2M8IA

Structure of pin1 ww domain
Total Genus 3
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
3
sequence length
43
structure length
43
Chain Sequence
GLEHMADEEKLPPGWEKRMSRSSGRVYYFNHITNASQWERPSG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Molecular crowding drives active Pin1 into nonspecific complexes with endogenous proteins prior to substrate recognition.
pubmed doi rcsb
molecule tags Isomerase
source organism Homo sapiens
molecule keywords Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
total genus 3
structure length 43
sequence length 43
ec nomenclature ec 5.2.1.8: Peptidylprolyl isomerase.
pdb deposition date 2013-05-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00397 WW WW domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.20.70.10 Mainly Beta Single Sheet Ubiquitin Ligase Nedd4; Chain: W; Ubiquitin Ligase Nedd4; Chain: W; 2m8iA01
2F21A 1PINA 3KAGA 4U85A 5CQ2A 2DMVA 2DK7A 2ZAJA 1YW5A 1I5HW 2DJYA 2XP3A 2XP9A 3ODKA 2LAJA 2ZQSA 2JMFA 3L4HA 2M8JA 3TDBA 1JMQA 2XP6A 2ZR5A 2M3OW 3KAHA 2ZR6A 2JV4A 2DK1A 2XP4A 3OOBA 2DWVA 2ZQVA 2RE3A 2YSBA 3KADA 1F8AB 1WMVA 1TK7A 5AHTA 3TCZA 1ZCNA 3M85A 3TC5A 3NTPA 2YSHA 3M7NA 2ZQUA 2YSGA 4QIBA 2YSIA 3KAFA 1EG4A 4U84A 2XP8A 1EG3A 1K9RA 2MDIA 2JXWA 2M8IA 2E45A 3KCEA 2JX8A 4U86A 3KAIA 2XP5A 2XPBA 3KABA 2BA1A 1O6WA 2EZ5W 2L4JA 2ITKA 1NMVA 1WR7A 3LE4A 2YSFA 2XP7A 3CNGA 2Q5AA 2XPAA 4E5RA 2ZR4A 2ZQTA 4REXA 1K9QA 2KXQA 3WH0A
chains in the Genus database with same CATH superfamily
2F21A 3MCBA 1PINA 3KAGA 4U85A 2YAJB 5CQ2A 2DMVA 1FLCA 2DK7A 2ZAJA 1YW5A 2OWOA 1I5HW 2DJYA 2XP3A 5E5WA 2XP9A 3ODKA 5U47A 2LAJA 2ZQSA 2JMFA 5E66A 3FSCA 3L4HA 2QRVA 3FSBA 2M8JA 3TDBA 1JMQA 2XP6A 4A0UA 2ZR5A 2M3OW 4A0TA 3KAHA 2ZR6A 1RP5A 2JV4A 2DK1A 2XP4A 3LKXA 3OOBA 2DWVA 2ZQVA 2RE3A 2YSBA 3LKXB 3KADA 1F8AB 3PQHA 1WMVA 1TK7A 3MCBB 5AHTA 3MQGA 3TCZA 1ZCNA 2WADA 3M85A 3TC5A 3NTPA 2YSHA 3M7NA 2ZQUA 2YSGA 4QIBA 4GLXA 2YSIA 3KAFA 5E64A 1EG4A 4U84A 2XP8A 1EG3A 1K9RA 2MDIA 2JXWA 2M8IA 2E45A 3KCEA 2JX8A 4U86A 3KAIA 2XP5A 2XPBA 3FS8A 3KABA 2BA1A 1O6WA 2WAEA 2EZ5W 1TR8A 2L4JA 2ITKA 1NMVA 1WR7A 3LE4A 2YSFA 2XP7A 2Y8NB 3CNGA 3MQHA 2Q5AA 2XPAA 4E5RA 2ZR4A 2ZQTA 4REXA 1K9QA 5E62A 5E65A 2KXQA 3WH0A
chains in the Genus database with same CATH topology
2F21A 3MCBA 1PINA 3KAGA 4U85A 2YAJB 5CQ2A 2DMVA 1FLCA 2DK7A 2ZAJA 1YW5A 2OWOA 1I5HW 2DJYA 2XP3A 5E5WA 2XP9A 3ODKA 5U47A 2LAJA 2ZQSA 2JMFA 5E66A 3FSCA 3L4HA 2QRVA 3FSBA 2M8JA 3TDBA 1JMQA 2XP6A 4A0UA 2ZR5A 2M3OW 4A0TA 3KAHA 2ZR6A 1RP5A 2JV4A 2DK1A 2XP4A 3LKXA 3OOBA 2DWVA 2ZQVA 2RE3A 2YSBA 3LKXB 3KADA 1F8AB 3PQHA 1WMVA 1TK7A 3MCBB 5AHTA 3MQGA 3TCZA 1ZCNA 2WADA 3M85A 3TC5A 3NTPA 2YSHA 3M7NA 2ZQUA 2YSGA 4QIBA 4GLXA 2YSIA 3KAFA 5E64A 1EG4A 4U84A 2XP8A 1EG3A 1K9RA 2MDIA 2JXWA 2M8IA 2E45A 3KCEA 2JX8A 4U86A 3KAIA 2XP5A 2XPBA 3FS8A 3KABA 2BA1A 1O6WA 2WAEA 2EZ5W 1TR8A 2L4JA 2ITKA 1NMVA 1WR7A 3LE4A 2YSFA 2XP7A 2Y8NB 3CNGA 3MQHA 2Q5AA 2XPAA 4E5RA 2ZR4A 2ZQTA 4REXA 1K9QA 5E62A 5E65A 2KXQA 3WH0A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2F21 A;  1PIN A;  3KAG A;  4U85 A;  5CQ2 A;  2DMV A;  2DK7 A;  2ZAJ A;  1YW5 A;  1I5H W;  2DJY A;  2XP3 A;  2XP9 A;  3ODK A;  2LAJ A;  2ZQS A;  2JMF A;  3L4H A;  2M8J A;  3TDB A;  1JMQ A;  2XP6 A;  2ZR5 A;  2M3O W;  3KAH A;  2ZR6 A;  2JV4 A;  2DK1 A;  2XP4 A;  3OOB A;  2DWV A;  2ZQV A;  2RE3 A;  2YSB A;  3KAD A;  1F8A B;  1WMV A;  1TK7 A;  5AHT A;  3TCZ A;  1ZCN A;  3M85 A;  3TC5 A;  3NTP A;  2YSH A;  3M7N A;  2ZQU A;  2YSG A;  4QIB A;  2YSI A;  3KAF A;  1EG4 A;  4U84 A;  2XP8 A;  1EG3 A;  1K9R A;  2MDI A;  2JXW A;  2M8I A;  2E45 A;  3KCE A;  2JX8 A;  4U86 A;  3KAI A;  2XP5 A;  2XPB A;  3KAB A;  2BA1 A;  1O6W A;  2EZ5 W;  2L4J A;  2ITK A;  1NMV A;  1WR7 A;  3LE4 A;  2YSF A;  2XP7 A;  3CNG A;  2Q5A A;  2XPA A;  4E5R A;  2ZR4 A;  2ZQT A;  4REX A;  1K9Q A;  2KXQ A;  3WH0 A; 
#chains in the Genus database with same CATH topology
 2F21 A;  3MCB A;  1PIN A;  3KAG A;  4U85 A;  2YAJ B;  5CQ2 A;  2DMV A;  1FLC A;  2DK7 A;  2ZAJ A;  1YW5 A;  2OWO A;  1I5H W;  2DJY A;  2XP3 A;  5E5W A;  2XP9 A;  3ODK A;  5U47 A;  2LAJ A;  2ZQS A;  2JMF A;  5E66 A;  3FSC A;  3L4H A;  2QRV A;  3FSB A;  2M8J A;  3TDB A;  1JMQ A;  2XP6 A;  4A0U A;  2ZR5 A;  2M3O W;  4A0T A;  3KAH A;  2ZR6 A;  1RP5 A;  2JV4 A;  2DK1 A;  2XP4 A;  3LKX A;  3OOB A;  2DWV A;  2ZQV A;  2RE3 A;  2YSB A;  3LKX B;  3KAD A;  1F8A B;  3PQH A;  1WMV A;  1TK7 A;  3MCB B;  5AHT A;  3MQG A;  3TCZ A;  1ZCN A;  2WAD A;  3M85 A;  3TC5 A;  3NTP A;  2YSH A;  3M7N A;  2ZQU A;  2YSG A;  4QIB A;  4GLX A;  2YSI A;  3KAF A;  5E64 A;  1EG4 A;  4U84 A;  2XP8 A;  1EG3 A;  1K9R A;  2MDI A;  2JXW A;  2M8I A;  2E45 A;  3KCE A;  2JX8 A;  4U86 A;  3KAI A;  2XP5 A;  2XPB A;  3FS8 A;  3KAB A;  2BA1 A;  1O6W A;  2WAE A;  2EZ5 W;  1TR8 A;  2L4J A;  2ITK A;  1NMV A;  1WR7 A;  3LE4 A;  2YSF A;  2XP7 A;  2Y8N B;  3CNG A;  3MQH A;  2Q5A A;  2XPA A;  4E5R A;  2ZR4 A;  2ZQT A;  4REX A;  1K9Q A;  5E62 A;  5E65 A;  2KXQ A;  3WH0 A; 
#chains in the Genus database with same CATH homology
 2F21 A;  3MCB A;  1PIN A;  3KAG A;  4U85 A;  2YAJ B;  5CQ2 A;  2DMV A;  1FLC A;  2DK7 A;  2ZAJ A;  1YW5 A;  2OWO A;  1I5H W;  2DJY A;  2XP3 A;  5E5W A;  2XP9 A;  3ODK A;  5U47 A;  2LAJ A;  2ZQS A;  2JMF A;  5E66 A;  3FSC A;  3L4H A;  2QRV A;  3FSB A;  2M8J A;  3TDB A;  1JMQ A;  2XP6 A;  4A0U A;  2ZR5 A;  2M3O W;  4A0T A;  3KAH A;  2ZR6 A;  1RP5 A;  2JV4 A;  2DK1 A;  2XP4 A;  3LKX A;  3OOB A;  2DWV A;  2ZQV A;  2RE3 A;  2YSB A;  3LKX B;  3KAD A;  1F8A B;  3PQH A;  1WMV A;  1TK7 A;  3MCB B;  5AHT A;  3MQG A;  3TCZ A;  1ZCN A;  2WAD A;  3M85 A;  3TC5 A;  3NTP A;  2YSH A;  3M7N A;  2ZQU A;  2YSG A;  4QIB A;  4GLX A;  2YSI A;  3KAF A;  5E64 A;  1EG4 A;  4U84 A;  2XP8 A;  1EG3 A;  1K9R A;  2MDI A;  2JXW A;  2M8I A;  2E45 A;  3KCE A;  2JX8 A;  4U86 A;  3KAI A;  2XP5 A;  2XPB A;  3FS8 A;  3KAB A;  2BA1 A;  1O6W A;  2WAE A;  2EZ5 W;  1TR8 A;  2L4J A;  2ITK A;  1NMV A;  1WR7 A;  3LE4 A;  2YSF A;  2XP7 A;  2Y8N B;  3CNG A;  3MQH A;  2Q5A A;  2XPA A;  4E5R A;  2ZR4 A;  2ZQT A;  4REX A;  1K9Q A;  5E62 A;  5E65 A;  2KXQ A;  3WH0 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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