2MPCA

Solution structure of the pyrin domain of human pyrin
Total Genus 27
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
27
sequence length
90
structure length
90
Chain Sequence
TPSDHLLSTLEELVPYDFEKFKFKLQNTSVQKEHSRIPRSQIQRARPVKMATLLVTYYGEEYAVQLTLQVLRAINQRLLAEELHRAAIQL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Identification of Multifaceted Binding Modes for Pyrin and ASC Pyrin Domains gives Insights into Pyrin Inflammasome Assembly
rcsb
molecule tags Signaling protein
source organism Homo sapiens
molecule keywords Pyrin
total genus 27
structure length 90
sequence length 90
ec nomenclature
pdb deposition date 2014-05-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02758 PYRIN PAAD/DAPIN/Pyrin domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.533.10 Mainly Alpha Orthogonal Bundle Death Domain, Fas Death Domain, Fas 2mpcA00
1DDFA 3J6JA 2BBZA 4M9SA 1ICHA 4EWIA 2YVIA 2G7RA 1WH4A 1D2ZA 2DBFA 2NZ7A 2O71A 2DBHA 1WXPA 4O7QA 4A2QA 4LWDA 2MS7A 3KATA 2LWEA 1NGRA 2OF5A 2YQFA 2OF5H 3CL3A 1Z6TA 2N7ZA 1N3KA 4P4HI 1A1ZA 2DO9A 4IZ5E 3LQRA 2BBRA 2KM6A 1WMGA 2NAQA 4O6XA 4I16A 2IB1A 4UZ0A 4F42A 4JUPA 2A5YB 2D96A 1E3YA 2YGSA 3EZQA 2MS8A 2DBDA 4JQWA 3LQQA 2MPCA 4DWNA 2N80A 4N1LA 1D2ZB 3MOPG 4O9LA 2L9MA 4QOBA 4P4HA 4RHWE 2GF5A 1YGOA 4A2WA 1C15A 3YGSC 2HM2Q 1FADA 2KN6A 2YU0A 4IZAB 4NQKA 2NSNA 4FH0A 4O9FA 2B1WA 2LWDA 2P1HA 3QF2A 2N00A 1E41A 1A1WA 2VGQA 1CWWA 2MN4A 2MB9A 3CRDA 2M5VA 4M9ZA 3J63A 3MOPA 2N1FA 4RHWA 2F1SA 4N1KA 4F44A 3EZQB 4D8OA 3YGSP 4M9XA 4ZBWA 2N83A 3T6PA 1PN5A 1DGNA 2L6AA 1CY5A 4E9MA 4N1JA 1UCPA 4IZ7B 3MOPK 2A9IA 2LS7A 2N97A 2DBGA
chains in the Genus database with same CATH superfamily
1DDFA 3J6JA 2BBZA 4M9SA 1ICHA 4EWIA 2YVIA 2G7RA 1WH4A 1D2ZA 2DBFA 2NZ7A 2O71A 2DBHA 1WXPA 4O7QA 4A2QA 4LWDA 2MS7A 3KATA 2LWEA 1NGRA 2OF5A 2YQFA 2OF5H 3CL3A 1Z6TA 2N7ZA 1N3KA 4P4HI 1A1ZA 2DO9A 4IZ5E 3LQRA 2BBRA 2XV9A 2KM6A 1WMGA 2NAQA 4O6XA 4I16A 2IB1A 4UZ0A 4F42A 4JUPA 2A5YB 2D96A 1E3YA 2YGSA 3EZQA 2MS8A 2DBDA 4JQWA 3LQQA 2MPCA 4DWNA 2N80A 4N1LA 1D2ZB 3MOPG 4O9LA 2L9MA 4QOBA 4P4HA 4RHWE 2GF5A 1YGOA 4A2WA 1C15A 3YGSC 2HM2Q 1FADA 2KN6A 2YU0A 4IZAB 4NQKA 2NSNA 4FH0A 4O9FA 2B1WA 2LWDA 2P1HA 3QF2A 2N00A 1E41A 1A1WA 2VGQA 1CWWA 2MN4A 2MB9A 3CRDA 2M5VA 4M9ZA 3J63A 3MOPA 2N1FA 4RHWA 2F1SA 4N1KA 4F44A 3EZQB 4D8OA 3YGSP 4M9XA 4ZBWA 2N83A 3T6PA 1PN5A 1DGNA 2L6AA 1CY5A 2MJMA 4E9MA 4N1JA 1UCPA 4IZ7B 3MOPK 2A9IA 2LS7A 2N97A 2DBGA
chains in the Genus database with same CATH topology
1DDFA 3J6JA 2BBZA 4M9SA 1ICHA 4EWIA 2YVIA 2G7RA 1WH4A 1D2ZA 2DBFA 2NZ7A 2O71A 2DBHA 1WXPA 4O7QA 4A2QA 4LWDA 2MS7A 3KATA 2LWEA 1NGRA 2OF5A 2YQFA 2OF5H 3CL3A 1Z6TA 2N7ZA 1N3KA 4P4HI 1A1ZA 2DO9A 4IZ5E 3LQRA 2BBRA 2XV9A 2KM6A 1WMGA 2NAQA 4O6XA 4I16A 2IB1A 4UZ0A 4F42A 4JUPA 2A5YB 2D96A 1E3YA 2YGSA 3EZQA 2MS8A 2DBDA 4JQWA 3LQQA 2MPCA 4DWNA 2N80A 4N1LA 1D2ZB 3MOPG 4O9LA 2L9MA 4QOBA 4P4HA 4RHWE 2GF5A 1YGOA 4A2WA 1C15A 3YGSC 2HM2Q 1FADA 2KN6A 2YU0A 4IZAB 4NQKA 2NSNA 4FH0A 4O9FA 2B1WA 2LWDA 2P1HA 3QF2A 2N00A 1E41A 1A1WA 2VGQA 1CWWA 2MN4A 2MB9A 3CRDA 2M5VA 4M9ZA 3J63A 3MOPA 2N1FA 4RHWA 2F1SA 4N1KA 4F44A 3EZQB 4D8OA 3YGSP 4M9XA 4ZBWA 2N83A 3T6PA 1PN5A 1DGNA 2L6AA 1CY5A 2MJMA 4E9MA 4N1JA 1UCPA 4IZ7B 3MOPK 2A9IA 2LS7A 2N97A 2DBGA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1DDF A;  3J6J A;  2BBZ A;  4M9S A;  1ICH A;  4EWI A;  2YVI A;  2G7R A;  1WH4 A;  1D2Z A;  2DBF A;  2NZ7 A;  2O71 A;  2DBH A;  1WXP A;  4O7Q A;  4A2Q A;  4LWD A;  2MS7 A;  3KAT A;  2LWE A;  1NGR A;  2OF5 A;  2YQF A;  2OF5 H;  3CL3 A;  1Z6T A;  2N7Z A;  1N3K A;  4P4H I;  1A1Z A;  2DO9 A;  4IZ5 E;  3LQR A;  2BBR A;  2KM6 A;  1WMG A;  2NAQ A;  4O6X A;  4I16 A;  2IB1 A;  4UZ0 A;  4F42 A;  4JUP A;  2A5Y B;  2D96 A;  1E3Y A;  2YGS A;  3EZQ A;  2MS8 A;  2DBD A;  4JQW A;  3LQQ A;  2MPC A;  4DWN A;  2N80 A;  4N1L A;  1D2Z B;  3MOP G;  4O9L A;  2L9M A;  4QOB A;  4P4H A;  4RHW E;  2GF5 A;  1YGO A;  4A2W A;  1C15 A;  3YGS C;  2HM2 Q;  1FAD A;  2KN6 A;  2YU0 A;  4IZA B;  4NQK A;  2NSN A;  4FH0 A;  4O9F A;  2B1W A;  2LWD A;  2P1H A;  3QF2 A;  2N00 A;  1E41 A;  1A1W A;  2VGQ A;  1CWW A;  2MN4 A;  2MB9 A;  3CRD A;  2M5V A;  4M9Z A;  3J63 A;  3MOP A;  2N1F A;  4RHW A;  2F1S A;  4N1K A;  4F44 A;  3EZQ B;  4D8O A;  3YGS P;  4M9X A;  4ZBW A;  2N83 A;  3T6P A;  1PN5 A;  1DGN A;  2L6A A;  1CY5 A;  4E9M A;  4N1J A;  1UCP A;  4IZ7 B;  3MOP K;  2A9I A;  2LS7 A;  2N97 A;  2DBG A; 
#chains in the Genus database with same CATH topology
 1DDF A;  3J6J A;  2BBZ A;  4M9S A;  1ICH A;  4EWI A;  2YVI A;  2G7R A;  1WH4 A;  1D2Z A;  2DBF A;  2NZ7 A;  2O71 A;  2DBH A;  1WXP A;  4O7Q A;  4A2Q A;  4LWD A;  2MS7 A;  3KAT A;  2LWE A;  1NGR A;  2OF5 A;  2YQF A;  2OF5 H;  3CL3 A;  1Z6T A;  2N7Z A;  1N3K A;  4P4H I;  1A1Z A;  2DO9 A;  4IZ5 E;  3LQR A;  2BBR A;  2XV9 A;  2KM6 A;  1WMG A;  2NAQ A;  4O6X A;  4I16 A;  2IB1 A;  4UZ0 A;  4F42 A;  4JUP A;  2A5Y B;  2D96 A;  1E3Y A;  2YGS A;  3EZQ A;  2MS8 A;  2DBD A;  4JQW A;  3LQQ A;  2MPC A;  4DWN A;  2N80 A;  4N1L A;  1D2Z B;  3MOP G;  4O9L A;  2L9M A;  4QOB A;  4P4H A;  4RHW E;  2GF5 A;  1YGO A;  4A2W A;  1C15 A;  3YGS C;  2HM2 Q;  1FAD A;  2KN6 A;  2YU0 A;  4IZA B;  4NQK A;  2NSN A;  4FH0 A;  4O9F A;  2B1W A;  2LWD A;  2P1H A;  3QF2 A;  2N00 A;  1E41 A;  1A1W A;  2VGQ A;  1CWW A;  2MN4 A;  2MB9 A;  3CRD A;  2M5V A;  4M9Z A;  3J63 A;  3MOP A;  2N1F A;  4RHW A;  2F1S A;  4N1K A;  4F44 A;  3EZQ B;  4D8O A;  3YGS P;  4M9X A;  4ZBW A;  2N83 A;  3T6P A;  1PN5 A;  1DGN A;  2L6A A;  1CY5 A;  2MJM A;  4E9M A;  4N1J A;  1UCP A;  4IZ7 B;  3MOP K;  2A9I A;  2LS7 A;  2N97 A;  2DBG A; 
#chains in the Genus database with same CATH homology
 1DDF A;  3J6J A;  2BBZ A;  4M9S A;  1ICH A;  4EWI A;  2YVI A;  2G7R A;  1WH4 A;  1D2Z A;  2DBF A;  2NZ7 A;  2O71 A;  2DBH A;  1WXP A;  4O7Q A;  4A2Q A;  4LWD A;  2MS7 A;  3KAT A;  2LWE A;  1NGR A;  2OF5 A;  2YQF A;  2OF5 H;  3CL3 A;  1Z6T A;  2N7Z A;  1N3K A;  4P4H I;  1A1Z A;  2DO9 A;  4IZ5 E;  3LQR A;  2BBR A;  2XV9 A;  2KM6 A;  1WMG A;  2NAQ A;  4O6X A;  4I16 A;  2IB1 A;  4UZ0 A;  4F42 A;  4JUP A;  2A5Y B;  2D96 A;  1E3Y A;  2YGS A;  3EZQ A;  2MS8 A;  2DBD A;  4JQW A;  3LQQ A;  2MPC A;  4DWN A;  2N80 A;  4N1L A;  1D2Z B;  3MOP G;  4O9L A;  2L9M A;  4QOB A;  4P4H A;  4RHW E;  2GF5 A;  1YGO A;  4A2W A;  1C15 A;  3YGS C;  2HM2 Q;  1FAD A;  2KN6 A;  2YU0 A;  4IZA B;  4NQK A;  2NSN A;  4FH0 A;  4O9F A;  2B1W A;  2LWD A;  2P1H A;  3QF2 A;  2N00 A;  1E41 A;  1A1W A;  2VGQ A;  1CWW A;  2MN4 A;  2MB9 A;  3CRD A;  2M5V A;  4M9Z A;  3J63 A;  3MOP A;  2N1F A;  4RHW A;  2F1S A;  4N1K A;  4F44 A;  3EZQ B;  4D8O A;  3YGS P;  4M9X A;  4ZBW A;  2N83 A;  3T6P A;  1PN5 A;  1DGN A;  2L6A A;  1CY5 A;  2MJM A;  4E9M A;  4N1J A;  1UCP A;  4IZ7 B;  3MOP K;  2A9I A;  2LS7 A;  2N97 A;  2DBG A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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