2YSFA

Solution structure of the fourth ww domain from the human e3 ubiquitin-protein ligase itchy homolog, itch
Total Genus 1
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
1
sequence length
40
structure length
40
Chain Sequence
GSSGSSGLPEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Solution structure of the fourth WW domain from the human E3 ubiquitin-protein ligase Itchy homolog, ITCH
rcsb
molecule tags Protein binding
source organism Homo sapiens
molecule keywords E3 ubiquitin-protein ligase Itchy homolog
total genus 1
structure length 40
sequence length 40
ec nomenclature ec 2.3.2.26: HECT-type E3 ubiquitin transferase.
pdb deposition date 2007-04-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00397 WW WW domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.20.70.10 Mainly Beta Single Sheet Ubiquitin Ligase Nedd4; Chain: W; Ubiquitin Ligase Nedd4; Chain: W; 2ysfA01
3M85A 5AHTA 2XP8A 2ZQUA 2KXQA 3KADA 2JXWA 2XPBA 1K9RA 2DK1A 3L4HA 2ZR4A 1EG4A 2M8JA 4QIBA 2YSBA 2L4JA 2EZ5W 2M3OW 2YSIA 3NTPA 3LE4A 4U84A 5CQ2A 1PINA 3KCEA 2BA1A 2DJYA 2F21A 3M7NA 1O6WA 2XP4A 3ODKA 2YSFA 2JMFA 2MDIA 3TDBA 2DMVA 2ZQTA 3KAFA 1TK7A 2XP7A 2M8IA 3OOBA 2XP3A 1WR7A 1EG3A 2ITKA 2ZAJA 1NMVA 2JX8A 2YSHA 3KABA 1K9QA 1JMQA 2DWVA 2XP5A 1WMVA 4E5RA 2E45A 1F8AB 2ZR6A 3CNGA 2XPAA 3KAIA 1I5HW 2DK7A 2RE3A 2LAJA 4REXA 3TC5A 2ZR5A 1ZCNA 2YSGA 2Q5AA 2ZQSA 2ZQVA 2XP9A 3KAHA 3WH0A 4U85A 3TCZA 4U86A 2JV4A 2XP6A 3KAGA 1YW5A
chains in the Genus database with same CATH superfamily
2Y8NB 3M85A 5AHTA 2XP8A 2ZQUA 2KXQA 2WADA 3KADA 2JXWA 2XPBA 3MQHA 1K9RA 2DK1A 3L4HA 2ZR4A 1EG4A 2M8JA 4QIBA 2YSBA 2L4JA 5E64A 2WAEA 2EZ5W 2M3OW 3MCBA 5U47A 2YSIA 3NTPA 3LE4A 4U84A 5CQ2A 1FLCA 2QRVA 5E66A 3MCBB 1PINA 3FSBA 3KCEA 2BA1A 2DJYA 2F21A 5E5WA 3M7NA 1O6WA 4GLXA 2XP4A 3ODKA 2YSFA 2JMFA 3FS8A 2MDIA 3TDBA 2DMVA 5E65A 3PQHA 2ZQTA 3KAFA 4A0TA 1TK7A 2XP7A 2M8IA 3OOBA 2XP3A 1WR7A 1EG3A 2ITKA 2ZAJA 1NMVA 2JX8A 2YSHA 3KABA 1K9QA 1JMQA 2YAJB 2DWVA 2XP5A 1WMVA 4E5RA 2E45A 1F8AB 2ZR6A 3CNGA 3LKXA 2XPAA 3KAIA 3MQGA 1I5HW 2DK7A 4A0UA 2RE3A 2LAJA 3LKXB 4REXA 3TC5A 2ZR5A 1ZCNA 2YSGA 1RP5A 1TR8A 2Q5AA 3FSCA 2ZQSA 2OWOA 2ZQVA 2XP9A 3KAHA 3WH0A 4U85A 3TCZA 4U86A 5E62A 2JV4A 2XP6A 3KAGA 1YW5A
chains in the Genus database with same CATH topology
2Y8NB 3M85A 5AHTA 2XP8A 2ZQUA 2KXQA 2WADA 3KADA 2JXWA 2XPBA 3MQHA 1K9RA 2DK1A 3L4HA 2ZR4A 1EG4A 2M8JA 4QIBA 2YSBA 2L4JA 5E64A 2WAEA 2EZ5W 2M3OW 3MCBA 5U47A 2YSIA 3NTPA 3LE4A 4U84A 5CQ2A 1FLCA 2QRVA 5E66A 3MCBB 1PINA 3FSBA 3KCEA 2BA1A 2DJYA 2F21A 5E5WA 3M7NA 1O6WA 4GLXA 2XP4A 3ODKA 2YSFA 2JMFA 3FS8A 2MDIA 3TDBA 2DMVA 5E65A 3PQHA 2ZQTA 3KAFA 4A0TA 1TK7A 2XP7A 2M8IA 3OOBA 2XP3A 1WR7A 1EG3A 2ITKA 2ZAJA 1NMVA 2JX8A 2YSHA 3KABA 1K9QA 1JMQA 2YAJB 2DWVA 2XP5A 1WMVA 4E5RA 2E45A 1F8AB 2ZR6A 3CNGA 3LKXA 2XPAA 3KAIA 3MQGA 1I5HW 2DK7A 4A0UA 2RE3A 2LAJA 3LKXB 4REXA 3TC5A 2ZR5A 1ZCNA 2YSGA 1RP5A 1TR8A 2Q5AA 3FSCA 2ZQSA 2OWOA 2ZQVA 2XP9A 3KAHA 3WH0A 4U85A 3TCZA 4U86A 5E62A 2JV4A 2XP6A 3KAGA 1YW5A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3M85 A;  5AHT A;  2XP8 A;  2ZQU A;  2KXQ A;  3KAD A;  2JXW A;  2XPB A;  1K9R A;  2DK1 A;  3L4H A;  2ZR4 A;  1EG4 A;  2M8J A;  4QIB A;  2YSB A;  2L4J A;  2EZ5 W;  2M3O W;  2YSI A;  3NTP A;  3LE4 A;  4U84 A;  5CQ2 A;  1PIN A;  3KCE A;  2BA1 A;  2DJY A;  2F21 A;  3M7N A;  1O6W A;  2XP4 A;  3ODK A;  2YSF A;  2JMF A;  2MDI A;  3TDB A;  2DMV A;  2ZQT A;  3KAF A;  1TK7 A;  2XP7 A;  2M8I A;  3OOB A;  2XP3 A;  1WR7 A;  1EG3 A;  2ITK A;  2ZAJ A;  1NMV A;  2JX8 A;  2YSH A;  3KAB A;  1K9Q A;  1JMQ A;  2DWV A;  2XP5 A;  1WMV A;  4E5R A;  2E45 A;  1F8A B;  2ZR6 A;  3CNG A;  2XPA A;  3KAI A;  1I5H W;  2DK7 A;  2RE3 A;  2LAJ A;  4REX A;  3TC5 A;  2ZR5 A;  1ZCN A;  2YSG A;  2Q5A A;  2ZQS A;  2ZQV A;  2XP9 A;  3KAH A;  3WH0 A;  4U85 A;  3TCZ A;  4U86 A;  2JV4 A;  2XP6 A;  3KAG A;  1YW5 A; 
#chains in the Genus database with same CATH topology
 2Y8N B;  3M85 A;  5AHT A;  2XP8 A;  2ZQU A;  2KXQ A;  2WAD A;  3KAD A;  2JXW A;  2XPB A;  3MQH A;  1K9R A;  2DK1 A;  3L4H A;  2ZR4 A;  1EG4 A;  2M8J A;  4QIB A;  2YSB A;  2L4J A;  5E64 A;  2WAE A;  2EZ5 W;  2M3O W;  3MCB A;  5U47 A;  2YSI A;  3NTP A;  3LE4 A;  4U84 A;  5CQ2 A;  1FLC A;  2QRV A;  5E66 A;  3MCB B;  1PIN A;  3FSB A;  3KCE A;  2BA1 A;  2DJY A;  2F21 A;  5E5W A;  3M7N A;  1O6W A;  4GLX A;  2XP4 A;  3ODK A;  2YSF A;  2JMF A;  3FS8 A;  2MDI A;  3TDB A;  2DMV A;  5E65 A;  3PQH A;  2ZQT A;  3KAF A;  4A0T A;  1TK7 A;  2XP7 A;  2M8I A;  3OOB A;  2XP3 A;  1WR7 A;  1EG3 A;  2ITK A;  2ZAJ A;  1NMV A;  2JX8 A;  2YSH A;  3KAB A;  1K9Q A;  1JMQ A;  2YAJ B;  2DWV A;  2XP5 A;  1WMV A;  4E5R A;  2E45 A;  1F8A B;  2ZR6 A;  3CNG A;  3LKX A;  2XPA A;  3KAI A;  3MQG A;  1I5H W;  2DK7 A;  4A0U A;  2RE3 A;  2LAJ A;  3LKX B;  4REX A;  3TC5 A;  2ZR5 A;  1ZCN A;  2YSG A;  1RP5 A;  1TR8 A;  2Q5A A;  3FSC A;  2ZQS A;  2OWO A;  2ZQV A;  2XP9 A;  3KAH A;  3WH0 A;  4U85 A;  3TCZ A;  4U86 A;  5E62 A;  2JV4 A;  2XP6 A;  3KAG A;  1YW5 A; 
#chains in the Genus database with same CATH homology
 2Y8N B;  3M85 A;  5AHT A;  2XP8 A;  2ZQU A;  2KXQ A;  2WAD A;  3KAD A;  2JXW A;  2XPB A;  3MQH A;  1K9R A;  2DK1 A;  3L4H A;  2ZR4 A;  1EG4 A;  2M8J A;  4QIB A;  2YSB A;  2L4J A;  5E64 A;  2WAE A;  2EZ5 W;  2M3O W;  3MCB A;  5U47 A;  2YSI A;  3NTP A;  3LE4 A;  4U84 A;  5CQ2 A;  1FLC A;  2QRV A;  5E66 A;  3MCB B;  1PIN A;  3FSB A;  3KCE A;  2BA1 A;  2DJY A;  2F21 A;  5E5W A;  3M7N A;  1O6W A;  4GLX A;  2XP4 A;  3ODK A;  2YSF A;  2JMF A;  3FS8 A;  2MDI A;  3TDB A;  2DMV A;  5E65 A;  3PQH A;  2ZQT A;  3KAF A;  4A0T A;  1TK7 A;  2XP7 A;  2M8I A;  3OOB A;  2XP3 A;  1WR7 A;  1EG3 A;  2ITK A;  2ZAJ A;  1NMV A;  2JX8 A;  2YSH A;  3KAB A;  1K9Q A;  1JMQ A;  2YAJ B;  2DWV A;  2XP5 A;  1WMV A;  4E5R A;  2E45 A;  1F8A B;  2ZR6 A;  3CNG A;  3LKX A;  2XPA A;  3KAI A;  3MQG A;  1I5H W;  2DK7 A;  4A0U A;  2RE3 A;  2LAJ A;  3LKX B;  4REX A;  3TC5 A;  2ZR5 A;  1ZCN A;  2YSG A;  1RP5 A;  1TR8 A;  2Q5A A;  3FSC A;  2ZQS A;  2OWO A;  2ZQV A;  2XP9 A;  3KAH A;  3WH0 A;  4U85 A;  3TCZ A;  4U86 A;  5E62 A;  2JV4 A;  2XP6 A;  3KAG A;  1YW5 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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