2LWDA

Solution structure of second card of human rig-i
Total Genus 35
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
35
sequence length
96
structure length
96
Chain Sequence
KKIEKLEEYRLLLKRLQPEFKTRIIPTDIISDLSECLINQECEEILQICSTKGMMAGAEKLVECLLRSDKENWPKTLKLALEKERNKFSELWIVEK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structure and Dynamics of the Second CARD of Human RIG-I Provide Mechanistic Insights into Regulation of RIG-I Activation.
pubmed doi rcsb
molecule tags Signaling protein
source organism Homo sapiens
molecule keywords Probable ATP-dependent RNA helicase DDX58
total genus 35
structure length 96
sequence length 96
ec nomenclature ec 3.6.4.13: RNA helicase.
pdb deposition date 2012-07-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF16739 CARD_2 Caspase recruitment domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.533.10 Mainly Alpha Orthogonal Bundle Death Domain, Fas Death Domain, Fas 2lwdA00
1A1WA 3YGSC 1E41A 4A2QA 2N80A 1ICHA 4O7QA 2MS7A 4FH0A 4O9FA 2N1FA 3MOPA 3KATA 2N83A 3CRDA 2B1WA 4F44A 4ZBWA 1C15A 1N3KA 2BBRA 2IB1A 1DDFA 3QF2A 2N00A 2YVIA 4RHWE 3MOPG 4I16A 2YU0A 1D2ZA 4IZ7B 4M9XA 2DBHA 1WH4A 2VGQA 2DO9A 2YQFA 2D96A 4P4HA 4EWIA 3J6JA 4N1KA 2DBFA 2MS8A 2N7ZA 2KM6A 3MOPK 2A5YB 4JUPA 3T6PA 2GF5A 3EZQA 2YGSA 4RHWA 2HM2Q 2NAQA 1WMGA 1WXPA 4A2WA 2KN6A 3J63A 4NQKA 4D8OA 2BBZA 4O6XA 1UCPA 3CL3A 1CY5A 2A9IA 4LWDA 2G7RA 2L9MA 2N97A 1Z6TA 2LWDA 4JQWA 1PN5A 4P4HI 4DWNA 4IZAB 1NGRA 2O71A 3LQRA 2NSNA 2LS7A 2M5VA 4UZ0A 1CWWA 2MB9A 1FADA 2L6AA 2MPCA 1DGNA 2P1HA 4E9MA 4N1JA 1D2ZB 4M9ZA 4QOBA 4O9LA 1A1ZA 2OF5A 1E3YA 2LWEA 4F42A 2F1SA 1YGOA 2DBGA 2NZ7A 4M9SA 4IZ5E 3YGSP 2DBDA 4N1LA 3EZQB 3LQQA 2OF5H 2MN4A
chains in the Genus database with same CATH superfamily
1A1WA 3YGSC 1E41A 4A2QA 2N80A 1ICHA 4O7QA 2MS7A 4FH0A 4O9FA 2N1FA 3MOPA 3KATA 2N83A 3CRDA 2B1WA 4F44A 4ZBWA 1C15A 1N3KA 2BBRA 2IB1A 1DDFA 2N00A 3QF2A 2YVIA 4RHWE 3MOPG 4I16A 2YU0A 1D2ZA 4IZ7B 4M9XA 2DBHA 1WH4A 2VGQA 2DO9A 2YQFA 2D96A 4P4HA 4EWIA 3J6JA 4N1KA 2DBFA 2MS8A 2N7ZA 2KM6A 3MOPK 2A5YB 4JUPA 3T6PA 2GF5A 3EZQA 2YGSA 4RHWA 2HM2Q 2NAQA 1WMGA 1WXPA 4A2WA 2KN6A 3J63A 4NQKA 4D8OA 2BBZA 4O6XA 1UCPA 3CL3A 1CY5A 2A9IA 4LWDA 2G7RA 2L9MA 2N97A 1Z6TA 2LWDA 4JQWA 1PN5A 4P4HI 4DWNA 4IZAB 1NGRA 2O71A 3LQRA 2NSNA 2LS7A 2M5VA 4UZ0A 1CWWA 2MB9A 1FADA 2L6AA 2MPCA 1DGNA 2P1HA 4E9MA 4N1JA 1D2ZB 4M9ZA 4QOBA 4O9LA 1A1ZA 2OF5A 1E3YA 2LWEA 4F42A 2F1SA 1YGOA 2XV9A 2DBGA 2NZ7A 4M9SA 4IZ5E 3YGSP 2MJMA 2DBDA 4N1LA 3EZQB 3LQQA 2OF5H 2MN4A
chains in the Genus database with same CATH topology
1A1WA 3YGSC 1E41A 4A2QA 2N80A 1ICHA 4O7QA 2MS7A 4FH0A 4O9FA 2N1FA 3MOPA 3KATA 2N83A 3CRDA 2B1WA 4F44A 4ZBWA 1C15A 1N3KA 2BBRA 2IB1A 1DDFA 2N00A 3QF2A 2YVIA 4RHWE 3MOPG 4I16A 2YU0A 1D2ZA 4IZ7B 4M9XA 2DBHA 1WH4A 2VGQA 2DO9A 2YQFA 2D96A 4P4HA 4EWIA 3J6JA 4N1KA 2DBFA 2MS8A 2N7ZA 2KM6A 3MOPK 2A5YB 4JUPA 3T6PA 2GF5A 3EZQA 2YGSA 4RHWA 2HM2Q 2NAQA 1WMGA 1WXPA 4A2WA 2KN6A 3J63A 4NQKA 4D8OA 2BBZA 4O6XA 1UCPA 3CL3A 1CY5A 2A9IA 4LWDA 2G7RA 2L9MA 2N97A 1Z6TA 2LWDA 4JQWA 1PN5A 4P4HI 4DWNA 4IZAB 1NGRA 2O71A 3LQRA 2NSNA 2LS7A 2M5VA 4UZ0A 1CWWA 2MB9A 1FADA 2L6AA 2MPCA 1DGNA 2P1HA 4E9MA 4N1JA 1D2ZB 4M9ZA 4QOBA 4O9LA 1A1ZA 2OF5A 1E3YA 2LWEA 4F42A 2F1SA 1YGOA 2XV9A 2DBGA 2NZ7A 4M9SA 4IZ5E 3YGSP 2MJMA 2DBDA 4N1LA 3EZQB 3LQQA 2OF5H 2MN4A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1A1W A;  3YGS C;  1E41 A;  4A2Q A;  2N80 A;  1ICH A;  4O7Q A;  2MS7 A;  4FH0 A;  4O9F A;  2N1F A;  3MOP A;  3KAT A;  2N83 A;  3CRD A;  2B1W A;  4F44 A;  4ZBW A;  1C15 A;  1N3K A;  2BBR A;  2IB1 A;  1DDF A;  3QF2 A;  2N00 A;  2YVI A;  4RHW E;  3MOP G;  4I16 A;  2YU0 A;  1D2Z A;  4IZ7 B;  4M9X A;  2DBH A;  1WH4 A;  2VGQ A;  2DO9 A;  2YQF A;  2D96 A;  4P4H A;  4EWI A;  3J6J A;  4N1K A;  2DBF A;  2MS8 A;  2N7Z A;  2KM6 A;  3MOP K;  2A5Y B;  4JUP A;  3T6P A;  2GF5 A;  3EZQ A;  2YGS A;  4RHW A;  2HM2 Q;  2NAQ A;  1WMG A;  1WXP A;  4A2W A;  2KN6 A;  3J63 A;  4NQK A;  4D8O A;  2BBZ A;  4O6X A;  1UCP A;  3CL3 A;  1CY5 A;  2A9I A;  4LWD A;  2G7R A;  2L9M A;  2N97 A;  1Z6T A;  2LWD A;  4JQW A;  1PN5 A;  4P4H I;  4DWN A;  4IZA B;  1NGR A;  2O71 A;  3LQR A;  2NSN A;  2LS7 A;  2M5V A;  4UZ0 A;  1CWW A;  2MB9 A;  1FAD A;  2L6A A;  2MPC A;  1DGN A;  2P1H A;  4E9M A;  4N1J A;  1D2Z B;  4M9Z A;  4QOB A;  4O9L A;  1A1Z A;  2OF5 A;  1E3Y A;  2LWE A;  4F42 A;  2F1S A;  1YGO A;  2DBG A;  2NZ7 A;  4M9S A;  4IZ5 E;  3YGS P;  2DBD A;  4N1L A;  3EZQ B;  3LQQ A;  2OF5 H;  2MN4 A; 
#chains in the Genus database with same CATH topology
 1A1W A;  3YGS C;  1E41 A;  4A2Q A;  2N80 A;  1ICH A;  4O7Q A;  2MS7 A;  4FH0 A;  4O9F A;  2N1F A;  3MOP A;  3KAT A;  2N83 A;  3CRD A;  2B1W A;  4F44 A;  4ZBW A;  1C15 A;  1N3K A;  2BBR A;  2IB1 A;  1DDF A;  2N00 A;  3QF2 A;  2YVI A;  4RHW E;  3MOP G;  4I16 A;  2YU0 A;  1D2Z A;  4IZ7 B;  4M9X A;  2DBH A;  1WH4 A;  2VGQ A;  2DO9 A;  2YQF A;  2D96 A;  4P4H A;  4EWI A;  3J6J A;  4N1K A;  2DBF A;  2MS8 A;  2N7Z A;  2KM6 A;  3MOP K;  2A5Y B;  4JUP A;  3T6P A;  2GF5 A;  3EZQ A;  2YGS A;  4RHW A;  2HM2 Q;  2NAQ A;  1WMG A;  1WXP A;  4A2W A;  2KN6 A;  3J63 A;  4NQK A;  4D8O A;  2BBZ A;  4O6X A;  1UCP A;  3CL3 A;  1CY5 A;  2A9I A;  4LWD A;  2G7R A;  2L9M A;  2N97 A;  1Z6T A;  2LWD A;  4JQW A;  1PN5 A;  4P4H I;  4DWN A;  4IZA B;  1NGR A;  2O71 A;  3LQR A;  2NSN A;  2LS7 A;  2M5V A;  4UZ0 A;  1CWW A;  2MB9 A;  1FAD A;  2L6A A;  2MPC A;  1DGN A;  2P1H A;  4E9M A;  4N1J A;  1D2Z B;  4M9Z A;  4QOB A;  4O9L A;  1A1Z A;  2OF5 A;  1E3Y A;  2LWE A;  4F42 A;  2F1S A;  1YGO A;  2XV9 A;  2DBG A;  2NZ7 A;  4M9S A;  4IZ5 E;  3YGS P;  2MJM A;  2DBD A;  4N1L A;  3EZQ B;  3LQQ A;  2OF5 H;  2MN4 A; 
#chains in the Genus database with same CATH homology
 1A1W A;  3YGS C;  1E41 A;  4A2Q A;  2N80 A;  1ICH A;  4O7Q A;  2MS7 A;  4FH0 A;  4O9F A;  2N1F A;  3MOP A;  3KAT A;  2N83 A;  3CRD A;  2B1W A;  4F44 A;  4ZBW A;  1C15 A;  1N3K A;  2BBR A;  2IB1 A;  1DDF A;  2N00 A;  3QF2 A;  2YVI A;  4RHW E;  3MOP G;  4I16 A;  2YU0 A;  1D2Z A;  4IZ7 B;  4M9X A;  2DBH A;  1WH4 A;  2VGQ A;  2DO9 A;  2YQF A;  2D96 A;  4P4H A;  4EWI A;  3J6J A;  4N1K A;  2DBF A;  2MS8 A;  2N7Z A;  2KM6 A;  3MOP K;  2A5Y B;  4JUP A;  3T6P A;  2GF5 A;  3EZQ A;  2YGS A;  4RHW A;  2HM2 Q;  2NAQ A;  1WMG A;  1WXP A;  4A2W A;  2KN6 A;  3J63 A;  4NQK A;  4D8O A;  2BBZ A;  4O6X A;  1UCP A;  3CL3 A;  1CY5 A;  2A9I A;  4LWD A;  2G7R A;  2L9M A;  2N97 A;  1Z6T A;  2LWD A;  4JQW A;  1PN5 A;  4P4H I;  4DWN A;  4IZA B;  1NGR A;  2O71 A;  3LQR A;  2NSN A;  2LS7 A;  2M5V A;  4UZ0 A;  1CWW A;  2MB9 A;  1FAD A;  2L6A A;  2MPC A;  1DGN A;  2P1H A;  4E9M A;  4N1J A;  1D2Z B;  4M9Z A;  4QOB A;  4O9L A;  1A1Z A;  2OF5 A;  1E3Y A;  2LWE A;  4F42 A;  2F1S A;  1YGO A;  2XV9 A;  2DBG A;  2NZ7 A;  4M9S A;  4IZ5 E;  3YGS P;  2MJM A;  2DBD A;  4N1L A;  3EZQ B;  3LQQ A;  2OF5 H;  2MN4 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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