4N1K | Genus

Total Genus 30

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	30
sequence length	88
structure length	88
Chain Sequence	SSSFFPDFGLLLYLEELNKEELNTFKLFLKETMEPEHGLTPWNEVKKARREDLANLMKKYYPGEKAWSVSLKIFGKMNLKVLCERAKE

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

loadScript /static/js/j2s/core/package.js

loadScript /static/js/j2s/core/corejmol.z.js

loadScript /static/js/j2s/core/corescript.z.js

JSmol exec jmolApplet0 start applet null

Jmol JavaScript applet jmolApplet0__532820536863777__ initializing

Jmol getValue debug null

Jmol getValue logLevel null

Jmol getValue allowjavascript null

AppletRegistry.checkIn(jmolApplet0__532820536863777__)

vwrOptions:

{ "name":"jmolApplet0","applet":true,"documentBase":"https://genus.fuw.edu.pl/view/4N1K/A/","platform":"J.awtjs2d.Platform","fullName":"jmolApplet0__532820536863777__","codePath":"https:/static/js/j2s/","display":"jmolApplet0_canvas2d","signedApplet":"true","appletReadyCallback":"Jmol._readyCallback","statusListener":"[J.appletjs.Jmol object]","syncId":"532820536863777","bgcolor":"white" }

setting document base to "https://genus.fuw.edu.pl/view/4N1K/A/"

Jmol Version: 14.29.13 2018-04-17 17:17

java.vendor: Java2Script (HTML5)

java.version: 2018-01-28 23:38:52 (JSmol/j2s)

os.name: Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)

Access: ALL

memory: 0.0/0.0

processors available: 1

useCommandThread: false

appletId:jmolApplet0 (signed)

Jmol getValue emulate null

defaults = "Jmol"

Jmol getValue boxbgcolor null

Jmol getValue bgcolor white

backgroundColor = "white"

Jmol getValue ANIMFRAMECallback null

Jmol getValue APPLETREADYCallback Jmol._readyCallback

APPLETREADYCallback = "Jmol._readyCallback"

callback set for APPLETREADYCallback Jmol._readyCallback APPLETREADY

Jmol getValue ATOMMOVEDCallback null

Jmol getValue AUDIOCallback null

Jmol getValue CLICKCallback null

Jmol getValue DRAGDROPCallback null

Jmol getValue ECHOCallback null

Jmol getValue ERRORCallback null

Jmol getValue EVALCallback null

Jmol getValue HOVERCallback null

Jmol getValue IMAGECallback null

Jmol getValue LOADSTRUCTCallback null

Jmol getValue MEASURECallback null

Jmol getValue MESSAGECallback null

Jmol getValue MINIMIZATIONCallback null

Jmol getValue SERVICECallback null

Jmol getValue PICKCallback null

Jmol getValue RESIZECallback null

Jmol getValue SCRIPTCallback null

Jmol getValue SYNCCallback null

Jmol getValue STRUCTUREMODIFIEDCallback null

Jmol getValue doTranslate null

language=en_US

Jmol getValue popupMenu null

Jmol getValue script null

Jmol getValue loadInline null

Jmol getValue load null

Jmol applet jmolApplet0__532820536863777__ ready

script 1 started

platformSpeed = 8

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Signaling protein
source organism	Homo sapiens
publication title	Structures of the NLRP14 pyrin domain reveal a conformational switch mechanism regulating its molecular interactions. pubmed doi rcsb
molecule keywords	NACHT, LRR and PYD domains-containing protein 14
total genus	30
structure length	88
sequence length	88
chains with identical sequence	B, C, D
ec nomenclature
pdb deposition date	2013-10-04

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF02758	PYRIN	PAAD/DAPIN/Pyrin domain

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
1.10.533.10	Mainly Alpha	Orthogonal Bundle	Death Domain, Fas	Death Domain, Fas	4n1kA00

3LQRA 1ICHA 1Z6TA 4EWIA 1E3YA 4NQKA 4M9ZA 3LQQA 1A1ZA 2LS7A 3CRDA 3EZQB 4M9SA 3CL3A 2N83A 4IZ5E 2BBRA 3YGSC 4O7QA 4E9MA 1CY5A 2N00A 2P1HA 3J6JA 4I16A 2NAQA 4UZ0A 1DDFA 2GF5A 2O71A 2G7RA 2DBDA 4QOBA 1WMGA 2A5YB 3J63A 3MOPA 1UCPA 1NGRA 1PN5A 2N80A 2DBHA 2MN4A 1A1WA 1C15A 1N3KA 4P4HI 2LWEA 3MOPG 4IZ7B 4JUPA 4N1KA 1E41A 3EZQA 2YQFA 2N97A 2YVIA 1D2ZA 2DO9A 4LWDA 4A2WA 2MS8A 4P4HA 2L9MA 4JQWA 2B1WA 2M5VA 4IZAB 4D8OA 2L6AA 3T6PA 3YGSP 1WXPA 2NZ7A 2D96A 1CWWA 4ZBWA 4N1LA 2IB1A 1FADA 2NSNA 4A2QA 1WH4A 2F1SA 2VGQA 4FH0A 2N7ZA 4RHWA 1DGNA 3MOPK 2DBFA 2BBZA 2A9IA 3QF2A 4O6XA 4RHWE 4O9LA 4F44A 2LWDA 1YGOA 2KM6A 2OF5A 2YU0A 1D2ZB 2N1FA 2MPCA 4DWNA 3KATA 2YGSA 2KN6A 4O9FA 4N1JA 2OF5H 4F42A 4M9XA 2MS7A 2DBGA 2HM2Q 2MB9A
chains in the Genus database with same CATH superfamily

3LQRA 1ICHA 1Z6TA 4EWIA 1E3YA 4NQKA 4M9ZA 3LQQA 1A1ZA 2LS7A 3CRDA 3EZQB 4M9SA 3CL3A 2N83A 4IZ5E 2BBRA 3YGSC 4O7QA 4E9MA 1CY5A 2N00A 2P1HA 3J6JA 4I16A 2NAQA 4UZ0A 1DDFA 2GF5A 2O71A 2G7RA 2DBDA 4QOBA 1WMGA 2MJMA 2A5YB 3J63A 3MOPA 1UCPA 1NGRA 1PN5A 2N80A 2DBHA 2MN4A 1A1WA 1C15A 1N3KA 4P4HI 2LWEA 3MOPG 4IZ7B 4JUPA 4N1KA 1E41A 3EZQA 2YQFA 2N97A 2YVIA 1D2ZA 2DO9A 4LWDA 4A2WA 2MS8A 4P4HA 2L9MA 4JQWA 2B1WA 2M5VA 4IZAB 4D8OA 2L6AA 3T6PA 3YGSP 1WXPA 2NZ7A 2D96A 1CWWA 4ZBWA 4N1LA 2IB1A 1FADA 2NSNA 4A2QA 1WH4A 2F1SA 2VGQA 4FH0A 2N7ZA 4RHWA 1DGNA 3MOPK 2DBFA 2BBZA 2A9IA 3QF2A 4O6XA 4RHWE 4O9LA 4F44A 2LWDA 1YGOA 2KM6A 2OF5A 2XV9A 2YU0A 1D2ZB 2N1FA 2MPCA 4DWNA 3KATA 2YGSA 2KN6A 4O9FA 4N1JA 2OF5H 4F42A 4M9XA 2MS7A 2DBGA 2HM2Q 2MB9A
chains in the Genus database with same CATH topology

3LQRA 1ICHA 1Z6TA 4EWIA 1E3YA 4NQKA 4M9ZA 3LQQA 1A1ZA 2LS7A 3CRDA 3EZQB 4M9SA 3CL3A 2N83A 4IZ5E 2BBRA 3YGSC 4O7QA 4E9MA 1CY5A 2N00A 2P1HA 3J6JA 4I16A 2NAQA 4UZ0A 1DDFA 2GF5A 2O71A 2G7RA 2DBDA 4QOBA 1WMGA 2MJMA 2A5YB 3J63A 3MOPA 1UCPA 1NGRA 1PN5A 2N80A 2DBHA 2MN4A 1A1WA 1C15A 1N3KA 4P4HI 2LWEA 3MOPG 4IZ7B 4JUPA 4N1KA 1E41A 3EZQA 2YQFA 2N97A 2YVIA 1D2ZA 2DO9A 4LWDA 4A2WA 2MS8A 4P4HA 2L9MA 4JQWA 2B1WA 2M5VA 4IZAB 4D8OA 2L6AA 3T6PA 3YGSP 1WXPA 2NZ7A 2D96A 1CWWA 4ZBWA 4N1LA 2IB1A 1FADA 2NSNA 4A2QA 1WH4A 2F1SA 2VGQA 4FH0A 2N7ZA 4RHWA 1DGNA 3MOPK 2DBFA 2BBZA 2A9IA 3QF2A 4O6XA 4RHWE 4O9LA 4F44A 2LWDA 1YGOA 2KM6A 2OF5A 2XV9A 2YU0A 1D2ZB 2N1FA 2MPCA 4DWNA 3KATA 2YGSA 2KN6A 4O9FA 4N1JA 2OF5H 4F42A 4M9XA 2MS7A 2DBGA 2HM2Q 2MB9A
chains in the Genus database with same CATH homology

#chains in the Genus database with same CATH superfamily
 3LQR A;  1ICH A;  1Z6T A;  4EWI A;  1E3Y A;  4NQK A;  4M9Z A;  3LQQ A;  1A1Z A;  2LS7 A;  3CRD A;  3EZQ B;  4M9S A;  3CL3 A;  2N83 A;  4IZ5 E;  2BBR A;  3YGS C;  4O7Q A;  4E9M A;  1CY5 A;  2N00 A;  2P1H A;  3J6J A;  4I16 A;  2NAQ A;  4UZ0 A;  1DDF A;  2GF5 A;  2O71 A;  2G7R A;  2DBD A;  4QOB A;  1WMG A;  2A5Y B;  3J63 A;  3MOP A;  1UCP A;  1NGR A;  1PN5 A;  2N80 A;  2DBH A;  2MN4 A;  1A1W A;  1C15 A;  1N3K A;  4P4H I;  2LWE A;  3MOP G;  4IZ7 B;  4JUP A;  4N1K A;  1E41 A;  3EZQ A;  2YQF A;  2N97 A;  2YVI A;  1D2Z A;  2DO9 A;  4LWD A;  4A2W A;  2MS8 A;  4P4H A;  2L9M A;  4JQW A;  2B1W A;  2M5V A;  4IZA B;  4D8O A;  2L6A A;  3T6P A;  3YGS P;  1WXP A;  2NZ7 A;  2D96 A;  1CWW A;  4ZBW A;  4N1L A;  2IB1 A;  1FAD A;  2NSN A;  4A2Q A;  1WH4 A;  2F1S A;  2VGQ A;  4FH0 A;  2N7Z A;  4RHW A;  1DGN A;  3MOP K;  2DBF A;  2BBZ A;  2A9I A;  3QF2 A;  4O6X A;  4RHW E;  4O9L A;  4F44 A;  2LWD A;  1YGO A;  2KM6 A;  2OF5 A;  2YU0 A;  1D2Z B;  2N1F A;  2MPC A;  4DWN A;  3KAT A;  2YGS A;  2KN6 A;  4O9F A;  4N1J A;  2OF5 H;  4F42 A;  4M9X A;  2MS7 A;  2DBG A;  2HM2 Q;  2MB9 A; 
#chains in the Genus database with same CATH topology
 3LQR A;  1ICH A;  1Z6T A;  4EWI A;  1E3Y A;  4NQK A;  4M9Z A;  3LQQ A;  1A1Z A;  2LS7 A;  3CRD A;  3EZQ B;  4M9S A;  3CL3 A;  2N83 A;  4IZ5 E;  2BBR A;  3YGS C;  4O7Q A;  4E9M A;  1CY5 A;  2N00 A;  2P1H A;  3J6J A;  4I16 A;  2NAQ A;  4UZ0 A;  1DDF A;  2GF5 A;  2O71 A;  2G7R A;  2DBD A;  4QOB A;  1WMG A;  2MJM A;  2A5Y B;  3J63 A;  3MOP A;  1UCP A;  1NGR A;  1PN5 A;  2N80 A;  2DBH A;  2MN4 A;  1A1W A;  1C15 A;  1N3K A;  4P4H I;  2LWE A;  3MOP G;  4IZ7 B;  4JUP A;  4N1K A;  1E41 A;  3EZQ A;  2YQF A;  2N97 A;  2YVI A;  1D2Z A;  2DO9 A;  4LWD A;  4A2W A;  2MS8 A;  4P4H A;  2L9M A;  4JQW A;  2B1W A;  2M5V A;  4IZA B;  4D8O A;  2L6A A;  3T6P A;  3YGS P;  1WXP A;  2NZ7 A;  2D96 A;  1CWW A;  4ZBW A;  4N1L A;  2IB1 A;  1FAD A;  2NSN A;  4A2Q A;  1WH4 A;  2F1S A;  2VGQ A;  4FH0 A;  2N7Z A;  4RHW A;  1DGN A;  3MOP K;  2DBF A;  2BBZ A;  2A9I A;  3QF2 A;  4O6X A;  4RHW E;  4O9L A;  4F44 A;  2LWD A;  1YGO A;  2KM6 A;  2OF5 A;  2XV9 A;  2YU0 A;  1D2Z B;  2N1F A;  2MPC A;  4DWN A;  3KAT A;  2YGS A;  2KN6 A;  4O9F A;  4N1J A;  2OF5 H;  4F42 A;  4M9X A;  2MS7 A;  2DBG A;  2HM2 Q;  2MB9 A; 
#chains in the Genus database with same CATH homology
 3LQR A;  1ICH A;  1Z6T A;  4EWI A;  1E3Y A;  4NQK A;  4M9Z A;  3LQQ A;  1A1Z A;  2LS7 A;  3CRD A;  3EZQ B;  4M9S A;  3CL3 A;  2N83 A;  4IZ5 E;  2BBR A;  3YGS C;  4O7Q A;  4E9M A;  1CY5 A;  2N00 A;  2P1H A;  3J6J A;  4I16 A;  2NAQ A;  4UZ0 A;  1DDF A;  2GF5 A;  2O71 A;  2G7R A;  2DBD A;  4QOB A;  1WMG A;  2MJM A;  2A5Y B;  3J63 A;  3MOP A;  1UCP A;  1NGR A;  1PN5 A;  2N80 A;  2DBH A;  2MN4 A;  1A1W A;  1C15 A;  1N3K A;  4P4H I;  2LWE A;  3MOP G;  4IZ7 B;  4JUP A;  4N1K A;  1E41 A;  3EZQ A;  2YQF A;  2N97 A;  2YVI A;  1D2Z A;  2DO9 A;  4LWD A;  4A2W A;  2MS8 A;  4P4H A;  2L9M A;  4JQW A;  2B1W A;  2M5V A;  4IZA B;  4D8O A;  2L6A A;  3T6P A;  3YGS P;  1WXP A;  2NZ7 A;  2D96 A;  1CWW A;  4ZBW A;  4N1L A;  2IB1 A;  1FAD A;  2NSN A;  4A2Q A;  1WH4 A;  2F1S A;  2VGQ A;  4FH0 A;  2N7Z A;  4RHW A;  1DGN A;  3MOP K;  2DBF A;  2BBZ A;  2A9I A;  3QF2 A;  4O6X A;  4RHW E;  4O9L A;  4F44 A;  2LWD A;  1YGO A;  2KM6 A;  2OF5 A;  2XV9 A;  2YU0 A;  1D2Z B;  2N1F A;  2MPC A;  4DWN A;  3KAT A;  2YGS A;  2KN6 A;  4O9F A;  4N1J A;  2OF5 H;  4F42 A;  4M9X A;  2MS7 A;  2DBG A;  2HM2 Q;  2MB9 A;

...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)

...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...

4N1KA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations