4IZ7B

Structure of non-phosphorylated erk2 bound to the pea-15 death effector domain
Total Genus 33
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
33
sequence length
90
structure length
90
Chain Sequence
GMAEYGTLLQDLTNNITLEDLEQLKSACKEDIPSEKSEEITTGSAWFSFLESHNKLDKDNLSYIEHIFEISRRPDLLTMVVDYRTRVLKI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of ERK2 bound to PEA-15 reveals a mechanism for rapid release of activated MAPK.
pubmed doi rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords Mitogen-activated protein kinase 1
total genus 33
structure length 90
sequence length 90
ec nomenclature
pdb deposition date 2013-01-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF01335 DED Death effector domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.533.10 Mainly Alpha Orthogonal Bundle Death Domain, Fas Death Domain, Fas 4iz7B00
4A2WA 2OF5A 2N97A 4N1JA 2B1WA 1CY5A 2MPCA 2NSNA 1UCPA 1ICHA 2KN6A 3T6PA 2DO9A 2NAQA 4A2QA 4M9SA 4F42A 4M9XA 2GF5A 3LQRA 4UZ0A 4O9FA 2L6AA 4NQKA 1E41A 4D8OA 4N1LA 2KM6A 4IZ5E 2N80A 4P4HI 2A9IA 2O71A 1C15A 2D96A 1PN5A 3CRDA 3KATA 2MS8A 1Z6TA 2F1SA 2N7ZA 2P1HA 2OF5H 2MN4A 3J63A 4I16A 2L9MA 2G7RA 2DBHA 2YGSA 4IZAB 1DGNA 2N00A 3YGSC 4O9LA 4LWDA 3QF2A 1DDFA 3YGSP 2NZ7A 4FH0A 2MS7A 1A1ZA 2HM2Q 4N1KA 2N83A 4E9MA 2LS7A 4IZ7B 1WXPA 4O6XA 1E3YA 1NGRA 2N1FA 2YU0A 3J6JA 1CWWA 2BBZA 4RHWA 4JUPA 4ZBWA 2IB1A 3MOPG 2BBRA 2DBDA 1D2ZA 4DWNA 2M5VA 2A5YB 1YGOA 2DBFA 4F44A 2DBGA 3MOPK 4QOBA 1WMGA 4EWIA 3MOPA 4M9ZA 1WH4A 2YVIA 4JQWA 2MB9A 2LWEA 1A1WA 2LWDA 3LQQA 4O7QA 1N3KA 4P4HA 3EZQB 2YQFA 1FADA 4RHWE 1D2ZB 3CL3A 3EZQA 2VGQA
chains in the Genus database with same CATH superfamily
4A2WA 2OF5A 2N97A 4N1JA 2B1WA 1CY5A 2MPCA 2NSNA 1UCPA 1ICHA 2KN6A 3T6PA 2DO9A 2NAQA 4A2QA 4M9SA 4F42A 4M9XA 2GF5A 3LQRA 4UZ0A 4O9FA 2L6AA 4NQKA 1E41A 4D8OA 2XV9A 4N1LA 2KM6A 4IZ5E 2N80A 4P4HI 2A9IA 2O71A 1C15A 2D96A 1PN5A 3CRDA 3KATA 2MS8A 1Z6TA 2F1SA 2N7ZA 2P1HA 2OF5H 2MN4A 3J63A 4I16A 2L9MA 2G7RA 2DBHA 2YGSA 4IZAB 1DGNA 2N00A 3YGSC 4O9LA 4LWDA 3QF2A 1DDFA 3YGSP 2NZ7A 4FH0A 2MS7A 1A1ZA 2HM2Q 4N1KA 2N83A 4E9MA 2LS7A 4IZ7B 1WXPA 4O6XA 1E3YA 1NGRA 2N1FA 2YU0A 3J6JA 1CWWA 2BBZA 4RHWA 4JUPA 4ZBWA 2IB1A 3MOPG 2BBRA 2DBDA 1D2ZA 4DWNA 2M5VA 2A5YB 1YGOA 2DBFA 4F44A 2DBGA 3MOPK 4QOBA 1WMGA 4EWIA 3MOPA 4M9ZA 2MJMA 1WH4A 2YVIA 4JQWA 2MB9A 2LWEA 1A1WA 2LWDA 3LQQA 4O7QA 1N3KA 4P4HA 3EZQB 2YQFA 1FADA 4RHWE 1D2ZB 3CL3A 3EZQA 2VGQA
chains in the Genus database with same CATH topology
4A2WA 2OF5A 2N97A 4N1JA 2B1WA 1CY5A 2MPCA 2NSNA 1UCPA 1ICHA 2KN6A 3T6PA 2DO9A 2NAQA 4A2QA 4M9SA 4F42A 4M9XA 2GF5A 3LQRA 4UZ0A 4O9FA 2L6AA 4NQKA 1E41A 4D8OA 2XV9A 4N1LA 2KM6A 4IZ5E 2N80A 4P4HI 2A9IA 2O71A 1C15A 2D96A 1PN5A 3CRDA 3KATA 2MS8A 1Z6TA 2F1SA 2N7ZA 2P1HA 2OF5H 2MN4A 3J63A 4I16A 2L9MA 2G7RA 2DBHA 2YGSA 4IZAB 1DGNA 2N00A 3YGSC 4O9LA 4LWDA 3QF2A 1DDFA 3YGSP 2NZ7A 4FH0A 2MS7A 1A1ZA 2HM2Q 4N1KA 2N83A 4E9MA 2LS7A 4IZ7B 1WXPA 4O6XA 1E3YA 1NGRA 2N1FA 2YU0A 3J6JA 1CWWA 2BBZA 4RHWA 4JUPA 4ZBWA 2IB1A 3MOPG 2BBRA 2DBDA 1D2ZA 4DWNA 2M5VA 2A5YB 1YGOA 2DBFA 4F44A 2DBGA 3MOPK 4QOBA 1WMGA 4EWIA 3MOPA 4M9ZA 2MJMA 1WH4A 2YVIA 4JQWA 2MB9A 2LWEA 1A1WA 2LWDA 3LQQA 4O7QA 1N3KA 4P4HA 3EZQB 2YQFA 1FADA 4RHWE 1D2ZB 3CL3A 3EZQA 2VGQA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4A2W A;  2OF5 A;  2N97 A;  4N1J A;  2B1W A;  1CY5 A;  2MPC A;  2NSN A;  1UCP A;  1ICH A;  2KN6 A;  3T6P A;  2DO9 A;  2NAQ A;  4A2Q A;  4M9S A;  4F42 A;  4M9X A;  2GF5 A;  3LQR A;  4UZ0 A;  4O9F A;  2L6A A;  4NQK A;  1E41 A;  4D8O A;  4N1L A;  2KM6 A;  4IZ5 E;  2N80 A;  4P4H I;  2A9I A;  2O71 A;  1C15 A;  2D96 A;  1PN5 A;  3CRD A;  3KAT A;  2MS8 A;  1Z6T A;  2F1S A;  2N7Z A;  2P1H A;  2OF5 H;  2MN4 A;  3J63 A;  4I16 A;  2L9M A;  2G7R A;  2DBH A;  2YGS A;  4IZA B;  1DGN A;  2N00 A;  3YGS C;  4O9L A;  4LWD A;  3QF2 A;  1DDF A;  3YGS P;  2NZ7 A;  4FH0 A;  2MS7 A;  1A1Z A;  2HM2 Q;  4N1K A;  2N83 A;  4E9M A;  2LS7 A;  4IZ7 B;  1WXP A;  4O6X A;  1E3Y A;  1NGR A;  2N1F A;  2YU0 A;  3J6J A;  1CWW A;  2BBZ A;  4RHW A;  4JUP A;  4ZBW A;  2IB1 A;  3MOP G;  2BBR A;  2DBD A;  1D2Z A;  4DWN A;  2M5V A;  2A5Y B;  1YGO A;  2DBF A;  4F44 A;  2DBG A;  3MOP K;  4QOB A;  1WMG A;  4EWI A;  3MOP A;  4M9Z A;  1WH4 A;  2YVI A;  4JQW A;  2MB9 A;  2LWE A;  1A1W A;  2LWD A;  3LQQ A;  4O7Q A;  1N3K A;  4P4H A;  3EZQ B;  2YQF A;  1FAD A;  4RHW E;  1D2Z B;  3CL3 A;  3EZQ A;  2VGQ A; 
#chains in the Genus database with same CATH topology
 4A2W A;  2OF5 A;  2N97 A;  4N1J A;  2B1W A;  1CY5 A;  2MPC A;  2NSN A;  1UCP A;  1ICH A;  2KN6 A;  3T6P A;  2DO9 A;  2NAQ A;  4A2Q A;  4M9S A;  4F42 A;  4M9X A;  2GF5 A;  3LQR A;  4UZ0 A;  4O9F A;  2L6A A;  4NQK A;  1E41 A;  4D8O A;  2XV9 A;  4N1L A;  2KM6 A;  4IZ5 E;  2N80 A;  4P4H I;  2A9I A;  2O71 A;  1C15 A;  2D96 A;  1PN5 A;  3CRD A;  3KAT A;  2MS8 A;  1Z6T A;  2F1S A;  2N7Z A;  2P1H A;  2OF5 H;  2MN4 A;  3J63 A;  4I16 A;  2L9M A;  2G7R A;  2DBH A;  2YGS A;  4IZA B;  1DGN A;  2N00 A;  3YGS C;  4O9L A;  4LWD A;  3QF2 A;  1DDF A;  3YGS P;  2NZ7 A;  4FH0 A;  2MS7 A;  1A1Z A;  2HM2 Q;  4N1K A;  2N83 A;  4E9M A;  2LS7 A;  4IZ7 B;  1WXP A;  4O6X A;  1E3Y A;  1NGR A;  2N1F A;  2YU0 A;  3J6J A;  1CWW A;  2BBZ A;  4RHW A;  4JUP A;  4ZBW A;  2IB1 A;  3MOP G;  2BBR A;  2DBD A;  1D2Z A;  4DWN A;  2M5V A;  2A5Y B;  1YGO A;  2DBF A;  4F44 A;  2DBG A;  3MOP K;  4QOB A;  1WMG A;  4EWI A;  3MOP A;  4M9Z A;  2MJM A;  1WH4 A;  2YVI A;  4JQW A;  2MB9 A;  2LWE A;  1A1W A;  2LWD A;  3LQQ A;  4O7Q A;  1N3K A;  4P4H A;  3EZQ B;  2YQF A;  1FAD A;  4RHW E;  1D2Z B;  3CL3 A;  3EZQ A;  2VGQ A; 
#chains in the Genus database with same CATH homology
 4A2W A;  2OF5 A;  2N97 A;  4N1J A;  2B1W A;  1CY5 A;  2MPC A;  2NSN A;  1UCP A;  1ICH A;  2KN6 A;  3T6P A;  2DO9 A;  2NAQ A;  4A2Q A;  4M9S A;  4F42 A;  4M9X A;  2GF5 A;  3LQR A;  4UZ0 A;  4O9F A;  2L6A A;  4NQK A;  1E41 A;  4D8O A;  2XV9 A;  4N1L A;  2KM6 A;  4IZ5 E;  2N80 A;  4P4H I;  2A9I A;  2O71 A;  1C15 A;  2D96 A;  1PN5 A;  3CRD A;  3KAT A;  2MS8 A;  1Z6T A;  2F1S A;  2N7Z A;  2P1H A;  2OF5 H;  2MN4 A;  3J63 A;  4I16 A;  2L9M A;  2G7R A;  2DBH A;  2YGS A;  4IZA B;  1DGN A;  2N00 A;  3YGS C;  4O9L A;  4LWD A;  3QF2 A;  1DDF A;  3YGS P;  2NZ7 A;  4FH0 A;  2MS7 A;  1A1Z A;  2HM2 Q;  4N1K A;  2N83 A;  4E9M A;  2LS7 A;  4IZ7 B;  1WXP A;  4O6X A;  1E3Y A;  1NGR A;  2N1F A;  2YU0 A;  3J6J A;  1CWW A;  2BBZ A;  4RHW A;  4JUP A;  4ZBW A;  2IB1 A;  3MOP G;  2BBR A;  2DBD A;  1D2Z A;  4DWN A;  2M5V A;  2A5Y B;  1YGO A;  2DBF A;  4F44 A;  2DBG A;  3MOP K;  4QOB A;  1WMG A;  4EWI A;  3MOP A;  4M9Z A;  2MJM A;  1WH4 A;  2YVI A;  4JQW A;  2MB9 A;  2LWE A;  1A1W A;  2LWD A;  3LQQ A;  4O7Q A;  1N3K A;  4P4H A;  3EZQ B;  2YQF A;  1FAD A;  4RHW E;  1D2Z B;  3CL3 A;  3EZQ A;  2VGQ A; 
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similar chains in the pdb database (?% sequence similarity)

 
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