2MPCA

Solution structure of the pyrin domain of human pyrin
Total Genus 27
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
27
sequence length
90
structure length
90
Chain Sequence
TPSDHLLSTLEELVPYDFEKFKFKLQNTSVQKEHSRIPRSQIQRARPVKMATLLVTYYGEEYAVQLTLQVLRAINQRLLAEELHRAAIQL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Identification of Multifaceted Binding Modes for Pyrin and ASC Pyrin Domains gives Insights into Pyrin Inflammasome Assembly
rcsb
molecule tags Signaling protein
source organism Homo sapiens
molecule keywords Pyrin
total genus 27
structure length 90
sequence length 90
ec nomenclature
pdb deposition date 2014-05-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02758 PYRIN PAAD/DAPIN/Pyrin domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.533.10 Mainly Alpha Orthogonal Bundle Death Domain, Fas Death Domain, Fas 2mpcA00
2N83A 2YQFA 1UCPA 2B1WA 2DBHA 2DO9A 1A1WA 2DBGA 2P1HA 2N00A 4IZAB 4O7QA 2G7RA 2L9MA 2M5VA 1YGOA 4O9LA 2LWDA 2KM6A 4IZ7B 2F1SA 2OF5A 3J6JA 4QOBA 4N1LA 4UZ0A 4A2WA 2VGQA 4DWNA 1A1ZA 2MS7A 2OF5H 3J63A 4P4HA 4EWIA 3MOPA 2O71A 3LQQA 1WMGA 2DBDA 1DDFA 1C15A 1Z6TA 2MB9A 2NAQA 4A2QA 3EZQB 1WH4A 1DGNA 2N97A 2LWEA 2MN4A 2BBRA 2YVIA 3EZQA 3YGSC 4P4HI 2MPCA 1N3KA 4N1KA 1D2ZB 1E3YA 1PN5A 3LQRA 3T6PA 1CWWA 4N1JA 3QF2A 1ICHA 4JQWA 4M9XA 1D2ZA 3CL3A 2LS7A 4O6XA 4F44A 4IZ5E 4O9FA 2GF5A 4D8OA 4FH0A 4M9SA 4M9ZA 2BBZA 4RHWA 4I16A 4JUPA 3MOPK 2DBFA 2N7ZA 2N1FA 2MS8A 2HM2Q 1WXPA 2YU0A 4ZBWA 4F42A 2A9IA 3CRDA 2D96A 4RHWE 4E9MA 1FADA 2YGSA 3MOPG 4LWDA 2KN6A 2IB1A 1NGRA 2A5YB 3KATA 2N80A 2NZ7A 1E41A 3YGSP 2NSNA 1CY5A 2L6AA 4NQKA
chains in the Genus database with same CATH superfamily
2N83A 2YQFA 1UCPA 2B1WA 2DBHA 2DO9A 1A1WA 2DBGA 2P1HA 2N00A 4IZAB 4O7QA 2G7RA 2L9MA 2M5VA 1YGOA 4O9LA 2LWDA 2KM6A 4IZ7B 2F1SA 2OF5A 3J6JA 4QOBA 4N1LA 4UZ0A 4A2WA 2VGQA 4DWNA 1A1ZA 2MS7A 2OF5H 3J63A 4P4HA 4EWIA 3MOPA 2O71A 3LQQA 1WMGA 2DBDA 1DDFA 1C15A 1Z6TA 2MB9A 2NAQA 4A2QA 3EZQB 1WH4A 1DGNA 2N97A 2LWEA 2MN4A 2BBRA 2YVIA 3EZQA 3YGSC 4P4HI 2MPCA 1N3KA 4N1KA 1D2ZB 1E3YA 1PN5A 3LQRA 3T6PA 1CWWA 4N1JA 2MJMA 3QF2A 1ICHA 4JQWA 4M9XA 1D2ZA 3CL3A 2LS7A 4O6XA 4F44A 4IZ5E 4O9FA 2GF5A 4D8OA 4FH0A 4M9SA 2XV9A 4M9ZA 2BBZA 4RHWA 4I16A 4JUPA 3MOPK 2DBFA 2N7ZA 2N1FA 2MS8A 2HM2Q 1WXPA 2YU0A 4ZBWA 4F42A 2A9IA 3CRDA 2D96A 4RHWE 4E9MA 1FADA 2YGSA 3MOPG 4LWDA 2KN6A 2IB1A 1NGRA 2A5YB 3KATA 2N80A 2NZ7A 1E41A 3YGSP 2NSNA 1CY5A 2L6AA 4NQKA
chains in the Genus database with same CATH topology
2N83A 2YQFA 1UCPA 2B1WA 2DBHA 2DO9A 1A1WA 2DBGA 2P1HA 2N00A 4IZAB 4O7QA 2G7RA 2L9MA 2M5VA 1YGOA 4O9LA 2LWDA 2KM6A 4IZ7B 2F1SA 2OF5A 3J6JA 4QOBA 4N1LA 4UZ0A 4A2WA 2VGQA 4DWNA 1A1ZA 2MS7A 2OF5H 3J63A 4P4HA 4EWIA 3MOPA 2O71A 3LQQA 1WMGA 2DBDA 1DDFA 1C15A 1Z6TA 2MB9A 2NAQA 4A2QA 3EZQB 1WH4A 1DGNA 2N97A 2LWEA 2MN4A 2BBRA 2YVIA 3EZQA 3YGSC 4P4HI 2MPCA 1N3KA 4N1KA 1D2ZB 1E3YA 1PN5A 3LQRA 3T6PA 1CWWA 4N1JA 2MJMA 3QF2A 1ICHA 4JQWA 4M9XA 1D2ZA 3CL3A 2LS7A 4O6XA 4F44A 4IZ5E 4O9FA 2GF5A 4D8OA 4FH0A 4M9SA 2XV9A 4M9ZA 2BBZA 4RHWA 4I16A 4JUPA 3MOPK 2DBFA 2N7ZA 2N1FA 2MS8A 2HM2Q 1WXPA 2YU0A 4ZBWA 4F42A 2A9IA 3CRDA 2D96A 4RHWE 4E9MA 1FADA 2YGSA 3MOPG 4LWDA 2KN6A 2IB1A 1NGRA 2A5YB 3KATA 2N80A 2NZ7A 1E41A 3YGSP 2NSNA 1CY5A 2L6AA 4NQKA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2N83 A;  2YQF A;  1UCP A;  2B1W A;  2DBH A;  2DO9 A;  1A1W A;  2DBG A;  2P1H A;  2N00 A;  4IZA B;  4O7Q A;  2G7R A;  2L9M A;  2M5V A;  1YGO A;  4O9L A;  2LWD A;  2KM6 A;  4IZ7 B;  2F1S A;  2OF5 A;  3J6J A;  4QOB A;  4N1L A;  4UZ0 A;  4A2W A;  2VGQ A;  4DWN A;  1A1Z A;  2MS7 A;  2OF5 H;  3J63 A;  4P4H A;  4EWI A;  3MOP A;  2O71 A;  3LQQ A;  1WMG A;  2DBD A;  1DDF A;  1C15 A;  1Z6T A;  2MB9 A;  2NAQ A;  4A2Q A;  3EZQ B;  1WH4 A;  1DGN A;  2N97 A;  2LWE A;  2MN4 A;  2BBR A;  2YVI A;  3EZQ A;  3YGS C;  4P4H I;  2MPC A;  1N3K A;  4N1K A;  1D2Z B;  1E3Y A;  1PN5 A;  3LQR A;  3T6P A;  1CWW A;  4N1J A;  3QF2 A;  1ICH A;  4JQW A;  4M9X A;  1D2Z A;  3CL3 A;  2LS7 A;  4O6X A;  4F44 A;  4IZ5 E;  4O9F A;  2GF5 A;  4D8O A;  4FH0 A;  4M9S A;  4M9Z A;  2BBZ A;  4RHW A;  4I16 A;  4JUP A;  3MOP K;  2DBF A;  2N7Z A;  2N1F A;  2MS8 A;  2HM2 Q;  1WXP A;  2YU0 A;  4ZBW A;  4F42 A;  2A9I A;  3CRD A;  2D96 A;  4RHW E;  4E9M A;  1FAD A;  2YGS A;  3MOP G;  4LWD A;  2KN6 A;  2IB1 A;  1NGR A;  2A5Y B;  3KAT A;  2N80 A;  2NZ7 A;  1E41 A;  3YGS P;  2NSN A;  1CY5 A;  2L6A A;  4NQK A; 
#chains in the Genus database with same CATH topology
 2N83 A;  2YQF A;  1UCP A;  2B1W A;  2DBH A;  2DO9 A;  1A1W A;  2DBG A;  2P1H A;  2N00 A;  4IZA B;  4O7Q A;  2G7R A;  2L9M A;  2M5V A;  1YGO A;  4O9L A;  2LWD A;  2KM6 A;  4IZ7 B;  2F1S A;  2OF5 A;  3J6J A;  4QOB A;  4N1L A;  4UZ0 A;  4A2W A;  2VGQ A;  4DWN A;  1A1Z A;  2MS7 A;  2OF5 H;  3J63 A;  4P4H A;  4EWI A;  3MOP A;  2O71 A;  3LQQ A;  1WMG A;  2DBD A;  1DDF A;  1C15 A;  1Z6T A;  2MB9 A;  2NAQ A;  4A2Q A;  3EZQ B;  1WH4 A;  1DGN A;  2N97 A;  2LWE A;  2MN4 A;  2BBR A;  2YVI A;  3EZQ A;  3YGS C;  4P4H I;  2MPC A;  1N3K A;  4N1K A;  1D2Z B;  1E3Y A;  1PN5 A;  3LQR A;  3T6P A;  1CWW A;  4N1J A;  2MJM A;  3QF2 A;  1ICH A;  4JQW A;  4M9X A;  1D2Z A;  3CL3 A;  2LS7 A;  4O6X A;  4F44 A;  4IZ5 E;  4O9F A;  2GF5 A;  4D8O A;  4FH0 A;  4M9S A;  2XV9 A;  4M9Z A;  2BBZ A;  4RHW A;  4I16 A;  4JUP A;  3MOP K;  2DBF A;  2N7Z A;  2N1F A;  2MS8 A;  2HM2 Q;  1WXP A;  2YU0 A;  4ZBW A;  4F42 A;  2A9I A;  3CRD A;  2D96 A;  4RHW E;  4E9M A;  1FAD A;  2YGS A;  3MOP G;  4LWD A;  2KN6 A;  2IB1 A;  1NGR A;  2A5Y B;  3KAT A;  2N80 A;  2NZ7 A;  1E41 A;  3YGS P;  2NSN A;  1CY5 A;  2L6A A;  4NQK A; 
#chains in the Genus database with same CATH homology
 2N83 A;  2YQF A;  1UCP A;  2B1W A;  2DBH A;  2DO9 A;  1A1W A;  2DBG A;  2P1H A;  2N00 A;  4IZA B;  4O7Q A;  2G7R A;  2L9M A;  2M5V A;  1YGO A;  4O9L A;  2LWD A;  2KM6 A;  4IZ7 B;  2F1S A;  2OF5 A;  3J6J A;  4QOB A;  4N1L A;  4UZ0 A;  4A2W A;  2VGQ A;  4DWN A;  1A1Z A;  2MS7 A;  2OF5 H;  3J63 A;  4P4H A;  4EWI A;  3MOP A;  2O71 A;  3LQQ A;  1WMG A;  2DBD A;  1DDF A;  1C15 A;  1Z6T A;  2MB9 A;  2NAQ A;  4A2Q A;  3EZQ B;  1WH4 A;  1DGN A;  2N97 A;  2LWE A;  2MN4 A;  2BBR A;  2YVI A;  3EZQ A;  3YGS C;  4P4H I;  2MPC A;  1N3K A;  4N1K A;  1D2Z B;  1E3Y A;  1PN5 A;  3LQR A;  3T6P A;  1CWW A;  4N1J A;  2MJM A;  3QF2 A;  1ICH A;  4JQW A;  4M9X A;  1D2Z A;  3CL3 A;  2LS7 A;  4O6X A;  4F44 A;  4IZ5 E;  4O9F A;  2GF5 A;  4D8O A;  4FH0 A;  4M9S A;  2XV9 A;  4M9Z A;  2BBZ A;  4RHW A;  4I16 A;  4JUP A;  3MOP K;  2DBF A;  2N7Z A;  2N1F A;  2MS8 A;  2HM2 Q;  1WXP A;  2YU0 A;  4ZBW A;  4F42 A;  2A9I A;  3CRD A;  2D96 A;  4RHW E;  4E9M A;  1FAD A;  2YGS A;  3MOP G;  4LWD A;  2KN6 A;  2IB1 A;  1NGR A;  2A5Y B;  3KAT A;  2N80 A;  2NZ7 A;  1E41 A;  3YGS P;  2NSN A;  1CY5 A;  2L6A A;  4NQK A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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