2MPCA

Solution structure of the pyrin domain of human pyrin
Total Genus 27
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
27
sequence length
90
structure length
90
Chain Sequence
TPSDHLLSTLEELVPYDFEKFKFKLQNTSVQKEHSRIPRSQIQRARPVKMATLLVTYYGEEYAVQLTLQVLRAINQRLLAEELHRAAIQL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Identification of Multifaceted Binding Modes for Pyrin and ASC Pyrin Domains gives Insights into Pyrin Inflammasome Assembly
rcsb
molecule tags Signaling protein
source organism Homo sapiens
molecule keywords Pyrin
total genus 27
structure length 90
sequence length 90
ec nomenclature
pdb deposition date 2014-05-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02758 PYRIN PAAD/DAPIN/Pyrin domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.533.10 Mainly Alpha Orthogonal Bundle Death Domain, Fas Death Domain, Fas 2mpcA00
2L9MA 2O71A 4O6XA 2DBGA 4DWNA 2N1FA 2LWDA 3J63A 1A1WA 2D96A 3MOPA 1C15A 4IZAB 2DBHA 2BBZA 2DO9A 2F1SA 3MOPK 3MOPG 2YGSA 1N3KA 1WMGA 4A2QA 1WH4A 3QF2A 3J6JA 2MB9A 2OF5A 4NQKA 3T6PA 2OF5H 4A2WA 4M9XA 4N1LA 3EZQA 2HM2Q 4EWIA 4M9SA 4LWDA 2MN4A 2VGQA 2DBFA 1PN5A 2L6AA 4O7QA 2KM6A 4UZ0A 4P4HI 4JQWA 2MS8A 3CRDA 1Z6TA 3YGSC 4N1KA 2A5YB 2YU0A 2G7RA 4JUPA 4F42A 1A1ZA 4O9LA 2M5VA 2KN6A 1D2ZB 1UCPA 2YVIA 2NSNA 1YGOA 1CWWA 1NGRA 4N1JA 4O9FA 2N83A 1WXPA 4IZ5E 4RHWE 3LQQA 1DGNA 2GF5A 2A9IA 2N97A 2MS7A 2NZ7A 2YQFA 4RHWA 3LQRA 4M9ZA 2NAQA 2N80A 2MPCA 1E41A 2LS7A 4ZBWA 1ICHA 2BBRA 4P4HA 4QOBA 3KATA 2P1HA 1FADA 2LWEA 2IB1A 1DDFA 3YGSP 1D2ZA 2N00A 2N7ZA 1CY5A 4E9MA 4I16A 4F44A 3CL3A 3EZQB 1E3YA 2DBDA 4IZ7B 4D8OA 2B1WA 4FH0A
chains in the Genus database with same CATH superfamily
2L9MA 2O71A 4O6XA 2DBGA 4DWNA 2N1FA 2LWDA 3J63A 1A1WA 2D96A 3MOPA 1C15A 4IZAB 2DBHA 2BBZA 2DO9A 2F1SA 3MOPK 3MOPG 2YGSA 1N3KA 1WMGA 4A2QA 1WH4A 3QF2A 3J6JA 2MB9A 2OF5A 4NQKA 3T6PA 2OF5H 4A2WA 4M9XA 4N1LA 3EZQA 2HM2Q 4EWIA 4M9SA 4LWDA 2MN4A 2VGQA 2DBFA 1PN5A 2L6AA 4O7QA 2KM6A 4UZ0A 4P4HI 4JQWA 2MS8A 3CRDA 1Z6TA 3YGSC 4N1KA 2A5YB 2YU0A 2G7RA 2MJMA 4JUPA 4F42A 1A1ZA 4O9LA 2M5VA 2KN6A 1D2ZB 1UCPA 2YVIA 2NSNA 1YGOA 1CWWA 1NGRA 4N1JA 4O9FA 2N83A 1WXPA 4IZ5E 2XV9A 3LQQA 4RHWE 1DGNA 2GF5A 2A9IA 2N97A 2MS7A 2NZ7A 2YQFA 4RHWA 3LQRA 4M9ZA 2NAQA 2N80A 2MPCA 1E41A 2LS7A 4ZBWA 1ICHA 2BBRA 4P4HA 4QOBA 3KATA 2P1HA 1FADA 2LWEA 2IB1A 1DDFA 3YGSP 1D2ZA 2N00A 2N7ZA 1CY5A 4E9MA 4I16A 4F44A 3CL3A 3EZQB 1E3YA 2DBDA 4IZ7B 4D8OA 2B1WA 4FH0A
chains in the Genus database with same CATH topology
2L9MA 2O71A 4O6XA 2DBGA 4DWNA 2N1FA 2LWDA 3J63A 1A1WA 2D96A 3MOPA 1C15A 4IZAB 2DBHA 2BBZA 2DO9A 2F1SA 3MOPK 3MOPG 2YGSA 1N3KA 1WMGA 4A2QA 1WH4A 3QF2A 3J6JA 2MB9A 2OF5A 4NQKA 3T6PA 2OF5H 4A2WA 4M9XA 4N1LA 3EZQA 2HM2Q 4EWIA 4M9SA 4LWDA 2MN4A 2VGQA 2DBFA 1PN5A 2L6AA 4O7QA 2KM6A 4UZ0A 4P4HI 4JQWA 2MS8A 3CRDA 1Z6TA 3YGSC 4N1KA 2A5YB 2YU0A 2G7RA 2MJMA 4JUPA 4F42A 1A1ZA 4O9LA 2M5VA 2KN6A 1D2ZB 1UCPA 2YVIA 2NSNA 1YGOA 1CWWA 1NGRA 4N1JA 4O9FA 2N83A 1WXPA 4IZ5E 2XV9A 3LQQA 4RHWE 1DGNA 2GF5A 2A9IA 2N97A 2MS7A 2NZ7A 2YQFA 4RHWA 3LQRA 4M9ZA 2NAQA 2N80A 2MPCA 1E41A 2LS7A 4ZBWA 1ICHA 2BBRA 4P4HA 4QOBA 3KATA 2P1HA 1FADA 2LWEA 2IB1A 1DDFA 3YGSP 1D2ZA 2N00A 2N7ZA 1CY5A 4E9MA 4I16A 4F44A 3CL3A 3EZQB 1E3YA 2DBDA 4IZ7B 4D8OA 2B1WA 4FH0A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2L9M A;  2O71 A;  4O6X A;  2DBG A;  4DWN A;  2N1F A;  2LWD A;  3J63 A;  1A1W A;  2D96 A;  3MOP A;  1C15 A;  4IZA B;  2DBH A;  2BBZ A;  2DO9 A;  2F1S A;  3MOP K;  3MOP G;  2YGS A;  1N3K A;  1WMG A;  4A2Q A;  1WH4 A;  3QF2 A;  3J6J A;  2MB9 A;  2OF5 A;  4NQK A;  3T6P A;  2OF5 H;  4A2W A;  4M9X A;  4N1L A;  3EZQ A;  2HM2 Q;  4EWI A;  4M9S A;  4LWD A;  2MN4 A;  2VGQ A;  2DBF A;  1PN5 A;  2L6A A;  4O7Q A;  2KM6 A;  4UZ0 A;  4P4H I;  4JQW A;  2MS8 A;  3CRD A;  1Z6T A;  3YGS C;  4N1K A;  2A5Y B;  2YU0 A;  2G7R A;  4JUP A;  4F42 A;  1A1Z A;  4O9L A;  2M5V A;  2KN6 A;  1D2Z B;  1UCP A;  2YVI A;  2NSN A;  1YGO A;  1CWW A;  1NGR A;  4N1J A;  4O9F A;  2N83 A;  1WXP A;  4IZ5 E;  4RHW E;  3LQQ A;  1DGN A;  2GF5 A;  2A9I A;  2N97 A;  2MS7 A;  2NZ7 A;  2YQF A;  4RHW A;  3LQR A;  4M9Z A;  2NAQ A;  2N80 A;  2MPC A;  1E41 A;  2LS7 A;  4ZBW A;  1ICH A;  2BBR A;  4P4H A;  4QOB A;  3KAT A;  2P1H A;  1FAD A;  2LWE A;  2IB1 A;  1DDF A;  3YGS P;  1D2Z A;  2N00 A;  2N7Z A;  1CY5 A;  4E9M A;  4I16 A;  4F44 A;  3CL3 A;  3EZQ B;  1E3Y A;  2DBD A;  4IZ7 B;  4D8O A;  2B1W A;  4FH0 A; 
#chains in the Genus database with same CATH topology
 2L9M A;  2O71 A;  4O6X A;  2DBG A;  4DWN A;  2N1F A;  2LWD A;  3J63 A;  1A1W A;  2D96 A;  3MOP A;  1C15 A;  4IZA B;  2DBH A;  2BBZ A;  2DO9 A;  2F1S A;  3MOP K;  3MOP G;  2YGS A;  1N3K A;  1WMG A;  4A2Q A;  1WH4 A;  3QF2 A;  3J6J A;  2MB9 A;  2OF5 A;  4NQK A;  3T6P A;  2OF5 H;  4A2W A;  4M9X A;  4N1L A;  3EZQ A;  2HM2 Q;  4EWI A;  4M9S A;  4LWD A;  2MN4 A;  2VGQ A;  2DBF A;  1PN5 A;  2L6A A;  4O7Q A;  2KM6 A;  4UZ0 A;  4P4H I;  4JQW A;  2MS8 A;  3CRD A;  1Z6T A;  3YGS C;  4N1K A;  2A5Y B;  2YU0 A;  2G7R A;  2MJM A;  4JUP A;  4F42 A;  1A1Z A;  4O9L A;  2M5V A;  2KN6 A;  1D2Z B;  1UCP A;  2YVI A;  2NSN A;  1YGO A;  1CWW A;  1NGR A;  4N1J A;  4O9F A;  2N83 A;  1WXP A;  4IZ5 E;  2XV9 A;  3LQQ A;  4RHW E;  1DGN A;  2GF5 A;  2A9I A;  2N97 A;  2MS7 A;  2NZ7 A;  2YQF A;  4RHW A;  3LQR A;  4M9Z A;  2NAQ A;  2N80 A;  2MPC A;  1E41 A;  2LS7 A;  4ZBW A;  1ICH A;  2BBR A;  4P4H A;  4QOB A;  3KAT A;  2P1H A;  1FAD A;  2LWE A;  2IB1 A;  1DDF A;  3YGS P;  1D2Z A;  2N00 A;  2N7Z A;  1CY5 A;  4E9M A;  4I16 A;  4F44 A;  3CL3 A;  3EZQ B;  1E3Y A;  2DBD A;  4IZ7 B;  4D8O A;  2B1W A;  4FH0 A; 
#chains in the Genus database with same CATH homology
 2L9M A;  2O71 A;  4O6X A;  2DBG A;  4DWN A;  2N1F A;  2LWD A;  3J63 A;  1A1W A;  2D96 A;  3MOP A;  1C15 A;  4IZA B;  2DBH A;  2BBZ A;  2DO9 A;  2F1S A;  3MOP K;  3MOP G;  2YGS A;  1N3K A;  1WMG A;  4A2Q A;  1WH4 A;  3QF2 A;  3J6J A;  2MB9 A;  2OF5 A;  4NQK A;  3T6P A;  2OF5 H;  4A2W A;  4M9X A;  4N1L A;  3EZQ A;  2HM2 Q;  4EWI A;  4M9S A;  4LWD A;  2MN4 A;  2VGQ A;  2DBF A;  1PN5 A;  2L6A A;  4O7Q A;  2KM6 A;  4UZ0 A;  4P4H I;  4JQW A;  2MS8 A;  3CRD A;  1Z6T A;  3YGS C;  4N1K A;  2A5Y B;  2YU0 A;  2G7R A;  2MJM A;  4JUP A;  4F42 A;  1A1Z A;  4O9L A;  2M5V A;  2KN6 A;  1D2Z B;  1UCP A;  2YVI A;  2NSN A;  1YGO A;  1CWW A;  1NGR A;  4N1J A;  4O9F A;  2N83 A;  1WXP A;  4IZ5 E;  2XV9 A;  3LQQ A;  4RHW E;  1DGN A;  2GF5 A;  2A9I A;  2N97 A;  2MS7 A;  2NZ7 A;  2YQF A;  4RHW A;  3LQR A;  4M9Z A;  2NAQ A;  2N80 A;  2MPC A;  1E41 A;  2LS7 A;  4ZBW A;  1ICH A;  2BBR A;  4P4H A;  4QOB A;  3KAT A;  2P1H A;  1FAD A;  2LWE A;  2IB1 A;  1DDF A;  3YGS P;  1D2Z A;  2N00 A;  2N7Z A;  1CY5 A;  4E9M A;  4I16 A;  4F44 A;  3CL3 A;  3EZQ B;  1E3Y A;  2DBD A;  4IZ7 B;  4D8O A;  2B1W A;  4FH0 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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