2DMVA

Solution structure of the second ww domain of itchy homolog e3 ubiquitin protein ligase (itch)
Total Genus 3
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
3
sequence length
43
structure length
43
Chain Sequence
GSSGSSGLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPSGPSSG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Solution structure of the second ww domain of Itchy homolog E3 ubiquitin protein ligase (Itch)
rcsb
molecule tags Ligase
source organism Homo sapiens
molecule keywords Itchy homolog E3 ubiquitin protein ligase
total genus 3
structure length 43
sequence length 43
ec nomenclature ec 2.3.2.26: HECT-type E3 ubiquitin transferase.
pdb deposition date 2006-04-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00397 WW WW domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.20.70.10 Mainly Beta Single Sheet Ubiquitin Ligase Nedd4; Chain: W; Ubiquitin Ligase Nedd4; Chain: W; 2dmvA01
2JXWA 2XP7A 2M8JA 2XP9A 1NMVA 2L4JA 2XP3A 2EZ5W 3OOBA 2RE3A 1WR7A 4U84A 2XP5A 3TC5A 3WH0A 3M7NA 2Q5AA 2YSBA 2DMVA 2YSIA 2LAJA 3KAGA 2DWVA 2YSHA 3LE4A 4QIBA 1YW5A 2XP6A 4E5RA 5AHTA 1K9QA 2E45A 3TDBA 5CQ2A 1EG4A 2XPBA 2ZAJA 4U85A 1JMQA 2ZR6A 2M3OW 3KAHA 2KXQA 2DK1A 2DJYA 2ITKA 2ZQSA 2XP4A 4U86A 2DK7A 3TCZA 2XP8A 3KAFA 3M85A 1EG3A 2JV4A 1ZCNA 2YSGA 2YSFA 2ZR5A 1TK7A 3KABA 2M8IA 1I5HW 1PINA 1O6WA 2ZR4A 2JMFA 3KAIA 3CNGA 2ZQVA 2XPAA 3ODKA 1F8AB 2JX8A 2F21A 2ZQTA 1WMVA 3KCEA 1K9RA 3NTPA 3KADA 3L4HA 4REXA 2BA1A 2ZQUA 2MDIA
chains in the Genus database with same CATH superfamily
2JXWA 2XP7A 2M8JA 2XP9A 2OWOA 1NMVA 1TR8A 2L4JA 2XP3A 2EZ5W 2QRVA 3OOBA 2RE3A 1WR7A 4U84A 2XP5A 3TC5A 3WH0A 3M7NA 2Q5AA 2YSBA 2DMVA 2YSIA 5E66A 2LAJA 5U47A 3KAGA 3FSBA 2DWVA 2YSHA 3LE4A 4QIBA 1YW5A 2XP6A 4E5RA 5AHTA 1K9QA 2E45A 3TDBA 3LKXB 3LKXA 5CQ2A 1EG4A 2XPBA 2ZAJA 4U85A 1JMQA 2ZR6A 2M3OW 3KAHA 2KXQA 5E64A 4A0UA 2DK1A 2DJYA 2ITKA 2ZQSA 2XP4A 4U86A 2DK7A 5E65A 3TCZA 2XP8A 3KAFA 3M85A 1EG3A 2JV4A 3PQHA 1ZCNA 2YSGA 2YSFA 2ZR5A 1TK7A 4GLXA 3MCBB 3KABA 3MCBA 2M8IA 2YAJB 1I5HW 2Y8NB 1PINA 1O6WA 2ZR4A 1FLCA 3MQGA 2JMFA 5E62A 3KAIA 2WAEA 3CNGA 2ZQVA 2XPAA 3ODKA 1F8AB 2JX8A 2F21A 5E5WA 2ZQTA 1WMVA 3FS8A 3KCEA 1K9RA 4A0TA 2WADA 3MQHA 1RP5A 3FSCA 3KADA 3L4HA 3NTPA 4REXA 2BA1A 2ZQUA 2MDIA
chains in the Genus database with same CATH topology
2JXWA 2XP7A 2M8JA 2XP9A 2OWOA 1NMVA 1TR8A 2L4JA 2XP3A 2EZ5W 2QRVA 3OOBA 2RE3A 1WR7A 4U84A 2XP5A 3TC5A 3WH0A 3M7NA 2Q5AA 2YSBA 2DMVA 2YSIA 5E66A 2LAJA 5U47A 3KAGA 3FSBA 2DWVA 2YSHA 3LE4A 4QIBA 1YW5A 2XP6A 4E5RA 5AHTA 1K9QA 2E45A 3TDBA 3LKXB 3LKXA 5CQ2A 1EG4A 2XPBA 2ZAJA 4U85A 1JMQA 2ZR6A 2M3OW 3KAHA 2KXQA 5E64A 4A0UA 2DK1A 2DJYA 2ITKA 2ZQSA 2XP4A 4U86A 2DK7A 5E65A 3TCZA 2XP8A 3KAFA 3M85A 1EG3A 2JV4A 3PQHA 1ZCNA 2YSGA 2YSFA 2ZR5A 1TK7A 4GLXA 3MCBB 3KABA 3MCBA 2M8IA 2YAJB 1I5HW 2Y8NB 1PINA 1O6WA 2ZR4A 1FLCA 3MQGA 2JMFA 5E62A 3KAIA 2WAEA 3CNGA 2ZQVA 2XPAA 3ODKA 1F8AB 2JX8A 2F21A 5E5WA 2ZQTA 1WMVA 3FS8A 3KCEA 1K9RA 4A0TA 2WADA 3MQHA 1RP5A 3FSCA 3KADA 3L4HA 3NTPA 4REXA 2BA1A 2ZQUA 2MDIA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2JXW A;  2XP7 A;  2M8J A;  2XP9 A;  1NMV A;  2L4J A;  2XP3 A;  2EZ5 W;  3OOB A;  2RE3 A;  1WR7 A;  4U84 A;  2XP5 A;  3TC5 A;  3WH0 A;  3M7N A;  2Q5A A;  2YSB A;  2DMV A;  2YSI A;  2LAJ A;  3KAG A;  2DWV A;  2YSH A;  3LE4 A;  4QIB A;  1YW5 A;  2XP6 A;  4E5R A;  5AHT A;  1K9Q A;  2E45 A;  3TDB A;  5CQ2 A;  1EG4 A;  2XPB A;  2ZAJ A;  4U85 A;  1JMQ A;  2ZR6 A;  2M3O W;  3KAH A;  2KXQ A;  2DK1 A;  2DJY A;  2ITK A;  2ZQS A;  2XP4 A;  4U86 A;  2DK7 A;  3TCZ A;  2XP8 A;  3KAF A;  3M85 A;  1EG3 A;  2JV4 A;  1ZCN A;  2YSG A;  2YSF A;  2ZR5 A;  1TK7 A;  3KAB A;  2M8I A;  1I5H W;  1PIN A;  1O6W A;  2ZR4 A;  2JMF A;  3KAI A;  3CNG A;  2ZQV A;  2XPA A;  3ODK A;  1F8A B;  2JX8 A;  2F21 A;  2ZQT A;  1WMV A;  3KCE A;  1K9R A;  3NTP A;  3KAD A;  3L4H A;  4REX A;  2BA1 A;  2ZQU A;  2MDI A; 
#chains in the Genus database with same CATH topology
 2JXW A;  2XP7 A;  2M8J A;  2XP9 A;  2OWO A;  1NMV A;  1TR8 A;  2L4J A;  2XP3 A;  2EZ5 W;  2QRV A;  3OOB A;  2RE3 A;  1WR7 A;  4U84 A;  2XP5 A;  3TC5 A;  3WH0 A;  3M7N A;  2Q5A A;  2YSB A;  2DMV A;  2YSI A;  5E66 A;  2LAJ A;  5U47 A;  3KAG A;  3FSB A;  2DWV A;  2YSH A;  3LE4 A;  4QIB A;  1YW5 A;  2XP6 A;  4E5R A;  5AHT A;  1K9Q A;  2E45 A;  3TDB A;  3LKX B;  3LKX A;  5CQ2 A;  1EG4 A;  2XPB A;  2ZAJ A;  4U85 A;  1JMQ A;  2ZR6 A;  2M3O W;  3KAH A;  2KXQ A;  5E64 A;  4A0U A;  2DK1 A;  2DJY A;  2ITK A;  2ZQS A;  2XP4 A;  4U86 A;  2DK7 A;  5E65 A;  3TCZ A;  2XP8 A;  3KAF A;  3M85 A;  1EG3 A;  2JV4 A;  3PQH A;  1ZCN A;  2YSG A;  2YSF A;  2ZR5 A;  1TK7 A;  4GLX A;  3MCB B;  3KAB A;  3MCB A;  2M8I A;  2YAJ B;  1I5H W;  2Y8N B;  1PIN A;  1O6W A;  2ZR4 A;  1FLC A;  3MQG A;  2JMF A;  5E62 A;  3KAI A;  2WAE A;  3CNG A;  2ZQV A;  2XPA A;  3ODK A;  1F8A B;  2JX8 A;  2F21 A;  5E5W A;  2ZQT A;  1WMV A;  3FS8 A;  3KCE A;  1K9R A;  4A0T A;  2WAD A;  3MQH A;  1RP5 A;  3FSC A;  3KAD A;  3L4H A;  3NTP A;  4REX A;  2BA1 A;  2ZQU A;  2MDI A; 
#chains in the Genus database with same CATH homology
 2JXW A;  2XP7 A;  2M8J A;  2XP9 A;  2OWO A;  1NMV A;  1TR8 A;  2L4J A;  2XP3 A;  2EZ5 W;  2QRV A;  3OOB A;  2RE3 A;  1WR7 A;  4U84 A;  2XP5 A;  3TC5 A;  3WH0 A;  3M7N A;  2Q5A A;  2YSB A;  2DMV A;  2YSI A;  5E66 A;  2LAJ A;  5U47 A;  3KAG A;  3FSB A;  2DWV A;  2YSH A;  3LE4 A;  4QIB A;  1YW5 A;  2XP6 A;  4E5R A;  5AHT A;  1K9Q A;  2E45 A;  3TDB A;  3LKX B;  3LKX A;  5CQ2 A;  1EG4 A;  2XPB A;  2ZAJ A;  4U85 A;  1JMQ A;  2ZR6 A;  2M3O W;  3KAH A;  2KXQ A;  5E64 A;  4A0U A;  2DK1 A;  2DJY A;  2ITK A;  2ZQS A;  2XP4 A;  4U86 A;  2DK7 A;  5E65 A;  3TCZ A;  2XP8 A;  3KAF A;  3M85 A;  1EG3 A;  2JV4 A;  3PQH A;  1ZCN A;  2YSG A;  2YSF A;  2ZR5 A;  1TK7 A;  4GLX A;  3MCB B;  3KAB A;  3MCB A;  2M8I A;  2YAJ B;  1I5H W;  2Y8N B;  1PIN A;  1O6W A;  2ZR4 A;  1FLC A;  3MQG A;  2JMF A;  5E62 A;  3KAI A;  2WAE A;  3CNG A;  2ZQV A;  2XPA A;  3ODK A;  1F8A B;  2JX8 A;  2F21 A;  5E5W A;  2ZQT A;  1WMV A;  3FS8 A;  3KCE A;  1K9R A;  4A0T A;  2WAD A;  3MQH A;  1RP5 A;  3FSC A;  3KAD A;  3L4H A;  3NTP A;  4REX A;  2BA1 A;  2ZQU A;  2MDI A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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