGSC 4NQKA 1WXPA 2NAQA 4M9ZA 3EZQA 1WH4A 2DBFA 2DBGA 2DBDA 4ZBWA 2N00A 3MOPG 1Z6TA 1D2ZA 2GF5A 2NSNA 2DO9A 4RHWE 1CY5A 1A1WA 2MS7A 2VGQA 4RHWA 2LS7A 2OF5H 3LQQA 4IZ7B 2MJMA 4LWDA 3T6PA 4E9MA 4O7QA 2BBZA 4EWIA 4FH0A 2LWEA 1E41A 3KATA 2HM2Q 2N7ZA 4D8OA 2O71A 4I16A 3EZQB 4O6XA 4M9XA 1ICHA 2MPCA 3MOPA
chains in the Genus database with same CATH topology
4IZAB 1WMGA 2A9IA 4DWNA 3MOPK 2A5YB 1E3YA 4M9SA 2MS8A 4P4HI 4A2QA 2F1SA 3YGSP 1NGRA 2B1WA 2BBRA 2YGSA 2YU0A 3QF2A 1YGOA 2DBHA 4IZ5E 4N1JA 4UZ0A 3LQRA 4F44A 1DDFA 1C15A 2XV9A 4A2WA 2L9MA 2P1HA 4N1LA 1DGNA 2LWDA 1D2ZB 2MN4A 3CRDA 4QOBA 2OF5A 1FADA 1N3KA 2N97A 3CL3A 3J63A 2L6AA 2N80A 2D96A 4P4HA 3J6JA 2YVIA 2NZ7A 2M5VA 2G7RA 4F42A 2MB9A 2N83A 1PN5A 1CWWA 2KN6A 4N1KA 4JQWA 4O9LA 1UCPA 2N1FA 4JUPA 4O9FA 2KM6A 2YQFA 2IB1A 1A1ZA 3YGSC 4NQKA 1WXPA 2NAQA 4M9ZA 3EZQA 1WH4A 2DBFA 2DBGA 2DBDA 4ZBWA 2N00A 3MOPG 1Z6TA 1D2ZA 2GF5A 2NSNA 2DO9A 4RHWE 1CY5A 1A1WA 2MS7A 2VGQA 4RHWA 2LS7A 2OF5H 3LQQA 4IZ7B 2MJMA 4LWDA 3T6PA 4E9MA 4O7QA 2BBZA 4EWIA 4FH0A 2LWEA 1E41A 3KATA 2HM2Q 2N7ZA 4D8OA 2O71A 4I16A 3EZQB 4O6XA 4M9XA 1ICHA 2MPCA 3MOPA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 4IZA B;  1WMG A;  2A9I A;  4DWN A;  3MOP K;  2A5Y B;  1E3Y A;  4M9S A;  2MS8 A;  4P4H I;  4A2Q A;  2F1S A;  3YGS P;  1NGR A;  2B1W A;  2BBR A;  2YGS A;  2YU0 A;  3QF2 A;  1YGO A;  2DBH A;  4IZ5 E;  4N1J A;  4UZ0 A;  3LQR A;  4F44 A;  1DDF A;  1C15 A;  4A2W A;  2L9M A;  2P1H A;  4N1L A;  1DGN A;  2LWD A;  1D2Z B;  2MN4 A;  3CRD A;  4QOB A;  2OF5 A;  1FAD A;  1N3K A;  2N97 A;  3CL3 A;  3J63 A;  2L6A A;  2N80 A;  2D96 A;  4P4H A;  3J6J A;  2YVI A;  2NZ7 A;  2M5V A;  2G7R A;  4F42 A;  2MB9 A;  2N83 A;  1PN5 A;  1CWW A;  2KN6 A;  4N1K A;  4JQW A;  4O9L A;  1UCP A;  2N1F A;  4JUP A;  4O9F A;  2KM6 A;  2YQF A;  2IB1 A;  1A1Z A;  3YGS C;  4NQK A;  1WXP A;  2NAQ A;  4M9Z A;  3EZQ A;  1WH4 A;  2DBF A;  2DBG A;  2DBD A;  4ZBW A;  2N00 A;  3MOP G;  1Z6T A;  1D2Z A;  2GF5 A;  2NSN A;  2DO9 A;  4RHW E;  1CY5 A;  1A1W A;  2MS7 A;  2VGQ A;  4RHW A;  2LS7 A;  2OF5 H;  3LQQ A;  4IZ7 B;  4LWD A;  3T6P A;  4E9M A;  4O7Q A;  2BBZ A;  4EWI A;  4FH0 A;  2LWE A;  1E41 A;  3KAT A;  2HM2 Q;  2N7Z A;  4D8O A;  2O71 A;  4I16 A;  3EZQ B;  4O6X A;  4M9X A;  1ICH A;  2MPC A;  3MOP A; 
#chains in the Genus database with same CATH topology
 4IZA B;  1WMG A;  2A9I A;  4DWN A;  3MOP K;  2A5Y B;  1E3Y A;  4M9S A;  2MS8 A;  4P4H I;  4A2Q A;  2F1S A;  3YGS P;  1NGR A;  2B1W A;  2BBR A;  2YGS A;  2YU0 A;  3QF2 A;  1YGO A;  2DBH A;  4IZ5 E;  4N1J A;  4UZ0 A;  3LQR A;  4F44 A;  1DDF A;  1C15 A;  2XV9 A;  4A2W A;  2L9M A;  2P1H A;  4N1L A;  1DGN A;  2LWD A;  1D2Z B;  2MN4 A;  3CRD A;  4QOB A;  2OF5 A;  1FAD A;  1N3K A;  2N97 A;  3CL3 A;  3J63 A;  2L6A A;  2N80 A;  2D96 A;  4P4H A;  3J6J A;  2YVI A;  2NZ7 A;  2M5V A;  2G7R A;  4F42 A;  2MB9 A;  2N83 A;  1PN5 A;  1CWW A;  2KN6 A;  4N1K A;  4JQW A;  4O9L A;  1UCP A;  2N1F A;  4JUP A;  4O9F A;  2KM6 A;  2YQF A;  2IB1 A;  1A1Z A;  3YGS C;  4NQK A;  1WXP A;  2NAQ A;  4M9Z A;  3EZQ A;  1WH4 A;  2DBF A;  2DBG A;  2DBD A;  4ZBW A;  2N00 A;  3MOP G;  1Z6T A;  1D2Z A;  2GF5 A;  2NSN A;  2DO9 A;  4RHW E;  1CY5 A;  1A1W A;  2MS7 A;  2VGQ A;  4RHW A;  2LS7 A;  2OF5 H;  3LQQ A;  4IZ7 B;  2MJM A;  4LWD A;  3T6P A;  4E9M A;  4O7Q A;  2BBZ A;  4EWI A;  4FH0 A;  2LWE A;  1E41 A;  3KAT A;  2HM2 Q;  2N7Z A;  4D8O A;  2O71 A;  4I16 A;  3EZQ B;  4O6X A;  4M9X A;  1ICH A;  2MPC A;  3MOP A; 
#chains in the Genus database with same CATH homology
 4IZA B;  1WMG A;  2A9I A;  4DWN A;  3MOP K;  2A5Y B;  1E3Y A;  4M9S A;  2MS8 A;  4P4H I;  4A2Q A;  2F1S A;  3YGS P;  1NGR A;  2B1W A;  2BBR A;  2YGS A;  2YU0 A;  3QF2 A;  1YGO A;  2DBH A;  4IZ5 E;  4N1J A;  4UZ0 A;  3LQR A;  4F44 A;  1DDF A;  1C15 A;  2XV9 A;  4A2W A;  2L9M A;  2P1H A;  4N1L A;  1DGN A;  2LWD A;  1D2Z B;  2MN4 A;  3CRD A;  4QOB A;  2OF5 A;  1FAD A;  1N3K A;  2N97 A;  3CL3 A;  3J63 A;  2L6A A;  2N80 A;  2D96 A;  4P4H A;  3J6J A;  2YVI A;  2NZ7 A;  2M5V A;  2G7R A;  4F42 A;  2MB9 A;  2N83 A;  1PN5 A;  1CWW A;  2KN6 A;  4N1K A;  4JQW A;  4O9L A;  1UCP A;  2N1F A;  4JUP A;  4O9F A;  2KM6 A;  2YQF A;  2IB1 A;  1A1Z A;  3YGS C;  4NQK A;  1WXP A;  2NAQ A;  4M9Z A;  3EZQ A;  1WH4 A;  2DBF A;  2DBG A;  2DBD A;  4ZBW A;  2N00 A;  3MOP G;  1Z6T A;  1D2Z A;  2GF5 A;  2NSN A;  2DO9 A;  4RHW E;  1CY5 A;  1A1W A;  2MS7 A;  2VGQ A;  4RHW A;  2LS7 A;  2OF5 H;  3LQQ A;  4IZ7 B;  2MJM A;  4LWD A;  3T6P A;  4E9M A;  4O7Q A;  2BBZ A;  4EWI A;  4FH0 A;  2LWE A;  1E41 A;  3KAT A;  2HM2 Q;  2N7Z A;  4D8O A;  2O71 A;  4I16 A;  3EZQ B;  4O6X A;  4M9X A;  1ICH A;  2MPC A;  3MOP A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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