2M8IA

Structure of pin1 ww domain
Total Genus 3
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
3
sequence length
43
structure length
43
Chain Sequence
GLEHMADEEKLPPGWEKRMSRSSGRVYYFNHITNASQWERPSG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Isomerase
molecule keywords Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
publication title Molecular crowding drives active Pin1 into nonspecific complexes with endogenous proteins prior to substrate recognition.
pubmed doi rcsb
source organism Homo sapiens
total genus 3
structure length 43
sequence length 43
ec nomenclature ec 5.2.1.8: Peptidylprolyl isomerase.
pdb deposition date 2013-05-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00397 WW WW domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.20.70.10 Mainly Beta Single Sheet Ubiquitin Ligase Nedd4; Chain: W; Ubiquitin Ligase Nedd4; Chain: W; 2m8iA01
1F8AB 2KXQA 3WH0A 3KAIA 2XPAA 1ZCNA 4U85A 1NMVA 4E5RA 1JMQA 3TC5A 3L4HA 1EG4A 3KAGA 2E45A 2XP3A 2EZ5W 2ZQSA 4REXA 2DK1A 1TK7A 3TDBA 2XP4A 3KAFA 2ZAJA 1O6WA 2JV4A 2YSGA 3M7NA 2M8IA 2ZR5A 2JX8A 3NTPA 2MDIA 2LAJA 3OOBA 3M85A 1EG3A 1K9QA 2DWVA 2BA1A 3KCEA 2L4JA 2RE3A 2F21A 2DK7A 2Q5AA 2YSHA 1YW5A 2ZQTA 3ODKA 2JXWA 3KAHA 1WR7A 2XP9A 5CQ2A 4U84A 2XP8A 3CNGA 3KABA 2JMFA 2DJYA 1PINA 1I5HW 2ZQVA 3TCZA 3LE4A 4QIBA 1K9RA 5AHTA 2ZR6A 2YSIA 2XP7A 2M3OW 2YSFA 4U86A 2ITKA 2XP5A 2M8JA 2ZQUA 1WMVA 2XP6A 2XPBA 2ZR4A 3KADA 2YSBA 2DMVA
chains in the Genus database with same CATH superfamily
1F8AB 4GLXA 5E66A 2KXQA 3WH0A 3KAIA 3PQHA 2XPAA 1ZCNA 4U85A 1NMVA 4E5RA 3FS8A 1JMQA 3TC5A 2WADA 3L4HA 1EG4A 3KAGA 5E65A 2E45A 2XP3A 2EZ5W 2ZQSA 4REXA 2DK1A 1TK7A 3TDBA 2XP4A 3KAFA 4A0TA 2ZAJA 3LKXB 1O6WA 2JV4A 3FSBA 2YSGA 3M7NA 2M8IA 2ZR5A 1FLCA 5E5WA 2JX8A 5E64A 3NTPA 2MDIA 2LAJA 3OOBA 3M85A 1EG3A 5U47A 1K9QA 3MCBA 2DWVA 5E62A 2BA1A 3KCEA 2L4JA 2RE3A 2F21A 2DK7A 1RP5A 2Q5AA 3MQHA 2YSHA 1YW5A 2ZQTA 3ODKA 1TR8A 2JXWA 2Y8NB 2YAJB 3KAHA 1WR7A 2XP9A 5CQ2A 4U84A 3FSCA 2XP8A 3CNGA 3KABA 2JMFA 2DJYA 1PINA 1I5HW 2ZQVA 3TCZA 3LE4A 4QIBA 1K9RA 5AHTA 2ZR6A 2YSIA 2WAEA 2XP7A 2M3OW 2YSFA 4U86A 2ITKA 2XP5A 2M8JA 3LKXA 2ZQUA 2OWOA 1WMVA 3MCBB 2QRVA 2XP6A 2XPBA 2ZR4A 3KADA 4A0UA 2YSBA 2DMVA 3MQGA
chains in the Genus database with same CATH topology
1F8AB 4GLXA 5E66A 2KXQA 3WH0A 3KAIA 3PQHA 2XPAA 1ZCNA 4U85A 1NMVA 4E5RA 3FS8A 1JMQA 3TC5A 2WADA 3L4HA 1EG4A 3KAGA 5E65A 2E45A 2XP3A 2EZ5W 2ZQSA 4REXA 2DK1A 1TK7A 3TDBA 2XP4A 3KAFA 4A0TA 2ZAJA 3LKXB 1O6WA 2JV4A 3FSBA 2YSGA 3M7NA 2M8IA 2ZR5A 1FLCA 5E5WA 2JX8A 5E64A 3NTPA 2MDIA 2LAJA 3OOBA 3M85A 1EG3A 5U47A 1K9QA 3MCBA 2DWVA 5E62A 2BA1A 3KCEA 2L4JA 2RE3A 2F21A 2DK7A 1RP5A 2Q5AA 3MQHA 2YSHA 1YW5A 2ZQTA 3ODKA 1TR8A 2JXWA 2Y8NB 2YAJB 3KAHA 1WR7A 2XP9A 5CQ2A 4U84A 3FSCA 2XP8A 3CNGA 3KABA 2JMFA 2DJYA 1PINA 1I5HW 2ZQVA 3TCZA 3LE4A 4QIBA 1K9RA 5AHTA 2ZR6A 2YSIA 2WAEA 2XP7A 2M3OW 2YSFA 4U86A 2ITKA 2XP5A 2M8JA 3LKXA 2ZQUA 2OWOA 1WMVA 3MCBB 2QRVA 2XP6A 2XPBA 2ZR4A 3KADA 4A0UA 2YSBA 2DMVA 3MQGA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1F8A B;  2KXQ A;  3WH0 A;  3KAI A;  2XPA A;  1ZCN A;  4U85 A;  1NMV A;  4E5R A;  1JMQ A;  3TC5 A;  3L4H A;  1EG4 A;  3KAG A;  2E45 A;  2XP3 A;  2EZ5 W;  2ZQS A;  4REX A;  2DK1 A;  1TK7 A;  3TDB A;  2XP4 A;  3KAF A;  2ZAJ A;  1O6W A;  2JV4 A;  2YSG A;  3M7N A;  2M8I A;  2ZR5 A;  2JX8 A;  3NTP A;  2MDI A;  2LAJ A;  3OOB A;  3M85 A;  1EG3 A;  1K9Q A;  2DWV A;  2BA1 A;  3KCE A;  2L4J A;  2RE3 A;  2F21 A;  2DK7 A;  2Q5A A;  2YSH A;  1YW5 A;  2ZQT A;  3ODK A;  2JXW A;  3KAH A;  1WR7 A;  2XP9 A;  5CQ2 A;  4U84 A;  2XP8 A;  3CNG A;  3KAB A;  2JMF A;  2DJY A;  1PIN A;  1I5H W;  2ZQV A;  3TCZ A;  3LE4 A;  4QIB A;  1K9R A;  5AHT A;  2ZR6 A;  2YSI A;  2XP7 A;  2M3O W;  2YSF A;  4U86 A;  2ITK A;  2XP5 A;  2M8J A;  2ZQU A;  1WMV A;  2XP6 A;  2XPB A;  2ZR4 A;  3KAD A;  2YSB A;  2DMV A; 
#chains in the Genus database with same CATH topology
 1F8A B;  4GLX A;  5E66 A;  2KXQ A;  3WH0 A;  3KAI A;  3PQH A;  2XPA A;  1ZCN A;  4U85 A;  1NMV A;  4E5R A;  3FS8 A;  1JMQ A;  3TC5 A;  2WAD A;  3L4H A;  1EG4 A;  3KAG A;  5E65 A;  2E45 A;  2XP3 A;  2EZ5 W;  2ZQS A;  4REX A;  2DK1 A;  1TK7 A;  3TDB A;  2XP4 A;  3KAF A;  4A0T A;  2ZAJ A;  3LKX B;  1O6W A;  2JV4 A;  3FSB A;  2YSG A;  3M7N A;  2M8I A;  2ZR5 A;  1FLC A;  5E5W A;  2JX8 A;  5E64 A;  3NTP A;  2MDI A;  2LAJ A;  3OOB A;  3M85 A;  1EG3 A;  5U47 A;  1K9Q A;  3MCB A;  2DWV A;  5E62 A;  2BA1 A;  3KCE A;  2L4J A;  2RE3 A;  2F21 A;  2DK7 A;  1RP5 A;  2Q5A A;  3MQH A;  2YSH A;  1YW5 A;  2ZQT A;  3ODK A;  1TR8 A;  2JXW A;  2Y8N B;  2YAJ B;  3KAH A;  1WR7 A;  2XP9 A;  5CQ2 A;  4U84 A;  3FSC A;  2XP8 A;  3CNG A;  3KAB A;  2JMF A;  2DJY A;  1PIN A;  1I5H W;  2ZQV A;  3TCZ A;  3LE4 A;  4QIB A;  1K9R A;  5AHT A;  2ZR6 A;  2YSI A;  2WAE A;  2XP7 A;  2M3O W;  2YSF A;  4U86 A;  2ITK A;  2XP5 A;  2M8J A;  3LKX A;  2ZQU A;  2OWO A;  1WMV A;  3MCB B;  2QRV A;  2XP6 A;  2XPB A;  2ZR4 A;  3KAD A;  4A0U A;  2YSB A;  2DMV A;  3MQG A; 
#chains in the Genus database with same CATH homology
 1F8A B;  4GLX A;  5E66 A;  2KXQ A;  3WH0 A;  3KAI A;  3PQH A;  2XPA A;  1ZCN A;  4U85 A;  1NMV A;  4E5R A;  3FS8 A;  1JMQ A;  3TC5 A;  2WAD A;  3L4H A;  1EG4 A;  3KAG A;  5E65 A;  2E45 A;  2XP3 A;  2EZ5 W;  2ZQS A;  4REX A;  2DK1 A;  1TK7 A;  3TDB A;  2XP4 A;  3KAF A;  4A0T A;  2ZAJ A;  3LKX B;  1O6W A;  2JV4 A;  3FSB A;  2YSG A;  3M7N A;  2M8I A;  2ZR5 A;  1FLC A;  5E5W A;  2JX8 A;  5E64 A;  3NTP A;  2MDI A;  2LAJ A;  3OOB A;  3M85 A;  1EG3 A;  5U47 A;  1K9Q A;  3MCB A;  2DWV A;  5E62 A;  2BA1 A;  3KCE A;  2L4J A;  2RE3 A;  2F21 A;  2DK7 A;  1RP5 A;  2Q5A A;  3MQH A;  2YSH A;  1YW5 A;  2ZQT A;  3ODK A;  1TR8 A;  2JXW A;  2Y8N B;  2YAJ B;  3KAH A;  1WR7 A;  2XP9 A;  5CQ2 A;  4U84 A;  3FSC A;  2XP8 A;  3CNG A;  3KAB A;  2JMF A;  2DJY A;  1PIN A;  1I5H W;  2ZQV A;  3TCZ A;  3LE4 A;  4QIB A;  1K9R A;  5AHT A;  2ZR6 A;  2YSI A;  2WAE A;  2XP7 A;  2M3O W;  2YSF A;  4U86 A;  2ITK A;  2XP5 A;  2M8J A;  3LKX A;  2ZQU A;  2OWO A;  1WMV A;  3MCB B;  2QRV A;  2XP6 A;  2XPB A;  2ZR4 A;  3KAD A;  4A0U A;  2YSB A;  2DMV A;  3MQG A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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