4IZ5E

Structure of the complex between erk2 phosphomimetic mutant and pea-15
Total Genus 25
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
25
sequence length
127
structure length
86
Chain Sequence
MAEYGTLLQDLTNNITLEDLEQLKSACKEDEEITTGSAWFSFLESHNKLDKDNLSYIEHIFEISRRPDLLTMVVDYRTRVKLAPPP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Structure of ERK2 bound to PEA-15 reveals a mechanism for rapid release of activated MAPK.
pubmed doi rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords Mitogen-activated protein kinase 1
total genus 25
structure length 86
sequence length 127
chains with identical sequence F, G, H
ec nomenclature
pdb deposition date 2013-01-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
E PF01335 DED Death effector domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.533.10 Mainly Alpha Orthogonal Bundle Death Domain, Fas Death Domain, Fas 4iz5E00
2MPCA 3CL3A 2MS8A 1DDFA 2YVIA 4EWIA 2G7RA 2OF5A 4QOBA 2N7ZA 4O9FA 2LWDA 1E3YA 4I16A 2N1FA 2VGQA 1E41A 2DBDA 2DBGA 1A1WA 2BBRA 3MOPA 2KN6A 4F42A 2DBFA 1C15A 2IB1A 3YGSC 4A2QA 4NQKA 4O9LA 2NZ7A 2P1HA 2A5YB 1CWWA 2NSNA 4P4HA 3QF2A 1DGNA 1WXPA 1D2ZA 4JUPA 1CY5A 2MB9A 4P4HI 4FH0A 2N97A 3T6PA 3KATA 3LQQA 4IZ7B 2DO9A 2BBZA 4D8OA 4N1LA 2NAQA 4IZAB 1PN5A 2HM2Q 2YGSA 4DWNA 1FADA 1D2ZB 1Z6TA 2LS7A 2O71A 1WMGA 2F1SA 4E9MA 2OF5H 3EZQA 4M9SA 2YQFA 3J6JA 2L6AA 1ICHA 1WH4A 4N1KA 2L9MA 4UZ0A 4A2WA 3MOPG 4ZBWA 2A9IA 2D96A 2DBHA 2GF5A 3LQRA 2N00A 1N3KA 1A1ZA 2YU0A 2MS7A 1YGOA 4JQWA 2B1WA 1NGRA 3EZQB 2LWEA 2KM6A 4IZ5E 4O7QA 4O6XA 4LWDA 3CRDA 3J63A 3MOPK 3YGSP 4F44A 2N80A 2MN4A 4M9XA 4RHWA 4N1JA 2M5VA 2N83A 1UCPA 4RHWE 4M9ZA
chains in the Genus database with same CATH superfamily
2MPCA 3CL3A 2MS8A 1DDFA 2YVIA 4EWIA 2MJMA 2G7RA 2OF5A 4QOBA 2N7ZA 4O9FA 2LWDA 1E3YA 4I16A 2N1FA 2VGQA 1E41A 2DBDA 2DBGA 1A1WA 2BBRA 3MOPA 2KN6A 4F42A 2DBFA 1C15A 2IB1A 3YGSC 4A2QA 4NQKA 4O9LA 2NZ7A 2P1HA 2A5YB 1CWWA 2NSNA 4P4HA 3QF2A 1DGNA 1WXPA 1D2ZA 4JUPA 1CY5A 2MB9A 4P4HI 4FH0A 2N97A 3T6PA 3KATA 3LQQA 4IZ7B 2DO9A 2BBZA 4D8OA 4N1LA 2NAQA 4IZAB 1PN5A 2HM2Q 2YGSA 4DWNA 1FADA 1D2ZB 1Z6TA 2LS7A 2O71A 1WMGA 2F1SA 4E9MA 2OF5H 3EZQA 4M9SA 2XV9A 2YQFA 3J6JA 2L6AA 1ICHA 1WH4A 4N1KA 2L9MA 4UZ0A 4A2WA 3MOPG 4ZBWA 2A9IA 2D96A 2DBHA 2GF5A 3LQRA 2N00A 1N3KA 1A1ZA 2YU0A 2MS7A 1YGOA 4JQWA 2B1WA 1NGRA 3EZQB 2LWEA 2KM6A 4IZ5E 4O7QA 4O6XA 4LWDA 3CRDA 3J63A 3MOPK 3YGSP 4F44A 2N80A 2MN4A 4M9XA 4RHWA 4N1JA 2M5VA 2N83A 1UCPA 4RHWE 4M9ZA
chains in the Genus database with same CATH topology
2MPCA 3CL3A 2MS8A 1DDFA 2YVIA 4EWIA 2MJMA 2G7RA 2OF5A 4QOBA 2N7ZA 4O9FA 2LWDA 1E3YA 4I16A 2N1FA 2VGQA 1E41A 2DBDA 2DBGA 1A1WA 2BBRA 3MOPA 2KN6A 4F42A 2DBFA 1C15A 2IB1A 3YGSC 4A2QA 4NQKA 4O9LA 2NZ7A 2P1HA 2A5YB 1CWWA 2NSNA 4P4HA 3QF2A 1DGNA 1WXPA 1D2ZA 4JUPA 1CY5A 2MB9A 4P4HI 4FH0A 2N97A 3T6PA 3KATA 3LQQA 4IZ7B 2DO9A 2BBZA 4D8OA 4N1LA 2NAQA 4IZAB 1PN5A 2HM2Q 2YGSA 4DWNA 1FADA 1D2ZB 1Z6TA 2LS7A 2O71A 1WMGA 2F1SA 4E9MA 2OF5H 3EZQA 4M9SA 2XV9A 2YQFA 3J6JA 2L6AA 1ICHA 1WH4A 4N1KA 2L9MA 4UZ0A 4A2WA 3MOPG 4ZBWA 2A9IA 2D96A 2DBHA 2GF5A 3LQRA 2N00A 1N3KA 1A1ZA 2YU0A 2MS7A 1YGOA 4JQWA 2B1WA 1NGRA 3EZQB 2LWEA 2KM6A 4IZ5E 4O7QA 4O6XA 4LWDA 3CRDA 3J63A 3MOPK 3YGSP 4F44A 2N80A 2MN4A 4M9XA 4RHWA 4N1JA 2M5VA 2N83A 1UCPA 4RHWE 4M9ZA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 2MPC A;  3CL3 A;  2MS8 A;  1DDF A;  2YVI A;  4EWI A;  2G7R A;  2OF5 A;  4QOB A;  2N7Z A;  4O9F A;  2LWD A;  1E3Y A;  4I16 A;  2N1F A;  2VGQ A;  1E41 A;  2DBD A;  2DBG A;  1A1W A;  2BBR A;  3MOP A;  2KN6 A;  4F42 A;  2DBF A;  1C15 A;  2IB1 A;  3YGS C;  4A2Q A;  4NQK A;  4O9L A;  2NZ7 A;  2P1H A;  2A5Y B;  1CWW A;  2NSN A;  4P4H A;  3QF2 A;  1DGN A;  1WXP A;  1D2Z A;  4JUP A;  1CY5 A;  2MB9 A;  4P4H I;  4FH0 A;  2N97 A;  3T6P A;  3KAT A;  3LQQ A;  4IZ7 B;  2DO9 A;  2BBZ A;  4D8O A;  4N1L A;  2NAQ A;  4IZA B;  1PN5 A;  2HM2 Q;  2YGS A;  4DWN A;  1FAD A;  1D2Z B;  1Z6T A;  2LS7 A;  2O71 A;  1WMG A;  2F1S A;  4E9M A;  2OF5 H;  3EZQ A;  4M9S A;  2YQF A;  3J6J A;  2L6A A;  1ICH A;  1WH4 A;  4N1K A;  2L9M A;  4UZ0 A;  4A2W A;  3MOP G;  4ZBW A;  2A9I A;  2D96 A;  2DBH A;  2GF5 A;  3LQR A;  2N00 A;  1N3K A;  1A1Z A;  2YU0 A;  2MS7 A;  1YGO A;  4JQW A;  2B1W A;  1NGR A;  3EZQ B;  2LWE A;  2KM6 A;  4IZ5 E;  4O7Q A;  4O6X A;  4LWD A;  3CRD A;  3J63 A;  3MOP K;  3YGS P;  4F44 A;  2N80 A;  2MN4 A;  4M9X A;  4RHW A;  4N1J A;  2M5V A;  2N83 A;  1UCP A;  4RHW E;  4M9Z A; 
#chains in the Genus database with same CATH topology
 2MPC A;  3CL3 A;  2MS8 A;  1DDF A;  2YVI A;  4EWI A;  2MJM A;  2G7R A;  2OF5 A;  4QOB A;  2N7Z A;  4O9F A;  2LWD A;  1E3Y A;  4I16 A;  2N1F A;  2VGQ A;  1E41 A;  2DBD A;  2DBG A;  1A1W A;  2BBR A;  3MOP A;  2KN6 A;  4F42 A;  2DBF A;  1C15 A;  2IB1 A;  3YGS C;  4A2Q A;  4NQK A;  4O9L A;  2NZ7 A;  2P1H A;  2A5Y B;  1CWW A;  2NSN A;  4P4H A;  3QF2 A;  1DGN A;  1WXP A;  1D2Z A;  4JUP A;  1CY5 A;  2MB9 A;  4P4H I;  4FH0 A;  2N97 A;  3T6P A;  3KAT A;  3LQQ A;  4IZ7 B;  2DO9 A;  2BBZ A;  4D8O A;  4N1L A;  2NAQ A;  4IZA B;  1PN5 A;  2HM2 Q;  2YGS A;  4DWN A;  1FAD A;  1D2Z B;  1Z6T A;  2LS7 A;  2O71 A;  1WMG A;  2F1S A;  4E9M A;  2OF5 H;  3EZQ A;  4M9S A;  2XV9 A;  2YQF A;  3J6J A;  2L6A A;  1ICH A;  1WH4 A;  4N1K A;  2L9M A;  4UZ0 A;  4A2W A;  3MOP G;  4ZBW A;  2A9I A;  2D96 A;  2DBH A;  2GF5 A;  3LQR A;  2N00 A;  1N3K A;  1A1Z A;  2YU0 A;  2MS7 A;  1YGO A;  4JQW A;  2B1W A;  1NGR A;  3EZQ B;  2LWE A;  2KM6 A;  4IZ5 E;  4O7Q A;  4O6X A;  4LWD A;  3CRD A;  3J63 A;  3MOP K;  3YGS P;  4F44 A;  2N80 A;  2MN4 A;  4M9X A;  4RHW A;  4N1J A;  2M5V A;  2N83 A;  1UCP A;  4RHW E;  4M9Z A; 
#chains in the Genus database with same CATH homology
 2MPC A;  3CL3 A;  2MS8 A;  1DDF A;  2YVI A;  4EWI A;  2MJM A;  2G7R A;  2OF5 A;  4QOB A;  2N7Z A;  4O9F A;  2LWD A;  1E3Y A;  4I16 A;  2N1F A;  2VGQ A;  1E41 A;  2DBD A;  2DBG A;  1A1W A;  2BBR A;  3MOP A;  2KN6 A;  4F42 A;  2DBF A;  1C15 A;  2IB1 A;  3YGS C;  4A2Q A;  4NQK A;  4O9L A;  2NZ7 A;  2P1H A;  2A5Y B;  1CWW A;  2NSN A;  4P4H A;  3QF2 A;  1DGN A;  1WXP A;  1D2Z A;  4JUP A;  1CY5 A;  2MB9 A;  4P4H I;  4FH0 A;  2N97 A;  3T6P A;  3KAT A;  3LQQ A;  4IZ7 B;  2DO9 A;  2BBZ A;  4D8O A;  4N1L A;  2NAQ A;  4IZA B;  1PN5 A;  2HM2 Q;  2YGS A;  4DWN A;  1FAD A;  1D2Z B;  1Z6T A;  2LS7 A;  2O71 A;  1WMG A;  2F1S A;  4E9M A;  2OF5 H;  3EZQ A;  4M9S A;  2XV9 A;  2YQF A;  3J6J A;  2L6A A;  1ICH A;  1WH4 A;  4N1K A;  2L9M A;  4UZ0 A;  4A2W A;  3MOP G;  4ZBW A;  2A9I A;  2D96 A;  2DBH A;  2GF5 A;  3LQR A;  2N00 A;  1N3K A;  1A1Z A;  2YU0 A;  2MS7 A;  1YGO A;  4JQW A;  2B1W A;  1NGR A;  3EZQ B;  2LWE A;  2KM6 A;  4IZ5 E;  4O7Q A;  4O6X A;  4LWD A;  3CRD A;  3J63 A;  3MOP K;  3YGS P;  4F44 A;  2N80 A;  2MN4 A;  4M9X A;  4RHW A;  4N1J A;  2M5V A;  2N83 A;  1UCP A;  4RHW E;  4M9Z A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
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