4N1KA

Crystal structures of nlrp14 pyrin domain reveal a conformational switch mechanism, regulating its molecular interactions
Total Genus 30
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
30
sequence length
88
structure length
88
Chain Sequence
SSSFFPDFGLLLYLEELNKEELNTFKLFLKETMEPEHGLTPWNEVKKARREDLANLMKKYYPGEKAWSVSLKIFGKMNLKVLCERAKE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Signaling protein
source organism Homo sapiens
publication title Structures of the NLRP14 pyrin domain reveal a conformational switch mechanism regulating its molecular interactions.
pubmed doi rcsb
molecule keywords NACHT, LRR and PYD domains-containing protein 14
total genus 30
structure length 88
sequence length 88
chains with identical sequence B, C, D
ec nomenclature
pdb deposition date 2013-10-04

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02758 PYRIN PAAD/DAPIN/Pyrin domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.533.10 Mainly Alpha Orthogonal Bundle Death Domain, Fas Death Domain, Fas 4n1kA00
4E9MA 1DGNA 1WH4A 4QOBA 4NQKA 3YGSC 3EZQB 1E41A 4P4HA 4UZ0A 1FADA 2DBFA 2YGSA 2O71A 2L6AA 3J63A 3MOPA 4F44A 4FH0A 1D2ZA 4RHWA 3CRDA 3MOPK 1NGRA 4JUPA 4M9SA 1DDFA 1CY5A 4N1LA 4I16A 2YQFA 2MS7A 4ZBWA 2OF5A 2MN4A 2N97A 2N80A 2MS8A 2BBRA 2N00A 4LWDA 2DO9A 2G7RA 4P4HI 1UCPA 1ICHA 2N83A 3T6PA 2MPCA 3LQRA 4A2QA 2DBHA 1C15A 4O9LA 4IZ5E 2LWDA 2NZ7A 2GF5A 4IZAB 4M9XA 2MB9A 4F42A 4DWNA 1A1ZA 4A2WA 2KM6A 2L9MA 3EZQA 2OF5H 2HM2Q 1E3YA 4N1JA 1CWWA 2KN6A 4RHWE 2D96A 2M5VA 4N1KA 2NSNA 1D2ZB 4O9FA 4M9ZA 2NAQA 3YGSP 3MOPG 2YVIA 4IZ7B 1WXPA 4D8OA 2VGQA 2LWEA 1N3KA 2LS7A 2B1WA 2A5YB 2A9IA 2DBGA 2P1HA 2BBZA 2F1SA 3QF2A 3KATA 4O6XA 3LQQA 3J6JA 2DBDA 1Z6TA 3CL3A 4O7QA 2YU0A 4JQWA 4EWIA 1PN5A 1A1WA 2N1FA 1WMGA 2IB1A 1YGOA 2N7ZA
chains in the Genus database with same CATH superfamily
4E9MA 1DGNA 1WH4A 4QOBA 4NQKA 3YGSC 3EZQB 1E41A 4P4HA 4UZ0A 1FADA 2DBFA 2YGSA 2O71A 2L6AA 3J63A 3MOPA 4F44A 4FH0A 1D2ZA 4RHWA 3CRDA 3MOPK 1NGRA 4JUPA 4M9SA 1DDFA 1CY5A 4N1LA 4I16A 2YQFA 2MS7A 4ZBWA 2OF5A 2MN4A 2N97A 2N80A 2MS8A 2BBRA 2N00A 4LWDA 2DO9A 2XV9A 2G7RA 4P4HI 1UCPA 1ICHA 2N83A 3T6PA 2MPCA 3LQRA 4A2QA 2DBHA 1C15A 4O9LA 4IZ5E 2LWDA 2NZ7A 2GF5A 4IZAB 4M9XA 2MB9A 4F42A 4DWNA 1A1ZA 4A2WA 2KM6A 2L9MA 3EZQA 2OF5H 2HM2Q 1E3YA 4N1JA 1CWWA 2KN6A 4RHWE 2D96A 2M5VA 4N1KA 2NSNA 1D2ZB 4O9FA 4M9ZA 2NAQA 2MJMA 3YGSP 3MOPG 2YVIA 4IZ7B 1WXPA 4D8OA 2VGQA 2LWEA 1N3KA 2LS7A 2B1WA 2A5YB 2A9IA 2DBGA 2P1HA 2BBZA 2F1SA 3QF2A 3KATA 4O6XA 3LQQA 3J6JA 2DBDA 1Z6TA 3CL3A 4O7QA 2YU0A 4JQWA 4EWIA 1PN5A 1A1WA 2N1FA 1WMGA 2IB1A 1YGOA 2N7ZA
chains in the Genus database with same CATH topology
4E9MA 1DGNA 1WH4A 4QOBA 4NQKA 3YGSC 3EZQB 1E41A 4P4HA 4UZ0A 1FADA 2DBFA 2YGSA 2O71A 2L6AA 3J63A 3MOPA 4F44A 4FH0A 1D2ZA 4RHWA 3CRDA 3MOPK 1NGRA 4JUPA 4M9SA 1DDFA 1CY5A 4N1LA 4I16A 2YQFA 2MS7A 4ZBWA 2OF5A 2MN4A 2N97A 2N80A 2MS8A 2BBRA 2N00A 4LWDA 2DO9A 2XV9A 2G7RA 4P4HI 1UCPA 1ICHA 2N83A 3T6PA 2MPCA 3LQRA 4A2QA 2DBHA 1C15A 4O9LA 4IZ5E 2LWDA 2NZ7A 2GF5A 4IZAB 4M9XA 2MB9A 4F42A 4DWNA 1A1ZA 4A2WA 2KM6A 2L9MA 3EZQA 2OF5H 2HM2Q 1E3YA 4N1JA 1CWWA 2KN6A 4RHWE 2D96A 2M5VA 4N1KA 2NSNA 1D2ZB 4O9FA 4M9ZA 2NAQA 2MJMA 3YGSP 3MOPG 2YVIA 4IZ7B 1WXPA 4D8OA 2VGQA 2LWEA 1N3KA 2LS7A 2B1WA 2A5YB 2A9IA 2DBGA 2P1HA 2BBZA 2F1SA 3QF2A 3KATA 4O6XA 3LQQA 3J6JA 2DBDA 1Z6TA 3CL3A 4O7QA 2YU0A 4JQWA 4EWIA 1PN5A 1A1WA 2N1FA 1WMGA 2IB1A 1YGOA 2N7ZA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4E9M A;  1DGN A;  1WH4 A;  4QOB A;  4NQK A;  3YGS C;  3EZQ B;  1E41 A;  4P4H A;  4UZ0 A;  1FAD A;  2DBF A;  2YGS A;  2O71 A;  2L6A A;  3J63 A;  3MOP A;  4F44 A;  4FH0 A;  1D2Z A;  4RHW A;  3CRD A;  3MOP K;  1NGR A;  4JUP A;  4M9S A;  1DDF A;  1CY5 A;  4N1L A;  4I16 A;  2YQF A;  2MS7 A;  4ZBW A;  2OF5 A;  2MN4 A;  2N97 A;  2N80 A;  2MS8 A;  2BBR A;  2N00 A;  4LWD A;  2DO9 A;  2G7R A;  4P4H I;  1UCP A;  1ICH A;  2N83 A;  3T6P A;  2MPC A;  3LQR A;  4A2Q A;  2DBH A;  1C15 A;  4O9L A;  4IZ5 E;  2LWD A;  2NZ7 A;  2GF5 A;  4IZA B;  4M9X A;  2MB9 A;  4F42 A;  4DWN A;  1A1Z A;  4A2W A;  2KM6 A;  2L9M A;  3EZQ A;  2OF5 H;  2HM2 Q;  1E3Y A;  4N1J A;  1CWW A;  2KN6 A;  4RHW E;  2D96 A;  2M5V A;  4N1K A;  2NSN A;  1D2Z B;  4O9F A;  4M9Z A;  2NAQ A;  3YGS P;  3MOP G;  2YVI A;  4IZ7 B;  1WXP A;  4D8O A;  2VGQ A;  2LWE A;  1N3K A;  2LS7 A;  2B1W A;  2A5Y B;  2A9I A;  2DBG A;  2P1H A;  2BBZ A;  2F1S A;  3QF2 A;  3KAT A;  4O6X A;  3LQQ A;  3J6J A;  2DBD A;  1Z6T A;  3CL3 A;  4O7Q A;  2YU0 A;  4JQW A;  4EWI A;  1PN5 A;  1A1W A;  2N1F A;  1WMG A;  2IB1 A;  1YGO A;  2N7Z A; 
#chains in the Genus database with same CATH topology
 4E9M A;  1DGN A;  1WH4 A;  4QOB A;  4NQK A;  3YGS C;  3EZQ B;  1E41 A;  4P4H A;  4UZ0 A;  1FAD A;  2DBF A;  2YGS A;  2O71 A;  2L6A A;  3J63 A;  3MOP A;  4F44 A;  4FH0 A;  1D2Z A;  4RHW A;  3CRD A;  3MOP K;  1NGR A;  4JUP A;  4M9S A;  1DDF A;  1CY5 A;  4N1L A;  4I16 A;  2YQF A;  2MS7 A;  4ZBW A;  2OF5 A;  2MN4 A;  2N97 A;  2N80 A;  2MS8 A;  2BBR A;  2N00 A;  4LWD A;  2DO9 A;  2XV9 A;  2G7R A;  4P4H I;  1UCP A;  1ICH A;  2N83 A;  3T6P A;  2MPC A;  3LQR A;  4A2Q A;  2DBH A;  1C15 A;  4O9L A;  4IZ5 E;  2LWD A;  2NZ7 A;  2GF5 A;  4IZA B;  4M9X A;  2MB9 A;  4F42 A;  4DWN A;  1A1Z A;  4A2W A;  2KM6 A;  2L9M A;  3EZQ A;  2OF5 H;  2HM2 Q;  1E3Y A;  4N1J A;  1CWW A;  2KN6 A;  4RHW E;  2D96 A;  2M5V A;  4N1K A;  2NSN A;  1D2Z B;  4O9F A;  4M9Z A;  2NAQ A;  2MJM A;  3YGS P;  3MOP G;  2YVI A;  4IZ7 B;  1WXP A;  4D8O A;  2VGQ A;  2LWE A;  1N3K A;  2LS7 A;  2B1W A;  2A5Y B;  2A9I A;  2DBG A;  2P1H A;  2BBZ A;  2F1S A;  3QF2 A;  3KAT A;  4O6X A;  3LQQ A;  3J6J A;  2DBD A;  1Z6T A;  3CL3 A;  4O7Q A;  2YU0 A;  4JQW A;  4EWI A;  1PN5 A;  1A1W A;  2N1F A;  1WMG A;  2IB1 A;  1YGO A;  2N7Z A; 
#chains in the Genus database with same CATH homology
 4E9M A;  1DGN A;  1WH4 A;  4QOB A;  4NQK A;  3YGS C;  3EZQ B;  1E41 A;  4P4H A;  4UZ0 A;  1FAD A;  2DBF A;  2YGS A;  2O71 A;  2L6A A;  3J63 A;  3MOP A;  4F44 A;  4FH0 A;  1D2Z A;  4RHW A;  3CRD A;  3MOP K;  1NGR A;  4JUP A;  4M9S A;  1DDF A;  1CY5 A;  4N1L A;  4I16 A;  2YQF A;  2MS7 A;  4ZBW A;  2OF5 A;  2MN4 A;  2N97 A;  2N80 A;  2MS8 A;  2BBR A;  2N00 A;  4LWD A;  2DO9 A;  2XV9 A;  2G7R A;  4P4H I;  1UCP A;  1ICH A;  2N83 A;  3T6P A;  2MPC A;  3LQR A;  4A2Q A;  2DBH A;  1C15 A;  4O9L A;  4IZ5 E;  2LWD A;  2NZ7 A;  2GF5 A;  4IZA B;  4M9X A;  2MB9 A;  4F42 A;  4DWN A;  1A1Z A;  4A2W A;  2KM6 A;  2L9M A;  3EZQ A;  2OF5 H;  2HM2 Q;  1E3Y A;  4N1J A;  1CWW A;  2KN6 A;  4RHW E;  2D96 A;  2M5V A;  4N1K A;  2NSN A;  1D2Z B;  4O9F A;  4M9Z A;  2NAQ A;  2MJM A;  3YGS P;  3MOP G;  2YVI A;  4IZ7 B;  1WXP A;  4D8O A;  2VGQ A;  2LWE A;  1N3K A;  2LS7 A;  2B1W A;  2A5Y B;  2A9I A;  2DBG A;  2P1H A;  2BBZ A;  2F1S A;  3QF2 A;  3KAT A;  4O6X A;  3LQQ A;  3J6J A;  2DBD A;  1Z6T A;  3CL3 A;  4O7Q A;  2YU0 A;  4JQW A;  4EWI A;  1PN5 A;  1A1W A;  2N1F A;  1WMG A;  2IB1 A;  1YGO A;  2N7Z A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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