4IZ5E

Structure of the complex between erk2 phosphomimetic mutant and pea-15
Total Genus 25
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
25
sequence length
127
structure length
86
Chain Sequence
MAEYGTLLQDLTNNITLEDLEQLKSACKEDEEITTGSAWFSFLESHNKLDKDNLSYIEHIFEISRRPDLLTMVVDYRTRVKLAPPP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Structure of ERK2 bound to PEA-15 reveals a mechanism for rapid release of activated MAPK.
pubmed doi rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords Mitogen-activated protein kinase 1
total genus 25
structure length 86
sequence length 127
chains with identical sequence F, G, H
ec nomenclature
pdb deposition date 2013-01-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
E PF01335 DED Death effector domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.533.10 Mainly Alpha Orthogonal Bundle Death Domain, Fas Death Domain, Fas 4iz5E00
1PN5A 3EZQA 3YGSP 4O9LA 2DBFA 1ICHA 2KN6A 2DO9A 4A2QA 1D2ZA 1C15A 2N83A 4N1KA 3MOPK 1WXPA 3J63A 3CRDA 4RHWA 2B1WA 1WH4A 4RHWE 4M9SA 4IZ7B 4M9ZA 4I16A 2MS8A 2NAQA 2L9MA 1UCPA 4IZAB 2NSNA 2O71A 4P4HI 2MS7A 3LQQA 2N00A 3QF2A 2KM6A 4N1LA 3KATA 2D96A 2HM2Q 4N1JA 4F44A 1DDFA 2LWEA 1N3KA 2F1SA 4LWDA 4FH0A 3CL3A 2VGQA 4IZ5E 2BBZA 3LQRA 2LWDA 4O7QA 2P1HA 4E9MA 2OF5A 2MN4A 2G7RA 2YVIA 3MOPA 3MOPG 1FADA 3T6PA 2LS7A 2A9IA 2OF5H 2MPCA 4A2WA 2YQFA 4P4HA 2N97A 1A1ZA 2N7ZA 2GF5A 4QOBA 3EZQB 3YGSC 2IB1A 1WMGA 1DGNA 2DBGA 1Z6TA 2DBHA 4M9XA 2NZ7A 4ZBWA 1CWWA 2M5VA 3J6JA 4O6XA 1NGRA 4DWNA 2YU0A 2DBDA 4UZ0A 4JQWA 4EWIA 4D8OA 4JUPA 2L6AA 2YGSA 2N80A 1E3YA 4O9FA 4F42A 2A5YB 1CY5A 2MB9A 1E41A 1YGOA 2N1FA 4NQKA 1A1WA 1D2ZB 2BBRA
chains in the Genus database with same CATH superfamily
1PN5A 3EZQA 3YGSP 4O9LA 2DBFA 1ICHA 2KN6A 2DO9A 4A2QA 1D2ZA 1C15A 2N83A 4N1KA 2MJMA 3MOPK 1WXPA 3J63A 3CRDA 4RHWA 2B1WA 1WH4A 4RHWE 4M9SA 4IZ7B 4M9ZA 4I16A 2MS8A 2NAQA 2L9MA 1UCPA 4IZAB 2NSNA 2O71A 4P4HI 2MS7A 3LQQA 2N00A 3QF2A 2KM6A 4N1LA 3KATA 2D96A 2HM2Q 4N1JA 4F44A 1DDFA 2LWEA 1N3KA 2F1SA 4LWDA 4FH0A 3CL3A 2VGQA 4IZ5E 2BBZA 3LQRA 2LWDA 4O7QA 2P1HA 4E9MA 2OF5A 2MN4A 2G7RA 2YVIA 3MOPA 3MOPG 1FADA 3T6PA 2LS7A 2A9IA 2OF5H 2MPCA 4A2WA 2YQFA 4P4HA 2N97A 1A1ZA 2N7ZA 2GF5A 4QOBA 3EZQB 3YGSC 2IB1A 1WMGA 1DGNA 2DBGA 1Z6TA 2DBHA 4M9XA 2NZ7A 4ZBWA 1CWWA 2M5VA 3J6JA 4O6XA 1NGRA 4DWNA 2YU0A 2DBDA 4UZ0A 4JQWA 4EWIA 4D8OA 4JUPA 2L6AA 2YGSA 2N80A 1E3YA 4O9FA 4F42A 2XV9A 2A5YB 1CY5A 2MB9A 1E41A 1YGOA 2N1FA 4NQKA 1A1WA 1D2ZB 2BBRA
chains in the Genus database with same CATH topology
1PN5A 3EZQA 3YGSP 4O9LA 2DBFA 1ICHA 2KN6A 2DO9A 4A2QA 1D2ZA 1C15A 2N83A 4N1KA 2MJMA 3MOPK 1WXPA 3J63A 3CRDA 4RHWA 2B1WA 1WH4A 4RHWE 4M9SA 4IZ7B 4M9ZA 4I16A 2MS8A 2NAQA 2L9MA 1UCPA 4IZAB 2NSNA 2O71A 4P4HI 2MS7A 3LQQA 2N00A 3QF2A 2KM6A 4N1LA 3KATA 2D96A 2HM2Q 4N1JA 4F44A 1DDFA 2LWEA 1N3KA 2F1SA 4LWDA 4FH0A 3CL3A 2VGQA 4IZ5E 2BBZA 3LQRA 2LWDA 4O7QA 2P1HA 4E9MA 2OF5A 2MN4A 2G7RA 2YVIA 3MOPA 3MOPG 1FADA 3T6PA 2LS7A 2A9IA 2OF5H 2MPCA 4A2WA 2YQFA 4P4HA 2N97A 1A1ZA 2N7ZA 2GF5A 4QOBA 3EZQB 3YGSC 2IB1A 1WMGA 1DGNA 2DBGA 1Z6TA 2DBHA 4M9XA 2NZ7A 4ZBWA 1CWWA 2M5VA 3J6JA 4O6XA 1NGRA 4DWNA 2YU0A 2DBDA 4UZ0A 4JQWA 4EWIA 4D8OA 4JUPA 2L6AA 2YGSA 2N80A 1E3YA 4O9FA 4F42A 2XV9A 2A5YB 1CY5A 2MB9A 1E41A 1YGOA 2N1FA 4NQKA 1A1WA 1D2ZB 2BBRA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 1PN5 A;  3EZQ A;  3YGS P;  4O9L A;  2DBF A;  1ICH A;  2KN6 A;  2DO9 A;  4A2Q A;  1D2Z A;  1C15 A;  2N83 A;  4N1K A;  3MOP K;  1WXP A;  3J63 A;  3CRD A;  4RHW A;  2B1W A;  1WH4 A;  4RHW E;  4M9S A;  4IZ7 B;  4M9Z A;  4I16 A;  2MS8 A;  2NAQ A;  2L9M A;  1UCP A;  4IZA B;  2NSN A;  2O71 A;  4P4H I;  2MS7 A;  3LQQ A;  2N00 A;  3QF2 A;  2KM6 A;  4N1L A;  3KAT A;  2D96 A;  2HM2 Q;  4N1J A;  4F44 A;  1DDF A;  2LWE A;  1N3K A;  2F1S A;  4LWD A;  4FH0 A;  3CL3 A;  2VGQ A;  4IZ5 E;  2BBZ A;  3LQR A;  2LWD A;  4O7Q A;  2P1H A;  4E9M A;  2OF5 A;  2MN4 A;  2G7R A;  2YVI A;  3MOP A;  3MOP G;  1FAD A;  3T6P A;  2LS7 A;  2A9I A;  2OF5 H;  2MPC A;  4A2W A;  2YQF A;  4P4H A;  2N97 A;  1A1Z A;  2N7Z A;  2GF5 A;  4QOB A;  3EZQ B;  3YGS C;  2IB1 A;  1WMG A;  1DGN A;  2DBG A;  1Z6T A;  2DBH A;  4M9X A;  2NZ7 A;  4ZBW A;  1CWW A;  2M5V A;  3J6J A;  4O6X A;  1NGR A;  4DWN A;  2YU0 A;  2DBD A;  4UZ0 A;  4JQW A;  4EWI A;  4D8O A;  4JUP A;  2L6A A;  2YGS A;  2N80 A;  1E3Y A;  4O9F A;  4F42 A;  2A5Y B;  1CY5 A;  2MB9 A;  1E41 A;  1YGO A;  2N1F A;  4NQK A;  1A1W A;  1D2Z B;  2BBR A; 
#chains in the Genus database with same CATH topology
 1PN5 A;  3EZQ A;  3YGS P;  4O9L A;  2DBF A;  1ICH A;  2KN6 A;  2DO9 A;  4A2Q A;  1D2Z A;  1C15 A;  2N83 A;  4N1K A;  2MJM A;  3MOP K;  1WXP A;  3J63 A;  3CRD A;  4RHW A;  2B1W A;  1WH4 A;  4RHW E;  4M9S A;  4IZ7 B;  4M9Z A;  4I16 A;  2MS8 A;  2NAQ A;  2L9M A;  1UCP A;  4IZA B;  2NSN A;  2O71 A;  4P4H I;  2MS7 A;  3LQQ A;  2N00 A;  3QF2 A;  2KM6 A;  4N1L A;  3KAT A;  2D96 A;  2HM2 Q;  4N1J A;  4F44 A;  1DDF A;  2LWE A;  1N3K A;  2F1S A;  4LWD A;  4FH0 A;  3CL3 A;  2VGQ A;  4IZ5 E;  2BBZ A;  3LQR A;  2LWD A;  4O7Q A;  2P1H A;  4E9M A;  2OF5 A;  2MN4 A;  2G7R A;  2YVI A;  3MOP A;  3MOP G;  1FAD A;  3T6P A;  2LS7 A;  2A9I A;  2OF5 H;  2MPC A;  4A2W A;  2YQF A;  4P4H A;  2N97 A;  1A1Z A;  2N7Z A;  2GF5 A;  4QOB A;  3EZQ B;  3YGS C;  2IB1 A;  1WMG A;  1DGN A;  2DBG A;  1Z6T A;  2DBH A;  4M9X A;  2NZ7 A;  4ZBW A;  1CWW A;  2M5V A;  3J6J A;  4O6X A;  1NGR A;  4DWN A;  2YU0 A;  2DBD A;  4UZ0 A;  4JQW A;  4EWI A;  4D8O A;  4JUP A;  2L6A A;  2YGS A;  2N80 A;  1E3Y A;  4O9F A;  4F42 A;  2XV9 A;  2A5Y B;  1CY5 A;  2MB9 A;  1E41 A;  1YGO A;  2N1F A;  4NQK A;  1A1W A;  1D2Z B;  2BBR A; 
#chains in the Genus database with same CATH homology
 1PN5 A;  3EZQ A;  3YGS P;  4O9L A;  2DBF A;  1ICH A;  2KN6 A;  2DO9 A;  4A2Q A;  1D2Z A;  1C15 A;  2N83 A;  4N1K A;  2MJM A;  3MOP K;  1WXP A;  3J63 A;  3CRD A;  4RHW A;  2B1W A;  1WH4 A;  4RHW E;  4M9S A;  4IZ7 B;  4M9Z A;  4I16 A;  2MS8 A;  2NAQ A;  2L9M A;  1UCP A;  4IZA B;  2NSN A;  2O71 A;  4P4H I;  2MS7 A;  3LQQ A;  2N00 A;  3QF2 A;  2KM6 A;  4N1L A;  3KAT A;  2D96 A;  2HM2 Q;  4N1J A;  4F44 A;  1DDF A;  2LWE A;  1N3K A;  2F1S A;  4LWD A;  4FH0 A;  3CL3 A;  2VGQ A;  4IZ5 E;  2BBZ A;  3LQR A;  2LWD A;  4O7Q A;  2P1H A;  4E9M A;  2OF5 A;  2MN4 A;  2G7R A;  2YVI A;  3MOP A;  3MOP G;  1FAD A;  3T6P A;  2LS7 A;  2A9I A;  2OF5 H;  2MPC A;  4A2W A;  2YQF A;  4P4H A;  2N97 A;  1A1Z A;  2N7Z A;  2GF5 A;  4QOB A;  3EZQ B;  3YGS C;  2IB1 A;  1WMG A;  1DGN A;  2DBG A;  1Z6T A;  2DBH A;  4M9X A;  2NZ7 A;  4ZBW A;  1CWW A;  2M5V A;  3J6J A;  4O6X A;  1NGR A;  4DWN A;  2YU0 A;  2DBD A;  4UZ0 A;  4JQW A;  4EWI A;  4D8O A;  4JUP A;  2L6A A;  2YGS A;  2N80 A;  1E3Y A;  4O9F A;  4F42 A;  2XV9 A;  2A5Y B;  1CY5 A;  2MB9 A;  1E41 A;  1YGO A;  2N1F A;  4NQK A;  1A1W A;  1D2Z B;  2BBR A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
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