4IZ7B

Structure of non-phosphorylated erk2 bound to the pea-15 death effector domain
Total Genus 33
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
33
sequence length
90
structure length
90
Chain Sequence
GMAEYGTLLQDLTNNITLEDLEQLKSACKEDIPSEKSEEITTGSAWFSFLESHNKLDKDNLSYIEHIFEISRRPDLLTMVVDYRTRVLKI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of ERK2 bound to PEA-15 reveals a mechanism for rapid release of activated MAPK.
pubmed doi rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords Mitogen-activated protein kinase 1
total genus 33
structure length 90
sequence length 90
ec nomenclature
pdb deposition date 2013-01-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF01335 DED Death effector domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.533.10 Mainly Alpha Orthogonal Bundle Death Domain, Fas Death Domain, Fas 4iz7B00
2YQFA 4QOBA 2YVIA 1D2ZA 2N80A 1CWWA 3EZQA 2L6AA 2GF5A 4NQKA 4N1LA 2YU0A 2KN6A 2MS8A 3MOPK 2IB1A 1CY5A 2N7ZA 2DBFA 2NSNA 1FADA 4N1KA 2NAQA 4RHWE 1DDFA 1A1WA 2M5VA 4JQWA 4P4HA 3YGSP 1D2ZB 4M9SA 2G7RA 3EZQB 1N3KA 2BBZA 1Z6TA 4P4HI 1NGRA 4F44A 2F1SA 2HM2Q 2MS7A 4E9MA 4I16A 3MOPA 4IZ5E 1A1ZA 1PN5A 3LQRA 1ICHA 2MPCA 1YGOA 2DBDA 4O7QA 2P1HA 3CL3A 4O9FA 2O71A 2MB9A 4LWDA 3J63A 2VGQA 2OF5H 2B1WA 3T6PA 3LQQA 1WXPA 1UCPA 2N97A 4F42A 1E3YA 2L9MA 4A2QA 2N83A 4A2WA 4UZ0A 2N00A 3YGSC 2LWEA 1C15A 1WH4A 1WMGA 2LWDA 2A5YB 4RHWA 1DGNA 4M9ZA 4ZBWA 2D96A 4JUPA 3CRDA 3KATA 4M9XA 2MN4A 2A9IA 4D8OA 4EWIA 1E41A 3J6JA 2NZ7A 4O9LA 3QF2A 4IZAB 4FH0A 3MOPG 2DBGA 2DO9A 2KM6A 2BBRA 4DWNA 4N1JA 4IZ7B 2DBHA 2LS7A 2N1FA 2OF5A 2YGSA 4O6XA
chains in the Genus database with same CATH superfamily
2YQFA 4QOBA 2YVIA 1D2ZA 2N80A 1CWWA 3EZQA 2L6AA 2GF5A 4NQKA 4N1LA 2YU0A 2KN6A 2MS8A 3MOPK 2IB1A 2MJMA 1CY5A 2N7ZA 2DBFA 2NSNA 1FADA 4N1KA 2NAQA 4RHWE 1DDFA 1A1WA 2M5VA 4JQWA 4P4HA 3YGSP 1D2ZB 4M9SA 2XV9A 2G7RA 3EZQB 1N3KA 2BBZA 1Z6TA 4P4HI 1NGRA 4F44A 2F1SA 2HM2Q 2MS7A 4E9MA 4I16A 3MOPA 4IZ5E 1A1ZA 1PN5A 3LQRA 1ICHA 2MPCA 1YGOA 2DBDA 4O7QA 2P1HA 3CL3A 4O9FA 2O71A 2MB9A 4LWDA 3J63A 2VGQA 2OF5H 2B1WA 3T6PA 3LQQA 1WXPA 1UCPA 2N97A 4F42A 1E3YA 2L9MA 4A2QA 2N83A 4A2WA 4UZ0A 2N00A 3YGSC 2LWEA 1C15A 1WH4A 1WMGA 2LWDA 2A5YB 4RHWA 1DGNA 4M9ZA 4ZBWA 2D96A 4JUPA 3CRDA 3KATA 4M9XA 2MN4A 2A9IA 4D8OA 4EWIA 1E41A 3J6JA 2NZ7A 4O9LA 3QF2A 4IZAB 4FH0A 3MOPG 2DBGA 2DO9A 2KM6A 2BBRA 4DWNA 4N1JA 4IZ7B 2DBHA 2LS7A 2N1FA 2OF5A 2YGSA 4O6XA
chains in the Genus database with same CATH topology
2YQFA 4QOBA 2YVIA 1D2ZA 2N80A 1CWWA 3EZQA 2L6AA 2GF5A 4NQKA 4N1LA 2YU0A 2KN6A 2MS8A 3MOPK 2IB1A 2MJMA 1CY5A 2N7ZA 2DBFA 2NSNA 1FADA 4N1KA 2NAQA 4RHWE 1DDFA 1A1WA 2M5VA 4JQWA 4P4HA 3YGSP 1D2ZB 4M9SA 2XV9A 2G7RA 3EZQB 1N3KA 2BBZA 1Z6TA 4P4HI 1NGRA 4F44A 2F1SA 2HM2Q 2MS7A 4E9MA 4I16A 3MOPA 4IZ5E 1A1ZA 1PN5A 3LQRA 1ICHA 2MPCA 1YGOA 2DBDA 4O7QA 2P1HA 3CL3A 4O9FA 2O71A 2MB9A 4LWDA 3J63A 2VGQA 2OF5H 2B1WA 3T6PA 3LQQA 1WXPA 1UCPA 2N97A 4F42A 1E3YA 2L9MA 4A2QA 2N83A 4A2WA 4UZ0A 2N00A 3YGSC 2LWEA 1C15A 1WH4A 1WMGA 2LWDA 2A5YB 4RHWA 1DGNA 4M9ZA 4ZBWA 2D96A 4JUPA 3CRDA 3KATA 4M9XA 2MN4A 2A9IA 4D8OA 4EWIA 1E41A 3J6JA 2NZ7A 4O9LA 3QF2A 4IZAB 4FH0A 3MOPG 2DBGA 2DO9A 2KM6A 2BBRA 4DWNA 4N1JA 4IZ7B 2DBHA 2LS7A 2N1FA 2OF5A 2YGSA 4O6XA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2YQF A;  4QOB A;  2YVI A;  1D2Z A;  2N80 A;  1CWW A;  3EZQ A;  2L6A A;  2GF5 A;  4NQK A;  4N1L A;  2YU0 A;  2KN6 A;  2MS8 A;  3MOP K;  2IB1 A;  1CY5 A;  2N7Z A;  2DBF A;  2NSN A;  1FAD A;  4N1K A;  2NAQ A;  4RHW E;  1DDF A;  1A1W A;  2M5V A;  4JQW A;  4P4H A;  3YGS P;  1D2Z B;  4M9S A;  2G7R A;  3EZQ B;  1N3K A;  2BBZ A;  1Z6T A;  4P4H I;  1NGR A;  4F44 A;  2F1S A;  2HM2 Q;  2MS7 A;  4E9M A;  4I16 A;  3MOP A;  4IZ5 E;  1A1Z A;  1PN5 A;  3LQR A;  1ICH A;  2MPC A;  1YGO A;  2DBD A;  4O7Q A;  2P1H A;  3CL3 A;  4O9F A;  2O71 A;  2MB9 A;  4LWD A;  3J63 A;  2VGQ A;  2OF5 H;  2B1W A;  3T6P A;  3LQQ A;  1WXP A;  1UCP A;  2N97 A;  4F42 A;  1E3Y A;  2L9M A;  4A2Q A;  2N83 A;  4A2W A;  4UZ0 A;  2N00 A;  3YGS C;  2LWE A;  1C15 A;  1WH4 A;  1WMG A;  2LWD A;  2A5Y B;  4RHW A;  1DGN A;  4M9Z A;  4ZBW A;  2D96 A;  4JUP A;  3CRD A;  3KAT A;  4M9X A;  2MN4 A;  2A9I A;  4D8O A;  4EWI A;  1E41 A;  3J6J A;  2NZ7 A;  4O9L A;  3QF2 A;  4IZA B;  4FH0 A;  3MOP G;  2DBG A;  2DO9 A;  2KM6 A;  2BBR A;  4DWN A;  4N1J A;  4IZ7 B;  2DBH A;  2LS7 A;  2N1F A;  2OF5 A;  2YGS A;  4O6X A; 
#chains in the Genus database with same CATH topology
 2YQF A;  4QOB A;  2YVI A;  1D2Z A;  2N80 A;  1CWW A;  3EZQ A;  2L6A A;  2GF5 A;  4NQK A;  4N1L A;  2YU0 A;  2KN6 A;  2MS8 A;  3MOP K;  2IB1 A;  2MJM A;  1CY5 A;  2N7Z A;  2DBF A;  2NSN A;  1FAD A;  4N1K A;  2NAQ A;  4RHW E;  1DDF A;  1A1W A;  2M5V A;  4JQW A;  4P4H A;  3YGS P;  1D2Z B;  4M9S A;  2XV9 A;  2G7R A;  3EZQ B;  1N3K A;  2BBZ A;  1Z6T A;  4P4H I;  1NGR A;  4F44 A;  2F1S A;  2HM2 Q;  2MS7 A;  4E9M A;  4I16 A;  3MOP A;  4IZ5 E;  1A1Z A;  1PN5 A;  3LQR A;  1ICH A;  2MPC A;  1YGO A;  2DBD A;  4O7Q A;  2P1H A;  3CL3 A;  4O9F A;  2O71 A;  2MB9 A;  4LWD A;  3J63 A;  2VGQ A;  2OF5 H;  2B1W A;  3T6P A;  3LQQ A;  1WXP A;  1UCP A;  2N97 A;  4F42 A;  1E3Y A;  2L9M A;  4A2Q A;  2N83 A;  4A2W A;  4UZ0 A;  2N00 A;  3YGS C;  2LWE A;  1C15 A;  1WH4 A;  1WMG A;  2LWD A;  2A5Y B;  4RHW A;  1DGN A;  4M9Z A;  4ZBW A;  2D96 A;  4JUP A;  3CRD A;  3KAT A;  4M9X A;  2MN4 A;  2A9I A;  4D8O A;  4EWI A;  1E41 A;  3J6J A;  2NZ7 A;  4O9L A;  3QF2 A;  4IZA B;  4FH0 A;  3MOP G;  2DBG A;  2DO9 A;  2KM6 A;  2BBR A;  4DWN A;  4N1J A;  4IZ7 B;  2DBH A;  2LS7 A;  2N1F A;  2OF5 A;  2YGS A;  4O6X A; 
#chains in the Genus database with same CATH homology
 2YQF A;  4QOB A;  2YVI A;  1D2Z A;  2N80 A;  1CWW A;  3EZQ A;  2L6A A;  2GF5 A;  4NQK A;  4N1L A;  2YU0 A;  2KN6 A;  2MS8 A;  3MOP K;  2IB1 A;  2MJM A;  1CY5 A;  2N7Z A;  2DBF A;  2NSN A;  1FAD A;  4N1K A;  2NAQ A;  4RHW E;  1DDF A;  1A1W A;  2M5V A;  4JQW A;  4P4H A;  3YGS P;  1D2Z B;  4M9S A;  2XV9 A;  2G7R A;  3EZQ B;  1N3K A;  2BBZ A;  1Z6T A;  4P4H I;  1NGR A;  4F44 A;  2F1S A;  2HM2 Q;  2MS7 A;  4E9M A;  4I16 A;  3MOP A;  4IZ5 E;  1A1Z A;  1PN5 A;  3LQR A;  1ICH A;  2MPC A;  1YGO A;  2DBD A;  4O7Q A;  2P1H A;  3CL3 A;  4O9F A;  2O71 A;  2MB9 A;  4LWD A;  3J63 A;  2VGQ A;  2OF5 H;  2B1W A;  3T6P A;  3LQQ A;  1WXP A;  1UCP A;  2N97 A;  4F42 A;  1E3Y A;  2L9M A;  4A2Q A;  2N83 A;  4A2W A;  4UZ0 A;  2N00 A;  3YGS C;  2LWE A;  1C15 A;  1WH4 A;  1WMG A;  2LWD A;  2A5Y B;  4RHW A;  1DGN A;  4M9Z A;  4ZBW A;  2D96 A;  4JUP A;  3CRD A;  3KAT A;  4M9X A;  2MN4 A;  2A9I A;  4D8O A;  4EWI A;  1E41 A;  3J6J A;  2NZ7 A;  4O9L A;  3QF2 A;  4IZA B;  4FH0 A;  3MOP G;  2DBG A;  2DO9 A;  2KM6 A;  2BBR A;  4DWN A;  4N1J A;  4IZ7 B;  2DBH A;  2LS7 A;  2N1F A;  2OF5 A;  2YGS A;  4O6X A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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