2P1HA

Rapid folding and unfolding of apaf-1 card
Total Genus 34
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
34
sequence length
94
structure length
94
Chain Sequence
GSMDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMILKKDNDSYVSFYNALLHEGYKDLAALLHDGIP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Rapid Folding and Unfolding of Apaf-1 CARD.
pubmed doi rcsb
molecule tags Apoptosis
source organism Homo sapiens
molecule keywords Apoptotic protease-activating factor 1
total genus 34
structure length 94
sequence length 94
ec nomenclature
pdb deposition date 2007-03-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00619 CARD Caspase recruitment domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.533.10 Mainly Alpha Orthogonal Bundle Death Domain, Fas Death Domain, Fas 2p1hA00
4JQWA 2KN6A 4RHWE 1YGOA 3CL3A 2L9MA 4O9FA 4P4HA 4F42A 2N7ZA 1NGRA 4D8OA 4O6XA 2P1HA 2N1FA 1CWWA 4JUPA 1A1ZA 2DBFA 2VGQA 4IZ5E 4QOBA 4RHWA 2YU0A 2MPCA 3EZQA 2MS7A 2F1SA 1UCPA 1C15A 2DBDA 4P4HI 4A2WA 4NQKA 2NZ7A 1N3KA 2MS8A 4DWNA 4UZ0A 2M5VA 2HM2Q 2KM6A 3MOPK 2YGSA 2D96A 3J6JA 2IB1A 4I16A 1FADA 3MOPG 2DBGA 3YGSC 2DO9A 3T6PA 3YGSP 2BBZA 2LWEA 1E3YA 4E9MA 2OF5H 3EZQB 1CY5A 2A5YB 3LQQA 1D2ZB 2MN4A 4LWDA 3CRDA 1E41A 1Z6TA 2B1WA 3MOPA 4IZ7B 2BBRA 4EWIA 1PN5A 2N00A 4FH0A 1DGNA 2N97A 2YVIA 2G7RA 2LS7A 4M9ZA 1WXPA 2A9IA 3KATA 2O71A 4N1KA 4N1JA 4M9SA 2N80A 4F44A 3QF2A 4A2QA 4ZBWA 1WMGA 2YQFA 3LQRA 4M9XA 4N1LA 3J63A 2NSNA 2GF5A 4IZAB 1WH4A 4O9LA 2OF5A 2L6AA 4O7QA 1DDFA 1D2ZA 2NAQA 2MB9A 2DBHA 1A1WA 2N83A 1ICHA 2LWDA
chains in the Genus database with same CATH superfamily
4JQWA 2KN6A 4RHWE 1YGOA 3CL3A 2L9MA 4O9FA 4P4HA 4F42A 2N7ZA 1NGRA 4D8OA 4O6XA 2P1HA 2N1FA 1CWWA 4JUPA 1A1ZA 2DBFA 2VGQA 4IZ5E 4QOBA 4RHWA 2YU0A 2MPCA 3EZQA 2MS7A 2F1SA 1UCPA 1C15A 2DBDA 4P4HI 4A2WA 4NQKA 2NZ7A 1N3KA 2MS8A 4DWNA 2MJMA 4UZ0A 2M5VA 2HM2Q 2KM6A 3MOPK 2YGSA 2D96A 3J6JA 2IB1A 4I16A 1FADA 3MOPG 2DBGA 3YGSC 2DO9A 3T6PA 3YGSP 2BBZA 2LWEA 1E3YA 4E9MA 2OF5H 3EZQB 1CY5A 2A5YB 3LQQA 1D2ZB 2MN4A 4LWDA 3CRDA 1E41A 1Z6TA 2B1WA 3MOPA 4IZ7B 2BBRA 4EWIA 1PN5A 2N00A 4FH0A 1DGNA 2N97A 2YVIA 2G7RA 2LS7A 2XV9A 4M9ZA 1WXPA 2A9IA 3KATA 2O71A 4N1KA 4N1JA 4M9SA 2N80A 4F44A 3QF2A 4A2QA 4ZBWA 1WMGA 2YQFA 3LQRA 4M9XA 4N1LA 3J63A 2NSNA 2GF5A 4IZAB 1WH4A 4O9LA 2OF5A 2L6AA 4O7QA 1DDFA 1D2ZA 2NAQA 2MB9A 2DBHA 1A1WA 2N83A 1ICHA 2LWDA
chains in the Genus database with same CATH topology
4JQWA 2KN6A 4RHWE 1YGOA 3CL3A 2L9MA 4O9FA 4P4HA 4F42A 2N7ZA 1NGRA 4D8OA 4O6XA 2P1HA 2N1FA 1CWWA 4JUPA 1A1ZA 2DBFA 2VGQA 4IZ5E 4QOBA 4RHWA 2YU0A 2MPCA 3EZQA 2MS7A 2F1SA 1UCPA 1C15A 2DBDA 4P4HI 4A2WA 4NQKA 2NZ7A 1N3KA 2MS8A 4DWNA 2MJMA 4UZ0A 2M5VA 2HM2Q 2KM6A 3MOPK 2YGSA 2D96A 3J6JA 2IB1A 4I16A 1FADA 3MOPG 2DBGA 3YGSC 2DO9A 3T6PA 3YGSP 2BBZA 2LWEA 1E3YA 4E9MA 2OF5H 3EZQB 1CY5A 2A5YB 3LQQA 1D2ZB 2MN4A 4LWDA 3CRDA 1E41A 1Z6TA 2B1WA 3MOPA 4IZ7B 2BBRA 4EWIA 1PN5A 2N00A 4FH0A 1DGNA 2N97A 2YVIA 2G7RA 2LS7A 2XV9A 4M9ZA 1WXPA 2A9IA 3KATA 2O71A 4N1KA 4N1JA 4M9SA 2N80A 4F44A 3QF2A 4A2QA 4ZBWA 1WMGA 2YQFA 3LQRA 4M9XA 4N1LA 3J63A 2NSNA 2GF5A 4IZAB 1WH4A 4O9LA 2OF5A 2L6AA 4O7QA 1DDFA 1D2ZA 2NAQA 2MB9A 2DBHA 1A1WA 2N83A 1ICHA 2LWDA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4JQW A;  2KN6 A;  4RHW E;  1YGO A;  3CL3 A;  2L9M A;  4O9F A;  4P4H A;  4F42 A;  2N7Z A;  1NGR A;  4D8O A;  4O6X A;  2P1H A;  2N1F A;  1CWW A;  4JUP A;  1A1Z A;  2DBF A;  2VGQ A;  4IZ5 E;  4QOB A;  4RHW A;  2YU0 A;  2MPC A;  3EZQ A;  2MS7 A;  2F1S A;  1UCP A;  1C15 A;  2DBD A;  4P4H I;  4A2W A;  4NQK A;  2NZ7 A;  1N3K A;  2MS8 A;  4DWN A;  4UZ0 A;  2M5V A;  2HM2 Q;  2KM6 A;  3MOP K;  2YGS A;  2D96 A;  3J6J A;  2IB1 A;  4I16 A;  1FAD A;  3MOP G;  2DBG A;  3YGS C;  2DO9 A;  3T6P A;  3YGS P;  2BBZ A;  2LWE A;  1E3Y A;  4E9M A;  2OF5 H;  3EZQ B;  1CY5 A;  2A5Y B;  3LQQ A;  1D2Z B;  2MN4 A;  4LWD A;  3CRD A;  1E41 A;  1Z6T A;  2B1W A;  3MOP A;  4IZ7 B;  2BBR A;  4EWI A;  1PN5 A;  2N00 A;  4FH0 A;  1DGN A;  2N97 A;  2YVI A;  2G7R A;  2LS7 A;  4M9Z A;  1WXP A;  2A9I A;  3KAT A;  2O71 A;  4N1K A;  4N1J A;  4M9S A;  2N80 A;  4F44 A;  3QF2 A;  4A2Q A;  4ZBW A;  1WMG A;  2YQF A;  3LQR A;  4M9X A;  4N1L A;  3J63 A;  2NSN A;  2GF5 A;  4IZA B;  1WH4 A;  4O9L A;  2OF5 A;  2L6A A;  4O7Q A;  1DDF A;  1D2Z A;  2NAQ A;  2MB9 A;  2DBH A;  1A1W A;  2N83 A;  1ICH A;  2LWD A; 
#chains in the Genus database with same CATH topology
 4JQW A;  2KN6 A;  4RHW E;  1YGO A;  3CL3 A;  2L9M A;  4O9F A;  4P4H A;  4F42 A;  2N7Z A;  1NGR A;  4D8O A;  4O6X A;  2P1H A;  2N1F A;  1CWW A;  4JUP A;  1A1Z A;  2DBF A;  2VGQ A;  4IZ5 E;  4QOB A;  4RHW A;  2YU0 A;  2MPC A;  3EZQ A;  2MS7 A;  2F1S A;  1UCP A;  1C15 A;  2DBD A;  4P4H I;  4A2W A;  4NQK A;  2NZ7 A;  1N3K A;  2MS8 A;  4DWN A;  2MJM A;  4UZ0 A;  2M5V A;  2HM2 Q;  2KM6 A;  3MOP K;  2YGS A;  2D96 A;  3J6J A;  2IB1 A;  4I16 A;  1FAD A;  3MOP G;  2DBG A;  3YGS C;  2DO9 A;  3T6P A;  3YGS P;  2BBZ A;  2LWE A;  1E3Y A;  4E9M A;  2OF5 H;  3EZQ B;  1CY5 A;  2A5Y B;  3LQQ A;  1D2Z B;  2MN4 A;  4LWD A;  3CRD A;  1E41 A;  1Z6T A;  2B1W A;  3MOP A;  4IZ7 B;  2BBR A;  4EWI A;  1PN5 A;  2N00 A;  4FH0 A;  1DGN A;  2N97 A;  2YVI A;  2G7R A;  2LS7 A;  2XV9 A;  4M9Z A;  1WXP A;  2A9I A;  3KAT A;  2O71 A;  4N1K A;  4N1J A;  4M9S A;  2N80 A;  4F44 A;  3QF2 A;  4A2Q A;  4ZBW A;  1WMG A;  2YQF A;  3LQR A;  4M9X A;  4N1L A;  3J63 A;  2NSN A;  2GF5 A;  4IZA B;  1WH4 A;  4O9L A;  2OF5 A;  2L6A A;  4O7Q A;  1DDF A;  1D2Z A;  2NAQ A;  2MB9 A;  2DBH A;  1A1W A;  2N83 A;  1ICH A;  2LWD A; 
#chains in the Genus database with same CATH homology
 4JQW A;  2KN6 A;  4RHW E;  1YGO A;  3CL3 A;  2L9M A;  4O9F A;  4P4H A;  4F42 A;  2N7Z A;  1NGR A;  4D8O A;  4O6X A;  2P1H A;  2N1F A;  1CWW A;  4JUP A;  1A1Z A;  2DBF A;  2VGQ A;  4IZ5 E;  4QOB A;  4RHW A;  2YU0 A;  2MPC A;  3EZQ A;  2MS7 A;  2F1S A;  1UCP A;  1C15 A;  2DBD A;  4P4H I;  4A2W A;  4NQK A;  2NZ7 A;  1N3K A;  2MS8 A;  4DWN A;  2MJM A;  4UZ0 A;  2M5V A;  2HM2 Q;  2KM6 A;  3MOP K;  2YGS A;  2D96 A;  3J6J A;  2IB1 A;  4I16 A;  1FAD A;  3MOP G;  2DBG A;  3YGS C;  2DO9 A;  3T6P A;  3YGS P;  2BBZ A;  2LWE A;  1E3Y A;  4E9M A;  2OF5 H;  3EZQ B;  1CY5 A;  2A5Y B;  3LQQ A;  1D2Z B;  2MN4 A;  4LWD A;  3CRD A;  1E41 A;  1Z6T A;  2B1W A;  3MOP A;  4IZ7 B;  2BBR A;  4EWI A;  1PN5 A;  2N00 A;  4FH0 A;  1DGN A;  2N97 A;  2YVI A;  2G7R A;  2LS7 A;  2XV9 A;  4M9Z A;  1WXP A;  2A9I A;  3KAT A;  2O71 A;  4N1K A;  4N1J A;  4M9S A;  2N80 A;  4F44 A;  3QF2 A;  4A2Q A;  4ZBW A;  1WMG A;  2YQF A;  3LQR A;  4M9X A;  4N1L A;  3J63 A;  2NSN A;  2GF5 A;  4IZA B;  1WH4 A;  4O9L A;  2OF5 A;  2L6A A;  4O7Q A;  1DDF A;  1D2Z A;  2NAQ A;  2MB9 A;  2DBH A;  1A1W A;  2N83 A;  1ICH A;  2LWD A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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