2LWDA

Solution structure of second card of human rig-i
Total Genus 35
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
35
sequence length
96
structure length
96
Chain Sequence
KKIEKLEEYRLLLKRLQPEFKTRIIPTDIISDLSECLINQECEEILQICSTKGMMAGAEKLVECLLRSDKENWPKTLKLALEKERNKFSELWIVEK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structure and Dynamics of the Second CARD of Human RIG-I Provide Mechanistic Insights into Regulation of RIG-I Activation.
pubmed doi rcsb
molecule tags Signaling protein
source organism Homo sapiens
molecule keywords Probable ATP-dependent RNA helicase DDX58
total genus 35
structure length 96
sequence length 96
ec nomenclature ec 3.6.4.13: RNA helicase.
pdb deposition date 2012-07-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF16739 CARD_2 Caspase recruitment domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.533.10 Mainly Alpha Orthogonal Bundle Death Domain, Fas Death Domain, Fas 2lwdA00
4IZAB 4O9LA 2G7RA 4M9SA 1E41A 3YGSC 2L9MA 4F44A 2N97A 2LWDA 3LQRA 1FADA 2GF5A 2DO9A 3MOPG 2YU0A 1Z6TA 3CRDA 2DBFA 1PN5A 3EZQA 2D96A 2N00A 1CY5A 4UZ0A 2MN4A 2NSNA 3J6JA 2N80A 4IZ5E 4JUPA 2MS8A 4N1KA 2OF5H 2LS7A 3KATA 4P4HA 4RHWA 3CL3A 2O71A 3YGSP 2N7ZA 3MOPK 1DDFA 2B1WA 2MB9A 4RHWE 4EWIA 1WH4A 1N3KA 2HM2Q 3T6PA 4F42A 1D2ZA 2OF5A 2DBGA 2KN6A 4JQWA 1C15A 1DGNA 4E9MA 1NGRA 4I16A 2N1FA 4QOBA 1A1ZA 4O9FA 2DBHA 3EZQB 3QF2A 4DWNA 2NAQA 3J63A 1YGOA 4IZ7B 2MPCA 4A2QA 1UCPA 4LWDA 4O7QA 2DBDA 3MOPA 4ZBWA 2YQFA 2LWEA 2YVIA 4A2WA 4NQKA 1WMGA 2N83A 4M9ZA 2NZ7A 4P4HI 2P1HA 2M5VA 4FH0A 4O6XA 2VGQA 1ICHA 1A1WA 4N1JA 4D8OA 2A9IA 1D2ZB 2BBZA 2MS7A 4M9XA 2YGSA 2L6AA 2BBRA 2F1SA 1E3YA 2KM6A 2A5YB 1WXPA 1CWWA 3LQQA 2IB1A 4N1LA
chains in the Genus database with same CATH superfamily
4IZAB 4O9LA 2G7RA 4M9SA 1E41A 3YGSC 2L9MA 4F44A 2N97A 2LWDA 3LQRA 1FADA 2GF5A 2DO9A 3MOPG 2YU0A 1Z6TA 3CRDA 2DBFA 1PN5A 3EZQA 2D96A 2N00A 1CY5A 4UZ0A 2MN4A 2NSNA 3J6JA 2N80A 2XV9A 2MJMA 4IZ5E 4JUPA 2MS8A 4N1KA 2OF5H 2LS7A 3KATA 4P4HA 4RHWA 3CL3A 2O71A 3YGSP 2N7ZA 3MOPK 1DDFA 2B1WA 2MB9A 4RHWE 4EWIA 1WH4A 1N3KA 2HM2Q 3T6PA 4F42A 1D2ZA 2OF5A 2DBGA 2KN6A 4JQWA 1C15A 1DGNA 4E9MA 1NGRA 4I16A 2N1FA 4QOBA 1A1ZA 4O9FA 2DBHA 3EZQB 3QF2A 4DWNA 2NAQA 3J63A 1YGOA 4IZ7B 2MPCA 4A2QA 1UCPA 4LWDA 4O7QA 2DBDA 3MOPA 4ZBWA 2YQFA 2LWEA 2YVIA 4A2WA 4NQKA 1WMGA 2N83A 4M9ZA 2NZ7A 4P4HI 2P1HA 2M5VA 4FH0A 4O6XA 2VGQA 1ICHA 1A1WA 4N1JA 4D8OA 2A9IA 1D2ZB 2BBZA 2MS7A 4M9XA 2YGSA 2L6AA 2BBRA 2F1SA 1E3YA 2KM6A 2A5YB 1WXPA 1CWWA 3LQQA 2IB1A 4N1LA
chains in the Genus database with same CATH topology
4IZAB 4O9LA 2G7RA 4M9SA 1E41A 3YGSC 2L9MA 4F44A 2N97A 2LWDA 3LQRA 1FADA 2GF5A 2DO9A 3MOPG 2YU0A 1Z6TA 3CRDA 2DBFA 1PN5A 3EZQA 2D96A 2N00A 1CY5A 4UZ0A 2MN4A 2NSNA 3J6JA 2N80A 2XV9A 2MJMA 4IZ5E 4JUPA 2MS8A 4N1KA 2OF5H 2LS7A 3KATA 4P4HA 4RHWA 3CL3A 2O71A 3YGSP 2N7ZA 3MOPK 1DDFA 2B1WA 2MB9A 4RHWE 4EWIA 1WH4A 1N3KA 2HM2Q 3T6PA 4F42A 1D2ZA 2OF5A 2DBGA 2KN6A 4JQWA 1C15A 1DGNA 4E9MA 1NGRA 4I16A 2N1FA 4QOBA 1A1ZA 4O9FA 2DBHA 3EZQB 3QF2A 4DWNA 2NAQA 3J63A 1YGOA 4IZ7B 2MPCA 4A2QA 1UCPA 4LWDA 4O7QA 2DBDA 3MOPA 4ZBWA 2YQFA 2LWEA 2YVIA 4A2WA 4NQKA 1WMGA 2N83A 4M9ZA 2NZ7A 4P4HI 2P1HA 2M5VA 4FH0A 4O6XA 2VGQA 1ICHA 1A1WA 4N1JA 4D8OA 2A9IA 1D2ZB 2BBZA 2MS7A 4M9XA 2YGSA 2L6AA 2BBRA 2F1SA 1E3YA 2KM6A 2A5YB 1WXPA 1CWWA 3LQQA 2IB1A 4N1LA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4IZA B;  4O9L A;  2G7R A;  4M9S A;  1E41 A;  3YGS C;  2L9M A;  4F44 A;  2N97 A;  2LWD A;  3LQR A;  1FAD A;  2GF5 A;  2DO9 A;  3MOP G;  2YU0 A;  1Z6T A;  3CRD A;  2DBF A;  1PN5 A;  3EZQ A;  2D96 A;  2N00 A;  1CY5 A;  4UZ0 A;  2MN4 A;  2NSN A;  3J6J A;  2N80 A;  4IZ5 E;  4JUP A;  2MS8 A;  4N1K A;  2OF5 H;  2LS7 A;  3KAT A;  4P4H A;  4RHW A;  3CL3 A;  2O71 A;  3YGS P;  2N7Z A;  3MOP K;  1DDF A;  2B1W A;  2MB9 A;  4RHW E;  4EWI A;  1WH4 A;  1N3K A;  2HM2 Q;  3T6P A;  4F42 A;  1D2Z A;  2OF5 A;  2DBG A;  2KN6 A;  4JQW A;  1C15 A;  1DGN A;  4E9M A;  1NGR A;  4I16 A;  2N1F A;  4QOB A;  1A1Z A;  4O9F A;  2DBH A;  3EZQ B;  3QF2 A;  4DWN A;  2NAQ A;  3J63 A;  1YGO A;  4IZ7 B;  2MPC A;  4A2Q A;  1UCP A;  4LWD A;  4O7Q A;  2DBD A;  3MOP A;  4ZBW A;  2YQF A;  2LWE A;  2YVI A;  4A2W A;  4NQK A;  1WMG A;  2N83 A;  4M9Z A;  2NZ7 A;  4P4H I;  2P1H A;  2M5V A;  4FH0 A;  4O6X A;  2VGQ A;  1ICH A;  1A1W A;  4N1J A;  4D8O A;  2A9I A;  1D2Z B;  2BBZ A;  2MS7 A;  4M9X A;  2YGS A;  2L6A A;  2BBR A;  2F1S A;  1E3Y A;  2KM6 A;  2A5Y B;  1WXP A;  1CWW A;  3LQQ A;  2IB1 A;  4N1L A; 
#chains in the Genus database with same CATH topology
 4IZA B;  4O9L A;  2G7R A;  4M9S A;  1E41 A;  3YGS C;  2L9M A;  4F44 A;  2N97 A;  2LWD A;  3LQR A;  1FAD A;  2GF5 A;  2DO9 A;  3MOP G;  2YU0 A;  1Z6T A;  3CRD A;  2DBF A;  1PN5 A;  3EZQ A;  2D96 A;  2N00 A;  1CY5 A;  4UZ0 A;  2MN4 A;  2NSN A;  3J6J A;  2N80 A;  2XV9 A;  2MJM A;  4IZ5 E;  4JUP A;  2MS8 A;  4N1K A;  2OF5 H;  2LS7 A;  3KAT A;  4P4H A;  4RHW A;  3CL3 A;  2O71 A;  3YGS P;  2N7Z A;  3MOP K;  1DDF A;  2B1W A;  2MB9 A;  4RHW E;  4EWI A;  1WH4 A;  1N3K A;  2HM2 Q;  3T6P A;  4F42 A;  1D2Z A;  2OF5 A;  2DBG A;  2KN6 A;  4JQW A;  1C15 A;  1DGN A;  4E9M A;  1NGR A;  4I16 A;  2N1F A;  4QOB A;  1A1Z A;  4O9F A;  2DBH A;  3EZQ B;  3QF2 A;  4DWN A;  2NAQ A;  3J63 A;  1YGO A;  4IZ7 B;  2MPC A;  4A2Q A;  1UCP A;  4LWD A;  4O7Q A;  2DBD A;  3MOP A;  4ZBW A;  2YQF A;  2LWE A;  2YVI A;  4A2W A;  4NQK A;  1WMG A;  2N83 A;  4M9Z A;  2NZ7 A;  4P4H I;  2P1H A;  2M5V A;  4FH0 A;  4O6X A;  2VGQ A;  1ICH A;  1A1W A;  4N1J A;  4D8O A;  2A9I A;  1D2Z B;  2BBZ A;  2MS7 A;  4M9X A;  2YGS A;  2L6A A;  2BBR A;  2F1S A;  1E3Y A;  2KM6 A;  2A5Y B;  1WXP A;  1CWW A;  3LQQ A;  2IB1 A;  4N1L A; 
#chains in the Genus database with same CATH homology
 4IZA B;  4O9L A;  2G7R A;  4M9S A;  1E41 A;  3YGS C;  2L9M A;  4F44 A;  2N97 A;  2LWD A;  3LQR A;  1FAD A;  2GF5 A;  2DO9 A;  3MOP G;  2YU0 A;  1Z6T A;  3CRD A;  2DBF A;  1PN5 A;  3EZQ A;  2D96 A;  2N00 A;  1CY5 A;  4UZ0 A;  2MN4 A;  2NSN A;  3J6J A;  2N80 A;  2XV9 A;  2MJM A;  4IZ5 E;  4JUP A;  2MS8 A;  4N1K A;  2OF5 H;  2LS7 A;  3KAT A;  4P4H A;  4RHW A;  3CL3 A;  2O71 A;  3YGS P;  2N7Z A;  3MOP K;  1DDF A;  2B1W A;  2MB9 A;  4RHW E;  4EWI A;  1WH4 A;  1N3K A;  2HM2 Q;  3T6P A;  4F42 A;  1D2Z A;  2OF5 A;  2DBG A;  2KN6 A;  4JQW A;  1C15 A;  1DGN A;  4E9M A;  1NGR A;  4I16 A;  2N1F A;  4QOB A;  1A1Z A;  4O9F A;  2DBH A;  3EZQ B;  3QF2 A;  4DWN A;  2NAQ A;  3J63 A;  1YGO A;  4IZ7 B;  2MPC A;  4A2Q A;  1UCP A;  4LWD A;  4O7Q A;  2DBD A;  3MOP A;  4ZBW A;  2YQF A;  2LWE A;  2YVI A;  4A2W A;  4NQK A;  1WMG A;  2N83 A;  4M9Z A;  2NZ7 A;  4P4H I;  2P1H A;  2M5V A;  4FH0 A;  4O6X A;  2VGQ A;  1ICH A;  1A1W A;  4N1J A;  4D8O A;  2A9I A;  1D2Z B;  2BBZ A;  2MS7 A;  4M9X A;  2YGS A;  2L6A A;  2BBR A;  2F1S A;  1E3Y A;  2KM6 A;  2A5Y B;  1WXP A;  1CWW A;  3LQQ A;  2IB1 A;  4N1L A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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