3YGSP

Apaf-1 card in complex with prodomain of procaspase-9
Total Genus 38
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
38
sequence length
97
structure length
97
Chain Sequence
SMDEADRRLLRRCRLRLVEELQVDQLWDVLLSRELFRPHMIEDIQRAGSGSRRDQARQLIIDLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Structural basis of procaspase-9 recruitment by the apoptotic protease-activating factor 1.
pubmed doi rcsb
molecule tags Apoptosis
source organism Homo sapiens
molecule keywords APOPTOTIC PROTEASE ACTIVATING FACTOR 1
total genus 38
structure length 97
sequence length 97
ec nomenclature ec 3.4.22.62: Caspase-9.
pdb deposition date 1999-05-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
P PF00619 CARD Caspase recruitment domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.533.10 Mainly Alpha Orthogonal Bundle Death Domain, Fas Death Domain, Fas 3ygsP00
2IB1A 1UCPA 2MPCA 1ICHA 4EWIA 4M9ZA 2YGSA 2MB9A 3LQRA 2P1HA 4IZ5E 2MN4A 4O9FA 3T6PA 4I16A 2G7RA 3CRDA 1CY5A 4F44A 1D2ZA 3EZQA 3YGSP 2KM6A 2HM2Q 2N7ZA 1DDFA 2OF5H 2LWEA 4F42A 1N3KA 4A2QA 2GF5A 2NAQA 1WMGA 2YQFA 4RHWA 1D2ZB 3EZQB 4O6XA 2M5VA 2NSNA 4QOBA 2A5YB 4P4HA 4M9SA 1CWWA 3MOPA 2N00A 2YVIA 4N1KA 3J63A 4FH0A 2N80A 2LWDA 3QF2A 3J6JA 4M9XA 2DBHA 4A2WA 4E9MA 2O71A 1A1ZA 1WH4A 2F1SA 2DBFA 2N83A 3CL3A 2DBGA 2A9IA 3MOPK 2L6AA 2N97A 4RHWE 2DBDA 1E41A 4LWDA 2LS7A 4O9LA 1NGRA 1YGOA 1DGNA 4D8OA 4UZ0A 2NZ7A 3YGSC 1WXPA 1Z6TA 4JUPA 1FADA 4N1JA 4IZAB 4DWNA 2L9MA 2D96A 3KATA 2B1WA 2MS7A 1C15A 4NQKA 1PN5A 4IZ7B 4O7QA 2MS8A 1E3YA 2BBZA 3LQQA 3MOPG 4N1LA 2N1FA 4ZBWA 2BBRA 2YU0A 2DO9A 1A1WA 4P4HI 2KN6A 2OF5A 4JQWA 2VGQA
chains in the Genus database with same CATH superfamily
2IB1A 1UCPA 2MPCA 1ICHA 4EWIA 4M9ZA 2YGSA 2MB9A 3LQRA 2P1HA 2XV9A 4IZ5E 2MN4A 4O9FA 3T6PA 4I16A 2G7RA 3CRDA 1CY5A 4F44A 1D2ZA 3EZQA 3YGSP 2KM6A 2HM2Q 2N7ZA 1DDFA 2OF5H 2LWEA 4F42A 1N3KA 4A2QA 2GF5A 2NAQA 1WMGA 2YQFA 4RHWA 1D2ZB 3EZQB 4O6XA 2M5VA 2NSNA 4QOBA 2A5YB 4P4HA 4M9SA 1CWWA 3MOPA 2MJMA 2N00A 2YVIA 4N1KA 3J63A 4FH0A 2N80A 2LWDA 3QF2A 3J6JA 4M9XA 2DBHA 4A2WA 4E9MA 2O71A 1A1ZA 1WH4A 2F1SA 2DBFA 2N83A 3CL3A 2DBGA 2A9IA 3MOPK 2L6AA 2N97A 4RHWE 2DBDA 1E41A 4LWDA 2LS7A 4O9LA 1NGRA 1YGOA 1DGNA 4D8OA 4UZ0A 2NZ7A 3YGSC 1WXPA 1Z6TA 4JUPA 1FADA 4N1JA 4IZAB 4DWNA 2L9MA 2D96A 3KATA 2B1WA 2MS7A 1C15A 4NQKA 1PN5A 4IZ7B 4O7QA 2MS8A 1E3YA 2BBZA 3LQQA 3MOPG 4N1LA 2N1FA 4ZBWA 2BBRA 2YU0A 2DO9A 1A1WA 4P4HI 2KN6A 2OF5A 4JQWA 2VGQA
chains in the Genus database with same CATH topology
2IB1A 1UCPA 2MPCA 1ICHA 4EWIA 4M9ZA 2YGSA 2MB9A 3LQRA 2P1HA 2XV9A 4IZ5E 2MN4A 4O9FA 3T6PA 4I16A 2G7RA 3CRDA 1CY5A 4F44A 1D2ZA 3EZQA 3YGSP 2KM6A 2HM2Q 2N7ZA 1DDFA 2OF5H 2LWEA 4F42A 1N3KA 4A2QA 2GF5A 2NAQA 1WMGA 2YQFA 4RHWA 1D2ZB 3EZQB 4O6XA 2M5VA 2NSNA 4QOBA 2A5YB 4P4HA 4M9SA 1CWWA 3MOPA 2MJMA 2N00A 2YVIA 4N1KA 3J63A 4FH0A 2N80A 2LWDA 3QF2A 3J6JA 4M9XA 2DBHA 4A2WA 4E9MA 2O71A 1A1ZA 1WH4A 2F1SA 2DBFA 2N83A 3CL3A 2DBGA 2A9IA 3MOPK 2L6AA 2N97A 4RHWE 2DBDA 1E41A 4LWDA 2LS7A 4O9LA 1NGRA 1YGOA 1DGNA 4D8OA 4UZ0A 2NZ7A 3YGSC 1WXPA 1Z6TA 4JUPA 1FADA 4N1JA 4IZAB 4DWNA 2L9MA 2D96A 3KATA 2B1WA 2MS7A 1C15A 4NQKA 1PN5A 4IZ7B 4O7QA 2MS8A 1E3YA 2BBZA 3LQQA 3MOPG 4N1LA 2N1FA 4ZBWA 2BBRA 2YU0A 2DO9A 1A1WA 4P4HI 2KN6A 2OF5A 4JQWA 2VGQA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 2IB1 A;  1UCP A;  2MPC A;  1ICH A;  4EWI A;  4M9Z A;  2YGS A;  2MB9 A;  3LQR A;  2P1H A;  4IZ5 E;  2MN4 A;  4O9F A;  3T6P A;  4I16 A;  2G7R A;  3CRD A;  1CY5 A;  4F44 A;  1D2Z A;  3EZQ A;  3YGS P;  2KM6 A;  2HM2 Q;  2N7Z A;  1DDF A;  2OF5 H;  2LWE A;  4F42 A;  1N3K A;  4A2Q A;  2GF5 A;  2NAQ A;  1WMG A;  2YQF A;  4RHW A;  1D2Z B;  3EZQ B;  4O6X A;  2M5V A;  2NSN A;  4QOB A;  2A5Y B;  4P4H A;  4M9S A;  1CWW A;  3MOP A;  2N00 A;  2YVI A;  4N1K A;  3J63 A;  4FH0 A;  2N80 A;  2LWD A;  3QF2 A;  3J6J A;  4M9X A;  2DBH A;  4A2W A;  4E9M A;  2O71 A;  1A1Z A;  1WH4 A;  2F1S A;  2DBF A;  2N83 A;  3CL3 A;  2DBG A;  2A9I A;  3MOP K;  2L6A A;  2N97 A;  4RHW E;  2DBD A;  1E41 A;  4LWD A;  2LS7 A;  4O9L A;  1NGR A;  1YGO A;  1DGN A;  4D8O A;  4UZ0 A;  2NZ7 A;  3YGS C;  1WXP A;  1Z6T A;  4JUP A;  1FAD A;  4N1J A;  4IZA B;  4DWN A;  2L9M A;  2D96 A;  3KAT A;  2B1W A;  2MS7 A;  1C15 A;  4NQK A;  1PN5 A;  4IZ7 B;  4O7Q A;  2MS8 A;  1E3Y A;  2BBZ A;  3LQQ A;  3MOP G;  4N1L A;  2N1F A;  4ZBW A;  2BBR A;  2YU0 A;  2DO9 A;  1A1W A;  4P4H I;  2KN6 A;  2OF5 A;  4JQW A;  2VGQ A; 
#chains in the Genus database with same CATH topology
 2IB1 A;  1UCP A;  2MPC A;  1ICH A;  4EWI A;  4M9Z A;  2YGS A;  2MB9 A;  3LQR A;  2P1H A;  2XV9 A;  4IZ5 E;  2MN4 A;  4O9F A;  3T6P A;  4I16 A;  2G7R A;  3CRD A;  1CY5 A;  4F44 A;  1D2Z A;  3EZQ A;  3YGS P;  2KM6 A;  2HM2 Q;  2N7Z A;  1DDF A;  2OF5 H;  2LWE A;  4F42 A;  1N3K A;  4A2Q A;  2GF5 A;  2NAQ A;  1WMG A;  2YQF A;  4RHW A;  1D2Z B;  3EZQ B;  4O6X A;  2M5V A;  2NSN A;  4QOB A;  2A5Y B;  4P4H A;  4M9S A;  1CWW A;  3MOP A;  2MJM A;  2N00 A;  2YVI A;  4N1K A;  3J63 A;  4FH0 A;  2N80 A;  2LWD A;  3QF2 A;  3J6J A;  4M9X A;  2DBH A;  4A2W A;  4E9M A;  2O71 A;  1A1Z A;  1WH4 A;  2F1S A;  2DBF A;  2N83 A;  3CL3 A;  2DBG A;  2A9I A;  3MOP K;  2L6A A;  2N97 A;  4RHW E;  2DBD A;  1E41 A;  4LWD A;  2LS7 A;  4O9L A;  1NGR A;  1YGO A;  1DGN A;  4D8O A;  4UZ0 A;  2NZ7 A;  3YGS C;  1WXP A;  1Z6T A;  4JUP A;  1FAD A;  4N1J A;  4IZA B;  4DWN A;  2L9M A;  2D96 A;  3KAT A;  2B1W A;  2MS7 A;  1C15 A;  4NQK A;  1PN5 A;  4IZ7 B;  4O7Q A;  2MS8 A;  1E3Y A;  2BBZ A;  3LQQ A;  3MOP G;  4N1L A;  2N1F A;  4ZBW A;  2BBR A;  2YU0 A;  2DO9 A;  1A1W A;  4P4H I;  2KN6 A;  2OF5 A;  4JQW A;  2VGQ A; 
#chains in the Genus database with same CATH homology
 2IB1 A;  1UCP A;  2MPC A;  1ICH A;  4EWI A;  4M9Z A;  2YGS A;  2MB9 A;  3LQR A;  2P1H A;  2XV9 A;  4IZ5 E;  2MN4 A;  4O9F A;  3T6P A;  4I16 A;  2G7R A;  3CRD A;  1CY5 A;  4F44 A;  1D2Z A;  3EZQ A;  3YGS P;  2KM6 A;  2HM2 Q;  2N7Z A;  1DDF A;  2OF5 H;  2LWE A;  4F42 A;  1N3K A;  4A2Q A;  2GF5 A;  2NAQ A;  1WMG A;  2YQF A;  4RHW A;  1D2Z B;  3EZQ B;  4O6X A;  2M5V A;  2NSN A;  4QOB A;  2A5Y B;  4P4H A;  4M9S A;  1CWW A;  3MOP A;  2MJM A;  2N00 A;  2YVI A;  4N1K A;  3J63 A;  4FH0 A;  2N80 A;  2LWD A;  3QF2 A;  3J6J A;  4M9X A;  2DBH A;  4A2W A;  4E9M A;  2O71 A;  1A1Z A;  1WH4 A;  2F1S A;  2DBF A;  2N83 A;  3CL3 A;  2DBG A;  2A9I A;  3MOP K;  2L6A A;  2N97 A;  4RHW E;  2DBD A;  1E41 A;  4LWD A;  2LS7 A;  4O9L A;  1NGR A;  1YGO A;  1DGN A;  4D8O A;  4UZ0 A;  2NZ7 A;  3YGS C;  1WXP A;  1Z6T A;  4JUP A;  1FAD A;  4N1J A;  4IZA B;  4DWN A;  2L9M A;  2D96 A;  3KAT A;  2B1W A;  2MS7 A;  1C15 A;  4NQK A;  1PN5 A;  4IZ7 B;  4O7Q A;  2MS8 A;  1E3Y A;  2BBZ A;  3LQQ A;  3MOP G;  4N1L A;  2N1F A;  4ZBW A;  2BBR A;  2YU0 A;  2DO9 A;  1A1W A;  4P4H I;  2KN6 A;  2OF5 A;  4JQW A;  2VGQ A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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