3YGSP

Apaf-1 card in complex with prodomain of procaspase-9
Total Genus 38
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
38
sequence length
97
structure length
97
Chain Sequence
SMDEADRRLLRRCRLRLVEELQVDQLWDVLLSRELFRPHMIEDIQRAGSGSRRDQARQLIIDLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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molecule tags Apoptosis
source organism Homo sapiens
publication title Structural basis of procaspase-9 recruitment by the apoptotic protease-activating factor 1.
pubmed doi rcsb
molecule keywords APOPTOTIC PROTEASE ACTIVATING FACTOR 1
total genus 38
structure length 97
sequence length 97
ec nomenclature ec 3.4.22.62: Caspase-9.
pdb deposition date 1999-05-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
P PF00619 CARD Caspase recruitment domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.533.10 Mainly Alpha Orthogonal Bundle Death Domain, Fas Death Domain, Fas 3ygsP00
3EZQB 4JQWA 1NGRA 2N00A 2F1SA 3MOPG 4IZ5E 2MPCA 4O6XA 3MOPA 3YGSC 1Z6TA 2DBFA 1ICHA 2NAQA 1A1WA 4RHWE 4IZAB 2M5VA 2YGSA 3QF2A 4M9XA 1WH4A 3CRDA 1YGOA 4N1KA 4O9LA 1D2ZB 3KATA 1PN5A 2O71A 4E9MA 2G7RA 2MB9A 4I16A 1FADA 1E41A 4LWDA 1UCPA 1DGNA 4RHWA 1DDFA 2N80A 4UZ0A 2KM6A 1C15A 4JUPA 3CL3A 1CY5A 4N1LA 2L9MA 3EZQA 1E3YA 4O9FA 2N7ZA 2HM2Q 2A5YB 2BBRA 2LWDA 2YVIA 2L6AA 3J63A 4NQKA 4IZ7B 2N83A 3MOPK 1WXPA 1A1ZA 2IB1A 2BBZA 2N1FA 2NSNA 2MS7A 3LQRA 2DBDA 2MN4A 1N3KA 2GF5A 2DBGA 4ZBWA 4M9ZA 3LQQA 3T6PA 2P1HA 4P4HA 3YGSP 2OF5A 4P4HI 2YU0A 4F42A 2LS7A 1D2ZA 4D8OA 2LWEA 2MS8A 4N1JA 2YQFA 1CWWA 2DO9A 2B1WA 2D96A 3J6JA 4A2WA 2KN6A 4DWNA 4EWIA 4O7QA 2NZ7A 4F44A 4A2QA 2DBHA 4M9SA 2A9IA 4QOBA 2VGQA 4FH0A 2OF5H 2N97A 1WMGA
chains in the Genus database with same CATH superfamily
3EZQB 4JQWA 1NGRA 2N00A 2F1SA 3MOPG 4IZ5E 2MPCA 4O6XA 3MOPA 3YGSC 1Z6TA 2DBFA 1ICHA 2NAQA 1A1WA 4RHWE 2XV9A 4IZAB 2M5VA 2YGSA 3QF2A 4M9XA 1WH4A 3CRDA 1YGOA 4N1KA 4O9LA 1D2ZB 3KATA 1PN5A 2O71A 4E9MA 2G7RA 2MB9A 4I16A 1FADA 1E41A 4LWDA 1UCPA 1DGNA 4RHWA 1DDFA 2N80A 4UZ0A 2MJMA 2KM6A 1C15A 4JUPA 3CL3A 1CY5A 4N1LA 2L9MA 3EZQA 1E3YA 4O9FA 2N7ZA 2HM2Q 2A5YB 2BBRA 2LWDA 2YVIA 2L6AA 3J63A 4NQKA 4IZ7B 2N83A 3MOPK 1WXPA 1A1ZA 2IB1A 2BBZA 2N1FA 2NSNA 2MS7A 3LQRA 2DBDA 2MN4A 1N3KA 2GF5A 2DBGA 4ZBWA 4M9ZA 3LQQA 3T6PA 2P1HA 4P4HA 3YGSP 2OF5A 4P4HI 2YU0A 4F42A 2LS7A 1D2ZA 4D8OA 2LWEA 2MS8A 4N1JA 2YQFA 1CWWA 2DO9A 2B1WA 2D96A 3J6JA 4A2WA 2KN6A 4DWNA 4EWIA 4O7QA 2NZ7A 4F44A 4A2QA 2DBHA 4M9SA 2A9IA 4QOBA 2VGQA 4FH0A 2OF5H 2N97A 1WMGA
chains in the Genus database with same CATH topology
3EZQB 4JQWA 1NGRA 2N00A 2F1SA 3MOPG 4IZ5E 2MPCA 4O6XA 3MOPA 3YGSC 1Z6TA 2DBFA 1ICHA 2NAQA 1A1WA 4RHWE 2XV9A 4IZAB 2M5VA 2YGSA 3QF2A 4M9XA 1WH4A 3CRDA 1YGOA 4N1KA 4O9LA 1D2ZB 3KATA 1PN5A 2O71A 4E9MA 2G7RA 2MB9A 4I16A 1FADA 1E41A 4LWDA 1UCPA 1DGNA 4RHWA 1DDFA 2N80A 4UZ0A 2MJMA 2KM6A 1C15A 4JUPA 3CL3A 1CY5A 4N1LA 2L9MA 3EZQA 1E3YA 4O9FA 2N7ZA 2HM2Q 2A5YB 2BBRA 2LWDA 2YVIA 2L6AA 3J63A 4NQKA 4IZ7B 2N83A 3MOPK 1WXPA 1A1ZA 2IB1A 2BBZA 2N1FA 2NSNA 2MS7A 3LQRA 2DBDA 2MN4A 1N3KA 2GF5A 2DBGA 4ZBWA 4M9ZA 3LQQA 3T6PA 2P1HA 4P4HA 3YGSP 2OF5A 4P4HI 2YU0A 4F42A 2LS7A 1D2ZA 4D8OA 2LWEA 2MS8A 4N1JA 2YQFA 1CWWA 2DO9A 2B1WA 2D96A 3J6JA 4A2WA 2KN6A 4DWNA 4EWIA 4O7QA 2NZ7A 4F44A 4A2QA 2DBHA 4M9SA 2A9IA 4QOBA 2VGQA 4FH0A 2OF5H 2N97A 1WMGA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 3EZQ B;  4JQW A;  1NGR A;  2N00 A;  2F1S A;  3MOP G;  4IZ5 E;  2MPC A;  4O6X A;  3MOP A;  3YGS C;  1Z6T A;  2DBF A;  1ICH A;  2NAQ A;  1A1W A;  4RHW E;  4IZA B;  2M5V A;  2YGS A;  3QF2 A;  4M9X A;  1WH4 A;  3CRD A;  1YGO A;  4N1K A;  4O9L A;  1D2Z B;  3KAT A;  1PN5 A;  2O71 A;  4E9M A;  2G7R A;  2MB9 A;  4I16 A;  1FAD A;  1E41 A;  4LWD A;  1UCP A;  1DGN A;  4RHW A;  1DDF A;  2N80 A;  4UZ0 A;  2KM6 A;  1C15 A;  4JUP A;  3CL3 A;  1CY5 A;  4N1L A;  2L9M A;  3EZQ A;  1E3Y A;  4O9F A;  2N7Z A;  2HM2 Q;  2A5Y B;  2BBR A;  2LWD A;  2YVI A;  2L6A A;  3J63 A;  4NQK A;  4IZ7 B;  2N83 A;  3MOP K;  1WXP A;  1A1Z A;  2IB1 A;  2BBZ A;  2N1F A;  2NSN A;  2MS7 A;  3LQR A;  2DBD A;  2MN4 A;  1N3K A;  2GF5 A;  2DBG A;  4ZBW A;  4M9Z A;  3LQQ A;  3T6P A;  2P1H A;  4P4H A;  3YGS P;  2OF5 A;  4P4H I;  2YU0 A;  4F42 A;  2LS7 A;  1D2Z A;  4D8O A;  2LWE A;  2MS8 A;  4N1J A;  2YQF A;  1CWW A;  2DO9 A;  2B1W A;  2D96 A;  3J6J A;  4A2W A;  2KN6 A;  4DWN A;  4EWI A;  4O7Q A;  2NZ7 A;  4F44 A;  4A2Q A;  2DBH A;  4M9S A;  2A9I A;  4QOB A;  2VGQ A;  4FH0 A;  2OF5 H;  2N97 A;  1WMG A; 
#chains in the Genus database with same CATH topology
 3EZQ B;  4JQW A;  1NGR A;  2N00 A;  2F1S A;  3MOP G;  4IZ5 E;  2MPC A;  4O6X A;  3MOP A;  3YGS C;  1Z6T A;  2DBF A;  1ICH A;  2NAQ A;  1A1W A;  4RHW E;  2XV9 A;  4IZA B;  2M5V A;  2YGS A;  3QF2 A;  4M9X A;  1WH4 A;  3CRD A;  1YGO A;  4N1K A;  4O9L A;  1D2Z B;  3KAT A;  1PN5 A;  2O71 A;  4E9M A;  2G7R A;  2MB9 A;  4I16 A;  1FAD A;  1E41 A;  4LWD A;  1UCP A;  1DGN A;  4RHW A;  1DDF A;  2N80 A;  4UZ0 A;  2MJM A;  2KM6 A;  1C15 A;  4JUP A;  3CL3 A;  1CY5 A;  4N1L A;  2L9M A;  3EZQ A;  1E3Y A;  4O9F A;  2N7Z A;  2HM2 Q;  2A5Y B;  2BBR A;  2LWD A;  2YVI A;  2L6A A;  3J63 A;  4NQK A;  4IZ7 B;  2N83 A;  3MOP K;  1WXP A;  1A1Z A;  2IB1 A;  2BBZ A;  2N1F A;  2NSN A;  2MS7 A;  3LQR A;  2DBD A;  2MN4 A;  1N3K A;  2GF5 A;  2DBG A;  4ZBW A;  4M9Z A;  3LQQ A;  3T6P A;  2P1H A;  4P4H A;  3YGS P;  2OF5 A;  4P4H I;  2YU0 A;  4F42 A;  2LS7 A;  1D2Z A;  4D8O A;  2LWE A;  2MS8 A;  4N1J A;  2YQF A;  1CWW A;  2DO9 A;  2B1W A;  2D96 A;  3J6J A;  4A2W A;  2KN6 A;  4DWN A;  4EWI A;  4O7Q A;  2NZ7 A;  4F44 A;  4A2Q A;  2DBH A;  4M9S A;  2A9I A;  4QOB A;  2VGQ A;  4FH0 A;  2OF5 H;  2N97 A;  1WMG A; 
#chains in the Genus database with same CATH homology
 3EZQ B;  4JQW A;  1NGR A;  2N00 A;  2F1S A;  3MOP G;  4IZ5 E;  2MPC A;  4O6X A;  3MOP A;  3YGS C;  1Z6T A;  2DBF A;  1ICH A;  2NAQ A;  1A1W A;  4RHW E;  2XV9 A;  4IZA B;  2M5V A;  2YGS A;  3QF2 A;  4M9X A;  1WH4 A;  3CRD A;  1YGO A;  4N1K A;  4O9L A;  1D2Z B;  3KAT A;  1PN5 A;  2O71 A;  4E9M A;  2G7R A;  2MB9 A;  4I16 A;  1FAD A;  1E41 A;  4LWD A;  1UCP A;  1DGN A;  4RHW A;  1DDF A;  2N80 A;  4UZ0 A;  2MJM A;  2KM6 A;  1C15 A;  4JUP A;  3CL3 A;  1CY5 A;  4N1L A;  2L9M A;  3EZQ A;  1E3Y A;  4O9F A;  2N7Z A;  2HM2 Q;  2A5Y B;  2BBR A;  2LWD A;  2YVI A;  2L6A A;  3J63 A;  4NQK A;  4IZ7 B;  2N83 A;  3MOP K;  1WXP A;  1A1Z A;  2IB1 A;  2BBZ A;  2N1F A;  2NSN A;  2MS7 A;  3LQR A;  2DBD A;  2MN4 A;  1N3K A;  2GF5 A;  2DBG A;  4ZBW A;  4M9Z A;  3LQQ A;  3T6P A;  2P1H A;  4P4H A;  3YGS P;  2OF5 A;  4P4H I;  2YU0 A;  4F42 A;  2LS7 A;  1D2Z A;  4D8O A;  2LWE A;  2MS8 A;  4N1J A;  2YQF A;  1CWW A;  2DO9 A;  2B1W A;  2D96 A;  3J6J A;  4A2W A;  2KN6 A;  4DWN A;  4EWI A;  4O7Q A;  2NZ7 A;  4F44 A;  4A2Q A;  2DBH A;  4M9S A;  2A9I A;  4QOB A;  2VGQ A;  4FH0 A;  2OF5 H;  2N97 A;  1WMG A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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