2DJYA

Solution structure of smurf2 ww3 domain-smad7 py peptide complex
Total Genus 3
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
3
sequence length
42
structure length
42
Chain Sequence
GPLGSGPLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRLSAN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Ligase/signaling protein
source organism Homo sapiens
publication title An Expanded WW Domain Recognition Motif Revealed by the Interaction between Smad7 and the E3 Ubiquitin Ligase Smurf2.
pubmed doi rcsb
molecule keywords Smad ubiquitination regulatory factor 2
total genus 3
structure length 42
sequence length 42
ec nomenclature ec 2.3.2.26: HECT-type E3 ubiquitin transferase.
pdb deposition date 2006-04-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00397 WW WW domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.20.70.10 Mainly Beta Single Sheet Ubiquitin Ligase Nedd4; Chain: W; Ubiquitin Ligase Nedd4; Chain: W; 2djyA01
3WH0A 3M7NA 2M3OW 2YSFA 2ZR6A 1I5HW 2M8JA 1TK7A 3L4HA 4U86A 2JMFA 3TCZA 4U85A 2ZR4A 1K9RA 2EZ5W 2ZQSA 2XP8A 1EG4A 3KABA 2XPAA 2XP5A 2ZQVA 3TC5A 3NTPA 3KAGA 2M8IA 5AHTA 3KADA 2DMVA 2YSBA 3LE4A 2XPBA 1WR7A 4REXA 2MDIA 3M85A 2ZR5A 2JV4A 4QIBA 1K9QA 2ZAJA 2JX8A 5CQ2A 3ODKA 2F21A 1F8AB 1WMVA 2DK1A 2JXWA 2DWVA 2ZQUA 1ZCNA 2XP7A 2E45A 2BA1A 1NMVA 2Q5AA 3OOBA 3TDBA 4U84A 3KCEA 2KXQA 2DJYA 1PINA 3KAHA 2XP3A 1JMQA 2XP6A 1EG3A 2YSIA 2YSHA 3CNGA 3KAFA 2ITKA 1O6WA 2RE3A 3KAIA 1YW5A 4E5RA 2L4JA 2LAJA 2XP9A 2ZQTA 2DK7A 2XP4A 2YSGA
chains in the Genus database with same CATH superfamily
3WH0A 3M7NA 2M3OW 2YSFA 3MCBB 2ZR6A 3FSCA 1I5HW 2M8JA 1TK7A 3L4HA 4U86A 5E64A 2JMFA 5E5WA 3TCZA 4U85A 2ZR4A 1K9RA 2EZ5W 2ZQSA 2XP8A 1EG4A 3KABA 2XPAA 2XP5A 2ZQVA 3MQGA 3LKXA 3TC5A 3NTPA 3KAGA 1RP5A 2M8IA 5AHTA 3KADA 1TR8A 5E65A 2DMVA 2YSBA 3LE4A 2XPBA 1WR7A 1FLCA 4REXA 5E66A 2MDIA 3M85A 2ZR5A 4GLXA 2JV4A 4QIBA 1K9QA 2ZAJA 3MCBA 2JX8A 5CQ2A 4A0TA 3ODKA 2OWOA 3LKXB 3PQHA 2F21A 3FSBA 2QRVA 5E62A 1F8AB 1WMVA 2DK1A 2Y8NB 2JXWA 2DWVA 2ZQUA 5U47A 1ZCNA 2XP7A 2WAEA 2E45A 2BA1A 1NMVA 2Q5AA 3FS8A 3OOBA 3TDBA 2YAJB 4U84A 3KCEA 2KXQA 2DJYA 1PINA 3KAHA 2WADA 2XP3A 1JMQA 2XP6A 1EG3A 2YSIA 2YSHA 3CNGA 3KAFA 2ITKA 3MQHA 1O6WA 2RE3A 3KAIA 1YW5A 4E5RA 2L4JA 2LAJA 2XP9A 4A0UA 2ZQTA 2DK7A 2XP4A 2YSGA
chains in the Genus database with same CATH topology
3WH0A 3M7NA 2M3OW 2YSFA 3MCBB 2ZR6A 3FSCA 1I5HW 2M8JA 1TK7A 3L4HA 4U86A 5E64A 2JMFA 5E5WA 3TCZA 4U85A 2ZR4A 1K9RA 2EZ5W 2ZQSA 2XP8A 1EG4A 3KABA 2XPAA 2XP5A 2ZQVA 3MQGA 3LKXA 3TC5A 3NTPA 3KAGA 1RP5A 2M8IA 5AHTA 3KADA 1TR8A 5E65A 2DMVA 2YSBA 3LE4A 2XPBA 1WR7A 1FLCA 4REXA 5E66A 2MDIA 3M85A 2ZR5A 4GLXA 2JV4A 4QIBA 1K9QA 2ZAJA 3MCBA 2JX8A 5CQ2A 4A0TA 3ODKA 2OWOA 3LKXB 3PQHA 2F21A 3FSBA 2QRVA 5E62A 1F8AB 1WMVA 2DK1A 2Y8NB 2JXWA 2DWVA 2ZQUA 5U47A 1ZCNA 2XP7A 2WAEA 2E45A 2BA1A 1NMVA 2Q5AA 3FS8A 3OOBA 3TDBA 2YAJB 4U84A 3KCEA 2KXQA 2DJYA 1PINA 3KAHA 2WADA 2XP3A 1JMQA 2XP6A 1EG3A 2YSIA 2YSHA 3CNGA 3KAFA 2ITKA 3MQHA 1O6WA 2RE3A 3KAIA 1YW5A 4E5RA 2L4JA 2LAJA 2XP9A 4A0UA 2ZQTA 2DK7A 2XP4A 2YSGA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3WH0 A;  3M7N A;  2M3O W;  2YSF A;  2ZR6 A;  1I5H W;  2M8J A;  1TK7 A;  3L4H A;  4U86 A;  2JMF A;  3TCZ A;  4U85 A;  2ZR4 A;  1K9R A;  2EZ5 W;  2ZQS A;  2XP8 A;  1EG4 A;  3KAB A;  2XPA A;  2XP5 A;  2ZQV A;  3TC5 A;  3NTP A;  3KAG A;  2M8I A;  5AHT A;  3KAD A;  2DMV A;  2YSB A;  3LE4 A;  2XPB A;  1WR7 A;  4REX A;  2MDI A;  3M85 A;  2ZR5 A;  2JV4 A;  4QIB A;  1K9Q A;  2ZAJ A;  2JX8 A;  5CQ2 A;  3ODK A;  2F21 A;  1F8A B;  1WMV A;  2DK1 A;  2JXW A;  2DWV A;  2ZQU A;  1ZCN A;  2XP7 A;  2E45 A;  2BA1 A;  1NMV A;  2Q5A A;  3OOB A;  3TDB A;  4U84 A;  3KCE A;  2KXQ A;  2DJY A;  1PIN A;  3KAH A;  2XP3 A;  1JMQ A;  2XP6 A;  1EG3 A;  2YSI A;  2YSH A;  3CNG A;  3KAF A;  2ITK A;  1O6W A;  2RE3 A;  3KAI A;  1YW5 A;  4E5R A;  2L4J A;  2LAJ A;  2XP9 A;  2ZQT A;  2DK7 A;  2XP4 A;  2YSG A; 
#chains in the Genus database with same CATH topology
 3WH0 A;  3M7N A;  2M3O W;  2YSF A;  3MCB B;  2ZR6 A;  3FSC A;  1I5H W;  2M8J A;  1TK7 A;  3L4H A;  4U86 A;  5E64 A;  2JMF A;  5E5W A;  3TCZ A;  4U85 A;  2ZR4 A;  1K9R A;  2EZ5 W;  2ZQS A;  2XP8 A;  1EG4 A;  3KAB A;  2XPA A;  2XP5 A;  2ZQV A;  3MQG A;  3LKX A;  3TC5 A;  3NTP A;  3KAG A;  1RP5 A;  2M8I A;  5AHT A;  3KAD A;  1TR8 A;  5E65 A;  2DMV A;  2YSB A;  3LE4 A;  2XPB A;  1WR7 A;  1FLC A;  4REX A;  5E66 A;  2MDI A;  3M85 A;  2ZR5 A;  4GLX A;  2JV4 A;  4QIB A;  1K9Q A;  2ZAJ A;  3MCB A;  2JX8 A;  5CQ2 A;  4A0T A;  3ODK A;  2OWO A;  3LKX B;  3PQH A;  2F21 A;  3FSB A;  2QRV A;  5E62 A;  1F8A B;  1WMV A;  2DK1 A;  2Y8N B;  2JXW A;  2DWV A;  2ZQU A;  5U47 A;  1ZCN A;  2XP7 A;  2WAE A;  2E45 A;  2BA1 A;  1NMV A;  2Q5A A;  3FS8 A;  3OOB A;  3TDB A;  2YAJ B;  4U84 A;  3KCE A;  2KXQ A;  2DJY A;  1PIN A;  3KAH A;  2WAD A;  2XP3 A;  1JMQ A;  2XP6 A;  1EG3 A;  2YSI A;  2YSH A;  3CNG A;  3KAF A;  2ITK A;  3MQH A;  1O6W A;  2RE3 A;  3KAI A;  1YW5 A;  4E5R A;  2L4J A;  2LAJ A;  2XP9 A;  4A0U A;  2ZQT A;  2DK7 A;  2XP4 A;  2YSG A; 
#chains in the Genus database with same CATH homology
 3WH0 A;  3M7N A;  2M3O W;  2YSF A;  3MCB B;  2ZR6 A;  3FSC A;  1I5H W;  2M8J A;  1TK7 A;  3L4H A;  4U86 A;  5E64 A;  2JMF A;  5E5W A;  3TCZ A;  4U85 A;  2ZR4 A;  1K9R A;  2EZ5 W;  2ZQS A;  2XP8 A;  1EG4 A;  3KAB A;  2XPA A;  2XP5 A;  2ZQV A;  3MQG A;  3LKX A;  3TC5 A;  3NTP A;  3KAG A;  1RP5 A;  2M8I A;  5AHT A;  3KAD A;  1TR8 A;  5E65 A;  2DMV A;  2YSB A;  3LE4 A;  2XPB A;  1WR7 A;  1FLC A;  4REX A;  5E66 A;  2MDI A;  3M85 A;  2ZR5 A;  4GLX A;  2JV4 A;  4QIB A;  1K9Q A;  2ZAJ A;  3MCB A;  2JX8 A;  5CQ2 A;  4A0T A;  3ODK A;  2OWO A;  3LKX B;  3PQH A;  2F21 A;  3FSB A;  2QRV A;  5E62 A;  1F8A B;  1WMV A;  2DK1 A;  2Y8N B;  2JXW A;  2DWV A;  2ZQU A;  5U47 A;  1ZCN A;  2XP7 A;  2WAE A;  2E45 A;  2BA1 A;  1NMV A;  2Q5A A;  3FS8 A;  3OOB A;  3TDB A;  2YAJ B;  4U84 A;  3KCE A;  2KXQ A;  2DJY A;  1PIN A;  3KAH A;  2WAD A;  2XP3 A;  1JMQ A;  2XP6 A;  1EG3 A;  2YSI A;  2YSH A;  3CNG A;  3KAF A;  2ITK A;  3MQH A;  1O6W A;  2RE3 A;  3KAI A;  1YW5 A;  4E5R A;  2L4J A;  2LAJ A;  2XP9 A;  4A0U A;  2ZQT A;  2DK7 A;  2XP4 A;  2YSG A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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