3YGSP

Apaf-1 card in complex with prodomain of procaspase-9
Total Genus 38
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
38
sequence length
97
structure length
97
Chain Sequence
SMDEADRRLLRRCRLRLVEELQVDQLWDVLLSRELFRPHMIEDIQRAGSGSRRDQARQLIIDLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Structural basis of procaspase-9 recruitment by the apoptotic protease-activating factor 1.
pubmed doi rcsb
molecule keywords APOPTOTIC PROTEASE ACTIVATING FACTOR 1
molecule tags Apoptosis
source organism Homo sapiens
total genus 38
structure length 97
sequence length 97
ec nomenclature ec 3.4.22.62: Caspase-9.
pdb deposition date 1999-05-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
P PF00619 CARD Caspase recruitment domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.533.10 Mainly Alpha Orthogonal Bundle Death Domain, Fas Death Domain, Fas 3ygsP00
2N97A 2MPCA 2DBGA 3LQQA 1E3YA 2OF5H 2LWEA 4N1JA 3EZQA 2MS7A 3KATA 4P4HI 2LWDA 3J63A 2O71A 3T6PA 1Z6TA 2NSNA 3MOPA 2MN4A 2KM6A 4JQWA 2DO9A 4RHWE 2MS8A 4N1LA 1WMGA 1DGNA 4F44A 2MB9A 2LS7A 2YQFA 3CRDA 2P1HA 3LQRA 2F1SA 2L9MA 4IZAB 2BBRA 4QOBA 2NAQA 4DWNA 2N1FA 3MOPG 2M5VA 2IB1A 4IZ5E 1WXPA 4EWIA 2GF5A 4ZBWA 3YGSP 2YVIA 1WH4A 4FH0A 4N1KA 4F42A 2DBDA 2D96A 1NGRA 4O9FA 4M9ZA 2OF5A 2BBZA 1A1ZA 2A5YB 4M9SA 2VGQA 4IZ7B 4LWDA 2YGSA 2B1WA 4P4HA 4O7QA 2DBHA 1CY5A 4E9MA 4RHWA 3YGSC 1C15A 2DBFA 2NZ7A 4O6XA 1CWWA 1YGOA 1D2ZB 4A2WA 2L6AA 2N00A 2A9IA 2N80A 2N7ZA 3QF2A 4I16A 1PN5A 4NQKA 1N3KA 3EZQB 4O9LA 2KN6A 1A1WA 2HM2Q 4M9XA 1FADA 4UZ0A 1UCPA 2N83A 4JUPA 4D8OA 2YU0A 3J6JA 3MOPK 1DDFA 2G7RA 1D2ZA 1ICHA 3CL3A 4A2QA 1E41A
chains in the Genus database with same CATH superfamily
2N97A 2MPCA 2DBGA 3LQQA 1E3YA 2OF5H 2LWEA 4N1JA 3EZQA 2MS7A 3KATA 4P4HI 2LWDA 3J63A 2O71A 3T6PA 1Z6TA 2NSNA 3MOPA 2MN4A 2KM6A 4JQWA 2DO9A 4RHWE 2MS8A 4N1LA 1WMGA 1DGNA 4F44A 2MB9A 2LS7A 2YQFA 3CRDA 2P1HA 3LQRA 2F1SA 2L9MA 4IZAB 2BBRA 4QOBA 2NAQA 4DWNA 2N1FA 3MOPG 2MJMA 2M5VA 2IB1A 4IZ5E 1WXPA 4EWIA 2GF5A 4ZBWA 3YGSP 2YVIA 1WH4A 4FH0A 4N1KA 4F42A 2DBDA 2D96A 1NGRA 4O9FA 4M9ZA 2OF5A 2BBZA 1A1ZA 2A5YB 4M9SA 2VGQA 4IZ7B 4LWDA 2YGSA 2B1WA 4P4HA 4O7QA 2DBHA 1CY5A 4E9MA 4RHWA 3YGSC 2XV9A 1C15A 2DBFA 2NZ7A 4O6XA 1CWWA 1YGOA 1D2ZB 4A2WA 2L6AA 2N00A 2A9IA 2N80A 2N7ZA 3QF2A 4I16A 1PN5A 4NQKA 1N3KA 3EZQB 4O9LA 2KN6A 1A1WA 2HM2Q 4M9XA 1FADA 4UZ0A 1UCPA 2N83A 4JUPA 4D8OA 3J6JA 2YU0A 3MOPK 1DDFA 2G7RA 1D2ZA 1ICHA 3CL3A 4A2QA 1E41A
chains in the Genus database with same CATH topology
2N97A 2MPCA 2DBGA 3LQQA 1E3YA 2OF5H 2LWEA 4N1JA 3EZQA 2MS7A 3KATA 4P4HI 2LWDA 3J63A 2O71A 3T6PA 1Z6TA 2NSNA 3MOPA 2MN4A 2KM6A 4JQWA 2DO9A 4RHWE 2MS8A 4N1LA 1WMGA 1DGNA 4F44A 2MB9A 2LS7A 2YQFA 3CRDA 2P1HA 3LQRA 2F1SA 2L9MA 4IZAB 2BBRA 4QOBA 2NAQA 4DWNA 2N1FA 3MOPG 2MJMA 2M5VA 2IB1A 4IZ5E 1WXPA 4EWIA 2GF5A 4ZBWA 3YGSP 2YVIA 1WH4A 4FH0A 4N1KA 4F42A 2DBDA 2D96A 1NGRA 4O9FA 4M9ZA 2OF5A 2BBZA 1A1ZA 2A5YB 4M9SA 2VGQA 4IZ7B 4LWDA 2YGSA 2B1WA 4P4HA 4O7QA 2DBHA 1CY5A 4E9MA 4RHWA 3YGSC 2XV9A 1C15A 2DBFA 2NZ7A 4O6XA 1CWWA 1YGOA 1D2ZB 4A2WA 2L6AA 2N00A 2A9IA 2N80A 2N7ZA 3QF2A 4I16A 1PN5A 4NQKA 1N3KA 3EZQB 4O9LA 2KN6A 1A1WA 2HM2Q 4M9XA 1FADA 4UZ0A 1UCPA 2N83A 4JUPA 4D8OA 3J6JA 2YU0A 3MOPK 1DDFA 2G7RA 1D2ZA 1ICHA 3CL3A 4A2QA 1E41A
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 2N97 A;  2MPC A;  2DBG A;  3LQQ A;  1E3Y A;  2OF5 H;  2LWE A;  4N1J A;  3EZQ A;  2MS7 A;  3KAT A;  4P4H I;  2LWD A;  3J63 A;  2O71 A;  3T6P A;  1Z6T A;  2NSN A;  3MOP A;  2MN4 A;  2KM6 A;  4JQW A;  2DO9 A;  4RHW E;  2MS8 A;  4N1L A;  1WMG A;  1DGN A;  4F44 A;  2MB9 A;  2LS7 A;  2YQF A;  3CRD A;  2P1H A;  3LQR A;  2F1S A;  2L9M A;  4IZA B;  2BBR A;  4QOB A;  2NAQ A;  4DWN A;  2N1F A;  3MOP G;  2M5V A;  2IB1 A;  4IZ5 E;  1WXP A;  4EWI A;  2GF5 A;  4ZBW A;  3YGS P;  2YVI A;  1WH4 A;  4FH0 A;  4N1K A;  4F42 A;  2DBD A;  2D96 A;  1NGR A;  4O9F A;  4M9Z A;  2OF5 A;  2BBZ A;  1A1Z A;  2A5Y B;  4M9S A;  2VGQ A;  4IZ7 B;  4LWD A;  2YGS A;  2B1W A;  4P4H A;  4O7Q A;  2DBH A;  1CY5 A;  4E9M A;  4RHW A;  3YGS C;  1C15 A;  2DBF A;  2NZ7 A;  4O6X A;  1CWW A;  1YGO A;  1D2Z B;  4A2W A;  2L6A A;  2N00 A;  2A9I A;  2N80 A;  2N7Z A;  3QF2 A;  4I16 A;  1PN5 A;  4NQK A;  1N3K A;  3EZQ B;  4O9L A;  2KN6 A;  1A1W A;  2HM2 Q;  4M9X A;  1FAD A;  4UZ0 A;  1UCP A;  2N83 A;  4JUP A;  4D8O A;  2YU0 A;  3J6J A;  3MOP K;  1DDF A;  2G7R A;  1D2Z A;  1ICH A;  3CL3 A;  4A2Q A;  1E41 A; 
#chains in the Genus database with same CATH topology
 2N97 A;  2MPC A;  2DBG A;  3LQQ A;  1E3Y A;  2OF5 H;  2LWE A;  4N1J A;  3EZQ A;  2MS7 A;  3KAT A;  4P4H I;  2LWD A;  3J63 A;  2O71 A;  3T6P A;  1Z6T A;  2NSN A;  3MOP A;  2MN4 A;  2KM6 A;  4JQW A;  2DO9 A;  4RHW E;  2MS8 A;  4N1L A;  1WMG A;  1DGN A;  4F44 A;  2MB9 A;  2LS7 A;  2YQF A;  3CRD A;  2P1H A;  3LQR A;  2F1S A;  2L9M A;  4IZA B;  2BBR A;  4QOB A;  2NAQ A;  4DWN A;  2N1F A;  3MOP G;  2MJM A;  2M5V A;  2IB1 A;  4IZ5 E;  1WXP A;  4EWI A;  2GF5 A;  4ZBW A;  3YGS P;  2YVI A;  1WH4 A;  4FH0 A;  4N1K A;  4F42 A;  2DBD A;  2D96 A;  1NGR A;  4O9F A;  4M9Z A;  2OF5 A;  2BBZ A;  1A1Z A;  2A5Y B;  4M9S A;  2VGQ A;  4IZ7 B;  4LWD A;  2YGS A;  2B1W A;  4P4H A;  4O7Q A;  2DBH A;  1CY5 A;  4E9M A;  4RHW A;  3YGS C;  2XV9 A;  1C15 A;  2DBF A;  2NZ7 A;  4O6X A;  1CWW A;  1YGO A;  1D2Z B;  4A2W A;  2L6A A;  2N00 A;  2A9I A;  2N80 A;  2N7Z A;  3QF2 A;  4I16 A;  1PN5 A;  4NQK A;  1N3K A;  3EZQ B;  4O9L A;  2KN6 A;  1A1W A;  2HM2 Q;  4M9X A;  1FAD A;  4UZ0 A;  1UCP A;  2N83 A;  4JUP A;  4D8O A;  3J6J A;  2YU0 A;  3MOP K;  1DDF A;  2G7R A;  1D2Z A;  1ICH A;  3CL3 A;  4A2Q A;  1E41 A; 
#chains in the Genus database with same CATH homology
 2N97 A;  2MPC A;  2DBG A;  3LQQ A;  1E3Y A;  2OF5 H;  2LWE A;  4N1J A;  3EZQ A;  2MS7 A;  3KAT A;  4P4H I;  2LWD A;  3J63 A;  2O71 A;  3T6P A;  1Z6T A;  2NSN A;  3MOP A;  2MN4 A;  2KM6 A;  4JQW A;  2DO9 A;  4RHW E;  2MS8 A;  4N1L A;  1WMG A;  1DGN A;  4F44 A;  2MB9 A;  2LS7 A;  2YQF A;  3CRD A;  2P1H A;  3LQR A;  2F1S A;  2L9M A;  4IZA B;  2BBR A;  4QOB A;  2NAQ A;  4DWN A;  2N1F A;  3MOP G;  2MJM A;  2M5V A;  2IB1 A;  4IZ5 E;  1WXP A;  4EWI A;  2GF5 A;  4ZBW A;  3YGS P;  2YVI A;  1WH4 A;  4FH0 A;  4N1K A;  4F42 A;  2DBD A;  2D96 A;  1NGR A;  4O9F A;  4M9Z A;  2OF5 A;  2BBZ A;  1A1Z A;  2A5Y B;  4M9S A;  2VGQ A;  4IZ7 B;  4LWD A;  2YGS A;  2B1W A;  4P4H A;  4O7Q A;  2DBH A;  1CY5 A;  4E9M A;  4RHW A;  3YGS C;  2XV9 A;  1C15 A;  2DBF A;  2NZ7 A;  4O6X A;  1CWW A;  1YGO A;  1D2Z B;  4A2W A;  2L6A A;  2N00 A;  2A9I A;  2N80 A;  2N7Z A;  3QF2 A;  4I16 A;  1PN5 A;  4NQK A;  1N3K A;  3EZQ B;  4O9L A;  2KN6 A;  1A1W A;  2HM2 Q;  4M9X A;  1FAD A;  4UZ0 A;  1UCP A;  2N83 A;  4JUP A;  4D8O A;  3J6J A;  2YU0 A;  3MOP K;  1DDF A;  2G7R A;  1D2Z A;  1ICH A;  3CL3 A;  4A2Q A;  1E41 A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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