2LWEA

Solution structure of mutant (t170e) second card of human rig-i
Total Genus 37
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
37
sequence length
96
structure length
96
Chain Sequence
KKIEKLEEYRLLLKRLQPEFKTRIIPTDIISDLSECLINQECEEILQICSTKGMMAGAEKLVECLLRSDKENWPKELKLALEKERNKFSELWIVEK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure and Dynamics of the Second CARD of Human RIG-I Provide Mechanistic Insights into Regulation of RIG-I Activation.
pubmed doi rcsb
molecule tags Signaling protein
source organism Homo sapiens
molecule keywords Probable ATP-dependent RNA helicase DDX58
total genus 37
structure length 96
sequence length 96
ec nomenclature ec 3.6.4.13: RNA helicase.
pdb deposition date 2012-07-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF16739 CARD_2 Caspase recruitment domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.533.10 Mainly Alpha Orthogonal Bundle Death Domain, Fas Death Domain, Fas 2lweA00
4IZ5E 2MS7A 1C15A 2VGQA 2HM2Q 3J63A 2IB1A 2F1SA 2N97A 2MS8A 2N00A 2DO9A 4RHWA 4M9XA 2KN6A 2N7ZA 1CWWA 1DGNA 4UZ0A 4EWIA 2MB9A 2DBFA 2NAQA 1A1WA 4N1LA 4F42A 4IZAB 1WMGA 1A1ZA 2B1WA 4M9SA 1CY5A 2OF5H 3LQQA 1D2ZA 2L6AA 2DBDA 2LWEA 2M5VA 4M9ZA 2N80A 2NZ7A 1N3KA 1D2ZB 2N1FA 1E41A 2BBZA 2O71A 3KATA 2BBRA 3CRDA 3MOPA 4IZ7B 4LWDA 4D8OA 3CL3A 3MOPK 2DBGA 1WXPA 3LQRA 2YGSA 4O9LA 1FADA 2MN4A 3T6PA 2D96A 1PN5A 4O7QA 2YVIA 4I16A 4F44A 4A2QA 1NGRA 1UCPA 1Z6TA 3J6JA 2OF5A 1E3YA 4FH0A 1YGOA 4P4HA 4E9MA 4ZBWA 2NSNA 2KM6A 4QOBA 1ICHA 2A5YB 4RHWE 2LWDA 4N1JA 3YGSC 2A9IA 4A2WA 4NQKA 3QF2A 1DDFA 4JUPA 4O6XA 2MPCA 4N1KA 3YGSP 4O9FA 2G7RA 2YQFA 2L9MA 2N83A 3MOPG 4DWNA 2GF5A 2P1HA 2LS7A 4P4HI 3EZQA 2YU0A 1WH4A 2DBHA 3EZQB 4JQWA
chains in the Genus database with same CATH superfamily
4IZ5E 2MS7A 1C15A 2VGQA 2HM2Q 3J63A 2IB1A 2F1SA 2N97A 2MS8A 2N00A 2DO9A 2XV9A 4RHWA 4M9XA 2KN6A 2N7ZA 1CWWA 1DGNA 4UZ0A 4EWIA 2MB9A 2DBFA 2NAQA 1A1WA 4N1LA 4F42A 4IZAB 1WMGA 1A1ZA 2B1WA 4M9SA 1CY5A 2OF5H 3LQQA 1D2ZA 2L6AA 2DBDA 2LWEA 2M5VA 4M9ZA 2N80A 2NZ7A 1N3KA 1D2ZB 2N1FA 1E41A 2BBZA 2O71A 3KATA 2BBRA 3CRDA 3MOPA 4IZ7B 4LWDA 4D8OA 3CL3A 3MOPK 2DBGA 1WXPA 3LQRA 2YGSA 4O9LA 1FADA 2MN4A 3T6PA 2D96A 1PN5A 4O7QA 2YVIA 4I16A 4F44A 4A2QA 1NGRA 1UCPA 1Z6TA 3J6JA 2OF5A 1E3YA 4FH0A 1YGOA 4P4HA 4E9MA 4ZBWA 2NSNA 2KM6A 4QOBA 1ICHA 2A5YB 4RHWE 2LWDA 4N1JA 3YGSC 2A9IA 4A2WA 4NQKA 3QF2A 1DDFA 4JUPA 4O6XA 2MPCA 4N1KA 3YGSP 4O9FA 2G7RA 2YQFA 2L9MA 2N83A 3MOPG 4DWNA 2GF5A 2P1HA 2LS7A 4P4HI 3EZQA 2YU0A 1WH4A 2MJMA 2DBHA 3EZQB 4JQWA
chains in the Genus database with same CATH topology
4IZ5E 2MS7A 1C15A 2VGQA 2HM2Q 3J63A 2IB1A 2F1SA 2N97A 2MS8A 2N00A 2DO9A 2XV9A 4RHWA 4M9XA 2KN6A 2N7ZA 1CWWA 1DGNA 4UZ0A 4EWIA 2MB9A 2DBFA 2NAQA 1A1WA 4N1LA 4F42A 4IZAB 1WMGA 1A1ZA 2B1WA 4M9SA 1CY5A 2OF5H 3LQQA 1D2ZA 2L6AA 2DBDA 2LWEA 2M5VA 4M9ZA 2N80A 2NZ7A 1N3KA 1D2ZB 2N1FA 1E41A 2BBZA 2O71A 3KATA 2BBRA 3CRDA 3MOPA 4IZ7B 4LWDA 4D8OA 3CL3A 3MOPK 2DBGA 1WXPA 3LQRA 2YGSA 4O9LA 1FADA 2MN4A 3T6PA 2D96A 1PN5A 4O7QA 2YVIA 4I16A 4F44A 4A2QA 1NGRA 1UCPA 1Z6TA 3J6JA 2OF5A 1E3YA 4FH0A 1YGOA 4P4HA 4E9MA 4ZBWA 2NSNA 2KM6A 4QOBA 1ICHA 2A5YB 4RHWE 2LWDA 4N1JA 3YGSC 2A9IA 4A2WA 4NQKA 3QF2A 1DDFA 4JUPA 4O6XA 2MPCA 4N1KA 3YGSP 4O9FA 2G7RA 2YQFA 2L9MA 2N83A 3MOPG 4DWNA 2GF5A 2P1HA 2LS7A 4P4HI 3EZQA 2YU0A 1WH4A 2MJMA 2DBHA 3EZQB 4JQWA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4IZ5 E;  2MS7 A;  1C15 A;  2VGQ A;  2HM2 Q;  3J63 A;  2IB1 A;  2F1S A;  2N97 A;  2MS8 A;  2N00 A;  2DO9 A;  4RHW A;  4M9X A;  2KN6 A;  2N7Z A;  1CWW A;  1DGN A;  4UZ0 A;  4EWI A;  2MB9 A;  2DBF A;  2NAQ A;  1A1W A;  4N1L A;  4F42 A;  4IZA B;  1WMG A;  1A1Z A;  2B1W A;  4M9S A;  1CY5 A;  2OF5 H;  3LQQ A;  1D2Z A;  2L6A A;  2DBD A;  2LWE A;  2M5V A;  4M9Z A;  2N80 A;  2NZ7 A;  1N3K A;  1D2Z B;  2N1F A;  1E41 A;  2BBZ A;  2O71 A;  3KAT A;  2BBR A;  3CRD A;  3MOP A;  4IZ7 B;  4LWD A;  4D8O A;  3CL3 A;  3MOP K;  2DBG A;  1WXP A;  3LQR A;  2YGS A;  4O9L A;  1FAD A;  2MN4 A;  3T6P A;  2D96 A;  1PN5 A;  4O7Q A;  2YVI A;  4I16 A;  4F44 A;  4A2Q A;  1NGR A;  1UCP A;  1Z6T A;  3J6J A;  2OF5 A;  1E3Y A;  4FH0 A;  1YGO A;  4P4H A;  4E9M A;  4ZBW A;  2NSN A;  2KM6 A;  4QOB A;  1ICH A;  2A5Y B;  4RHW E;  2LWD A;  4N1J A;  3YGS C;  2A9I A;  4A2W A;  4NQK A;  3QF2 A;  1DDF A;  4JUP A;  4O6X A;  2MPC A;  4N1K A;  3YGS P;  4O9F A;  2G7R A;  2YQF A;  2L9M A;  2N83 A;  3MOP G;  4DWN A;  2GF5 A;  2P1H A;  2LS7 A;  4P4H I;  3EZQ A;  2YU0 A;  1WH4 A;  2DBH A;  3EZQ B;  4JQW A; 
#chains in the Genus database with same CATH topology
 4IZ5 E;  2MS7 A;  1C15 A;  2VGQ A;  2HM2 Q;  3J63 A;  2IB1 A;  2F1S A;  2N97 A;  2MS8 A;  2N00 A;  2DO9 A;  2XV9 A;  4RHW A;  4M9X A;  2KN6 A;  2N7Z A;  1CWW A;  1DGN A;  4UZ0 A;  4EWI A;  2MB9 A;  2DBF A;  2NAQ A;  1A1W A;  4N1L A;  4F42 A;  4IZA B;  1WMG A;  1A1Z A;  2B1W A;  4M9S A;  1CY5 A;  2OF5 H;  3LQQ A;  1D2Z A;  2L6A A;  2DBD A;  2LWE A;  2M5V A;  4M9Z A;  2N80 A;  2NZ7 A;  1N3K A;  1D2Z B;  2N1F A;  1E41 A;  2BBZ A;  2O71 A;  3KAT A;  2BBR A;  3CRD A;  3MOP A;  4IZ7 B;  4LWD A;  4D8O A;  3CL3 A;  3MOP K;  2DBG A;  1WXP A;  3LQR A;  2YGS A;  4O9L A;  1FAD A;  2MN4 A;  3T6P A;  2D96 A;  1PN5 A;  4O7Q A;  2YVI A;  4I16 A;  4F44 A;  4A2Q A;  1NGR A;  1UCP A;  1Z6T A;  3J6J A;  2OF5 A;  1E3Y A;  4FH0 A;  1YGO A;  4P4H A;  4E9M A;  4ZBW A;  2NSN A;  2KM6 A;  4QOB A;  1ICH A;  2A5Y B;  4RHW E;  2LWD A;  4N1J A;  3YGS C;  2A9I A;  4A2W A;  4NQK A;  3QF2 A;  1DDF A;  4JUP A;  4O6X A;  2MPC A;  4N1K A;  3YGS P;  4O9F A;  2G7R A;  2YQF A;  2L9M A;  2N83 A;  3MOP G;  4DWN A;  2GF5 A;  2P1H A;  2LS7 A;  4P4H I;  3EZQ A;  2YU0 A;  1WH4 A;  2MJM A;  2DBH A;  3EZQ B;  4JQW A; 
#chains in the Genus database with same CATH homology
 4IZ5 E;  2MS7 A;  1C15 A;  2VGQ A;  2HM2 Q;  3J63 A;  2IB1 A;  2F1S A;  2N97 A;  2MS8 A;  2N00 A;  2DO9 A;  2XV9 A;  4RHW A;  4M9X A;  2KN6 A;  2N7Z A;  1CWW A;  1DGN A;  4UZ0 A;  4EWI A;  2MB9 A;  2DBF A;  2NAQ A;  1A1W A;  4N1L A;  4F42 A;  4IZA B;  1WMG A;  1A1Z A;  2B1W A;  4M9S A;  1CY5 A;  2OF5 H;  3LQQ A;  1D2Z A;  2L6A A;  2DBD A;  2LWE A;  2M5V A;  4M9Z A;  2N80 A;  2NZ7 A;  1N3K A;  1D2Z B;  2N1F A;  1E41 A;  2BBZ A;  2O71 A;  3KAT A;  2BBR A;  3CRD A;  3MOP A;  4IZ7 B;  4LWD A;  4D8O A;  3CL3 A;  3MOP K;  2DBG A;  1WXP A;  3LQR A;  2YGS A;  4O9L A;  1FAD A;  2MN4 A;  3T6P A;  2D96 A;  1PN5 A;  4O7Q A;  2YVI A;  4I16 A;  4F44 A;  4A2Q A;  1NGR A;  1UCP A;  1Z6T A;  3J6J A;  2OF5 A;  1E3Y A;  4FH0 A;  1YGO A;  4P4H A;  4E9M A;  4ZBW A;  2NSN A;  2KM6 A;  4QOB A;  1ICH A;  2A5Y B;  4RHW E;  2LWD A;  4N1J A;  3YGS C;  2A9I A;  4A2W A;  4NQK A;  3QF2 A;  1DDF A;  4JUP A;  4O6X A;  2MPC A;  4N1K A;  3YGS P;  4O9F A;  2G7R A;  2YQF A;  2L9M A;  2N83 A;  3MOP G;  4DWN A;  2GF5 A;  2P1H A;  2LS7 A;  4P4H I;  3EZQ A;  2YU0 A;  1WH4 A;  2MJM A;  2DBH A;  3EZQ B;  4JQW A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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