2M8IA

Structure of pin1 ww domain
Total Genus 3
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
3
sequence length
43
structure length
43
Chain Sequence
GLEHMADEEKLPPGWEKRMSRSSGRVYYFNHITNASQWERPSG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
publication title Molecular crowding drives active Pin1 into nonspecific complexes with endogenous proteins prior to substrate recognition.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Isomerase
total genus 3
structure length 43
sequence length 43
ec nomenclature ec 5.2.1.8: Peptidylprolyl isomerase.
pdb deposition date 2013-05-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00397 WW WW domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.20.70.10 Mainly Beta Single Sheet Ubiquitin Ligase Nedd4; Chain: W; Ubiquitin Ligase Nedd4; Chain: W; 2m8iA01
2YSBA 2DJYA 2M8JA 5CQ2A 2L4JA 2XP3A 2JV4A 2YSIA 1PINA 3NTPA 2E45A 2F21A 3KABA 4U84A 2RE3A 2ZQUA 1EG4A 2JMFA 3TDBA 1K9RA 2DK1A 4QIBA 1NMVA 3CNGA 4E5RA 2LAJA 2YSGA 1O6WA 3WH0A 2ZR4A 2XP8A 3TC5A 2ZR5A 4REXA 2JXWA 2DK7A 3KCEA 2ZR6A 1I5HW 2XP7A 2EZ5W 1TK7A 2DMVA 2ZAJA 2YSFA 3KAHA 1F8AB 1K9QA 2ZQTA 2XP9A 3KAGA 3M85A 3LE4A 3KAFA 2Q5AA 2XPAA 4U85A 2XP4A 2XP6A 3KADA 4U86A 2M3OW 3KAIA 2ITKA 2ZQVA 2M8IA 3L4HA 3M7NA 2XPBA 1WR7A 2JX8A 3ODKA 1WMVA 2YSHA 3TCZA 1YW5A 5AHTA 3OOBA 1JMQA 2DWVA 2XP5A 1EG3A 2BA1A 2KXQA 2MDIA 1ZCNA 2ZQSA
chains in the Genus database with same CATH superfamily
2YSBA 3FSBA 2DJYA 2M8JA 5CQ2A 2L4JA 2XP3A 2JV4A 2YSIA 3PQHA 1PINA 5E62A 3NTPA 2E45A 2F21A 3KABA 4U84A 2RE3A 3MCBB 2ZQUA 1EG4A 2JMFA 3TDBA 3LKXB 1K9RA 2DK1A 4QIBA 1NMVA 5E66A 1RP5A 3CNGA 4E5RA 1TR8A 2LAJA 2YSGA 1O6WA 3WH0A 2ZR4A 5E5WA 2XP8A 3TC5A 5E64A 2ZR5A 4REXA 2JXWA 2QRVA 2DK7A 3KCEA 2ZR6A 1I5HW 2XP7A 2EZ5W 1TK7A 2YAJB 3MCBA 2DMVA 2WADA 3LKXA 2ZAJA 2YSFA 3KAHA 1F8AB 1K9QA 2ZQTA 2XP9A 3KAGA 3M85A 3LE4A 3KAFA 2Q5AA 2XPAA 4U85A 2XP4A 2Y8NB 2XP6A 3KADA 4U86A 2M3OW 4A0TA 4A0UA 3KAIA 3MQHA 3MQGA 2ITKA 2ZQVA 2M8IA 2WAEA 3L4HA 3M7NA 3FSCA 4GLXA 2XPBA 1WR7A 2JX8A 3ODKA 1WMVA 5E65A 2YSHA 3TCZA 1FLCA 1YW5A 5AHTA 3OOBA 1JMQA 3FS8A 2DWVA 2XP5A 2OWOA 1EG3A 2BA1A 2KXQA 2MDIA 1ZCNA 2ZQSA 5U47A
chains in the Genus database with same CATH topology
2YSBA 3FSBA 2DJYA 2M8JA 5CQ2A 2L4JA 2XP3A 2JV4A 2YSIA 3PQHA 1PINA 5E62A 3NTPA 2E45A 2F21A 3KABA 4U84A 2RE3A 3MCBB 2ZQUA 1EG4A 2JMFA 3TDBA 3LKXB 1K9RA 2DK1A 4QIBA 1NMVA 5E66A 1RP5A 3CNGA 4E5RA 1TR8A 2LAJA 2YSGA 1O6WA 3WH0A 2ZR4A 5E5WA 2XP8A 3TC5A 5E64A 2ZR5A 4REXA 2JXWA 2QRVA 2DK7A 3KCEA 2ZR6A 1I5HW 2XP7A 2EZ5W 1TK7A 2YAJB 3MCBA 2DMVA 2WADA 3LKXA 2ZAJA 2YSFA 3KAHA 1F8AB 1K9QA 2ZQTA 2XP9A 3KAGA 3M85A 3LE4A 3KAFA 2Q5AA 2XPAA 4U85A 2XP4A 2Y8NB 2XP6A 3KADA 4U86A 2M3OW 4A0TA 4A0UA 3KAIA 3MQHA 3MQGA 2ITKA 2ZQVA 2M8IA 2WAEA 3L4HA 3M7NA 3FSCA 4GLXA 2XPBA 1WR7A 2JX8A 3ODKA 1WMVA 5E65A 2YSHA 3TCZA 1FLCA 1YW5A 5AHTA 3OOBA 1JMQA 3FS8A 2DWVA 2XP5A 2OWOA 1EG3A 2BA1A 2KXQA 2MDIA 1ZCNA 2ZQSA 5U47A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2YSB A;  2DJY A;  2M8J A;  5CQ2 A;  2L4J A;  2XP3 A;  2JV4 A;  2YSI A;  1PIN A;  3NTP A;  2E45 A;  2F21 A;  3KAB A;  4U84 A;  2RE3 A;  2ZQU A;  1EG4 A;  2JMF A;  3TDB A;  1K9R A;  2DK1 A;  4QIB A;  1NMV A;  3CNG A;  4E5R A;  2LAJ A;  2YSG A;  1O6W A;  3WH0 A;  2ZR4 A;  2XP8 A;  3TC5 A;  2ZR5 A;  4REX A;  2JXW A;  2DK7 A;  3KCE A;  2ZR6 A;  1I5H W;  2XP7 A;  2EZ5 W;  1TK7 A;  2DMV A;  2ZAJ A;  2YSF A;  3KAH A;  1F8A B;  1K9Q A;  2ZQT A;  2XP9 A;  3KAG A;  3M85 A;  3LE4 A;  3KAF A;  2Q5A A;  2XPA A;  4U85 A;  2XP4 A;  2XP6 A;  3KAD A;  4U86 A;  2M3O W;  3KAI A;  2ITK A;  2ZQV A;  2M8I A;  3L4H A;  3M7N A;  2XPB A;  1WR7 A;  2JX8 A;  3ODK A;  1WMV A;  2YSH A;  3TCZ A;  1YW5 A;  5AHT A;  3OOB A;  1JMQ A;  2DWV A;  2XP5 A;  1EG3 A;  2BA1 A;  2KXQ A;  2MDI A;  1ZCN A;  2ZQS A; 
#chains in the Genus database with same CATH topology
 2YSB A;  3FSB A;  2DJY A;  2M8J A;  5CQ2 A;  2L4J A;  2XP3 A;  2JV4 A;  2YSI A;  3PQH A;  1PIN A;  5E62 A;  3NTP A;  2E45 A;  2F21 A;  3KAB A;  4U84 A;  2RE3 A;  3MCB B;  2ZQU A;  1EG4 A;  2JMF A;  3TDB A;  3LKX B;  1K9R A;  2DK1 A;  4QIB A;  1NMV A;  5E66 A;  1RP5 A;  3CNG A;  4E5R A;  1TR8 A;  2LAJ A;  2YSG A;  1O6W A;  3WH0 A;  2ZR4 A;  5E5W A;  2XP8 A;  3TC5 A;  5E64 A;  2ZR5 A;  4REX A;  2JXW A;  2QRV A;  2DK7 A;  3KCE A;  2ZR6 A;  1I5H W;  2XP7 A;  2EZ5 W;  1TK7 A;  2YAJ B;  3MCB A;  2DMV A;  2WAD A;  3LKX A;  2ZAJ A;  2YSF A;  3KAH A;  1F8A B;  1K9Q A;  2ZQT A;  2XP9 A;  3KAG A;  3M85 A;  3LE4 A;  3KAF A;  2Q5A A;  2XPA A;  4U85 A;  2XP4 A;  2Y8N B;  2XP6 A;  3KAD A;  4U86 A;  2M3O W;  4A0T A;  4A0U A;  3KAI A;  3MQH A;  3MQG A;  2ITK A;  2ZQV A;  2M8I A;  2WAE A;  3L4H A;  3M7N A;  3FSC A;  4GLX A;  2XPB A;  1WR7 A;  2JX8 A;  3ODK A;  1WMV A;  5E65 A;  2YSH A;  3TCZ A;  1FLC A;  1YW5 A;  5AHT A;  3OOB A;  1JMQ A;  3FS8 A;  2DWV A;  2XP5 A;  2OWO A;  1EG3 A;  2BA1 A;  2KXQ A;  2MDI A;  1ZCN A;  2ZQS A;  5U47 A; 
#chains in the Genus database with same CATH homology
 2YSB A;  3FSB A;  2DJY A;  2M8J A;  5CQ2 A;  2L4J A;  2XP3 A;  2JV4 A;  2YSI A;  3PQH A;  1PIN A;  5E62 A;  3NTP A;  2E45 A;  2F21 A;  3KAB A;  4U84 A;  2RE3 A;  3MCB B;  2ZQU A;  1EG4 A;  2JMF A;  3TDB A;  3LKX B;  1K9R A;  2DK1 A;  4QIB A;  1NMV A;  5E66 A;  1RP5 A;  3CNG A;  4E5R A;  1TR8 A;  2LAJ A;  2YSG A;  1O6W A;  3WH0 A;  2ZR4 A;  5E5W A;  2XP8 A;  3TC5 A;  5E64 A;  2ZR5 A;  4REX A;  2JXW A;  2QRV A;  2DK7 A;  3KCE A;  2ZR6 A;  1I5H W;  2XP7 A;  2EZ5 W;  1TK7 A;  2YAJ B;  3MCB A;  2DMV A;  2WAD A;  3LKX A;  2ZAJ A;  2YSF A;  3KAH A;  1F8A B;  1K9Q A;  2ZQT A;  2XP9 A;  3KAG A;  3M85 A;  3LE4 A;  3KAF A;  2Q5A A;  2XPA A;  4U85 A;  2XP4 A;  2Y8N B;  2XP6 A;  3KAD A;  4U86 A;  2M3O W;  4A0T A;  4A0U A;  3KAI A;  3MQH A;  3MQG A;  2ITK A;  2ZQV A;  2M8I A;  2WAE A;  3L4H A;  3M7N A;  3FSC A;  4GLX A;  2XPB A;  1WR7 A;  2JX8 A;  3ODK A;  1WMV A;  5E65 A;  2YSH A;  3TCZ A;  1FLC A;  1YW5 A;  5AHT A;  3OOB A;  1JMQ A;  3FS8 A;  2DWV A;  2XP5 A;  2OWO A;  1EG3 A;  2BA1 A;  2KXQ A;  2MDI A;  1ZCN A;  2ZQS A;  5U47 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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